| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Kang, Qiumin Qu, Zhen Xie, Bingqing Ca. NDRG4 Alleviates Aβ1-40 Induction of SH-SY5Y Cell Injury via Activation of BDNF-Inducing Signalling Pathways. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32166572. |
we also determined that the inhibitory effects of ndrg4 on cell apoptosis and reactive oxygen species release were partially reversed by bdnf silencing, and by application of the pi3k specific inhibitor (ly294002) or erk inhibitor (pd98059). |
2021-03-29 |
2023-08-13 |
Not clear |
| Chul Jung, Mi Hee Kim, Ye Yeong Kim, Ji Ae Kim, Eun Jae Ko, Seung Hak Lee, Dae Yul Ki. Determining the Optimal Administration Conditions under Which MIF Exerts Neuroprotective Effects by Inducing BDNF Expression and Inhibiting Apoptosis in an In Vitro Stroke Model. Brain sciences. vol 11. issue 2. 2021-03-16. PMID:33672416. |
determining the optimal administration conditions under which mif exerts neuroprotective effects by inducing bdnf expression and inhibiting apoptosis in an in vitro stroke model. |
2021-03-16 |
2023-08-13 |
human |
| Chul Jung, Mi Hee Kim, Ye Yeong Kim, Ji Ae Kim, Eun Jae Ko, Seung Hak Lee, Dae Yul Ki. Determining the Optimal Administration Conditions under Which MIF Exerts Neuroprotective Effects by Inducing BDNF Expression and Inhibiting Apoptosis in an In Vitro Stroke Model. Brain sciences. vol 11. issue 2. 2021-03-16. PMID:33672416. |
macrophage migration inhibitory factor (mif) exerts neuroprotective effects against cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis and inducing the expression of brain-derived neurotrophic factor (bdnf). |
2021-03-16 |
2023-08-13 |
human |
| Lei Tong, Ming-Da Li, Peng-Yin Nie, Yao Chen, Yu-Lu Chen, Li-Li J. miR-132 downregulation alleviates behavioral impairment of rats exposed to single prolonged stress, reduces the level of apoptosis in PFC, and upregulates the expression of MeCP2 and BDNF. Neurobiology of stress. vol 14. 2021-03-16. PMID:33718536. |
mir-132 downregulation alleviates behavioral impairment of rats exposed to single prolonged stress, reduces the level of apoptosis in pfc, and upregulates the expression of mecp2 and bdnf. |
2021-03-16 |
2023-08-13 |
rat |
| Anna O Giarratana, Cynthia Zheng, Sahithi Reddi, Shavonne L Teng, David Berger, Derek Adler, Patrick Sullivan, Smita Thakker-Varia, Janet Alde. APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Scientific reports. vol 10. issue 1. 2021-03-11. PMID:33199792. |
relative to injured apoe3 tr mice, injured apoe4 tr mice had more inflammation, neurodegeneration, apoptosis, p-tau, and activated microglia and less total brain-derived neurotrophic factor (bdnf) in the cortex and/or hippocampus at 1 and/or 21 days post-injury. |
2021-03-11 |
2023-08-13 |
mouse |
| Honghong Zhang, Xiaohui Chen, Ting Zheng, Mingxue Lin, Pinzhong Chen, Yanling Liao, Cansheng Gong, Fei Gao, Xiaochun Zhen. Amitriptyline Protects Against Lidocaine-induced Neurotoxicity in SH-SY5Y Cells via Inhibition of BDNF-mediated Autophagy. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:33156513. |
the overexpression of bdnf or application of exogenous recombinant bdnf significantly suppressed autophagy and protected sh-sy5y cells from apoptosis induced by lido, whereas the neuroprotection of ami was abolished by either knockdown of bdnf or use of a tropomyosin-related kinase b (trkb) inhibitor ana-12 in sh-sy5y cells. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Efthalia Angelopoulou, Christina Piper. Beneficial Effects of Fingolimod in Alzheimer's Disease: Molecular Mechanisms and Therapeutic Potential. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31313064. |
recent in vitro and in vivo evidence indicate that fingolimod may suppress aβ secretion and deposition, inhibit apoptosis and enhance brain-derived neurotrophic factor (bdnf) production. |
2021-01-22 |
2023-08-13 |
Not clear |
| Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet, Nathalie Gachard, Julie Abraham, Arnaud Jaccard, Danielle Troutaud, Fabrice Lalloué, Thomas Naves, Anne-Laure Fauchais, Marie-Odile Jaubertea. BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32724091. |
previously, we demonstrated that brain-derived neurotrophic factor (bdnf) protects b-cll cells from spontaneous apoptosis by activating the oncogenic complex ntsr2-trkb (neurotensin receptor 2-tropomyosin-related kinase receptor b), only overexpressed in b-cll cells, inducing anti-apoptotic protein bcl-2 (b-cell lymphoma 2) expression and src kinase survival signaling pathways. |
2020-12-11 |
2023-08-13 |
Not clear |
| Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet, Nathalie Gachard, Julie Abraham, Arnaud Jaccard, Danielle Troutaud, Fabrice Lalloué, Thomas Naves, Anne-Laure Fauchais, Marie-Odile Jaubertea. BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32724091. |
inhibition of bdnf in co-cultures, enhances b-cll apoptosis, whereas its exogenous recombinant activates pro-survival pathways in b-cll cultured alone (i.e. |
2020-12-11 |
2023-08-13 |
Not clear |
| Hongxia Che, Lingyu Zhang, Lin Ding, Wancui Xie, Xiaoming Jiang, Changhu Xue, Tiantian Zhang, Yuming Wan. EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. Food & function. vol 11. issue 2. 2020-11-23. PMID:32043504. |
in the present study, primary cultured hippocampal neurons and cognitive deficiency rats were used to compare the effects of epa-ppe and epa-pe on brain-derived neurotrophic factor (bdnf)/tropomyosin receptor kinase b (trkb)/camp response element-binding protein (creb) signaling and neuronal apoptosis. |
2020-11-23 |
2023-08-13 |
rat |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Xiqiong Han, Bilei Wang, Yuning Sun, Jia Huang, Xin Wang, Wenqi Ma, Yi Zhu, Rongfeng Xu, Hong Jin, Naifeng Li. Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30459620. |
in our study, we demonstrated that high glucose (hg) reduced cell proliferation and induced cell apoptosis via changes in bdnf expression and that metformin reversed the effects of hg injury by upregulating bdnf expression. |
2020-10-01 |
2023-08-13 |
human |
| Yu Zhao, Jinling Wang, Jiwei Du, Baixiang Li, Xingchun Gou, Jiannan Liu, Lichao Hou, Hanfei Sang, Bin Den. TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618628. |
furthermore, tat-ngn2 alleviated hippocampal neuronal damage and apoptosis, and inhibited the cytochrome c (cytc) leak from the mitochondria to the cytoplasm through regulating the expression levels of brain-derived neurotrophic factor (bdnf), phosphorylation tropomyosin-related kinase b (ptrkb), bcl-2, bax and cleaved caspase-3 after reperfusion injury |
2020-10-01 |
2023-08-13 |
mouse |
| Pouneh Kermani, Barbara Hempstea. BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury. Frontiers in physiology. vol 10. 2020-10-01. PMID:31105581. |
here we review the compartmentally distinct realm of cardiac myocytes, vascular smooth muscle cells, endothelial cells, and hematopoietic cells, focusing upon the actions of bdnf to modulate contractility, migration, neoangiogenesis, apoptosis and survival. |
2020-10-01 |
2023-08-13 |
Not clear |
| Y-H Wang, B-L Huo, C Li, G Ma, W Ca. Knockdown of long noncoding RNA SNHG7 inhibits the proliferation and promotes apoptosis of thyroid cancer cells by downregulating BDNF. European review for medical and pharmacological sciences. vol 23. issue 11. 2020-10-01. PMID:31210313. |
knockdown of long noncoding rna snhg7 inhibits the proliferation and promotes apoptosis of thyroid cancer cells by downregulating bdnf. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & diseases. vol 6. issue 4. 2020-10-01. PMID:31832525. |
moreover, we found that ndrg4 increased expression of bdnf, which is strongly related to cerebral ischemia and cellular apoptosis. |
2020-10-01 |
2023-08-13 |
rat |
| Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & diseases. vol 6. issue 4. 2020-10-01. PMID:31832525. |
altogether, our findings demonstrate that ndrg4 protects cerebral ir injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing bdnf expression. |
2020-10-01 |
2023-08-13 |
rat |