| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
this study examined the role of the phosphatidylinositol-3 kinase (pi3k)/akt and extracellular signal-regulated kinase (erk) pathways in bdnf protection of pcp-induced apoptosis in corticostriatal organotypic cultures. |
2010-04-13 |
2023-08-12 |
rat |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
it was observed that bdnf inhibited pcp-induced apoptosis in a concentration-dependent fashion. |
2010-04-13 |
2023-08-12 |
rat |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
these data demonstrate that the protective effect of bdnf against pcp-induced apoptosis is mediated by parallel activation of the pi-3k/akt and erk pathways, most likely involves inhibition of gsk-3beta and activation of creb. |
2010-04-13 |
2023-08-12 |
rat |
| Bruno Manadas, Ana Rita Santos, Krisztina Szabadfi, João R Gomes, Spiros D Garbis, Michael Fountoulakis, Carlos B Duart. BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. Journal of proteome research. vol 8. issue 10. 2010-02-01. PMID:19702335. |
bdnf changed the abundance of proteins involved in (i) nucleobase, nucleoside, nucleotide and nucleic acid metabolism, (ii) protein metabolism, (iii) carbohydrate metabolism, (iv) regulators of apoptosis, and (v) regulators of cell proliferation. |
2010-02-01 |
2023-08-12 |
Not clear |
| Ling Liu, Renliang Zhang, Kui Liu, Houguang Zhou, Yuping Tang, Jinjin Su, Xiaoyan Yu, Xuelian Yang, Min Tang, Qiang Don. Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1. Journal of neuroscience research. vol 87. issue 16. 2010-01-05. PMID:19598250. |
collectively, these findings demonstrate that tk attenuates glutamate-induced apoptosis through an intracellular signaling pathway including activation of b2r, erk1/2, and nf-kappab and up-regulation of bdnf and bcl-2 expression. |
2010-01-05 |
2023-08-12 |
human |
| D Jantas, M Szymanska, B Budziszewska, W Laso. An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. Apoptosis : an international journal on programmed cell death. vol 14. issue 7. 2009-09-14. PMID:19521778. |
the obtained data suggest an nmdar-independent action of memantine in attenuation of neuronal apoptosis and point to the engagement of bdnf and pi3-k/akt pathway in these processes. |
2009-09-14 |
2023-08-12 |
Not clear |
| Zhitao Wang, Quanjun Deng, Xiaohui Zhang, Jianning Zhan. Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro. Journal of molecular neuroscience : MN. vol 38. issue 3. 2009-08-17. PMID:19459071. |
our data demonstrated that graft rbmscs transfected by htert and ad-bdnf could increase the expression of bdnf in injured neurons and alleviate apoptosis of the injured neurons. |
2009-08-17 |
2023-08-12 |
human |
| Zhixiong Li, Gernot Beutel, Mathias Rhein, Johann Meyer, Christian Koenecke, Thomas Neumann, Min Yang, Jürgen Krauter, Nils von Neuhoff, Michael Heuser, Helmut Diedrich, Gudrun Göhring, Ludwig Wilkens, Brigitte Schlegelberger, Arnold Ganser, Christopher Bau. High-affinity neurotrophin receptors and ligands promote leukemogenesis. Blood. vol 113. issue 9. 2009-04-10. PMID:19059881. |
activation of trka or trkb by ngf and bdnf, respectively, efficiently rescued murine myeloid cells from irradiation-induced apoptosis. |
2009-04-10 |
2023-08-12 |
human |
| Lorenzo De Santi, Loredana Cantalupo, Maristella Tassi, Donatella Raspadori, Chiara Cioni, Pasquale Annunziat. Higher expression of BDNF receptor gp145trkB is associated with lower apoptosis intensity in T cell lines in multiple sclerosis. Journal of the neurological sciences. vol 277. issue 1-2. 2009-04-02. PMID:18992902. |
higher expression of bdnf receptor gp145trkb is associated with lower apoptosis intensity in t cell lines in multiple sclerosis. |
2009-04-02 |
2023-08-12 |
human |
| R Fujita, M Ueda, K Fujiwara, H Ued. Prothymosin-alpha plays a defensive role in retinal ischemia through necrosis and apoptosis inhibition. Cell death and differentiation. vol 16. issue 2. 2009-03-16. PMID:18989338. |
treatments with anti-erythropoietin (epo) or brain-derived neurotrophic factor (bdnf) immunoglobulin g (igg) reversed protalpha-induced inhibition of apoptosis. |
2009-03-16 |
2023-08-12 |
mouse |
| M J M Bertrand, R S Kenchappa, D Andrieu, M Leclercq-Smekens, H N T Nguyen, B D Carter, F Muscatelli, P A Barker, O De Backe. NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo. Cell death and differentiation. vol 15. issue 12. 2009-01-28. PMID:18772898. |
primary sympathetic neurons derived from nrage knockout mice were resistant to apoptosis induced by brain-derived neurotrophic factor (bdnf), a pro-apoptotic p75ntr ligand, and nrage-deficient sympathetic neurons show attenuated bdnf-dependent jnk activation. |
2009-01-28 |
2023-08-12 |
mouse |
| Anilkumar Pillai, Rajalakshmi Veeranan-Karmegam, Krishnan M Dhandapani, Sahebarao P Mahadi. Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortex. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18786174. |
in addition, in vitro experiments with mouse cortical neurons showed that cys prevented the hal-induced reduction in neuronal cell viability and bdnf protein levels, and increase in apoptosis. |
2009-01-15 |
2023-08-12 |
mouse |
| V Corsetti, G Amadoro, A Gentile, S Capsoni, M T Ciotti, M T Cencioni, A Atlante, N Canu, T T Rohn, A Cattaneo, P Calissan. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Molecular and cellular neurosciences. vol 38. issue 3. 2008-12-09. PMID:18511295. |
we provide biochemical evidence that a caspase(s)-cleaved nh2-terminal tau fragment of 20-22 kda, consistent with the size of the nh2 26-230aa neurotoxic fragment of tau, is generated in vitro in differentiated human sh-sy5y cells undergoing apoptosis by bdnf withdrawal or following treatment with staurosporine. |
2008-12-09 |
2023-08-12 |
mouse |
| Giorgi Kharebava, Denys Makonchuk, Katarzyna B Kalita, Jing-Juan Zheng, Michal Hetma. Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 44. 2008-11-18. PMID:18971483. |
in trophic-deprived cortical neurons, knockdown of endogenous pdk1 attenuated the antiapoptotic survival response to 10 ng/ml bdnf, whereas an overexpressed active mutant form of pdk1 reduced apoptosis. |
2008-11-18 |
2023-08-12 |
rat |
| Angela Berzi, C Korcan Ayata, Paola Cavalcante, Chiara Falcone, Elisabetta Candiago, Teresio Motta, Pia Bernasconi, Reinhard Hohlfeld, Renato Mantegazza, Edgar Meinl, Cinthia Farin. BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathology. Journal of neuroimmunology. vol 197. issue 2. 2008-11-05. PMID:18555538. |
finally, all tec dying of apoptosis expressed bdnf receptors, indicating that this neurotrophin is involved in tec turnover. |
2008-11-05 |
2023-08-12 |
human |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
brain-derived neurotrophic factor (bdnf) is associated with the main symptoms of chronic fatigue syndrome (cfs) and neuron apoptosis. |
2008-10-31 |
2023-08-12 |
mouse |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
nevertheless, no study has been performed directly to explore the relationship between cfs, bdnf and neuron apoptosis. |
2008-10-31 |
2023-08-12 |
mouse |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
in this model, reduced daily activity might have been associated with decreased hippocampal bdnf mrna expression, hippocampal apoptosis and brain atrophy. |
2008-10-31 |
2023-08-12 |
mouse |
| Christian Montag, Ulrike Basten, Christine Stelzel, Christian J Fiebach, Martin Reute. The BDNF Val66Met polymorphism and smoking. Neuroscience letters. vol 442. issue 1. 2008-10-14. PMID:18602452. |
bdnf represents a protein which crucially influences several processes in the cell ranging from growth to apoptosis. |
2008-10-14 |
2023-08-12 |
human |
| Tapas K Makar, David Trisler, Karna T Sura, Shireen Sultana, Niraj Patel, Christopher T Beve. Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. Journal of the neurological sciences. vol 270. issue 1-2. 2008-09-24. PMID:18374360. |
we have developed a novel delivery system for bdnf using transformed bone marrow stem cells (bmsc) and undertook studies of eae to determine whether the delivery of bdnf could reduce inflammation and apoptosis. |
2008-09-24 |
2023-08-12 |
mouse |