| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Kawamura, Nanami Kawamura, Jun Fukuda, Jin Kumagai, Aaron J W Hsueh, Toshinobu Tanak. Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Developmental biology. vol 311. issue 1. 2007-12-03. PMID:17880937. |
treatment with bdnf promoted the development of two-cell-stage embryos into blastocysts showing increased proliferation and decreased apoptosis. |
2007-12-03 |
2023-08-12 |
Not clear |
| Erzsebet Szatmari, Katarzyna B Kalita, Giorgi Kharebava, Michal Hetma. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942733. |
in cultured rat cortical neurons, bdnf activates erk1/2 to enhance neuronal survival by suppressing dna damage- or trophic deprivation-induced apoptosis. |
2007-11-08 |
2023-08-12 |
rat |
| Erzsebet Szatmari, Katarzyna B Kalita, Giorgi Kharebava, Michal Hetma. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942733. |
in contrast, bdnf suppression of trophic deprivation-induced apoptosis was unaffected by shksr1 although blocked by sherk1/2. |
2007-11-08 |
2023-08-12 |
rat |
| R Brooks Wilson, Kannan Kunchithapautham, Bärbel Rohre. Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Investigative ophthalmology & visual science. vol 48. issue 6. 2007-07-02. PMID:17525224. |
photoreceptors can be prevented from undergoing apoptosis in response to constant light by the application of exogenous neuroprotective agents, including brain-derived neurotrophic factor (bdnf). |
2007-07-02 |
2023-08-12 |
Not clear |
| Rachel L Nosheny, Alessia Bachis, Sadia A Aden, Maria A De Bernardi, Italo Mocchett. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Journal of neurobiology. vol 66. issue 12. 2006-12-11. PMID:16967504. |
because glial cell line-derived neurotrophic factor (gdnf) and bdnf are neurotrophic factors crucial for the survival of dopaminergic neurons of the sn, we investigated whether gp120 reduces gdnf and bdnf levels concomitantly to induce apoptosis. |
2006-12-11 |
2023-08-12 |
human |
| Andrew P Hibbert, Bianca M R Kramer, Freda D Miller, David R Kapla. The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Molecular and cellular neurosciences. vol 32. issue 4. 2006-10-24. PMID:16843677. |
bdnf, through p75ntr, promotes apoptosis and inhibits axonal growth of sympathetic neurons, antagonizing the pro-survival and axon growth-promoting actions of ngf through trka. |
2006-10-24 |
2023-08-12 |
Not clear |
| Susan G Dorsey, Cynthia L Renn, Laura Carim-Todd, Colleen A Barrick, Linda Bambrick, Bruce K Krueger, Christopher W Ward, Lino Tessaroll. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. vol 51. issue 1. 2006-08-31. PMID:16815329. |
in the trisomy 16 (ts16) mouse there is increased apoptosis in the cortex, and hippocampal neurons undergo accelerated cell death that cannot be rescued by administration of brain-derived neurotrophic factor (bdnf). |
2006-08-31 |
2023-08-12 |
mouse |
| Alessia Bachis, Italo Mocchett. Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179530. |
the neurotrophin brain-derived neurotrophic factor (bdnf) has been shown to block neuronal apoptosis. |
2006-06-06 |
2023-08-12 |
human |
| Alessia Bachis, Italo Mocchett. Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179530. |
preexposure of cerebellar granule cells to bdnf prior to both gp120s decreased apoptosis and consequently enhanced their survival. |
2006-06-06 |
2023-08-12 |
human |
| Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdi. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179541. |
in a model of serum withdrawal-induced apoptosis of rat pheochromocytoma pc12 cells, rasagiline and its propargyl moiety, n-propargylamine, decreased cell death via multiple neuroprotective pathways that include the stimulation of pkc phosphorylation; upregulation of pkcepsilon mrna; induction of bcl-x(l), bcl-w, and brain-derived neurotrophic factor (bdnf) mrnas; and downregulation of pkcgamma, bad, and bax mrnas. |
2006-06-06 |
2023-08-12 |
rat |
| Alessia Bachis, Italo Mocchett. Semisynthetic sphingoglycolipid LIGA20 is neuroprotective against human immunodeficiency virus-gp120-mediated apoptosis. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477610. |
brain-derived neurotrophic factor (bdnf) prevents gp120-mediated apoptosis in cerebellar granule cells. |
2006-06-01 |
2023-08-12 |
human |
| Henry K Teng, Kenneth K Teng, Ramee Lee, Saundrene Wright, Seema Tevar, Ramiro D Almeida, Pouneh Kermani, Risa Torkin, Zhe-Yu Chen, Francis S Lee, Rosemary T Kraemer, Anders Nykjaer, Barbara L Hempstea. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 22. 2006-03-02. PMID:15930396. |
because recent studies suggest that prongf, the precursor form of ngf, is more active than mature ngf in inducing apoptosis after binding to p75ntr and a coreceptor, sortilin, we asked whether the precursor of bdnf (probdnf) is also a proapoptotic ligand in the nervous system. |
2006-03-02 |
2023-08-12 |
Not clear |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
after peripheral nerve injury, axotomized sensory neurons in dorsal root ganglia (drg) undergo apoptosis and up-regulate brain-derived neurotrophic factor (bdnf). |
2005-08-30 |
2023-08-12 |
mouse |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
in the in vitro model, treatment with bdnf antibody significantly reduced apoptosis of sensory neurons in drg explants from both adult and neonate rats and adult mice cultured for 48 h. consistently, exogenous bdnf increased the percentage of apoptotic neurons in the drgs from mice. |
2005-08-30 |
2023-08-12 |
mouse |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
while endogenous bdnf induced apoptosis of axotomized sensory neurons through p75ntr in vitro where more neurons expressed p75ntr, it prevented apoptosis in vivo where fewer neurons expressed p75ntr after sciatic nerve transection. |
2005-08-30 |
2023-08-12 |
mouse |
| Barbara Sitek, Ognjan Apostolov, Kai Stühler, Kathy Pfeiffer, Helmut E Meyer, Angelika Eggert, Alexander Schram. Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry. Molecular & cellular proteomics : MCP. vol 4. issue 3. 2005-07-21. PMID:15654083. |
the trka and trkb tyrosine kinases are members of the neurotrophin receptor family and mediate survival, differentiation, growth, and apoptosis of neurons in response to stimulation by their ligands, ngf and bdnf, respectively. |
2005-07-21 |
2023-08-12 |
human |
| Roger N Pearse, Steven L Swendeman, Ying Li, Dahlia Rafii, Barbara L Hempstea. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. vol 105. issue 11. 2005-07-12. PMID:15657181. |
addition of bdnf protects human mm cell lines (hmcls) from apoptosis induced by dexamethasone or bortezomib and prolongs the survival of primary mm cells cultured alone or with human bone marrow (bm) stroma. |
2005-07-12 |
2023-08-12 |
human |
| E Carden Yeiser, Nancy J Rutkoski, Asuka Naito, Jun-ichiro Inoue, Bruce D Carte. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 46. 2005-06-21. PMID:15548667. |
in sympathetic neurons cultured from traf6+/+ superior cervical ganglia (scgs), there was an increase in jnk activation and apoptosis after bdnf binding to p75; however, traf6-/- neurons did not respond. |
2005-06-21 |
2023-08-12 |
mouse |
| B Fayard, S Loeffler, J Weis, E Vögelin, A Krüttge. The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC. Journal of neuroscience research. vol 80. issue 1. 2005-05-26. PMID:15704182. |
the neurotrophin brain-derived neurotrophic factor (bdnf) binds to two cell surface receptors: trkb receptors that promote neuronal survival and differentiation and p75ntr that induces apoptosis or survival. |
2005-05-26 |
2023-08-12 |
Not clear |
| Kyoko Isoyama, Hiroshi Nagata, Yuji Shino, Naohisa Isegawa, Yukiko Arimoto, Masao Koda, Keiichiro Kumahara, Yoshitaka Okamoto, Hiroshi Shirasaw. Effects of adenoviral vector-mediated BDNF expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469885. |
effects of adenoviral vector-mediated bdnf expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. |
2005-04-19 |
2023-08-12 |
mouse |