| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxiang Yu, Qiaobing Guan, Yanping Wang, Heping Shen, Liping Zhai, Xudong Lu, Yuhua Ji. Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. Epilepsy research. vol 154. 2020-07-13. PMID:31112902. |
neuronal apoptosis is a regulated intrinsic cell mechanism and common pathological phenomenon after seizures, which involves the protein kinase b/camp response element binding protein / brain derived neurotrophic factor (akt/creb/ bdnf) signaling pathway. |
2020-07-13 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Hui-Feng Zhu, Yali Shao, Lei Qin, Jing-Huan Wang, Shan Feng, Yun-Bin Jiang, Dong Wa. Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway. Drug design, development and therapy. vol 13. 2020-06-17. PMID:31849446. |
catalpol enhances neurogenesis and inhibits apoptosis of new neurons via bdnf, but not the bdnf/trkb pathway. |
2020-06-17 |
2023-08-13 |
Not clear |
| Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabad. Crocin acts as a neuroprotective mediator against methylphenidate‑induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway. Acta neurobiologiae experimentalis. vol 79. issue 4. 2020-06-15. PMID:31885392. |
in contrast, crocin attenuated mph‑induced oxidative stress, inflammation, and apoptosis, and increased levels of p‑creb and bdnf. |
2020-06-15 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
the treatment of mir-124 agomir improved rats' spatial learning and memory ability and notably increased hippocampal neuron viability and resistance to apoptosis, corresponding to an increased brain-derived neurotrophic factor (bdnf) expression, inhibited expression of proapoptotic factors (cleaved-caspase-3 and bax), and enhanced the expression of antiapoptotic factor (bcl-2). |
2020-06-11 |
2023-08-13 |
rat |
| Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis Yug. Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats. Stem cell research. vol 41. 2020-06-02. PMID:31731179. |
microgravity-cultured msc-based therapy may improve functional recovery following spinal ischemia-reperfusion injury by promoting astrocytic bdnf release, thereby preventing apoptosis. |
2020-06-02 |
2023-08-13 |
rat |
| Yongyi Zhai, Yong Ma, Jingying Liu, Yulin Zhu, Kun Xie, Lingzhi Yu, Hao Zhan. Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-28. PMID:31885368. |
background brain-derived neurotrophic factor (bdnf) is one of the neurotrophic factors that modulate critical metabolic activities, including apoptosis, proliferation, and differentiation modulation. |
2020-05-28 |
2023-08-13 |
human |
| Yongyi Zhai, Yong Ma, Jingying Liu, Yulin Zhu, Kun Xie, Lingzhi Yu, Hao Zhan. Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-28. PMID:31885368. |
conclusions bdnf can alleviate ropivacaine-induced neuronal injury by activating akt signaling pathway, consequently modulating the proliferation and apoptosis of neurons. |
2020-05-28 |
2023-08-13 |
human |
| Qingfa Chen, Hongling Ma, Xuewen Guo, Jia Liu, Ting Gui, Zhibo Ga. Farnesoid X Receptor (FXR) Aggravates Amyloid-β-Triggered Apoptosis by Modulating the cAMP-Response Element-Binding Protein (CREB)/Brain-Derived Neurotrophic Factor (BDNF) Pathway In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31812977. |
farnesoid x receptor (fxr) aggravates amyloid-β-triggered apoptosis by modulating the camp-response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) pathway in vitro. |
2020-05-21 |
2023-08-13 |
mouse |
| Qingfa Chen, Hongling Ma, Xuewen Guo, Jia Liu, Ting Gui, Zhibo Ga. Farnesoid X Receptor (FXR) Aggravates Amyloid-β-Triggered Apoptosis by Modulating the cAMP-Response Element-Binding Protein (CREB)/Brain-Derived Neurotrophic Factor (BDNF) Pathway In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31812977. |
low expression of fxr mostly reversed the aß-triggered neuronal apoptosis effect and prevented the reduction in creb and bdnf. |
2020-05-21 |
2023-08-13 |
mouse |
| Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wan. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochemistry international. vol 129. 2020-05-11. PMID:31220473. |
dexmedetomidine ameliorated ka-induced apoptosis, and this neuroprotective effect was accompanied by inhibited the ka-induced caspase-3 expression as well as mapks phosphorylation, and reversed bcl-2 down-expression, coupled with increased nrf2, bdnf and trkb expression in ka-treated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Hong Jin, Yi Zhu, Yiping Li, Xiuyu Ding, Wenqi Ma, Xiqiong Han, Bilei Wan. BDNF-mediated mitophagy alleviates high-glucose-induced brain microvascular endothelial cell injury. Apoptosis : an international journal on programmed cell death. vol 24. issue 5-6. 2020-05-05. PMID:30877409. |
the high-glucose treatment caused cell dysfunction, as evaluated by oxidative stress and cell apoptosis, which could be alleviated by bdnf. |
2020-05-05 |
2023-08-13 |
Not clear |
| Lu Gan, Menghuan Guo, Jing Si, Jinhua Zhang, Zhiyuan Liu, Jin Zhao, Fang Wang, Junfang Yan, Hongyan Li, Hong Zhan. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-03-23. PMID:31713449. |
in addition, expression levels of multiple genes related to neural development and apoptosis (sod2, bdnf, ache, p53, bax, and bcl-2) were compared by rt-pcr and associated protein expression levels by western blotting. |
2020-03-23 |
2023-08-13 |
cat |
| Feng Qiu, Yubo Zhou, Yeke Deng, Junzhi Yi, Mengting Gong, Ning Liu, Chenxi Wei, Shuanglin Xian. Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway. Chemosphere. vol 241. 2020-02-20. PMID:31683445. |
we found that exposure to dehp induced apoptosis and downregulated the expression of brain-derived neurotrophic factor (bdnf), synaptic proteins psd 95 and synapsin-1 while upregulated the expression of tnfaip1 and decreased the levels of phosphorylated akt, camk Ⅳ, catalytic subunits of pka and creb in creb signaling pathway. |
2020-02-20 |
2023-08-13 |
mouse |
| Feng Qiu, Yubo Zhou, Yeke Deng, Junzhi Yi, Mengting Gong, Ning Liu, Chenxi Wei, Shuanglin Xian. Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway. Chemosphere. vol 241. 2020-02-20. PMID:31683445. |
knockdown of tnfaip1 using tnfaip1 small interfering rna (sirna) expression vector prevented dehp from inhibiting creb pathway, thus reduced apoptosis and restored expression of bdnf, psd 95 and synapsin-1. |
2020-02-20 |
2023-08-13 |
mouse |
| Qin-Ying Li, Qiang Miao, Ruo-Xuan Sui, Liang Cao, Cun-Gen Ma, Bao-Guo Xiao, Wei Xiao, Wen-Bo Y. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis. International immunopharmacology. vol 75. 2020-02-13. PMID:31421546. |
further findings suggest that igf/pi3k, but not bdnf, was induced in the corpus callosum after gk treatment, revealing that nrf2 activation inhibited caspase-3 and apoptosis in o4+ oligodendrocytes possibly through igf/pi3k signaling molecules. |
2020-02-13 |
2023-08-13 |
Not clear |
| Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & function. vol 10. issue 9. 2020-02-11. PMID:31482900. |
in cultured mesencephalic dopamine neurons and sh-sy5y cell line, it was found that thsg protected the integrity of the cell body and neurite branching from mpp+-induced toxicity by restoring the expression of fgf2 and bdnf and their downstream signaling pathways to inhibit apoptosis and promote cell survival. |
2020-02-11 |
2023-08-13 |
mouse |
| Yutaro Obara, Norimichi Nakahat. The Signaling Pathway of Neurotrophic Factor Biosynthesis. Drug news & perspectives. vol 15. issue 5. 2019-11-20. PMID:12677225. |
there are various neurotrophic factors, such as nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), glial cell line-derived neurotrophic factor (gdnf) and interleukin-6 (il-6), which are essential for the promotion of neuronal survival (prevention of apoptosis), differentiation and regeneration in the central nervous system. |
2019-11-20 |
2023-08-12 |
Not clear |
| Alessia Bachis, Stuart J Rabin, Marina Del Fiacco, Italo Mocchett. Gangliosides prevent excitotoxicity through activation of TrkB receptor. Neurotoxicity research. vol 4. issue 3. 2019-11-20. PMID:12829403. |
we first examined the relative potency of the neurotrophins, brain derived neurotrophic factor (bdnf), neurotrophin-3 and nerve growth factor to prevent glutamate-mediated apoptosis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Alessia Bachis, Stuart J Rabin, Marina Del Fiacco, Italo Mocchett. Gangliosides prevent excitotoxicity through activation of TrkB receptor. Neurotoxicity research. vol 4. issue 3. 2019-11-20. PMID:12829403. |
both liga20 and bdnf blocked glutamate-mediated activation of caspase-3 and consequently apoptosis; however, the anticaspase-3 activity was seen only when these compounds were added to the cultures several hours before glutamate, suggesting that liga20 and bdnf share an identical molecular mechanism. |
2019-11-20 |
2023-08-12 |
Not clear |