| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress. Brain research. vol 1701. 2019-11-04. PMID:30244113. |
in conclusion, our study revealed that resveratrol and dmf exerted promising antidepressant-like effects in cums rats that are mediated in part by suppressing the neuroinflammation, oxidative stress, apoptosis and up-regulating hippocampal bdnf and β-catenin levels. |
2019-11-04 |
2023-08-13 |
rat |
| Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa Liu, Feng-Yi Yan. Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction. Scientific reports. vol 8. issue 1. 2019-10-03. PMID:29615782. |
lipus pretreatment could also significantly decrease the neuronal cell apoptosis and upregulation of apoptosis-related signaling molecules and downregulation of brain-derived neurotrophic factor (bdnf) in brain tissues of mcao-treated mice. |
2019-10-03 |
2023-08-13 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa Liu, Feng-Yi Yan. Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction. Scientific reports. vol 8. issue 1. 2019-10-03. PMID:29615782. |
these results demonstrate that lipus effectively prevented the cerebral ischemia/reperfusion injury through apoptosis reduction and bdnf induction in a mcao mouse model. |
2019-10-03 |
2023-08-13 |
mouse |
| Maria S Spagnuolo, Aldo Donizetti, Lucia Iannotta, Vincenza Aliperti, Chiara Cupidi, Amalia C Bruni, Luisa Ciglian. Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29323721. |
the level of apoptosis markers, that is, cleaved caspase 3 and poly adp ribose polymerase (parp), was found increased in neurons treated with high cholesterol, but significantly lower when the cells were exposed to cholesterol in the presence of bdnf, thus suggesting a neuroprotective role of the neurotrophin, likely through its reducing effect of neuronal cholesterol uptake. |
2019-09-30 |
2023-08-13 |
human |
| Nandini H S, Yam Nath Paudel, Krishna K . Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk. Life sciences. vol 233. 2019-09-30. PMID:31348946. |
however, there is a growing understanding that metformin demonstrates its anti-epileptic effect mainly via ameliorating brain oxidative damage, activation of ampk, inhibition of mtor pathway, downregulation of α-synuclein, reducing apoptosis, downregulation of bdnf and trkb level. |
2019-09-30 |
2023-08-13 |
Not clear |
| Khaled S Abd-Elrahman, Stephen S G Ferguso. Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice. Molecular brain. vol 12. issue 1. 2019-07-31. PMID:30961637. |
we also show that ctep can facilitate camp response element-binding protein (creb)-mediated expression of brain-derived neurotrophic factor (bdnf) to foster neuronal survival and reduce apoptosis. |
2019-07-31 |
2023-08-13 |
mouse |
| Xinwang Ying, Wenzhan Tu, Sisi Li, Qiaoyun Wu, Xiaolong Chen, Ye Zhou, Jie Hu, Guanhu Yang, Songhe Jian. Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats. Life sciences. vol 229. 2019-07-05. PMID:31108095. |
we found hbot suppressed dendritic/synaptic degeneration and alleviated apoptosis, consistent with the increase of bdnf and trkb expression and improved neurological recovery. |
2019-07-05 |
2023-08-13 |
rat |
| Julieta Saba, Juan Turati, Delia Ramírez, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Carus. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29851427. |
we found that bdnf increased astrocyte viability, preventing apoptosis induced by serum deprivation by decreasing active caspase 3 and p53 expression. |
2019-06-26 |
2023-08-13 |
Not clear |
| L Gao, P Yan, F F Guo, H J Liu, Z F Zha. MiR-1-3p inhibits cell proliferation and invasion by regulating BDNF-TrkB signaling pathway in bladder cancer. Neoplasma. vol 65. issue 1. 2019-06-25. PMID:29322793. |
transfections of mir-1-3p mimics and bdnf sirnas can suppress bc cell proliferation, invasion and induce cell apoptosis. |
2019-06-25 |
2023-08-13 |
Not clear |
| R Ranjithkumar, Qasim Alhadidi, Zahoor A Shah, Muthiah Ramanatha. Tribulusterine Containing Tribulus terrestris Extract Exhibited Neuroprotection Through Attenuating Stress Kinases Mediated Inflammatory Mechanism: In Vitro and In Vivo Studies. Neurochemical research. vol 44. issue 5. 2019-06-11. PMID:30863969. |
the present study has been aimed to explore the different secondary messengers of the inflammatory pathway nf-κb, kinases (jnk, p38mapk, gsk3β/βcatenin), apoptosis pathway (caspase-3 and aif), and neuronal survival pathway (bdnf) in order to understand the neuroprotective mechanism of aqueous extract of tribulus terrestris (aqtt). |
2019-06-11 |
2023-08-13 |
Not clear |
| Ola A Salama, Maha M Attia, Mohamed A S Abdelraze. Modulatory effects of swimming exercise against malathion induced neurotoxicity in male and female rats. Pesticide biochemistry and physiology. vol 157. 2019-06-10. PMID:31153460. |
therefore, this study was planned to assess the modulatory effects of regular exercise performance on brain bdnf level, cholinergic activity, oxidative stress and apoptosis in male and female rats subjected to neurotoxicity induced by malathion administration. |
2019-06-10 |
2023-08-13 |
rat |
| Yan Luo, Daogong Zhang, Yueling Chen, Zhongsheng Cao, Zhaomin Fa. Dexamethasone protects against arsanilic acid‑induced rat vestibular dysfunction through the BDNF and JNK 1/2 signaling pathways. Molecular medicine reports. vol 19. issue 3. 2019-05-31. PMID:30628712. |
in brain tissues, histopathological alterations, cell apoptosis, expression levels and patterns of bdnf signaling pathway‑associated bdnf, tyrosine receptor kinase b (trkb) and k+/cl‑ cotransporter isoform 2 (kcc2), and the expression of apoptosis‑related cleaved‑caspase 3 and the jnk signaling pathway were detected. |
2019-05-31 |
2023-08-13 |
rat |
| Yan Luo, Daogong Zhang, Yueling Chen, Zhongsheng Cao, Zhaomin Fa. Dexamethasone protects against arsanilic acid‑induced rat vestibular dysfunction through the BDNF and JNK 1/2 signaling pathways. Molecular medicine reports. vol 19. issue 3. 2019-05-31. PMID:30628712. |
it was identified that dxms relieved aa‑induced vestibular dysfunction, leading to improvement in rat behavior scores to normal levels, minimizing brain damage at the histopatholojnnkngical level, reducing cell apoptosis, enhancing the expression of bdnf, trkb and kcc2, and downregulating cleaved‑caspase 3 and phosphorylated‑jnk1/2 in brain tissues. |
2019-05-31 |
2023-08-13 |
rat |
| Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian, Sara Soleimani As. Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats. The journal of physiological sciences : JPS. vol 69. issue 2. 2019-05-28. PMID:30680641. |
different doses of methamphetamine alter long-term potentiation, level of bdnf and neuronal apoptosis in the hippocampus of reinstated rats. |
2019-05-28 |
2023-08-13 |
rat |
| Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian, Sara Soleimani As. Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats. The journal of physiological sciences : JPS. vol 69. issue 2. 2019-05-28. PMID:30680641. |
therefore, we investigated the effects of different doses of meth on long-term potentiation (ltp), bdnf expression and neuronal apoptosis in the hippocampus of reinstated rats. |
2019-05-28 |
2023-08-13 |
rat |
| Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian, Sara Soleimani As. Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats. The journal of physiological sciences : JPS. vol 69. issue 2. 2019-05-28. PMID:30680641. |
following implementation of the reinstatement model, electrophysiology, western blotting and tunel assay were performed to assess behavior, ltp components, bdnf expression, and neuronal apoptosis, respectively. |
2019-05-28 |
2023-08-13 |
rat |
| Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian, Sara Soleimani As. Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats. The journal of physiological sciences : JPS. vol 69. issue 2. 2019-05-28. PMID:30680641. |
these results suggest that alterations in synaptic plasticity, expression of bdnf and neuronal apoptosis in the hippocampus has a vital role in the context-induced reinstatement of meth seeking. |
2019-05-28 |
2023-08-13 |
rat |
| Ganlin Zhu, Yiming Liu, Ye Zhi, Yang Jin, Jinlong Li, Weiwei Shi, Yuting Liu, Yu Han, Shali Yu, Junkang Jiang, Xinyuan Zha. PKA- and Ca Toxicology letters. vol 309. 2019-05-06. PMID:30951808. |
furthermore, downregulation of creb with shrna plasmid transfection significantly worsened the pc12 cell apoptosis by decreasing mrna and protein expression of brain-derived neurotrophic factor (bdnf). |
2019-05-06 |
2023-08-13 |
mouse |
| Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakil. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke. Neurochemical research. vol 43. issue 8. 2019-04-01. PMID:29882126. |
irisin peptide protects brain against ischemic injury through reducing apoptosis and enhancing bdnf in a rodent model of stroke. |
2019-04-01 |
2023-08-13 |
mouse |
| Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakil. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke. Neurochemical research. vol 43. issue 8. 2019-04-01. PMID:29882126. |
the present study aimed to assess the effects of recombinant irisin on the infarct size, neurological outcomes, blood-brain barrier (bbb) permeability, apoptosis and brain-derived neurotrophic factor (bdnf) expression in a mouse model of stroke. |
2019-04-01 |
2023-08-13 |
mouse |