| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Xing, Yuqian Zhang, Congqin Li, Lu Luo, Yan Hua, Jian Hu, Yulong Ba. Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models. Cellular and molecular neurobiology. 2022-08-02. PMID:35917043. |
rtms can prompt synaptic plasticity by increasing nmdar, ampar and bdnf expression; rtms can inhibit pro-inflammatory cytokines tnf and facilitate the expression of anti-inflammatory cytokines il-10 by shifting astrocytic phenotypes from a1 to a2, and shifting microglial phenotypes from m1 to m2; rtms facilitated the release of angiogenesis-related factors tgfβ and vegf in a2 astrocytes, which can contribute to vasculogenesis and angiogenesis; rtms can suppress apoptosis by increasing bcl-2 expression and inhibiting bax, caspase-3 expression; rtms can also suppress pyroptosis by decreasing caspase-1, il-1β, asc, gsdmd and nlrp1 expression. |
2022-08-02 |
2023-08-14 |
Not clear |
| Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinsk. Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806000. |
group ii metabotropic glutamate receptors reduce apoptosis and regulate bdnf and gdnf levels in hypoxic-ischemic injury in neonatal rats. |
2022-07-09 |
2023-08-14 |
rat |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
fisetin attenuated histological injury, malondialdehyde levels, inflammasome pathway activation, apoptosis, as well as increased bdnf expression, reduced astrocyte, microglial activation, and cognitive deficits. |
2022-06-24 |
2023-08-14 |
mouse |
| Jiangshan Liu, Bote Qi, Lin Gan, Yanli Shen, Yu Zo. A Bibliometric Analysis of the Literature on Irisin from 2012-2021. International journal of environmental research and public health. vol 19. issue 10. 2022-05-28. PMID:35627690. |
apoptosis, bdnf, and osteoporosis will likely become the focus of future research related to irisin. |
2022-05-28 |
2023-08-13 |
Not clear |
| Rekha Koravadi Narasimhamurthy, Daicy Andrade, Kamalesh Dattaram Mumbreka. Modulation of CREB and its associated upstream signaling pathways in pesticide-induced neurotoxicity. Molecular and cellular biochemistry. 2022-05-21. PMID:35596844. |
several genes, as well as protein kinases, are involved in the phosphorylation of creb, including bdnf (brain-derived neurotrophic factor), pi3k (phosphoinositide 3-kinase), akt (protein kinase b), ras (rat sarcoma), mek (mitogen-activated protein kinase), plc (phospholipase c), and pkc (protein kinase c) that play an essential role in neuronal plasticity, long-term potentiation, neuronal survival, learning, and memory formation, cognitive function, synaptic transmission, and suppressing apoptosis. |
2022-05-21 |
2023-08-13 |
human |
| Chen Chen, Bo Li, Haotian Chen, Yuhui Qin, Junying Cheng, Bo He, Yixuan Wan, Dongyong Zhu, Fabao Ga. Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment. Neurochemical research. 2022-05-13. PMID:35552996. |
oxidative stress (malondialdehyde, mda), apoptosis (caspase-3), and neural regeneration (brain-derived neurotrophic factor, bdnf) were detected by using elisa and western blotting. |
2022-05-13 |
2023-08-13 |
rat |
| Yongqi Sun, Baohong Cui, Lin Ye, Yunxin Hu, Yujun Pa. Pramipexole Inhibits Neuronal Apoptosis in Rats with Parkinson's Disease. Journal of healthcare engineering. vol 2022. 2022-04-25. PMID:35463692. |
to explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (bdnf), and serum mir-103a and mir-30b and inflammatory factors in rats with parkinson's disease. |
2022-04-25 |
2023-08-13 |
rat |
| Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Don. Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's disease. Food research international (Ottawa, Ont.). vol 155. 2022-04-11. PMID:35400445. |
when pd mice were administered with pm + lgg, pm as prebiotic favored bacterial growth (from bacilli class to lactobacillus genus) in the colon, which helped to improve blood brain barrier (bbb) integrity and increase brain-derived neurotrophic factor (bdnf) and gdnf expressions, thereby inhibiting apoptosis in the striatum. |
2022-04-11 |
2023-08-13 |
mouse |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
after testing anxiety-like behaviours in the elevated plus maze, the levels of corticosterone and bdnf in serum and bdnf and apoptosis markers (bax, bcl-2, and caspase) in hippocampus were measured. |
2022-04-11 |
2023-08-13 |
rat |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
sedentary male and female sps rats significantly (ps ranging <0.05 to <0.0001) exhibited increased anxiety levels in the elevated plus maze, enhanced serum corticosterone, reduced serum and hippocampal bdnf and enhanced hippocampal apoptosis than the corresponding control group. |
2022-04-11 |
2023-08-13 |
rat |
| Yu-Hai Xu, Yuan Luo, Jiang-Bei Cao, Yan-Hong Liu, Yu-Xiang Song, Xiao-Ying Zhang, Qiang Fu, Wei-Dong Mi, Hao L. lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway. Molecular neurobiology. 2022-03-26. PMID:35338452. |
brain-derived neurotrophic factor (bdnf), a neurotrophic factor, is associated with neuronal apoptosis. |
2022-03-26 |
2023-08-13 |
Not clear |
| Luting Yu, Shixi Liu, Ruixi Zhou, Hao Sun, Xiaojuan Su, Qian Liu, Shiping Li, Junjie Ying, Fengyan Zhao, Dezhi Mu, Yi Q. Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-18. PMID:35303316. |
furthermore, inhibition of camp or bdnf attenuated the effect of atorvastatin on the reduction of neuronal apoptosis, suggesting that atorvastatin inhibits hibd-induced neuronal apoptosis and alleviates brain injury in neonatal rats mainly by activating the camp/pka/p-creb/bdnf pathway. |
2022-03-18 |
2023-08-13 |
rat |
| Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chan. Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction. Molecular neurobiology. 2022-03-09. PMID:35262870. |
in vitro studies also confirmed that topical application of bdnf and/or ast reversed the aβ-induced cytotoxicity, apoptosis, mitochondrial distress, and synaptotoxicity and decreased expression of p-trkb, p-akt, p-gsk3β, and β-catenin in rat cortical neurons. |
2022-03-09 |
2023-08-13 |
rat |
| Safura Pournajaf, Leila Dargahi, Mohammad Javan, Mohammad Hossein Pourgholam. Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod. Frontiers in pharmacology. vol 13. 2022-03-07. PMID:35250559. |
furthermore, fingolimod induces apoptosis, autophagy, cell cycle arrest, epigenetic regulations, macrophages m1/m2 shift and enhances bdnf expression. |
2022-03-07 |
2023-08-13 |
Not clear |
| Lina Gao, Yun Zhang, Keenan Sterling, Weihong Son. Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential. Translational neurodegeneration. vol 11. issue 1. 2022-01-29. PMID:35090576. |
although depletion of bdnf has been linked with aβ accumulation, tau phosphorylation, neuroinflammation and neuronal apoptosis, the exact mechanisms underlying the effect of impaired bdnf signaling on ad are still unknown. |
2022-01-29 |
2023-08-13 |
Not clear |
| Aihua Yu, Shun Wang, Yiqiao Xing, Mengyao Han, Kun Sha. 7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway. International journal of medical sciences. vol 19. issue 1. 2022-01-03. PMID:34975295. |
our results showed that riri inhibited the conversion of bdnf precursor (probdnf) to mature bdnf (mbdnf) and increased the level of neuronal cell apoptosis. |
2022-01-03 |
2023-08-13 |
rat |
| Yang Zhai, Bu-Gu Liu, Xue-Ni Mo, Min Zou, Xiao-Ping Mei, Wei Chen, Guo-Dong Huang, Lin W. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. The Kaohsiung journal of medical sciences. 2021-12-28. PMID:34962339. |
inhibition of mir-210 resulted in increased viability and reduced apoptosis along with increased levels of bcl-2, bdnf, and trkb and reduced levels of bax and cleaved caspase 3 after hypoxia/reoxygenation. |
2021-12-28 |
2023-08-13 |
Not clear |
| Ghasem Majdi Yazdi, Gholamhasan Vaezi, Vida Hojati, Mohammad Mohammad-Zade. The Effect of 6-gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles. Basic and clinical neuroscience. vol 12. issue 3. 2021-12-17. PMID:34917289. |
given the antioxidant properties of gingerol (ging), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), dna oxidative damage, and the amount of bax and bcl2 apoptosis indices of rats exposed to aunps. |
2021-12-17 |
2023-08-13 |
rat |
| Ying Yu, Zhaokun Shi, Dan Xu, Ying Li, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32497709. |
the latter inhibits the hippocampal bdnf pathway, leading to the disruption of hippocampal neurogenesis, apoptosis and decreased synaptic plasticity. |
2021-12-06 |
2023-08-13 |
rat |
| Ismail S Zaitoun, Yong-Seok Song, Andrew Suscha, Mohamed El Ragaby, Christine M Sorenson, Nader Sheiban. 7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy. PloS one. vol 16. issue 12. 2021-12-06. PMID:34855884. |
lack of bdnf expression results in increased endothelial cell apoptosis and reduced endothelial cell-cell contact. |
2021-12-06 |
2023-08-13 |
mouse |