| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
these results revealed that saikosaponin a improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of bdnf, p-creb and bcl-2, as well as decreasing the level of bax, caspase-3. |
2021-06-18 |
2023-08-13 |
rat |
| b' Jessica Le Blanc, Samuel Fleury, Imane Boukhatem, Jean-Christophe B\\xc3\\xa9langer, M\\xc3\\xa9lanie Welman, Marie Lordkipanidz\\xc3\\xa. Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF. Frontiers in immunology. vol 11. 2021-06-14. PMID:33324399.' |
bdnf has well-established pro-survival effects, whereas its precursor protein, probdnf, induces apoptosis. |
2021-06-14 |
2023-08-13 |
human |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
besides, an obvious increase of the brain-derived neurotrophic factor (bdnf) and trkb levels are observed with down-regulated inflammation and apoptosis. |
2021-06-04 |
2023-08-13 |
mouse |
| Clément Barbereau, Alaa Yehya, Michelle Silhol, Nicolas Cubedo, Jean-Michel Verdier, Tangui Maurice, Mireille Rosse. Neuroprotective brain-derived neurotrophic factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. vol 158. 2021-06-04. PMID:32417505. |
rescue experiments with exogenous bdnf partially corrected neuronal alterations in tau-p301l by counteracting primary axonal growth impairment but without effect on apoptosis. |
2021-06-04 |
2023-08-13 |
zebrafish |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
by considering those relationships and microglia related nootrophic factors, such as the brain derived neurotrophic factor (bdnf) in cns, we attempted to assess the relationship between microglia dependent bdnf and its precursor with pain behavior through spinal cell apoptosis as well as the effect of noopept on this relationship. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
thermal hyperalgesia, paw edema, microglial activity, microglia dependent bdnf, pro-bdnf expression, and apoptosis were assessed in different experimental groups by confirmed behavioral and molecular methods on days 0, 7, and 21 of the study. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
our results also indicated that daily administration of noopept (during 21 days of the study) not only caused a significant decrease in hyperalgesia and microglia dependent bdnf expression but also changed the apoptosis process in relation to microglia activity alteration. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
it appears that the administration of noopept can decrease spinal cell apoptosis and hyperalgesia during cfa-induced inflammation due to its direct effects on microglial activity and microglia dependent bdnf and pro-bdnf expression. |
2021-05-27 |
2023-08-13 |
Not clear |
| Lizong Wang, Jinghan Jiang, Taofeng Zhou, Xiang Xue, Yongjun Ca. Improvement of Cerebral Ischemia-Reperfusion Injury via Regulation of Apoptosis by Exosomes Derived from BDNF-Overexpressing HEK293. BioMed research international. vol 2021. 2021-05-26. PMID:33763476. |
findings gained demonstrated that bdnf is a part of preventing cerebral i/r injury due to exosome mediation by regulating the cellular internal environment and inhibiting apoptosis. |
2021-05-26 |
2023-08-13 |
rat |
| Sining Feng, Shuai Wang, Shi Sun, Hao Su, Lixin Zhan. Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649786. |
notably, combination therapy further alleviated sci‑induced spinal cord lesions and neuronal apoptosis, increased gap‑43, ngf and bdnf expression levels, downregulated gfap expression levels and inhibited activation of the raf/mek/erk signaling pathway in sci model rats compared with the corresponding monotherapy groups. |
2021-05-17 |
2023-08-13 |
rat |
| Ming Cai, Jing Yun Hu, Bei Bei Liu, Jing Jing Li, Feng Li, Shujie Lo. The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2. Neuroscience. vol 431. 2021-05-14. PMID:32062019. |
results showed that the expression levels of glucose transporter 3 (glut3), fatty acid transport protein 1 (fatp1), er stress biomarkers (grp78, p-perk, p-ire1α and p-eif2α), er stress-mediated apoptosis biomarkers (caspase-12, chop and bax/bcl-2), and the activity of nlrp3-il-1β inflammatory pathway were significantly increased under high glucose and pa conditions, accompanied with depressed p38/erk-creb pathway and decreased levels of brain derived neurotrophic factor (bdnf) and synaptophysin (syn). |
2021-05-14 |
2023-08-13 |
Not clear |
| Ming Cai, Jing Yun Hu, Bei Bei Liu, Jing Jing Li, Feng Li, Shujie Lo. The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2. Neuroscience. vol 431. 2021-05-14. PMID:32062019. |
our findings suggest that high glucose and pa could induce excessive er stress and apoptosis via promoting the overexpression of glut3 and fatp1, and er stress could suppress bdnf and syn expression through negatively regulating p38/erk-creb pathway and positively regulating nlrp3-il-1β pathway, which could be reversed by activated nrf2-ho-1 pathway. |
2021-05-14 |
2023-08-13 |
Not clear |
| Bingjie Yang, Guodong Luo, Chen Zhang, Luqiu Feng, Xianmei Luo, Ling Ga. Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33335121. |
in the present study, for the first time, the protective effects of curcumin against prv-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rat hippocampal neurons and the brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) pathway were investigated. |
2021-05-10 |
2023-08-13 |
rat |
| Cheng Zhang, Junlai Li, Changtian L. Effects of 2D-Shear Wave Elastography on Brain-Derived Neurotrophic Factor (BDNF) in the Brains of Neonatal Mice and Exploration of the Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-04. PMID:32601265. |
background the aim of this study was to explore the effect and duration of 2-dimensional shear wave elastography (2d-swe) irradiation on the expression of brain-derived neurotrophic factor (bdnf) in the brains of neonatal mice and to preliminarily investigate whether its mechanism is neuronal apoptosis. |
2021-05-04 |
2023-08-13 |
mouse |
| Tae Woong Hwang, Eun-Ji Kim, DaBi Kim, Jin Young Jeong, Gun-Hwa Kim, Kyu Lim, Minho Moon, Kyung Ah Yoon, Dae Eun Choi, Jwa-Jin Ki. Fat-1 expression enhance hippocampal memory in scopolamine-induced amnesia. The Journal of nutritional biochemistry. vol 82. 2021-04-27. PMID:32454411. |
western blotting revealed increased brain-derived neurotrophic factor (bdnf) and phosphorylated camp response element-binding protein levels, and lower scopolamine-induced apoptosis based on the cleaved-caspase 3 protein level in fat-1 mice. |
2021-04-27 |
2023-08-13 |
mouse |
| Tae Woong Hwang, Eun-Ji Kim, DaBi Kim, Jin Young Jeong, Gun-Hwa Kim, Kyu Lim, Minho Moon, Kyung Ah Yoon, Dae Eun Choi, Jwa-Jin Ki. Fat-1 expression enhance hippocampal memory in scopolamine-induced amnesia. The Journal of nutritional biochemistry. vol 82. 2021-04-27. PMID:32454411. |
these findings suggest that higher endogenous omega-3 pufa prevented granular cell loss, increased bdnf signaling, and decreased apoptosis signaling in scopolamine-treated fat-1 mice. |
2021-04-27 |
2023-08-13 |
mouse |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-ht, da, and ne in the hippocampus were significantly lower, ang ii level in peripheral blood was significantly higher, and the expression of bdnf and c-fos in the hippocampus decreased significantly in the model group. |
2021-04-10 |
2023-08-13 |
rat |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
by contrast, candesartan or candesartan + music therapy ameliorated the changes in retina cell apoptosis, reduction of neurotransmitters, increase in aii, and the expression of c-fos and bdnf. |
2021-04-10 |
2023-08-13 |
rat |
| Bo Zheng, Tao Che. MiR-489-3p inhibits cell proliferation, migration, and invasion, and induces apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in glioblastoma. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817216. |
mir-489-3p re-expression or bdnf knockdown inhibited gbm cell proliferation, migration, and invasion, and promoted apoptosis. |
2021-04-06 |
2023-08-13 |
Not clear |
| Jun Xue, Yadong Liu, Sichong Zhang, Liucheng Ding, Baixin Shen, Yunpeng Shao, Zhongqing We. Caffeine improves bladder function in diabetic rats via a neuroprotective effect. Experimental and therapeutic medicine. vol 21. issue 5. 2021-04-02. PMID:33791010. |
relative to that in the dm group, the expression levels of ngf, bdnf and cgrp in the bladder tissue of dm + caffeine rats increased; cellular apoptosis in the drg of dm + caffeine rates decreased; and the expression levels of bcl-2, bax, cleaved caspase-3 and cleaved caspase-9 proteins in the drg of dm + caffeine rats were restored to a certain extent. |
2021-04-02 |
2023-08-13 |
rat |