| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiping Xu, Yang Wang, Zhe Chen, Yuxuan Zhang, Xuexue Zhang, Guichao Zhan. Esketamine improves propofol-induced brain injury and cognitive impairment in rats. Translational neuroscience. vol 13. issue 1. 2022-12-23. PMID:36561289. |
moreover, knocking down bdnf partially reversed esketamine-mediated activation of the mbdnf/trkb/pi3k signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. |
2022-12-23 |
2023-08-14 |
human |
| Zhe Chen, Hong Fan, Zi-Yi Chen, Chao Jiang, Ming-Zhe Feng, Xin-Yu Guo, Hao Yang, Ding-Jun Ha. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF. Journal of molecular neuroscience : MN. 2022-12-17. PMID:36527597. |
oecs prevented neuronal cells from apoptosis partially through exosome-derived bdnf. |
2022-12-17 |
2023-08-14 |
Not clear |
| Zhe Chen, Hong Fan, Zi-Yi Chen, Chao Jiang, Ming-Zhe Feng, Xin-Yu Guo, Hao Yang, Ding-Jun Ha. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF. Journal of molecular neuroscience : MN. 2022-12-17. PMID:36527597. |
furthermore, we demonstrated that oecs prevented tnf-α-induced apoptosis in neurons partially through exosome-derived bdnf. our data showed that oecs attenuated tnf-α-induced apoptosis in neurons partially through oec-exo-derived bdnf, which might provide a novel strategy for the neuroprotective effect of oec-exo-based treatment. |
2022-12-17 |
2023-08-14 |
Not clear |
| Su-Su Wang, Xi Xu, An-Xin Lu, Wan-He Li, Jun-Xia Liu, Chen Liu, Chong-Huai Ya. Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism. Ecotoxicology and environmental safety. vol 248. 2022-11-24. PMID:36423370. |
amelioration of cholesterol sulfate for lead-induced ctx cell apoptosis based on bdnf signaling pathway mediated cholesterol metabolism. |
2022-11-24 |
2023-08-14 |
rat |
| Su-Su Wang, Xi Xu, An-Xin Lu, Wan-He Li, Jun-Xia Liu, Chen Liu, Chong-Huai Ya. Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism. Ecotoxicology and environmental safety. vol 248. 2022-11-24. PMID:36423370. |
however, pretreatment with cs detoxified the negative impacts of lead-invoked ctx cell damage, acting as an effective remedy for apoptosis, imbalance of cholesterol metabolism and inhibition of bdnf signaling pathway. |
2022-11-24 |
2023-08-14 |
rat |
| Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, José Ávila-Mendoza, Carlos G Martínez-Moreno, Carlos Arámburo, Maricela Lun. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232848. |
additionally, gh treatment provoked a significant reduction in apoptosis and lipoperoxidation; decreased the mrna expression of the inflammatory mediators (tnfα, il-6, il-1β, and inos); and upregulated the expression of several neurotrophic factors (igf-1, vegf, and bdnf). |
2022-10-14 |
2023-08-14 |
chicken |
| Yaling Zhang, Dejian Chen, Daojuan Wang, Lei Wang, Yajing Weng, Hongwei Wang, Xiaoke Wu, Yong Wan. Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome. Journal of clinical medicine. vol 11. issue 19. 2022-10-14. PMID:36233452. |
our in vitro results state that treatment with bdnf ameliorated dihydrotestosterone (dht)-induced granulosa cells (gcs) apoptosis by provoking p-trkb activation and upregulating the pi3k/akt pathway. |
2022-10-14 |
2023-08-14 |
rat |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Chunshuai Wu, Guanhua Xu, Guofeng Bao, Hong Gao, Jiajia Chen, Jinlong Zhang, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Yang Liu, Jiayi Huang, Yue Sun, Jiawei Fu, Yiqiu Li, Zhiming Cu. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotropin. The Journal of biological chemistry. 2022-09-02. PMID:36055408. |
we also show using flow cytometry and astrocyte/neuronal co-culture assays that triad1 overexpression promoted ptn protein levels, neurotrophic growth factor (ngf) expression, brain-derived neurotrophic factor (bdnf) expression, astrocyte and neuronal viability, and neurite outgrowth, but suppressed astrocyte apoptosis, while shrna-mediated knockdown of triad1 and ptn had the opposite effects. |
2022-09-02 |
2023-08-14 |
rat |
| Tingting Zhou, Suli He, Xin Ye, Zhaolan Wei, Jian Wan, Hongmao Zhang, Shumao Din. Exposure to dibutyl phthalate adsorbed to multi-walled carbon nanotubes causes neurotoxicity in mice by inducing the release of BDNF. The Science of the total environment. 2022-08-30. PMID:36041608. |
the experimental results demonstrated that the mechanism of the combined-exposure injury to neurons in the hippocampus of mice may be that mwcnts with adsorbed dbp can induce the release of bdnf, accelerate the apoptosis of neurons, and reduce the number of nerve cells, which activates microglia, causing neuroinflammation and nervous system toxicity. |
2022-08-30 |
2023-08-14 |
mouse |
| A S Chukanova, M S Gulieva, E I Chukanova, S J Bagmanya. [A panel of serum biomarkers, including damage, apoptosis and neurotrophic markers, for the assessment of prognosis of the course of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 8. Vyp. 2. 2022-08-29. PMID:36036143. |
identification of the relationship between clinical and neuroimaging data and the content of serum biomarkers (damage marker - neuron-specific enolase (nse), apoptosis - p53 protein and neuroplasticity - brain-derived neurotrophic factor (bdnf)) in acute, early and late recovery periods of ischemic stroke. |
2022-08-29 |
2023-08-14 |
Not clear |
| Yasemin Bicer, Hulya Elbe, Melike Karayakali, Gurkan Yigitturk, Umit Yilmaz, Osman Cengil, Mohammed Raed Abdullah Al Gburi, Eyup Altino. Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats. Journal of chemical neuroanatomy. 2022-08-11. PMID:35952951. |
alterations of brain oxidant/antioxidant status, dopamine (da), brain-derived neurotropic factor (bdnf) inflammatory mediator and apoptosis during exposure to acr in pinealectomized rats were more than without pinealectomized rats. |
2022-08-11 |
2023-08-14 |
rat |
| Feng Zhou, Lipeng Chen, Shan Xu, Caijuan Si, Nan Li, Hui Dong, Peifen Zheng, Weifeng Wan. Upregulation of miR-151-5p promotes the apoptosis of intestinal epithelial cells by targeting brain-derived neurotrophic factor in ulcerative colitis mice. Cell cycle (Georgetown, Tex.). 2022-08-08. PMID:35938703. |
the exogenous bdnf effect on the uc cell model and intestinal cell apoptosis, viability and proliferation was detected by flow cytometry, cck-8 and edu experiment. |
2022-08-08 |
2023-08-14 |
mouse |
| Ying Xing, Yuqian Zhang, Congqin Li, Lu Luo, Yan Hua, Jian Hu, Yulong Ba. Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models. Cellular and molecular neurobiology. 2022-08-02. PMID:35917043. |
rtms can prompt synaptic plasticity by increasing nmdar, ampar and bdnf expression; rtms can inhibit pro-inflammatory cytokines tnf and facilitate the expression of anti-inflammatory cytokines il-10 by shifting astrocytic phenotypes from a1 to a2, and shifting microglial phenotypes from m1 to m2; rtms facilitated the release of angiogenesis-related factors tgfβ and vegf in a2 astrocytes, which can contribute to vasculogenesis and angiogenesis; rtms can suppress apoptosis by increasing bcl-2 expression and inhibiting bax, caspase-3 expression; rtms can also suppress pyroptosis by decreasing caspase-1, il-1β, asc, gsdmd and nlrp1 expression. |
2022-08-02 |
2023-08-14 |
Not clear |
| Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinsk. Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806000. |
group ii metabotropic glutamate receptors reduce apoptosis and regulate bdnf and gdnf levels in hypoxic-ischemic injury in neonatal rats. |
2022-07-09 |
2023-08-14 |
rat |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
fisetin attenuated histological injury, malondialdehyde levels, inflammasome pathway activation, apoptosis, as well as increased bdnf expression, reduced astrocyte, microglial activation, and cognitive deficits. |
2022-06-24 |
2023-08-14 |
mouse |
| Jiangshan Liu, Bote Qi, Lin Gan, Yanli Shen, Yu Zo. A Bibliometric Analysis of the Literature on Irisin from 2012-2021. International journal of environmental research and public health. vol 19. issue 10. 2022-05-28. PMID:35627690. |
apoptosis, bdnf, and osteoporosis will likely become the focus of future research related to irisin. |
2022-05-28 |
2023-08-13 |
Not clear |
| Rekha Koravadi Narasimhamurthy, Daicy Andrade, Kamalesh Dattaram Mumbreka. Modulation of CREB and its associated upstream signaling pathways in pesticide-induced neurotoxicity. Molecular and cellular biochemistry. 2022-05-21. PMID:35596844. |
several genes, as well as protein kinases, are involved in the phosphorylation of creb, including bdnf (brain-derived neurotrophic factor), pi3k (phosphoinositide 3-kinase), akt (protein kinase b), ras (rat sarcoma), mek (mitogen-activated protein kinase), plc (phospholipase c), and pkc (protein kinase c) that play an essential role in neuronal plasticity, long-term potentiation, neuronal survival, learning, and memory formation, cognitive function, synaptic transmission, and suppressing apoptosis. |
2022-05-21 |
2023-08-13 |
human |
| Chen Chen, Bo Li, Haotian Chen, Yuhui Qin, Junying Cheng, Bo He, Yixuan Wan, Dongyong Zhu, Fabao Ga. Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment. Neurochemical research. 2022-05-13. PMID:35552996. |
oxidative stress (malondialdehyde, mda), apoptosis (caspase-3), and neural regeneration (brain-derived neurotrophic factor, bdnf) were detected by using elisa and western blotting. |
2022-05-13 |
2023-08-13 |
rat |
| Yongqi Sun, Baohong Cui, Lin Ye, Yunxin Hu, Yujun Pa. Pramipexole Inhibits Neuronal Apoptosis in Rats with Parkinson's Disease. Journal of healthcare engineering. vol 2022. 2022-04-25. PMID:35463692. |
to explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (bdnf), and serum mir-103a and mir-30b and inflammatory factors in rats with parkinson's disease. |
2022-04-25 |
2023-08-13 |
rat |