| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espine. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30428894. |
contrarily to bdnf, the precursor form of bdnf (probdnf) induces apoptosis through the specific interaction with p75 and its co-receptor, sortilin.we used hippocampal tissue and cerebrospinal fluid from ad patients and controls. |
2019-03-04 |
2023-08-13 |
mouse |
| Hee Ra Park, Heeeun Lee, Jung-Jin Lee, Nam-Hui Yim, Min-Jung Gu, Jin Yeul M. Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28707073. |
in mcao-reperfusion injury, sce promoted neuronal survival and level of brain-derived neurotrophic factor (bdnf) by reducing glial activation, oxidative stress, and apoptosis in the ipsilateral cortex. |
2019-02-26 |
2023-08-13 |
rat |
| Yang Gou, Danyan Liu, Jinfeng Liu, Hongran Su. [Protective effect of transplantation of bone mesenchymal stem cells on demyelination in spinal cord injury]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 34. issue 5. 2019-02-11. PMID:29893084. |
bmscs protected neural myelin sheaths by inhibiting oligodendrocyte apoptosis via increased secretion of bdnf after sci. |
2019-02-11 |
2023-08-13 |
rat |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
compared with the blank and nc groups, the mir-216a mimic and sirna-gdnf groups had higher mrna and protein levels of c-fos, vegf and bax, cell number in the g1 phase and increased cell apoptosis but reduced bdnf, gdnf, gfrα1, ret and bcl-2 expression, cell proliferation and cell numbers in the s phase, while the opposite trend was observed in the mir-216a inhibitor group. |
2019-01-29 |
2023-08-13 |
rat |
| Min Chen, Guoping He, Qiang L. Maternal deprivation promotes hippocampal neuronal apoptosis via ERK1/2 signaling. Frontiers in bioscience (Landmark edition). vol 23. 2019-01-24. PMID:29772537. |
compared with controls, md group showed increased hippocampal neuronal apoptosis, higher mrna expressions of bax, caspase-3 and caspase-9mrnas, and lower expression of bcl-2 and bdnf. |
2019-01-24 |
2023-08-13 |
rat |
| Yun Pei, Zhexiao Jiao, Wanting Dong, Linguo Pei, Xia He, Hui Wang, Dan X. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 123. 2019-01-15. PMID:30389584. |
compared with the control group, fetal rats by pne showed increased hippocampal apoptosis, reduced synaptic plasticity and downregulation of the brain-derived neurotrophic factor (bdnf) pathway, whereas glutamic acid decarboxylase 67 (gad67) expression was upregulated. |
2019-01-15 |
2023-08-13 |
rat |
| Tengfei Zhao, Yingxue Fu, Hao Sun, Xiaoquan Li. Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. IUBMB life. vol 70. issue 1. 2018-12-17. PMID:29247598. |
pro- and anti-apoptotic biomarkers of multiple pathways including bdnf, mcp-1, and hcy played a joint role in triggering the activation of the mitochondria-related bax/bcl-2 and caspase-3 apoptosis pathway in vd. |
2018-12-17 |
2023-08-13 |
rat |
| Tengfei Zhao, Yingxue Fu, Hao Sun, Xiaoquan Li. Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. IUBMB life. vol 70. issue 1. 2018-12-17. PMID:29247598. |
ligustrazine attenuated vd by comprehensively regulating bdnf, mcp-1, and hcy and inactivating the bax/bcl-2 and caspase-3 apoptosis pathway. |
2018-12-17 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
[over-expression of bdnf inhibits angiotensin ii-induced apoptosis of cardiomyocytes in sd rats]. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
objective to investigate the role and molecular mechanism of brain-derived neurotrophic factor (bdnf) against the process of cardiomyocyte hypertrophy and apoptosis. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
the effect of bdnf transfection on the apoptosis of cardiomyocytes was assayed by flow cytometry. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
compared with the untransfected control cardiomyocytes, the surface area of cardiomyocytes, the rate of apoptosis, the levels of anp and bnp mrna and protein expression, the levels of p-camk2 and can protein in the bdnf over-expressed cardiomyocytes were remarkably reduced, while the level of p-nfatc3 protein rose significantly. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
conclusion bdnf inhibits the apoptosis of cardiomyocytes induced by ang ii, and it plays the role by inhibiting camk2 and can signaling pathways. |
2018-11-27 |
2023-08-13 |
rat |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
we aimed to investigate the effects of brain-derived neurotrophic factor (bdnf) on apoptosis of intestinal epithelial cells (iecs) and alterations of intestinal barrier integrity using bdnf knock-out mice model. |
2018-11-26 |
2023-08-13 |
mouse |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
compared with bdnf(+/+) mice, bdnf(+/-) mice displayed impaired integrity and ultrastructure alterations in their colonic mucosa, which was characterized by diminished microvilli, mitochondrial swelling and epithelial cells apoptosis. |
2018-11-26 |
2023-08-13 |
mouse |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
altered intestinal barrier function was linked to excessive apoptosis of iecs demonstrated by the higher proportion of tunel-positive apoptotic cells and enhanced caspase activities in bdnf(+/-) mice. |
2018-11-26 |
2023-08-13 |
mouse |
| Gorka Gerenu, Eva Martisova, Hilda Ferrero, Miguel Carracedo, Tomi Rantamäki, Maria Javier Ramirez, Francisco Javier Gil-Be. Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 4. 2018-11-19. PMID:28132883. |
however, insufficient proteolytic processing under pathology may lead to the precursor form of bdnf (probdnf) and thereby increased neuronal apoptosis and synaptic weakening. |
2018-11-19 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
the result showed that deficits in spatial learning and memory, and short-term memory in male offspring born to obese mothers was associated with decreases in brain-derived neurotrophic factor (bdnf) levels and neurogenesis, and an increase in apoptosis in the hippocampal dentate gyrus. |
2018-11-13 |
2023-08-13 |
rat |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
physical exercise improved spatial learning and memory, and short-term memory by enhancing bdnf levels and neurogenesis, and by inhibiting apoptosis in the hippocampal dentate gyrus of male offspring born to obese mothers. |
2018-11-13 |
2023-08-13 |
rat |
| Wei Duan, Yan Chen, Xiao-Rong Wan. MicroRNA‑155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901097. |
overexpression of mirna‑155 resulted in decreased brain‑derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) protein expression, increased caspase‑3 activity, tumor protein p53 (p53) and apoptosis regulator bax (bax) protein expression, and inhibited phosphoinositide 3‑kinase (pi3k), phosphorylated (p‑)protein kinase b (akt) and p‑mechanistic target of rapamycin (mtor) protein expression in epilepsy cells. |
2018-10-29 |
2023-08-13 |
human |