| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruyu Wang, Yiwei Chen, Zhiying Wang, Baorui Cao, Jinxin Du, Tingting Deng, Meina Yang, Jinxiang Ha. Antidepressant effect of licorice total flavonoids and liquiritin: A review. Heliyon. vol 9. issue 11. 2023-12-11. PMID:38074876. |
studies have shown that lf and liquiritin can exert their antidepressant effects by improving depressive behavior, regulating endocrine and hypothalamic-pituitary-adrenal (hpa) axis function, affecting the brain-derived neurotrophic factor (bdnf)/tyrosine kinase b (trkb) signaling pathway, enhancing synaptic plasticity, increasing monoamine neurotransmitter levels, protecting nerve cells, reducing inflammation, preventing apoptosis, reducing oxidation and other ways. |
2023-12-11 |
2023-12-17 |
Not clear |
| Dibyakanti Mishra, Priyam Narain, Upma Dave, James Gome. Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation. Molecular and cellular neurosciences. 2023-11-02. PMID:37918554. |
our results show that optn-k489e mutation changes the relative gene expressions of mirna-9, rest, corest and bdnf, and causes apoptosis. |
2023-11-02 |
2023-11-08 |
Not clear |
| Jingwen Shi, Yue Qi, Yuanchen Sun, Ying Huan. KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis. The American journal of pathology. 2023-11-02. PMID:37918799. |
finally, we showed that bdnf as a vital downstream substrate of klk4 maintained the proliferation, metastasis, and pro-angiogenesis abilities and inhibited apoptosis of escs through a rescue study. |
2023-11-02 |
2023-11-08 |
Not clear |
| Abdulhadi Bima, Basmah Eldakhakhny, Aliaa A Alamoudi, Zuhier Awan, Abrar Alnami, Salwa Mohamed Abo-Elkhair, Hussein Sakr, Fatma Mohamed Ghoneim, Ayman Elsamanoud. Molecular Study of the Protective Effect of a Low-Carbohydrate, High-Fat Diet against Brain Insulin Resistance in an Animal Model of Metabolic Syndrome. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891752. |
in conclusion, mets is associated with dysregulated cerebral gene expression of bdnf, s100b, and tnf-α and disturbed igf-1 signaling, with increased apoptosis and neuroinflammation. |
2023-10-30 |
2023-11-08 |
rat |
| Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760996. |
in investigating the function of se-cad, we found that immunodepletion of se-cad from the media of a549 cells untreated or treated with bdnf, nicotine, or epinephrine reduced activation of egfr and igf-1r, decreased pi3k and erk1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using h1299 cells under all conditions tested. |
2023-09-28 |
2023-10-07 |
Not clear |
| Anton Shkundin, Angelos Halari. Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder. Journal of personalized medicine. vol 13. issue 9. 2023-09-28. PMID:37763162. |
in contrast, bdnf antisense rna (bdnf-as) is linked to the regulation and control of bdnf, facilitating its suppression and contributing to neurotoxicity, apoptosis, and decreased cell viability. |
2023-09-28 |
2023-10-07 |
Not clear |
| Guoqing Wu, Yanyan W. Neuroprotective effect of Kurarinone against corticosterone-induced cytotoxicity on rat hippocampal neurons by targeting BACE1 to activate P13K-AKT signaling - A potential treatment in insomnia disorder. Pharmacology research & perspectives. vol 11. issue 5. 2023-09-23. PMID:37740616. |
kur reversed the impacts of corticosterone upon inhibiting viability (0.25-1 μm), pi3k (0.5-1 μm)/akt phosphorylation, and bdnf (1 μm) level, and enhancing the apoptosis (0.25-1 μm) and bace1 expression (1 μm) in hncs. |
2023-09-23 |
2023-10-07 |
rat |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Radwa S Raafat, Mohamed Z Habib, Amany A AbdElfattah, Nouran K Olama, Sahar M Abdelraouf, Nevien Hendawy, Khaled A Kamal, Salwa A Nawishy, Sawsan Aboul-Fotou. Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3β/β-catenin signaling in Wistar rats. International immunopharmacology. vol 124. issue Pt A. 2023-09-16. PMID:37716161. |
amisulpride enhanced wnt/gsk-3β/β-catenin signaling, increased bdnf levels, and abrogated 5-fu-induced neuroinflammation, apoptosis, β-amyloid accumulation, and neurodegenerative changes with an improvement of cognitive performance. |
2023-09-16 |
2023-10-07 |
human |
| Hao Lv, Ziang Gao, Yunfei Wang, Siyuan Chen, Peiqiang Liu, Yulie Xie, Mengting Guan, Jianchao Cong, Yu X. Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage. Neurochemical research. 2023-08-13. PMID:37574530. |
in conclusion, our findings suggest that metformin might be a viable strategy for treating ar-related depression, possibly by modulating neuroplasticity, neurogenesis, apoptosis, and bdnf signaling in the ob via the ampk/tet2 pathway. |
2023-08-13 |
2023-08-16 |
mouse |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
it was found that five days after administration of the protein into the fourth lateral ventricle, significant changes occurred in the expression of the genes involved in apoptosis and neurogenesis regulation, e. g., a notable decrease in the mrna level of the gene encoding the most important neurotrophic factor bdnf (brain-derived neurotrophic factor) was observed in the frontal cortex which could play an important role in neurodegeneration caused by pathological tau protein aggregation. |
2023-07-19 |
2023-08-14 |
mouse |
| Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoud. Dipeptide mimetic of BDNF ameliorates motor dysfunction and striatal apoptosis in 6-OHDA-induced Parkinson's rat model: Considering Akt and MAPKs signaling. Behavioural brain research. 2023-07-19. PMID:37467964. |
dipeptide mimetic of bdnf ameliorates motor dysfunction and striatal apoptosis in 6-ohda-induced parkinson's rat model: considering akt and mapks signaling. |
2023-07-19 |
2023-08-14 |
rat |
| Zhi Ma, Yue Wu, Juan Xu, Hui Cao, Mingyang Du, Haibo Jiang, Feng Qi. Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy. Neurochemical research. 2023-07-12. PMID:37436612. |
silencing of pp2a or administration of 3-methyladenine inhibited autophagy and decreased the production of anti-inflammatory factors (il-10, tgf-β and bdnf) and induced the release of proinflammatory cytokines (il-1β, il-2 and tnf-α) by sts-treated microglia, thereby inducing mitochondrial dysfunction and apoptosis of sts-treated neurons. |
2023-07-12 |
2023-08-14 |
Not clear |
| Yu Cai, Hua Yang, Zhen Wan, Pei-Yong Chen, Zhi-Bo Wang, Jin-Jing Guo, Daxiang Wang, Feng Wang, Yanli Zhan. A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy. BioFactors (Oxford, England). 2023-07-11. PMID:37431985. |
notably, either lncrna loc105613571 or bdnf silencing inhibited cell proliferation while promoted cell apoptosis. |
2023-07-11 |
2023-08-14 |
Not clear |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
these obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as tnf-α, cox-2, and caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as neun, ki-67, creb-p, and bdnf. |
2023-06-29 |
2023-08-14 |
mouse |
| Qing-Qing Zhang, Yi Q. Brain-derived neurotrophic factor in degenerative retinal diseases: Update and novel perspective. Journal of neuroscience research. 2023-06-19. PMID:37334646. |
although disorder of bdnf, whether depletion or augmentation, has been connected with neuronal apoptosis and neuroinflammation, the exact mechanisms underlying the effect of impaired bdnf expression on degenerative retinal diseases remain unclear. |
2023-06-19 |
2023-08-14 |
Not clear |
| Abhinav Anand, Navneet Khurana, Satinder Kaur, Nemat Ali, Abdullah F AlAsmari, Mohammad Waseem, Muzaffar Iqbal, Faris M Alzahrani, Neha Sharm. The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. European journal of pharmacology. 2023-06-17. PMID:37329974. |
these include oxidative stress, overexpression of acetylcholinesterase (ache), depletion of acetylcholine levels, increased beta-secretase mediated conversion of amyloid precursor protein (app) to amyloid beta (abeta), accumulation of abeta oligomers, decrease in brain derived neurotrophic factor (bdnf) and accelerated neuronal apoptosis due to elevated levels of caspase-3. |
2023-06-17 |
2023-08-14 |
mouse |
| Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Daniela A Bot. Cisplatin Induces BDNF Downregulation in Middle-Aged Female Rat Model while BDNF Enhancement Attenuates Cisplatin Neurotoxicity. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293048. |
our previous crci rodent studies have shown that cisplatin reduces hippocampal neurogenesis and bdnf expression and increases hippocampal apoptosis, which is associated with cognitive impairments. |
2023-06-09 |
2023-08-14 |
rat |
| Yuanlong Li, Hua Fan, Ming Ni, Wei Zhang, Fengqin Fang, Jun Sun, Pin Lyu, Peizhi M. Targeting lncRNA NEAT1 hampers Alzheimer's disease progression. Neuroscience. 2023-06-07. PMID:37286157. |
besides, lnc-neat1 knockdown reduced injury and apoptosis, decreased inflammatory cytokine levels, repressed oxidative stress level, and activated adenosine cyclophosphate response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) and nuclear factor erythroid 2-related factor 2 (nrf2)/nicotinamide adenine dinucleotide phosphate dehydrogenase 1 (nqo1) pathways in hippocampi of ad mice. |
2023-06-07 |
2023-08-14 |
mouse |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |