| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessia Bachis, Eugene O Major, Italo Mocchett. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843275. |
this effect correlated with the ability of bdnf to reduce gp120 internalization and apoptosis. |
2003-08-14 |
2023-08-12 |
human |
| Steven Poser, Soren Impey, Zhengui Xia, Daniel R Stor. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 11. 2003-07-01. PMID:12805282. |
here we report the surprising observation that camp attenuates the ability of bdnf to rescue cortical neurons from apoptosis after serum deprivation, a process mediated via the phosphatidylinositol 3 (pi3)-kinase signal transduction cascade. |
2003-07-01 |
2023-08-12 |
Not clear |
| Akiko Tabuchi, Kouhei Funaji, Jun Nakatsubo, Mamoru Fukuchi, Tomofusa Tsuchiya, Masaaki Tsud. Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548706. |
suppression of the apoptosis of cgcs mediated by the ca(2+) influx or neurotrophic factors such as brain-derived neurotrophic factor (bdnf) and adenylate cyclase activating polypeptide-38 (pacap-38) attenuated the aconitase inactivation as well as the lactate dehydrogenase (ldh)-release and the decrease in mtt reduction. |
2003-04-01 |
2023-08-12 |
mouse |
| Michal Hetman, Shih-Ling Hsuan, Agata Habas, Matthew J Higgins, Zhengui Xi. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12393899. |
activation of both endogenous erk1/2 and pi3k signaling pathways was required for bdnf to block apoptosis induced by expression of recombinant gsk3beta. |
2003-02-12 |
2023-08-12 |
Not clear |
| Michal Hetman, Shih-Ling Hsuan, Agata Habas, Matthew J Higgins, Zhengui Xi. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12393899. |
furthermore, cortical neuron apoptosis induced by ly294002-mediated activation of endogenous gsk3beta was blocked by expression of constitutively active mkk1 or by bdnf via stimulation of the endogenous erk1/2 pathway. |
2003-02-12 |
2023-08-12 |
Not clear |
| Sun H Kim, Seok J Won, Seonghyang Sohn, Hyuk J Kwon, Jee Y Lee, Jong H Park, Byoung J Gwa. Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase. The Journal of cell biology. vol 159. issue 5. 2003-01-23. PMID:12460985. |
since nts enhance survival and differentiation of cultured neurons in serum or defined media containing antioxidants, we set out experiments to delineate the patterns and underlying mechanisms of brain-derived neurotrophic factor (bdnf)-induced neuronal injury in mixed cortical cell cultures containing glia and neurons in serum-free media without antioxidants, where the three major routes of neuronal cell death, oxidative stress, excitotoxicity, and apoptosis, have been extensively studied. |
2003-01-23 |
2023-08-12 |
rat |
| Z H Wang, Y Ji, W Shan, B Zeng, N Raksadawan, G M Pastores, T Wisniewski, E H Kolodn. Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease. Neuroscience. vol 113. issue 3. 2002-11-13. PMID:12150782. |
bdnf protected the dopaminergic neurons from apoptosis induced by 6-hydroxydopamine, and significantly increased the long-term survival of th-positive cells in the striatum. |
2002-11-13 |
2023-08-12 |
rat |
| Masao Koda, Masazumi Murakami, Hidetoshi Ino, Katsunori Yoshinaga, Osamu Ikeda, Masayuki Hashimoto, Masashi Yamazaki, Chikao Nakayama, Hideshige Moriy. Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats. Journal of neurotrauma. vol 19. issue 6. 2002-09-13. PMID:12165137. |
these findings suggest that bdnf suppresses delayed apoptosis of oligodendrocytes after spinal cord injury, for which even delayed injections are effective. |
2002-09-13 |
2023-08-12 |
rat |
| M Palmada, S Kanwal, N J Rutkoski, C Gustafson-Brown, R S Johnson, R Wisdom, B D Carter, C Gufstafson-Brow. c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. The Journal of cell biology. vol 158. issue 3. 2002-09-09. PMID:12163468. |
in contrast, brain-derived neurotrophic factor (bdnf) binding to p75 resulted in an equivalent level of apoptosis in neurons expressing cre, gfp, and uninfected cells. |
2002-09-09 |
2023-08-12 |
mouse |
| A Petersén A, K E Larsen, G G Behr, N Romero, S Przedborski, P Brundin, D Sulze. Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain research bulletin. vol 56. issue 3-4. 2002-02-07. PMID:11719268. |
furthermore, bdnf inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. |
2002-02-07 |
2023-08-12 |
mouse |
| B Rohrer, M M LaVail, K R Jones, L F Reichard. Neurotrophin receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivo. Experimental neurology. vol 172. issue 1. 2001-12-05. PMID:11681842. |
the neurotrophins bdnf and nt-4, but not ngf, prevent the apoptosis of retinal ganglion cells that is otherwise observed after target ablation or axotomy. |
2001-12-05 |
2023-08-12 |
mouse |
| I Fariñas, K R Jones, L Tessarollo, A J Vigers, E Huang, M Kirstein, D C de Caprona, V Coppola, C Backus, L F Reichardt, B Fritzsc. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487640. |
during the period preceding apoptosis, nt-3 is expressed in supporting cells, whereas bdnf is expressed mainly in hair cells, which become postmitotic in an apical to basal temporal gradient. |
2001-08-30 |
2023-08-12 |
mouse |
| C S Von Bartheld, J E Johnso. Target-derived BDNF (brain-derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus. The Journal of comparative neurology. vol 433. issue 4. 2001-06-28. PMID:11304717. |
immunolabel for endogenous bdnf was sparse in pyknotic ion neurons, suggesting that ion neurons with low bdnf content were eliminated by apoptosis. |
2001-06-28 |
2023-08-12 |
chicken |
| J M Olson, A Asakura, L Snider, R Hawkes, A Strand, J Stoeck, A Hallahan, J Pritchard, S J Tapscot. NeuroD2 is necessary for development and survival of central nervous system neurons. Developmental biology. vol 234. issue 1. 2001-06-28. PMID:11356028. |
decreased levels of bdnf and higher rates of apoptosis in cerebellar granule cells of neurod2(-/-) mice indicate that neurod2 is necessary for the survival of specific populations of central nervous system neurons in addition to its known effects on cell cycle regulation and neuronal differentiation. |
2001-06-28 |
2023-08-12 |
mouse |
| K M Giehl, S Röhrig, H Bonatz, M Gutjahr, B Leiner, I Bartke, Q Yan, L F Reichardt, C Backus, A A Welcher, K Dethleffsen, P Mestres, M Meye. Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331378. |
the neurotrophins nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt-3) promote neuronal survival via tyrosine kinase (trk) receptors, whereas ngf and bdnf can also induce apoptosis in developing neurons through p75(ntr) receptors in the absence of their respective trk receptors. |
2001-06-21 |
2023-08-12 |
mouse |
| R R Krishnamoorthy, P Agarwal, G Prasanna, K Vopat, W Lambert, H J Sheedlo, I H Pang, D Shade, R J Wordinger, T Yorio, A F Clark, N Agarwa. Characterization of a transformed rat retinal ganglion cell line. Brain research. Molecular brain research. vol 86. issue 1-2. 2001-05-10. PMID:11165366. |
serum deprivation resulted in apoptosis and supplementation with both bdnf and nt-4 in the growth media, protected the rgc-5 cells from undergoing apoptosis. |
2001-05-10 |
2023-08-12 |
rat |
| E Adachi-Usam. [Optic neuritis--from diagnosis to optic nerve transplantation]. Nippon Ganka Gakkai zasshi. vol 104. issue 12. 2001-04-19. PMID:11193941. |
to prevent the apoptosis of ganglion cells, we injected various neurotrophic factors such as bdnf, gdnf, and hsp 27 into the vitreous. |
2001-04-19 |
2023-08-12 |
mouse |
| M J Donovan, M I Lin, P Wiegn, T Ringstedt, R Kraemer, R Hahn, S Wang, C F Ibañez, S Rafii, B L Hempstea. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development (Cambridge, England). vol 127. issue 21. 2000-12-22. PMID:11023857. |
bdnf deficiency results in a reduction in endothelial cell-cell contacts and in endothelial cell apoptosis, leading to intraventricular wall hemorrhage, depressed cardiac contractility and early postnatal death. |
2000-12-22 |
2023-08-12 |
mouse |
| N Klöcker, P Kermer, J H Weishaupt, M Labes, R Ankerhold, M Bäh. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995840. |
repeated intraocular injections of bdnf prevent the degeneration of rgcs 14 d after on lesion most likely by inhibition of apoptosis. |
2000-10-18 |
2023-08-12 |
rat |
| A Baldi, E Calia, A Ciampini, M Riccio, A Vetuschi, A M Persico, F Kelle. Deafferentation-induced apoptosis of neurons in thalamic somatosensory nuclei of the newborn rat: critical period and rescue from cell death by peripherally applied neurotrophins. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947807. |
nerve growth factor (ngf) or brain-derived neurotrophic factor (bdnf), applied on the ion stump alone or in combination, are able to partially rescue thalamic neurons from apoptosis. |
2000-09-19 |
2023-08-12 |
rat |