| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapan Behl, Anita Kotwan. Downregulated Brain-Derived Neurotrophic Factor-Induced Oxidative Stress in the Pathophysiology of Diabetic Retinopathy. Canadian journal of diabetes. vol 41. issue 2. 2017-05-31. PMID:27913110. |
however, in diabetic retinopathy (a neuromicrovascular disorder involving immense neuronal degeneration), bdnf fails to provide enough neuroprotection against oxidative stress-induced retinal neuronal apoptosis. |
2017-05-31 |
2023-08-13 |
Not clear |
| Dan Xie, G David H Croaker, Jimei Li, Zan-Min Son. Reduced cell proliferation and increased apoptosis in the hippocampal formation in a rat model of Hirschsprung's disease. Brain research. vol 1642. 2017-05-22. PMID:27017960. |
these results suggest that ednrb mutation reduces cell proliferation and increases apoptosis in the hippocampal formation of the sl/sl rat, but does not alter the levels of bdnf and gdnf. |
2017-05-22 |
2023-08-13 |
rat |
| Yi Wei, Junhua Hu, Yubing Liang, Yuling Zhong, Dan He, Yi Qin, Li Li, Jing Chen, Qiang Xiao, Yubo Xi. Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampus. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27571870. |
these results showed that propofol exposure (100 µm; 3 h) reduced neuronal viability, induced cell apoptosis and decreased the expression levels of bdnf, bcl‑2 and p‑creb. |
2017-04-17 |
2023-08-13 |
rat |
| Yi Wei, Junhua Hu, Yubing Liang, Yuling Zhong, Dan He, Yi Qin, Li Li, Jing Chen, Qiang Xiao, Yubo Xi. Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampus. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27571870. |
dexmedetomidine treatment (0.001‑100 µm) of the neurons prior to propofol exposure attenuated the propofol‑induced neuronal apoptosis and increased expression levels of bdnf, bcl‑2 and p‑creb compared with the propofol only group. |
2017-04-17 |
2023-08-13 |
rat |
| Bo Jiang, Lin Gao, Dawei Lei, Jiannan Liu, Zhengbo Shao, Xinrong Zhou, Renke Li, Donglai Wu, Fei Xue, Yuanmao Zhu, Huiping Yua. Decreased expression of miR‑9 due to E50K OPTN mutation causes disruption of the expression of BDNF leading to RGC‑5 cell apoptosis. Molecular medicine reports. vol 14. issue 5. 2017-04-06. PMID:27748809. |
decreased expression of mir‑9 due to e50k optn mutation causes disruption of the expression of bdnf leading to rgc‑5 cell apoptosis. |
2017-04-06 |
2023-08-13 |
Not clear |
| A Najafi, F Amidi, M A Sedighi Gilani, A R Moawad, E Asadi, N Khanlarkhni, P Fallah, Z Rezaiian, A Sobhan. Effect of brain-derived neurotrophic factor on sperm function, oxidative stress and membrane integrity in human. Andrologia. vol 49. issue 2. 2017-03-01. PMID:27136309. |
the brain-derived neurotrophic factor (bdnf) promotes the viability of nerve cells and is known to decrease oxidative stress and apoptosis in different cells. |
2017-03-01 |
2023-08-13 |
human |
| Edyta Paczkowska, Karolina Łuczkowska, Katarzyna Piecyk, Dorota Rogińska, Ewa Pius-Sadowska, Przemysław Ustianowski, Elżbieta Cecerska, Barbara Dołęgowska, Zbigniew Celewicz, Bogusław Machalińsk. The influence of BDNF on human umbilical cord blood stem/progenitor cells: implications for stem cell-based therapy of neurodegenerative disorders. Acta neurobiologiae experimentalis. vol 75. issue 2. 2016-12-13. PMID:26232994. |
next, after bdnf pre-treatment, lin- cells were extensively assessed with respect to apoptosis using western blotting and proliferation via brdu incorporation. |
2016-12-13 |
2023-08-13 |
human |
| Edyta Paczkowska, Karolina Łuczkowska, Katarzyna Piecyk, Dorota Rogińska, Ewa Pius-Sadowska, Przemysław Ustianowski, Elżbieta Cecerska, Barbara Dołęgowska, Zbigniew Celewicz, Bogusław Machalińsk. The influence of BDNF on human umbilical cord blood stem/progenitor cells: implications for stem cell-based therapy of neurodegenerative disorders. Acta neurobiologiae experimentalis. vol 75. issue 2. 2016-12-13. PMID:26232994. |
bdnf pre-treatment diminished apoptosis in lin- cells and influenced the proliferation of these cells. |
2016-12-13 |
2023-08-13 |
human |
| Shotaro Otsuka, Harutoshi Sakakima, Megumi Sumizono, Seiya Takada, Takuto Terashi, Yoshihiro Yoshid. The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats. Behavioural brain research. vol 303. 2016-12-13. PMID:26808606. |
our findings suggest that preconditioning exercise reduced the infract volume and ameliorated motor function, enhanced expression levels of mk and bdnf, increased astrocyte proliferation, increased angiogenesis, and reduced neuronal apoptosis and oxidative stress. |
2016-12-13 |
2023-08-13 |
rat |
| You-Cui Wang, Guo-Ying Feng, Qing-Jie Xia, Yue Hu, Yang Xu, Liu-Lin Xiong, Zhi-Wei Chen, Hang-Ping Wang, Ting-Hua Wang, Xue Zho. Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26822976. |
together, endogenous snca play a crucial role in motor and sensory function regulation, in which, the underlying mechanism may be linked to the regulation of apoptosis associated with apoptotic gene (bax, bcl2) and neurotrophic factors expression (ngf, bdnf and nt3). |
2016-12-13 |
2023-08-13 |
rat |
| Yu Gao, Ming Jing, Rongrong Ge, Lili Lan. Induction of hypoxia-inducible factor-1α by BDNF protects retinoblastoma cells against chemotherapy-induced apoptosis. Molecular and cellular biochemistry. vol 414. issue 1-2. 2016-12-13. PMID:26868822. |
induction of hypoxia-inducible factor-1α by bdnf protects retinoblastoma cells against chemotherapy-induced apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Yu Gao, Ming Jing, Rongrong Ge, Lili Lan. Induction of hypoxia-inducible factor-1α by BDNF protects retinoblastoma cells against chemotherapy-induced apoptosis. Molecular and cellular biochemistry. vol 414. issue 1-2. 2016-12-13. PMID:26868822. |
the results showed that bdnf could induce higher expression of hif-1α via activation of trkb in human y-79 retinoblastoma cells, which consequently contributed to its effect against chemotherapeutic agent-induced cytotoxicity and cell apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Shamayra Smail, Dalbir Bahga, Brittnee McDole, Kathleen Guthri. Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington's Disease R6/2 Mouse. Chemical senses. vol 41. issue 3. 2016-11-02. PMID:26783111. |
although we detected a decline in apoptosis, increased bdnf was not sufficient to normalize granule cell survival within their normal target in r6/2 mice. |
2016-11-02 |
2023-08-13 |
mouse |
| Juan Tang, Xing-ting Zheng, Ke Xiao, Kun-lun Wang, Jing Wang, Yun-xiao Wang, Ke Wang, Wei Wang, Shun Lu, Ke-li Yang, Peng-Peng Sun, Haseeb Khaliq, Juming Zhong, Ke-Mei Pen. Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain. Biological trace element research. vol 170. issue 1. 2016-10-28. PMID:26226831. |
adversely, when boric acid doses were higher than 320 mg/l(groups v, vi), the high-dose boric acid neuron structure was damaged with less neurites, particularly at 640 mg/l; (2) the quantity of bdnf expression in groups ii, iii, and iv was increased while it was decreased in groups v and vi when compared with that in group i; (3) tunel reaction and the caspase-3 mrna level showed that the amount of cell apoptosis in group ii, group iii, and group iv were decreased, but increased in group v and group vi significantly. |
2016-10-28 |
2023-08-13 |
chicken |
| Juan Tang, Xing-ting Zheng, Ke Xiao, Kun-lun Wang, Jing Wang, Yun-xiao Wang, Ke Wang, Wei Wang, Shun Lu, Ke-li Yang, Peng-Peng Sun, Haseeb Khaliq, Juming Zhong, Ke-Mei Pen. Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain. Biological trace element research. vol 170. issue 1. 2016-10-28. PMID:26226831. |
these results indicated that appropriate supplementation of boric acid, especially at 160 mg/l, could promote ostrich chicks' brain development by promoting the bdnf expression and reducing cell apoptosis. |
2016-10-28 |
2023-08-13 |
chicken |
| Juan Tang, Xing-ting Zheng, Ke Xiao, Kun-lun Wang, Jing Wang, Yun-xiao Wang, Ke Wang, Wei Wang, Shun Lu, Ke-li Yang, Peng-Peng Sun, Haseeb Khaliq, Juming Zhong, Ke-Mei Pen. Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain. Biological trace element research. vol 170. issue 1. 2016-10-28. PMID:26226831. |
conversely, high dose of boric acid particularly in 640 mg/l would damage the neuron structure of ostrich chick brain by inhibiting the bdnf expression and increasing cell apoptosis. |
2016-10-28 |
2023-08-13 |
chicken |
| S Streiter, B Fisch, B Sabbah, A Ao, R Abi. The importance of neuronal growth factors in the ovary. Molecular human reproduction. vol 22. issue 1. 2016-10-05. PMID:26487421. |
additionally, ngf, nt3 and gdnf promoted follicular cell proliferation; ngf, bdnf and vip were shown to be involved in ovulation; vip inhibited follicular apoptosis; nt4/5, bdnf and gdnf promoted oocyte maturation and ngf, nt3 and vip stimulated steroidogenesis. |
2016-10-05 |
2023-08-13 |
mouse |
| Jiaming Liu, Jing Sun, Fangyan Wang, Xichong Yu, Zongxin Ling, Haixiao Li, Huiqing Zhang, Jiangtao Jin, Wenqian Chen, Mengqi Pang, Junjie Yu, Yiwen He, Jiru X. Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate. BioMed research international. vol 2015. 2016-09-28. PMID:26523278. |
c. butyricum not only increased the levels of bdnf and bcl-2 and decreased level of bax but also induced akt phosphorylation (p-akt) and ultimately reduced neuronal apoptosis. |
2016-09-28 |
2023-08-13 |
mouse |
| Qian Ma, Jianmin Yang, Thomas Li, Teresa A Milner, Barbara L Hempstea. Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease. Neurobiology of disease. vol 82. 2016-08-24. PMID:26282324. |
probdnf, the precursor of mature bdnf (mbdnf), also can be secreted but promotes apoptosis of neurons expressing p75(ntr) and sortilin receptors. |
2016-08-24 |
2023-08-13 |
mouse |
| Zhi-wei Yang, Fei Wu, Sheng-Li Zhan. Effects of ganoderic acids on epileptiform discharge hippocampal neurons: insights from alterations of BDNF,TRPC3 and apoptosis. Die Pharmazie. vol 71. issue 6. 2016-08-17. PMID:27455554. |
effects of ganoderic acids on epileptiform discharge hippocampal neurons: insights from alterations of bdnf,trpc3 and apoptosis. |
2016-08-17 |
2023-08-13 |
rat |