| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A G Estévez, N Spear, S M Manuel, R Radi, C E Henderson, L Barbeito, J S Beckma. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 3. 1998-02-06. PMID:9437014. |
our results suggest that peroxynitrite, a strong oxidant formed by the reaction of no and superoxide, plays an important role in the induction of apoptosis in motor neurons deprived of trophic factors and that bdnf supports motor neuron survival in part by preventing neuronal nos expression. |
1998-02-06 |
2023-08-12 |
rat |
| K Shimoke, T Kubo, T Numakawa, Y Abiru, Y Enokido, N Takei, T Ikeuchi, H Hatanak. Involvement of phosphatidylinositol-3 kinase in prevention of low K(+)-induced apoptosis of cerebellar granule neurons. Brain research. Developmental brain research. vol 101. issue 1-2. 1997-10-01. PMID:9263593. |
a high concentration of potassium (26 mm) in the culture medium and bdnf can effectively prevent this apoptosis. |
1997-10-01 |
2023-08-12 |
rat |
| K Shimoke, T Kubo, T Numakawa, Y Abiru, Y Enokido, N Takei, T Ikeuchi, H Hatanak. Involvement of phosphatidylinositol-3 kinase in prevention of low K(+)-induced apoptosis of cerebellar granule neurons. Brain research. Developmental brain research. vol 101. issue 1-2. 1997-10-01. PMID:9263593. |
these results indicate that different survival-promoting agents, bdnf and high k+, can prevent apoptosis in cerebellar granule neurons via a common enzyme, pi-3 kinase. |
1997-10-01 |
2023-08-12 |
rat |
| Y Muller, K Tangre, J Clo. Autocrine regulation of apoptosis and bcl-2 expression by nerve growth factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor. Neurochemistry international. vol 31. issue 2. 1997-09-02. PMID:9220450. |
preliminary results strongly suggest that neurotrophin-3 (nt-3) and brain derived neurotrophic factor (bdnf) are also involved in the regulation of cell death, by first promoting necrosis and then protecting the remaining cells from apoptosis. |
1997-09-02 |
2023-08-12 |
Not clear |
| P Thajeb, Z D Ling, E D Potter, P M Carve. The effects of storage conditions and trophic supplementation on the survival of fetal mesencephalic cells. Cell transplantation. vol 6. issue 3. 1997-07-21. PMID:9171162. |
as klenow enzyme labeling technique indicated that 33% of stored rmt cells were undergoing apoptosis, we found that gdnf, bdnf, and hpcs reduced apoptosis by 50%. |
1997-07-21 |
2023-08-12 |
human |
| B Ni, X Wu, Y Du, Y Su, E Hamilton-Byrd, P K Rockey, P Rosteck, G G Poirier, S M Pau. Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 5. 1997-03-26. PMID:9030616. |
induction of irp mrna and cell death are blocked completely by adding depolarizing concentrations of k+ apoptosis) and partially blocked by brain-derived neurotrophic factor (bdnf), which also partially rescues granule neurons from low k+-induced apoptosis. |
1997-03-26 |
2023-08-12 |
human |
| G Taglialatela, C J Hibbert, L A Hutton, K Werrbach-Perez, J R Perez-Pol. Suppression of p140trkA does not abolish nerve growth factor-mediated rescue of serum-free PC12 cells. Journal of neurochemistry. vol 66. issue 5. 1997-01-14. PMID:8780007. |
neurotrophins (nts), such as nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and nt-3, are required for survival of certain neurons, and thus their clinical use to counteract age- and pathology-associated neurodegeneration has been suggested, although mechanistic descriptions for nt cell rescue from apoptosis are not definitive. |
1997-01-14 |
2023-08-12 |
Not clear |
| C Gaiddon, J P Loeffler, Y Larme. Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. Journal of neurochemistry. vol 66. issue 6. 1996-07-01. PMID:8632149. |
brain-derived neurotrophic factor (bdnf), a member of the neurotrophin family, regulates survival and apoptosis of several neuronal populations. |
1996-07-01 |
2023-08-12 |
Not clear |
| T Kubo, T Nonomura, Y Enokido, H Hatanak. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain research. Developmental brain research. vol 85. issue 2. 1995-08-10. PMID:7541321. |
brain-derived neurotrophic factor (bdnf) can prevent apoptosis of rat cerebellar granule neurons in culture. |
1995-08-10 |
2023-08-12 |
rat |
| T Kubo, T Nonomura, Y Enokido, H Hatanak. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain research. Developmental brain research. vol 85. issue 2. 1995-08-10. PMID:7541321. |
we found that brain-derived neurotrophic factor (bdnf) and neurotrophin-4/5 (nt-4/5) but not nerve growth factor (ngf) can protect these neurons from apoptosis in low k+. |
1995-08-10 |
2023-08-12 |
rat |
| T Kubo, T Nonomura, Y Enokido, H Hatanak. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain research. Developmental brain research. vol 85. issue 2. 1995-08-10. PMID:7541321. |
our results suggested that bdnf has a direct effect on mature cerebellar granule neurons and can protect these neurons from apoptosis in low k+. |
1995-08-10 |
2023-08-12 |
rat |