| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Qiu, Shengdi Hu, Libing Liu, Man Chen, Lai Wang, Xianwei Zeng, Shigong Zh. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion. Biochemical and biophysical research communications. vol 436. issue 4. 2013-10-21. PMID:23770418. |
in addition, the effects of cart on ischemia-induced neuronal apoptosis and er stress were suppressed by tyrosine receptor kinase b (trkb) igg, whereas the effects of cart on bdnf transcription, synthesis and secretion were abolished by creb sirna. |
2013-10-21 |
2023-08-12 |
rat |
| Bin Qiu, Shengdi Hu, Libing Liu, Man Chen, Lai Wang, Xianwei Zeng, Shigong Zh. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion. Biochemical and biophysical research communications. vol 436. issue 4. 2013-10-21. PMID:23770418. |
this work suggests that cart is functional in inhibiting the cerebral i/r-induced er stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of bdnf in a creb-dependent way. |
2013-10-21 |
2023-08-12 |
rat |
| M Shamsul Ola, Mohd Imtiaz Nawaz, Ahmed Abu El-Asrar, Marwan Abouammoh, Abdullah S Alhomid. Reduced levels of brain derived neurotrophic factor (BDNF) in the serum of diabetic retinopathy patients and in the retina of diabetic rats. Cellular and molecular neurobiology. vol 33. issue 3. 2013-09-04. PMID:23271640. |
our results indicate that reduced levels of bdnf in diabetes may cause apoptosis and neurodegeneration early in diabetic retina, which may lead to neuro-vascular damage later in dr. |
2013-09-04 |
2023-08-12 |
rat |
| Ying-Li Gu, Lu-Wei Yin, Zhuo Zhang, Jia Liu, Su-Juan Liu, Lian-Feng Zhang, Ting-Hua Wan. Neurotrophin expression in neural stem cells grafted acutely to transected spinal cord of adult rats linked to functional improvement. Cellular and molecular neurobiology. vol 32. issue 7. 2013-07-10. PMID:22573254. |
however, only mrna expression of bdnf and nt-3 but not ngf in injury segment following nsc transplantation was upregulated remarkably, while caspase-3, a crucial apoptosis gene, was downregulated simultaneously. |
2013-07-10 |
2023-08-12 |
rat |
| I Baranowska-Bosiacka, L Strużyńska, I Gutowska, A Machalińska, A Kolasa, P Kłos, G A Czapski, M Kurzawski, A Prokopowicz, M Marchlewicz, K Safranow, B Machaliński, B Wiszniewska, D Chlube. Perinatal exposure to lead induces morphological, ultrastructural and molecular alterations in the hippocampus. Toxicology. vol 303. 2013-03-07. PMID:23146751. |
we observed no morphological or molecular features of severe apoptosis or necrosis (no active casp-3 and aif translocation to nucleus) in young brains, despite the reduced levels of bdnf. |
2013-03-07 |
2023-08-12 |
rat |
| Wei Rong, Jun Wang, Xiaoguang Liu, Liang Jiang, Feng Wei, Xing Hu, Xiaoguang Han, Zhongjun Li. Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22453521. |
naringin treatment improves functional recovery by increasing bdnf and vegf expression, inhibiting neuronal apoptosis after spinal cord injury. |
2012-11-05 |
2023-08-12 |
rat |
| Wei Rong, Jun Wang, Xiaoguang Liu, Liang Jiang, Feng Wei, Xing Hu, Xiaoguang Han, Zhongjun Li. Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22453521. |
these findings suggest that naringin treatment starting 1 day after sci can significantly improve locomotor recovery, and this neuroprotective effect may be related to the upregulation of bdnf and vegf and the inhibition of neural apoptosis. |
2012-11-05 |
2023-08-12 |
rat |
| Jingyu Zhang, Zhigang Yu, Zhiqiang Yu, Zichao Yang, Hong Zhao, Luran Liu, Jiexu Zha. rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model. International journal of clinical and experimental pathology. vol 4. issue 5. 2012-10-31. PMID:21738820. |
cells infected with raav-bdnf could be able to produce functional bdnf which promoted neurite outgrowth and protected neurons from apoptosis induced by serum deprivation. |
2012-10-31 |
2023-08-12 |
Not clear |
| Bulent Satar, Yusuf Hidir, Muhittin A Serdar, Zulkuf Kucuktag, Ali Ugur Ural, Ferit Avcu, Mukerrem Safali, Serpil Oguztuzu. Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells. Cytotherapy. vol 14. issue 5. 2012-09-25. PMID:22268520. |
our aim was to compare apoptosis scores and the expression of myelin-associated glycoprotein (mag), myelin basic protein (mbp), neural cell adhesion molecule (ncam)-1,matrix metalloproteinase (mmp)-1a, tissue inhibitor of metalloproteinase (timp)-1, timp-1/mmp-1a ratio, nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), ciliary neurotrophic factor (cntf), neurotrophin (nt)-3, nt-4, glial cell-derived neurotropic factor (gdnf), leukemia inhibitory factor (lif), basic fibroblast growth factor (fgf)-2, insulin-like growth factor (igf)-1, platelet-derived growth factor (pdgf)-α and transforming growth factor (tgf)-β1 in anastomosed facial nerves that had been treated with or without msc. |
2012-09-25 |
2023-08-12 |
Not clear |
| T Ishrat, I Sayeed, F Atif, F Hua, D G Stei. Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway. Neuroscience. vol 210. 2012-09-21. PMID:22450229. |
the treatment also increased bdnf, and attenuated apoptosis by increasing akt phosphorylation compared with vehicle alone. |
2012-09-21 |
2023-08-12 |
rat |
| J Wang, W Rong, X Hu, X Liu, L Jiang, Y Ma, G Dang, Z Liu, F We. Hyaluronan tetrasaccharide in the cerebrospinal fluid is associated with self-repair of rats after chronic spinal cord compression. Neuroscience. vol 210. 2012-09-21. PMID:22450230. |
hyaluronan tetrasaccharide (ha(4)) induced nf-κb and c-iap(2) to suppress the h(2)o(2)-induced apoptosis in primary neuronal cultures and increased bdnf and vegf expression in astrocytic cultures in vitro. |
2012-09-21 |
2023-08-12 |
rat |
| Dawei Guo, Wenyu Sun, Lei Zhu, Hongbin Zhang, Xuezhong Hou, Jian Liang, Xiaofeng Jiang, Chen Li. Knockdown of BDNF suppressed invasion of HepG2 and HCCLM3 cells, a mechanism associated with inactivation of RhoA or Rac1 and actin skeleton disorganization. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 120. issue 6. 2012-09-11. PMID:22583359. |
bdnf knockdown also induced apoptosis and suppressed invasion of both hepg2 and hcclm3 cells. |
2012-09-11 |
2023-08-12 |
human |
| I-Neng Lee, Martin Hsiu-Chu Lin, Chiu-Yen Chung, Ming-Hsueh Lee, Hsu-Huei Weng, Jen-Tsung Yan. Chronic cigarette smoke exposure enhances brain-derived neurotrophic factor expression in rats with traumatic brain injury. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22476923. |
the aim of this study was to investigate the effects of chronic exposure to cigarette smoke on bdnf expression and apoptosis in rats with tbi. |
2012-09-07 |
2023-08-12 |
rat |
| Edward C Lauterbach, Leonardo F Fontenelle, Antonio L Teixeir. The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22254151. |
the most promising neuroprotective investigative priorities will involve disease-modifying trials of the safest agents alone or in combination to capture salutary effects on h3 histone deacetylase, gene transcription, glycogen synthase kinase-3, α-synuclein, reactive oxygen species (ros), reactive nitrogen species (rns), apoptosis, inflammation, and trophic factors including gdnf and bdnf. |
2012-08-23 |
2023-08-12 |
mouse |
| Lou-yan Ma, Dong-min Zhang, Yong Tang, Yang Lu, Yin Zhang, Yuan Gao, Li Xia, Ke-xiang Zhao, Li-Yin Chai, Qian Xia. Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats. Alzheimer disease and associated disorders. vol 25. issue 4. 2012-08-13. PMID:22005105. |
our results showed that the changes of bdnf, creb, and hippocampus neuronal apoptosis might be involved in the pathogenesis of diabetic encephalopathy. |
2012-08-13 |
2023-08-12 |
rat |
| Lou-yan Ma, Dong-min Zhang, Yong Tang, Yang Lu, Yin Zhang, Yuan Gao, Li Xia, Ke-xiang Zhao, Li-Yin Chai, Qian Xia. Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats. Alzheimer disease and associated disorders. vol 25. issue 4. 2012-08-13. PMID:22005105. |
we suggested that ghrelin improved cognitive ability in streptozotocin-induced diabetic rats by improving the expressions of bdnf and creb and by attenuating hippocampus neuronal apoptosis. |
2012-08-13 |
2023-08-12 |
rat |
| Tongrong He, Zvonimir S Katusi. Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells. Microvascular research. vol 83. issue 3. 2012-08-09. PMID:22261313. |
bdnf treatment inhibited apoptosis induced by a superoxide anion generator ly83583, and serum starvation-induced cell detachment. |
2012-08-09 |
2023-08-12 |
human |
| Martin Steinkamp, Nadine Schulte, Ulrike Spaniol, Carolin Pflüger, Christoph Hartmann, Joachim Kirsch, Georg B von Boye. Brain derived neurotrophic factor inhibits apoptosis in enteric glia during gut inflammation. Medical science monitor : international medical journal of experimental and clinical research. vol 18. issue 4. 2012-08-07. PMID:22460084. |
as a diminished egc network is postulated in crohn's disease (cd), we aimed to investigate if egcs could be a target of apoptosis during inflammation in cd, which can be influenced by brain derived neurotrophic factor (bdnf). |
2012-08-07 |
2023-08-12 |
Not clear |
| Felipe Ortega, Raquel Pérez-Sen, Esmerilda G Delicado, M Teresa Miras-Portuga. ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21798274. |
these two different erk-mediated pathways were involved in the neuroprotective effects displayed by both p2y(13) and p2x7 receptors against apoptosis induced by an excitotoxic concentration of glutamate, in a similar manner to the neurotrophin, bdnf. |
2012-08-01 |
2023-08-12 |
Not clear |
| Sivasankaran Balaratnasingam, Aleksandar Janc. Brain Derived Neurotrophic Factor: a novel neurotrophin involved in psychiatric and neurological disorders. Pharmacology & therapeutics. vol 134. issue 1. 2012-06-26. PMID:22281237. |
bdnf may be the "missing-link" that mediates the interaction between gene and environment, synaptic plasticity and apoptosis and transgenerational transmission of disease vulnerability. |
2012-06-26 |
2023-08-12 |
human |