| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
compared with bdnf(+/+) mice, bdnf(+/-) mice displayed impaired integrity and ultrastructure alterations in their colonic mucosa, which was characterized by diminished microvilli, mitochondrial swelling and epithelial cells apoptosis. |
2018-11-26 |
2023-08-13 |
mouse |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
altered intestinal barrier function was linked to excessive apoptosis of iecs demonstrated by the higher proportion of tunel-positive apoptotic cells and enhanced caspase activities in bdnf(+/-) mice. |
2018-11-26 |
2023-08-13 |
mouse |
| Gorka Gerenu, Eva Martisova, Hilda Ferrero, Miguel Carracedo, Tomi Rantamäki, Maria Javier Ramirez, Francisco Javier Gil-Be. Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 4. 2018-11-19. PMID:28132883. |
however, insufficient proteolytic processing under pathology may lead to the precursor form of bdnf (probdnf) and thereby increased neuronal apoptosis and synaptic weakening. |
2018-11-19 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
the result showed that deficits in spatial learning and memory, and short-term memory in male offspring born to obese mothers was associated with decreases in brain-derived neurotrophic factor (bdnf) levels and neurogenesis, and an increase in apoptosis in the hippocampal dentate gyrus. |
2018-11-13 |
2023-08-13 |
rat |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
physical exercise improved spatial learning and memory, and short-term memory by enhancing bdnf levels and neurogenesis, and by inhibiting apoptosis in the hippocampal dentate gyrus of male offspring born to obese mothers. |
2018-11-13 |
2023-08-13 |
rat |
| Wei Duan, Yan Chen, Xiao-Rong Wan. MicroRNA‑155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901097. |
overexpression of mirna‑155 resulted in decreased brain‑derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) protein expression, increased caspase‑3 activity, tumor protein p53 (p53) and apoptosis regulator bax (bax) protein expression, and inhibited phosphoinositide 3‑kinase (pi3k), phosphorylated (p‑)protein kinase b (akt) and p‑mechanistic target of rapamycin (mtor) protein expression in epilepsy cells. |
2018-10-29 |
2023-08-13 |
human |
| R U Ostrovskaya, S S Yagubova, T A Gudasheva, S B Seredeni. Antidiabetic Properties of Low-Molecular-Weight BDNF Mimetics Depend on the Type of Activation of Post-Receptor Signaling Pathways. Bulletin of experimental biology and medicine. vol 164. issue 6. 2018-09-19. PMID:29658083. |
reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (bdnf). |
2018-09-19 |
2023-08-13 |
mouse |
| Lili Zhang, Zhaomin Fan, Yuechen Han, Lei Xu, Wenwen Liu, Xiaohui Bai, Meijuan Zhou, Jianfeng Li, Haibo Wan. Valproic Acid Promotes Survival of Facial Motor Neurons in Adult Rats After Facial Nerve Transection: a Pilot Study. Journal of molecular neuroscience : MN. vol 64. issue 4. 2018-09-18. PMID:29532368. |
but treatment of vpa significantly reduced cell apoptosis by decreasing the expression of bax protein and increased neuronal survival by upregulating the level of brain-derived neurotrophic factor (bdnf) and growth associated protein-43 (gap-43) expression in injured fmns compared with group ns. |
2018-09-18 |
2023-08-13 |
rat |
| Nevim Aygu. Biological and Genetic Features of Neuroblastoma and Their Clinical Importance. Current pediatric reviews. vol 14. issue 2. 2018-09-05. PMID:29380702. |
tyrosine kinase receptors trka, trkb and trkc, their ligands ngf, brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), and aurora kinase a (aurka) play a regulatory role in differentiation, apoptosis, cell proliferation, tumourigenesis, angiogenesis or metastasis of neuroblastoma. |
2018-09-05 |
2023-08-13 |
Not clear |
| Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Fahimeh Faraji, Shiva Mozaffar. The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28608236. |
in contrast, various doses of curcumin attenuated nicotine-induced apoptosis, oxidative stress and inflammation; while elevating p-creb and bdnf levels. |
2018-08-07 |
2023-08-13 |
rat |
| Alessia Bachis, Lee A Campbell, Kierra Jenkins, Erin Wenzel, Italo Mocchett. Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor. Neurotoxicity research. vol 32. issue 3. 2018-08-06. PMID:28776309. |
however, little is known about the effect of morphine withdrawal on bdnf and its precursor protein, or probdnf, which induces neuronal apoptosis. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
background melatonin therapy shows positive effects on neuroprotective factor brain-derived neurotrophic factor (bdnf) expression and neuronal apoptosis in neonatal hemolytic hyperbilirubinemia. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
brain tissue levels of neuronal apoptosis, bdnf expression, plc activity, ip3 content, phospho- and total ca2+/calmodulin-dependent protein kinase type iv (camkiv) expression, and phospho- and total camp response element binding protein (creb) expression were also assayed. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
phz-induced hemolytic hyperbilirubinemia significantly decreased serum bdnf, brain bdnf, and plc/ip3/ca2+ pathway activation while increasing neuronal apoptosis levels (p<0.05), all of which were partially rescued by melatonin therapy (p<0.05). |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
pre-treatment with the plc inhibitor u73122 largely abolished the positive effects of melatonin on plc/ip3/ca2+ pathway activation, downstream bdnf levels, and neuronal apoptosis (p<0.05). |
2018-08-06 |
2023-08-13 |
rat |
| Jianhua Yuan, Ying Zhang, Xiaolin Wang, Hongbiao M. Exogenous Brain-Derived Neurotrophic Factor at a 50 ng/mL Concentration has a Significant Protective Effect on Bilirubin-Induced Cerebral Cortex Neuronal Injury. Clinical laboratory. vol 63. issue 9. 2018-08-01. PMID:28879697. |
this study aimed to investigate the effect of exogenous bdnf on the apoptosis and survival of in vitro cultured neurons injured by bilirubin as well as determine the optimal bdnf concentration. |
2018-08-01 |
2023-08-13 |
Not clear |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
long noncoding rna bdnf-as inversely regulated bdnf and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
the effects of bdnf-as downregulation on dgi apoptosis and bdnf expression were assessed by tunel assay, qpcr, and western blot, respectively. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
sirna-mediated bdnf-as downregulation ameliorated dgi apoptosis and upregulated bdnf in arpe-19 cells. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
in addition, inhibiting bdnf reversed the protective effect of bdnf-as downregulation on dgi apoptosis. |
2018-07-06 |
2023-08-13 |
human |