| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-wei Yang, Fei Wu, Sheng-Li Zhan. Effects of ganoderic acids on epileptiform discharge hippocampal neurons: insights from alterations of BDNF,TRPC3 and apoptosis. Die Pharmazie. vol 71. issue 6. 2016-08-17. PMID:27455554. |
the apoptosis rate of neurons was inversely proportional to bdnf and trpc3 changes (p < 0.01). |
2016-08-17 |
2023-08-13 |
rat |
| Ping Ma, Xiao-Yuan Mao, Xiao-Lei Li, Ying Ma, Yuan-Dong Qiao, Zhao-Qian Liu, Hong-Hao Zhou, Yong-Gang Ca. Baicalin alleviates diabetes‑associated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brain‑derived neurotrophic factor and apoptosis. Molecular medicine reports. vol 12. issue 4. 2016-07-21. PMID:26300488. |
the findings suggested that baicalin exerts neuroprotective effects against dacd via modulation of mapk cascades, bdnf and apoptosis. |
2016-07-21 |
2023-08-13 |
rat |
| Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Le. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural plasticity. vol 2015. 2016-07-19. PMID:26448879. |
next, we examined the role of h89 pretreatment on the expression of brain-derived neurotrophic factor (bdnf), psd95, map2, and the apoptosis regulators bcl2 and cleaved caspase-3 in cultured neuroblastoma cells exposed to hypoxia and reperfusion injury. |
2016-07-19 |
2023-08-13 |
mouse |
| Liguo Yang, Shigang Song, Hang L. MicroRNA-322 protects hypoxia-induced apoptosis in cardiomyocytes via BDNF gene. American journal of translational research. vol 8. issue 6. 2016-07-11. PMID:27398164. |
microrna-322 protects hypoxia-induced apoptosis in cardiomyocytes via bdnf gene. |
2016-07-11 |
2023-08-13 |
Not clear |
| Yong Zhang, Rui Lan, Jun Wang, Xiang-Yun Li, Deng-Na Zhu, Yun-Zhi Ma, Ji-Tao Wu, Zhen-Huan Li. Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia-ischemia in neonatal rats. Journal of ethnopharmacology. vol 172. 2016-06-03. PMID:26116163. |
acupuncture reduced apoptosis and up-regulated bdnf and gdnf expression in hippocampus following hypoxia-ischemia in neonatal rats. |
2016-06-03 |
2023-08-13 |
rat |
| Peifang Jiang, Tao Zhu, Zhezhi Xia, Feng Gao, Weizhong Gu, Xi Chen, Tianming Yuan, Huimin Y. Inhibition of MAPK/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats. European archives of psychiatry and clinical neuroscience. vol 265. issue 6. 2016-06-01. PMID:25721317. |
furthermore, inhibition of mapk/erk signaling could aggravate hippocampal neuronal apoptosis, decrease neurogenesis, and impair the offspring's cognitive performances and could also down-regulate the levels of p-erk, p-creb and bdnf. |
2016-06-01 |
2023-08-13 |
rat |
| Qi Li, Masayuki Tsuneki, Michael Krauthammer, Rachael Couture, Michael Schwartz, Joseph A Madr. Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. The American journal of pathology. vol 185. issue 9. 2016-05-10. PMID:26209807. |
specifically, there was induction of genes, including sox10, hif1a, hif2a, birc5, yap1, epo, bdnf, notch1 (cleaved), pcna, mag, mobp, plp1, synapsin, adgra2, pecam1, and reduction in activation of caspase 3, all known to affect proliferation, apoptosis, synaptic transmission, and nerve transmission. |
2016-05-10 |
2023-08-13 |
mouse |
| XiaoNing Chen, Jia Li, Lei Zeng, XueBo Zhang, XiaoHua Lu, MingXue Zuo, XinWen Zhang, ShaoJu Zen. Sexual Differences in Cell Loss during the Post-Hatch Development of Song Control Nuclei in the Bengalese Finch. PloS one. vol 10. issue 5. 2016-04-04. PMID:25938674. |
we reasoned that a decrease in the amount of bdnf transported via hvc afferent fibers might result in an increase in cell apoptosis in the female ra. |
2016-04-04 |
2023-08-13 |
Not clear |
| Junjia Tang, Qin Hu, Yujie Chen, Fei Liu, Yun Zheng, Jiping Tang, Jianmin Zhang, John H Zhan. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiology of disease. vol 78. 2016-03-28. PMID:25862938. |
hioc was more potent than bdnf in reduction of apoptosis 24h post-sah. |
2016-03-28 |
2023-08-13 |
rat |
| Mingyue Fan, Wei Jin, Haifeng Zhao, Yining Xiao, Yanqiu Jia, Yu Yin, Xin Jiang, Jing Xu, Nan Meng, Peiyuan L. Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus. Behavioural brain research. vol 291. 2016-03-28. PMID:26031381. |
lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing bdnf expression in hippocampus. |
2016-03-28 |
2023-08-13 |
mouse |
| Mingyue Fan, Wei Jin, Haifeng Zhao, Yining Xiao, Yanqiu Jia, Yu Yin, Xin Jiang, Jing Xu, Nan Meng, Peiyuan L. Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus. Behavioural brain research. vol 291. 2016-03-28. PMID:26031381. |
these effects may relay on the inhibition of apoptosis and increasing bdnf and p-creb expression. |
2016-03-28 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Haixiao Li, Huiqing Zhang, Jiangtao Jin, Wenqian Chen, Mengqi Pang, Junjie Yu, Yiwen He, Jiaming Liu, Chunfeng Li. Neuroprotective Effect of Sodium Butyrate against Cerebral Ischemia/Reperfusion Injury in Mice. BioMed research international. vol 2015. 2016-03-10. PMID:26064905. |
10 mg/kg nab treatment also remarkably inhibited the apoptosis, decreasing the levels of caspase-3 and bax and increasing the levels of bcl-2, p-akt, and bdnf. |
2016-03-10 |
2023-08-13 |
mouse |
| Diana Le Duc, Ana Spataru, Mihai Ceanga, Leon Zagrean, Torsten Schöneberg, Emil C Toescu, Ana-Maria Zagrea. Developmental exposure to ethanol increases the neuronal vulnerability to oxygen-glucose deprivation in cerebellar granule cell cultures. Brain research. vol 1614. 2016-02-22. PMID:25881894. |
in the ethanol-treated cerebellar granule neurons we find an increased expression of genes related to apoptosis (mapk8 and bax), but also of genes previously described as neuroprotective (dhcr24 and bdnf), which might suggest an actively maintained viability. |
2016-02-22 |
2023-08-13 |
mouse |
| Long-Xia Chen, Si-Min Ma, Peng Zhang, Zi-Chuan Fan, Man Xiong, Guo-Qiang Cheng, Yi Yang, Zi-Long Qiu, Wen-Hao Zhou, Jin L. Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury. PloS one. vol 10. issue 3. 2016-02-04. PMID:25790286. |
the results showed that transplanted opcs survived and formed a myelin sheath, and stimulated bdnf and bcl-2 expression and the proliferation of neural stem cells (nsc), while inhibiting hi-induced neuronal apoptosis relative to control animals. |
2016-02-04 |
2023-08-13 |
mouse |
| V S Naumenko, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, V N Sychev, E Y Bazhenova, N A Sinyakova, N K Popov. Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions. Neuroscience. vol 284. 2015-12-30. PMID:25451288. |
thus, long-term spaceflight (1) did not affect the expression of genes encoding bdnf as well as trkb and p75 receptors, (2) produced dysregulation in genetic control of the neuronal apoptosis, (3) implicated bcl-xl as the risk factor for spaceflight-induced behavioral abnormalities. |
2015-12-30 |
2023-08-13 |
mouse |
| Kyoung Joo Cho, Gyung Whan Ki. Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26297950. |
in this study, we investigated the relationship between reduced levels of brain-derived neurotrophic factor (bdnf) in lesioned brain regions and caspase activity, as well as involvement of apoptosis signal-regulating kinase 1 (ask1) in caspase activation. |
2015-11-27 |
2023-08-13 |
Not clear |
| Shangli Cai, Shucai Huang, Wei Ha. New hypothesis and treatment targets of depression: an integrated view of key findings. Neuroscience bulletin. vol 31. issue 1. 2015-09-18. PMID:25575479. |
by integrating mdd-related signal pathways, we highlight brain-derived neurotrophic factor (bdnf) dysfunction and increased apoptosis as the final common cascades, and new therapeutic strategies aiming to enhance bdnf function have been shown to exert a rapid and effective antidepressant action. |
2015-09-18 |
2023-08-13 |
Not clear |
| Bin He, Haiying Tao, Shiqing Li. [Effect of carboxymethylated chitosan on apoptosis and expression of brain derived neurotrophic factor and glial cell line derived neurotrophic factor in oxidative stress induced Schwann cells in vitro]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 28. issue 12. 2015-07-17. PMID:25826901. |
to investigate the protective effects of carboxymethylated chitosan (cmcs) on oxidative stress induced apoptosis of schwann cells (scs), and the expressions of brain derived neurotrophic factor (bdnf) and glial cell line derived neurotrophic factor (gdnf) in oxidative stress induced scs. |
2015-07-17 |
2023-08-13 |
Not clear |
| MuHuo Ji, Lin Dong, Min Jia, WenXue Liu, MingQiang Zhang, LinSha Ju, JiaoJiao Yang, Zhongcong Xie, JianJun Yan. Epigenetic enhancement of brain-derived neurotrophic factor signaling pathway improves cognitive impairments induced by isoflurane exposure in aged rats. Molecular neurobiology. vol 50. issue 3. 2015-07-08. PMID:24553857. |
our data showed that repeated isoflurane exposure significantly decreased the freezing time to context and the freezing time to tone in the fear conditioning test, which was associated with upregulated histone deacetylase 2, reduced histone acetylation, and increased inflammation and apoptosis in the hippocampus, and impairments of brain-derived neurotrophic factor (bdnf)-tyrosine kinase receptor b (trkb) and the downstream signaling pathway phospho-calmodulin-dependent protein kinase and phospho-camp response element-binding protein. |
2015-07-08 |
2023-08-12 |
rat |
| Raiha Tahir, Allyson Kennedy, Sarah H Elsea, Amanda J Dickinso. Retinoic acid induced-1 (Rai1) regulates craniofacial and brain development in Xenopus. Mechanisms of development. vol 133. 2015-06-22. PMID:24878353. |
such brain defects correlated with a decrease in the neurotrophic factor, bdnf, and increased forebrain apoptosis. |
2015-06-22 |
2023-08-13 |
mouse |