| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
downregulation of mir-383 significantly inhibited the apoptosis and inflammatory response of hippocampal neurons, and increased the expression levels of gfap, bdnf and creb which were impacted in depression, as well as neurotransmitters, then attenuated neural injury in rats induced by cums. |
2021-11-08 |
2023-08-13 |
rat |
| Meysam Hassani Moghaddam, Mahdi Eskandarian Boroujeni, Kimia Vakili, Mobina Fathi, Mohammad-Amin Abdollahifar, Neda Eskandari, Tahereh Esmaeilpour, Abbas Aliaghae. Functional and structural alternations in the choroid plexus upon methamphetamine exposure. Neuroscience letters. vol 764. 2021-11-08. PMID:34530114. |
moreover, the upregulation of neurotrophic factors such as bdnf and vegf as well as autophagy and apoptosis gene following meth administration were observed. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiaomei Yang, Tracey A Martin, Wen Guo Jian. Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255678. |
a set of anti-bdnf ribozymes were used to transfect colon cancer cells in order to generate bdnf knockdown cells to evaluate the effect on growth and apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Xiaomei Yang, Tracey A Martin, Wen Guo Jian. Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255678. |
it is concluded that bdnf, a neurotrophic growth factor aberrantly expressed in cancers such as colon cancer, has a profound impact on the cellular behavior of colon cancer cells and that bdnf is associated with a reduction in the apoptosis of colon cancer. |
2021-10-21 |
2023-08-12 |
human |
| Ai Chen, Li-Jing Xiong, Yu Tong, Meng Ma. The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648914. |
we initially examined the background of bdnf, and then focused on its neuroprotective mechanisms against ischemic brain injury, including its involvement in promoting neural regeneration/cognition/memory rehabilitation, angiogenesis within ischemic penumbra and the inhibition of the inflammatory process, neurotoxicity, epilepsy and apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Chen Xiang-Xin, Tao Tao, Gao Sen, Wang Han, Zhou Xiao-Ming, Gao Yong-Yue, Hang Chun-Hua, Li We. Knock-Down of CD24 in Astrocytes Aggravates Oxyhemoglobin-Induced Hippocampal Neuron Impairment. Neurochemical research. 2021-10-19. PMID:34665391. |
aggravated neuronal apoptosis was induced by the cd24 downregulation in astrocytes, which might be a result of a lower level of brain derived neurotrophic factor (bdnf). |
2021-10-19 |
2023-08-13 |
Not clear |
| Ningning Wang, Bailing Tia. Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630647. |
besides the role of bdnf in neuron repair, circulatory bdnf also enhances the proliferation and reduces apoptosis of lymphocytes. |
2021-10-12 |
2023-08-13 |
Not clear |
| Xuncui Wang, Wen Xu, Hejuntao Chen, Weizu Li, Weiping Li, Guoqi Zh. Astragaloside IV prevents Aβ Brain research. vol 1747. 2021-10-07. PMID:32739157. |
importantly, exogenous bdnf protected against neurotoxicity and apoptosis induced by aβo, whereas inhibition of pparγ reversed protective effects of as-iv against these outcomes. |
2021-10-07 |
2023-08-13 |
Not clear |
| Yangliang Yang, Jing Yi, Mengzhi Pan, Baoji Hu, Hongwei Dua. Edaravone alleviated propofol-induced neural injury in developing rats by BDNF/TrkB pathway. Journal of cellular and molecular medicine. vol 25. issue 11. 2021-09-30. PMID:33932098. |
additionally, the intraperitoneal injection of edaravone, the intraperitoneal injection of the brain-derived neurotrophic factor (bdnf)-mimicking small compound (7,8 dihydroxyflavone) and the intracranial injection of the exogenous bdnf were all respectively effective in alleviating the propofol-induced neural apoptosis and inflammation in the hippocampus. |
2021-09-30 |
2023-08-13 |
rat |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
ma-induced neurotoxicity is related to the down-regulation of bdnf and apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
thp attenuated the ma-induced neurotoxicity by decreasing cam, increasing trkb, phosphorylating akt, up-regulating nf-κb and bdnf, and inhibiting cell apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Wei Ma, Xiaowei Wei, Hui Gu, Dan Liu, Wenting Luo, Dong An, Yuzuo Bai, Zhengwei Yua. Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model. Gene therapy. vol 27. issue 12. 2021-08-18. PMID:32094517. |
we found that most of the overexpressed bdnf was present on the lesions of the spina bifida fetuses, the number of apoptosis cells in ad-gfp-bdnf-transfected spinal cords were reduced, mrna levels of bcl2/bax were upregulated and casp3 were downregulated compared with the controls, the proportion of brn3a positive neurons in drg were increased by activating the bdnf/trkb/akt signaling pathway, and most of the significant changes in cytokines in the amniotic fluid were related to the biological processes of regulation of apoptotic process and generation of neurons. |
2021-08-18 |
2023-08-13 |
rat |
| Candelaria Martín-González, Lucía Romero-Acevedo, Camino María Fernández-Rodríguez, Lilian Medina-Vega, Alen García-Rodríguez, Paula Ortega-Toledo, Lourdes González-Navarrete, Víctor Eugenio Vera-Delgado, Emilio González-Reimer. Brain-derived neurotrophic factor among patients with alcoholism. CNS spectrums. vol 26. issue 4. 2021-08-18. PMID:32423492. |
brain-derived neurotrophic factor (bdnf) is involved in neurogenesis and in the protection against oxidative damage and neuronal apoptosis. |
2021-08-18 |
2023-08-13 |
Not clear |
| Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-As. From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 1. 2021-08-17. PMID:32446786. |
brain-derived neurotrophic factor (bdnf) and serotonin are two neurotransmitters that can control cardiomyocyte apoptosis and myocardial fibrosis through their cardiac receptors. |
2021-08-17 |
2023-08-13 |
Not clear |
| Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-As. From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 1. 2021-08-17. PMID:32446786. |
in the present study, we investigated the impacts of l. plantarum and inulin supplementation on the inhibition of cardiac apoptosis and fibrosis by modulating intestinal, serum, and cardiac levels of serotonin and bdnf as well as their cardiac receptors. |
2021-08-17 |
2023-08-13 |
Not clear |
| Joyshikh Sonowal, Chhabi Lal Patel, Ravi Kumar Gandham, Basavaraj Sajjanar, Raja Ishaq Nabi Khan, Manas Ranjan Praharaj, Waseem Akram Malla, Deepak Kumar, Kapil Dev, N Barkathullah, Krishna Bharali, Amitesh Dubey, D Lalita, Insha Zafir, B P Mishra, Bina Mishr. Genome-wide expression analysis reveal host genes involved in immediate-early infections of different sheeppox virus strains. Gene. vol 801. 2021-08-16. PMID:34274484. |
sppv modulates the expression of several important host proteins such as cd40, fas, itgβ1, itgα1, pak1, pak2, cd14, ilk leading to viral attachment and entry; immune-related degs such as mapk, jnk, erk, nfkb, ikb, pi3k, stat which provide optimal cellular condition for early viral protein expression; and foxo3, atf, cdkna1, tcf, srf, bdnf which help in inducing apoptosis and mptp, bad and tp53 inhibits apoptosis or cell death at the immediate-early time. |
2021-08-16 |
2023-08-13 |
Not clear |
| Shotaro Otsuka, Harutoshi Sakakima, Akira Tani, Kazuki Nakanishi, Seiya Takada, Kosuke Norimatsu, Hiroshi Maejima, Ikuro Maruyam. Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats. Brain structure & function. vol 226. issue 7. 2021-08-11. PMID:34114048. |
infarct volume, neurological deficits, sensorimotor function, expression levels of brain-derived neurotrophic factor (bdnf), hypoxia-induced factor-1α (hif-1α), glial fibrillary acidic protein (gfap), and p2x7 receptors, and apoptosis activity were examined using immunohistochemical and western blot analyses. |
2021-08-11 |
2023-08-13 |
rat |
| S G Kalinichenko, N Y Matveeva, A V Korobtso. Brain-Derived Neurotrophic Factor (BDNF) As a Regulator of Apoptosis under Conditions of Focal Experimental Stroke. Bulletin of experimental biology and medicine. vol 169. issue 5. 2021-08-09. PMID:32990850. |
brain-derived neurotrophic factor (bdnf) as a regulator of apoptosis under conditions of focal experimental stroke. |
2021-08-09 |
2023-08-13 |
rat |
| Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Fili. Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299103. |
the aim of this study is to investigate the effects of escitalopram on oxidative stress, apoptosis, brain-derived neurotrophic factor (bdnf), methyl-cpg-binding protein 2 (mecp2), and oligodendrocytes number in the brain of chronic unpredictable mild stress-induced depressed rats. |
2021-07-30 |
2023-08-13 |
rat |
| Mary E Dail, Meghan L M Brino, Janice E Chamber. Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33682265. |
the hippocampus was examined via quantitative polymerase chain reaction for the expression of immediate-early genes involved in brain repair (bdnf), increasing neurotoxicity (fos), and apoptosis control (jdp2, bcl2l1, bcl2l11). |
2021-07-27 |
2023-08-13 |
rat |