| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haixia Yuan, Meng Yang, Xinmin Han, Xinqiang N. The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-09-29. PMID:30405737. |
catalpol, an active component of rehmanniae radix preparata, elevates brain-derived neurotrophic factor (bdnf), and attenuates neuronal apoptosis and energy metabolism failure. |
2020-09-29 |
2023-08-13 |
mouse |
| Zhenbo Liu, Jun Xie, Kai Lin, Liguo Q. Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542392. |
in conclusion, magnolol can increase the expression of bdnf and decrease the expression of bax, thereby inhibiting apoptosis to protect the nerves, and magnolol can improve cerebral ischemic stroke in rats. |
2020-09-29 |
2023-08-13 |
rat |
| Hanna Kletkiewicz, Justyna Rogalsk. Decreased body temperature during anoxia affects the endogenous BDNF level in tertiary phase of injury. Neuroscience letters. vol 711. 2020-09-28. PMID:31394123. |
therefore, our experiments aimed at determining the effects of low body temperature during simulated perinatal anoxia on the level of the neurotrophic brain-derived factor (bdnf) and on the correlation between the level of bdnf (probdnf and mbdnf) and the level of active caspase-3 (marker of apoptosis) in developing brain in tertiary phase after exposure. |
2020-09-28 |
2023-08-13 |
rat |
| Hanna Kletkiewicz, Justyna Rogalsk. Decreased body temperature during anoxia affects the endogenous BDNF level in tertiary phase of injury. Neuroscience letters. vol 711. 2020-09-28. PMID:31394123. |
the results demonstrated that the ability of bdnf to inhibit caspase-3 activation and subsequent apoptosis likely accounts in large part for its protection against neuronal damage only in rats maintaining the low body temperature. |
2020-09-28 |
2023-08-13 |
rat |
| Bo Dam Lee, Jae-Myung Yoo, Seong Yeon Baek, Fu Yi Li, Dai-Eun Sok, Mee Ree Ki. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861353. |
3,3'-diindolylmethane promotes bdnf and antioxidant enzyme formation via trkb/akt pathway activation for neuroprotection against oxidative stress-induced apoptosis in hippocampal neuronal cells. |
2020-09-28 |
2023-08-13 |
mouse |
| Bo Dam Lee, Jae-Myung Yoo, Seong Yeon Baek, Fu Yi Li, Dai-Eun Sok, Mee Ree Ki. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861353. |
in this study, we hypothesized dim may protect neuronal cells against oxidative stress-induced apoptosis by promoting the formation of brain-derived neurotrophic factor (bdnf) and antioxidant enzymes through stabilizing the activation of the tropomyosin-related kinase receptor b (trkb) cascade and we investigated the effect of dim on oxidative stress-mediated neurodegenerative models. |
2020-09-28 |
2023-08-13 |
mouse |
| Chen-Guang Zhao, Jie Qin, Wei Sun, Fen Ju, Yong-Lin Zhao, Rui Wang, Xiao-Long Sun, Xiang Mou, Hua Yua. rTMS Regulates the Balance Between Proliferation and Apoptosis of Spinal Cord Derived Neural Stem/Progenitor Cells. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32116552. |
the purpose of this study is to investigate the effect of different rtms stimulus parameters on proliferation and apoptosis of spinal cord-derived nspcs, the expression of brain-derived neurotrophic factor (bdnf) after rtms, and the potentially underlying pathways. |
2020-09-28 |
2023-08-13 |
mouse |
| Hao Zhao, Yunjun Li, Lihua Chen, Chunsen Shen, Zongyu Xiao, Ruxiang Xu, Ji Wang, Yongchun Lu. HucMSCs-Derived miR-206-Knockdown Exosomes Contribute to Neuroprotection in Subarachnoid Hemorrhage Induced Early Brain Injury by Targeting BDNF. Neuroscience. vol 417. 2020-09-24. PMID:31400488. |
the mir-206-knockdown exosomes could significantly improve neurological deficit and brain edema and suppress neuronal apoptosis by targeting bdnf. |
2020-09-24 |
2023-08-13 |
human |
| Ava Modirzadeh Tehrani, Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Mohammad Ali Hosseinpour Feizi, Reza Safaralizade. Methamphetamine induces neurotoxicity-associated pathways and stereological changes in prefrontal cortex. Neuroscience letters. vol 712. 2020-09-23. PMID:31491463. |
based on our findings, qpcr analysis revealed impaired autophagy, increased apoptosis and inflammation along with histological alterations in pfc, augmented astrogliosis as well as a significant reduction in the level of bdnf. |
2020-09-23 |
2023-08-13 |
rat |
| Y Xu, W-G Jiang, H-C Wang, T Martin, Y-X Zeng, J Zhang, Y-S Q. BDNF activates TrkB/PLCγ1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. European review for medical and pharmacological sciences. vol 23. issue 12. 2020-09-18. PMID:31298409. |
bdnf activates trkb/plcγ1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. |
2020-09-18 |
2023-08-13 |
Not clear |
| En-Yao Li, Peng-Ju Zhao, Jie Jian, Bao-Qi Yin, Zhen-Yu Sun, Cui-Xiang Xu, You-Cai Tang, Hong W. Vitamin B1 and B12 mitigates neuron apoptosis in cerebral palsy by augmenting BDNF expression through MALAT1/miR-1 axis. Cell cycle (Georgetown, Tex.). vol 18. issue 21. 2020-09-02. PMID:31500509. |
vitamin b1 and b12 mitigates neuron apoptosis in cerebral palsy by augmenting bdnf expression through malat1/mir-1 axis. |
2020-09-02 |
2023-08-13 |
Not clear |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
andrographolide enhances hippocampal bdnf signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. |
2020-08-31 |
2023-08-13 |
rat |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
astrocyte activation was examined by immunohistochemical staining and western blotting for glial fibrillary acid protein (gfap), while expression levels of the pro-inflammatory cytokine-tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), the apoptosis effector cysteinyl aspartate specific proteinase-3 (caspase-3), and the neuroprotectant brain-derived neurotrophic factor (bdnf) and the trkb receptor were estimated by western blotting. |
2020-08-31 |
2023-08-13 |
rat |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
therefore, we evaluate the ability of mir-153 to influence brain-derived neurotrophic factor (bdnf) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (jak-stat) signaling pathway by targeting leptin receptor (lepr). |
2020-08-07 |
2023-08-13 |
mouse |
| Xiaoxiang Yu, Qiaobing Guan, Yanping Wang, Heping Shen, Liping Zhai, Xudong Lu, Yuhua Ji. Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. Epilepsy research. vol 154. 2020-07-13. PMID:31112902. |
neuronal apoptosis is a regulated intrinsic cell mechanism and common pathological phenomenon after seizures, which involves the protein kinase b/camp response element binding protein / brain derived neurotrophic factor (akt/creb/ bdnf) signaling pathway. |
2020-07-13 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Hui-Feng Zhu, Yali Shao, Lei Qin, Jing-Huan Wang, Shan Feng, Yun-Bin Jiang, Dong Wa. Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway. Drug design, development and therapy. vol 13. 2020-06-17. PMID:31849446. |
catalpol enhances neurogenesis and inhibits apoptosis of new neurons via bdnf, but not the bdnf/trkb pathway. |
2020-06-17 |
2023-08-13 |
Not clear |
| Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabad. Crocin acts as a neuroprotective mediator against methylphenidate‑induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway. Acta neurobiologiae experimentalis. vol 79. issue 4. 2020-06-15. PMID:31885392. |
in contrast, crocin attenuated mph‑induced oxidative stress, inflammation, and apoptosis, and increased levels of p‑creb and bdnf. |
2020-06-15 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
the treatment of mir-124 agomir improved rats' spatial learning and memory ability and notably increased hippocampal neuron viability and resistance to apoptosis, corresponding to an increased brain-derived neurotrophic factor (bdnf) expression, inhibited expression of proapoptotic factors (cleaved-caspase-3 and bax), and enhanced the expression of antiapoptotic factor (bcl-2). |
2020-06-11 |
2023-08-13 |
rat |
| Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis Yug. Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats. Stem cell research. vol 41. 2020-06-02. PMID:31731179. |
microgravity-cultured msc-based therapy may improve functional recovery following spinal ischemia-reperfusion injury by promoting astrocytic bdnf release, thereby preventing apoptosis. |
2020-06-02 |
2023-08-13 |
rat |