| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakil. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke. Neurochemical research. vol 43. issue 8. 2019-04-01. PMID:29882126. |
the present study indicated that irisin attenuates brain damage via reducing apoptosis and increasing bdnf protein of brain cortex in the experimental model of stroke in mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Selim Çomakli, Mine Köktürk, Ahmet Topal, Mustafa Özkaraca, Saltuk Buğrahan Ceyhu. Immunofluorescence/fluorescence assessment of brain-derived neurotrophic factor, c-Fos activation, and apoptosis in the brain of zebrafish (Danio rerio) larvae exposed to glufosinate. Neurotoxicology. vol 69. 2019-03-15. PMID:30222997. |
in this study, we investigated the potential neuro-toxicological mechanism of the glufosinate in the brain of zebrafish larvae in terms of bdnf and c-fos proteins by evaluating apoptosis, immunofluorescence bdnf, and c-fos activation. |
2019-03-15 |
2023-08-13 |
zebrafish |
| Selim Çomakli, Mine Köktürk, Ahmet Topal, Mustafa Özkaraca, Saltuk Buğrahan Ceyhu. Immunofluorescence/fluorescence assessment of brain-derived neurotrophic factor, c-Fos activation, and apoptosis in the brain of zebrafish (Danio rerio) larvae exposed to glufosinate. Neurotoxicology. vol 69. 2019-03-15. PMID:30222997. |
the results have indicated that exposure to glufosinate caused to embryonic death, hatching delay, induction of apoptosis, increasing of c-fos activity and the level of bdnf in a dose-dependent manner. |
2019-03-15 |
2023-08-13 |
zebrafish |
| Selim Çomakli, Mine Köktürk, Ahmet Topal, Mustafa Özkaraca, Saltuk Buğrahan Ceyhu. Immunofluorescence/fluorescence assessment of brain-derived neurotrophic factor, c-Fos activation, and apoptosis in the brain of zebrafish (Danio rerio) larvae exposed to glufosinate. Neurotoxicology. vol 69. 2019-03-15. PMID:30222997. |
as a conclusion, we suggested that c-fos might play a role in the regulation of bdnf which responses to prevent the cell from apoptosis even in case of unsuccessful in zebrafish larvae exposed to glufosinate. |
2019-03-15 |
2023-08-13 |
zebrafish |
| Cassiano R A F Diniz, Plinio C Casarotto, Leonardo Resstel, Sâmia R L Joc. Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment. Neuroscience and biobehavioral reviews. vol 90. 2019-03-07. PMID:29626490. |
in contrast, both precursor probdnf and bdnf propeptide (another metabolic product from probdnf cleavage) have a high affinity to p75 receptor (p75r) and usually convey apoptosis and neuronal shrinkage. |
2019-03-07 |
2023-08-13 |
Not clear |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
it is not known whether brain‑derived neurotrophic factor (bdnf) protects hippocampal neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. |
2019-03-05 |
2023-08-13 |
rat |
| Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espine. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30428894. |
contrarily to bdnf, the precursor form of bdnf (probdnf) induces apoptosis through the specific interaction with p75 and its co-receptor, sortilin.we used hippocampal tissue and cerebrospinal fluid from ad patients and controls. |
2019-03-04 |
2023-08-13 |
mouse |
| Hee Ra Park, Heeeun Lee, Jung-Jin Lee, Nam-Hui Yim, Min-Jung Gu, Jin Yeul M. Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28707073. |
in mcao-reperfusion injury, sce promoted neuronal survival and level of brain-derived neurotrophic factor (bdnf) by reducing glial activation, oxidative stress, and apoptosis in the ipsilateral cortex. |
2019-02-26 |
2023-08-13 |
rat |
| Yang Gou, Danyan Liu, Jinfeng Liu, Hongran Su. [Protective effect of transplantation of bone mesenchymal stem cells on demyelination in spinal cord injury]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 34. issue 5. 2019-02-11. PMID:29893084. |
bmscs protected neural myelin sheaths by inhibiting oligodendrocyte apoptosis via increased secretion of bdnf after sci. |
2019-02-11 |
2023-08-13 |
rat |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
compared with the blank and nc groups, the mir-216a mimic and sirna-gdnf groups had higher mrna and protein levels of c-fos, vegf and bax, cell number in the g1 phase and increased cell apoptosis but reduced bdnf, gdnf, gfrα1, ret and bcl-2 expression, cell proliferation and cell numbers in the s phase, while the opposite trend was observed in the mir-216a inhibitor group. |
2019-01-29 |
2023-08-13 |
rat |
| Min Chen, Guoping He, Qiang L. Maternal deprivation promotes hippocampal neuronal apoptosis via ERK1/2 signaling. Frontiers in bioscience (Landmark edition). vol 23. 2019-01-24. PMID:29772537. |
compared with controls, md group showed increased hippocampal neuronal apoptosis, higher mrna expressions of bax, caspase-3 and caspase-9mrnas, and lower expression of bcl-2 and bdnf. |
2019-01-24 |
2023-08-13 |
rat |
| Yun Pei, Zhexiao Jiao, Wanting Dong, Linguo Pei, Xia He, Hui Wang, Dan X. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 123. 2019-01-15. PMID:30389584. |
compared with the control group, fetal rats by pne showed increased hippocampal apoptosis, reduced synaptic plasticity and downregulation of the brain-derived neurotrophic factor (bdnf) pathway, whereas glutamic acid decarboxylase 67 (gad67) expression was upregulated. |
2019-01-15 |
2023-08-13 |
rat |
| Tengfei Zhao, Yingxue Fu, Hao Sun, Xiaoquan Li. Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. IUBMB life. vol 70. issue 1. 2018-12-17. PMID:29247598. |
pro- and anti-apoptotic biomarkers of multiple pathways including bdnf, mcp-1, and hcy played a joint role in triggering the activation of the mitochondria-related bax/bcl-2 and caspase-3 apoptosis pathway in vd. |
2018-12-17 |
2023-08-13 |
rat |
| Tengfei Zhao, Yingxue Fu, Hao Sun, Xiaoquan Li. Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. IUBMB life. vol 70. issue 1. 2018-12-17. PMID:29247598. |
ligustrazine attenuated vd by comprehensively regulating bdnf, mcp-1, and hcy and inactivating the bax/bcl-2 and caspase-3 apoptosis pathway. |
2018-12-17 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
[over-expression of bdnf inhibits angiotensin ii-induced apoptosis of cardiomyocytes in sd rats]. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
objective to investigate the role and molecular mechanism of brain-derived neurotrophic factor (bdnf) against the process of cardiomyocyte hypertrophy and apoptosis. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
the effect of bdnf transfection on the apoptosis of cardiomyocytes was assayed by flow cytometry. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
compared with the untransfected control cardiomyocytes, the surface area of cardiomyocytes, the rate of apoptosis, the levels of anp and bnp mrna and protein expression, the levels of p-camk2 and can protein in the bdnf over-expressed cardiomyocytes were remarkably reduced, while the level of p-nfatc3 protein rose significantly. |
2018-11-27 |
2023-08-13 |
rat |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
conclusion bdnf inhibits the apoptosis of cardiomyocytes induced by ang ii, and it plays the role by inhibiting camk2 and can signaling pathways. |
2018-11-27 |
2023-08-13 |
rat |
| D Y Zhao, W X Zhang, Q Q Qi, X Long, X Li, Y B Yu, X L Zu. Brain-derived neurotrophic factor modulates intestinal barrier by inhibiting intestinal epithelial cells apoptosis in mice. Physiological research. vol 67. issue 3. 2018-11-26. PMID:29527912. |
we aimed to investigate the effects of brain-derived neurotrophic factor (bdnf) on apoptosis of intestinal epithelial cells (iecs) and alterations of intestinal barrier integrity using bdnf knock-out mice model. |
2018-11-26 |
2023-08-13 |
mouse |