| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meizhu Zheng, Chunming Liu, Fengguang Pan, Dongfang Shi, Fengshan Ma, Yuchi Zhang, Yujing Zhan. Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells. Cellular and molecular neurobiology. vol 31. issue 3. 2011-07-22. PMID:21170580. |
the results showed that av extract (25, 50, and 100 μg/ml) increased the a490 nm values, but decreased ldh release and ca(2+) concentration, suppressed the apoptosis of pc12 cells and up-regulated bdnf and map4 transcript abundances compared with the corresponding corticosterone-treated group. |
2011-07-22 |
2023-08-12 |
Not clear |
| José M Frade, Noelia López-Sánche. A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR). Cell cycle (Georgetown, Tex.). vol 9. issue 10. 2011-05-03. PMID:20436277. |
in contrast, bdnf inhibits g2/m transition in tetraploid rgcs, preventing their death by apoptosis. |
2011-05-03 |
2023-08-12 |
Not clear |
| Jing Huang, Chun-Yan Sun, Tao Guo, Zhang-Bo Chu, Ya-Dan Wang, Yu H. [Effect of RNA interference targeting brain-derived neurotrophic factor gene on HeLa cell proliferation and apoptosis]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 38. issue 10. 2011-03-24. PMID:20078974. |
to screen effective sequences of short hairpin rna on brain-derived neurotrophic factor (bdnf) gene and the effect of rna interference on the proliferation and apoptosis of hela cells, a cervix carcinoma cell line with high expression of bdnf. |
2011-03-24 |
2023-08-12 |
Not clear |
| Lorna C Gleeson, Katie J Ryan, Eadaoin W Griffin, Thomas J Connor, Andrew Harki. The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity. Brain, behavior, and immunity. vol 24. issue 8. 2011-01-21. PMID:20599496. |
whilst clenbuterol treatment did not significantly alter ka-induced epileptic behavior it ameliorated ka-induced apoptosis, and this neuroprotective effect was accompanied by reduced inflammatory cytokine expression, reduced expression of inos, ido, kmo and cd11b, coupled with increased bdnf and ngf expression in ka-treated rats. |
2011-01-21 |
2023-08-12 |
rat |
| Wen-Sheng Wen, Zhe Zhang, Ying Xie, Xiang Yi, Wei-Min Zhao, Zhi-Wen Xu, An-Zhou Tang, Guang-Wu Huan. [Relationship between the expression of TrkB and anoikis resistance in nasopharyngeal carcinoma line]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 43. issue 8. 2011-01-11. PMID:18959266. |
proliferation rate and apoptosis, that change in cells by treating the trkb inhibitor k252a and specificity ligand bdnf respectively under suspension culture, were measured by cell counting kit-8 (cck-8) assay and the flow cytometry assay. |
2011-01-11 |
2023-08-12 |
human |
| Yunfei Tan, Jinfeng Duan, Yufeng Li, Wei Ca. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Die Pharmazie. vol 65. issue 11. 2011-01-10. PMID:21155393. |
effects of citalopram on serum deprivation induced pc12 cell apoptosis and bdnf expression. |
2011-01-10 |
2023-08-12 |
Not clear |
| Wenyu Song, Marta Volosin, Andrea B Cragnolini, Barbara L Hempstead, Wilma J Friedma. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084616. |
simultaneous activation of p75(ntr) by prongf and trkb signaling by bdnf elicited apoptosis despite trkb phosphorylation. |
2010-12-23 |
2023-08-12 |
rat |
| Toshiyuki Oshitari, Natsuyo Yoshida-Hata, Shuichi Yamamot. Effect of neurotrophic factors on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose. Brain research. vol 1346. 2010-10-19. PMID:20573599. |
the purpose of this study was to investigate the effect of brain-derived neurotrophic factor (bdnf), neurotrophin-4 (nt-4), and citicoline on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose (hg). |
2010-10-19 |
2023-08-12 |
rat |
| Xiu-Mei Yan, Guang-Qian L. [Expression of brain-derived neurotrophic factor and apoptosis in the brain of rats with repeated febrile seizures]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 12. issue 5. 2010-08-26. PMID:20497649. |
to study the changes of brain-derived neurotrophic factor (bdnf) following repeated febrile seizures in rats and its possible correlation with neurocyte apoptosis. |
2010-08-26 |
2023-08-12 |
rat |
| Li Kong, Xiaohong Zhou, Feng Li, Juni Yodoi, James McGinnis, Wei Ca. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiology of disease. vol 38. issue 3. 2010-08-17. PMID:20298786. |
analysis of signal pathways showed that thioredoxin up-regulated neurotrophic factors bdnf and gdnf and activated survival signaling pathways akt, ras/raf1/ and the erks while inhibiting the ask1/jnk apoptosis pathway. |
2010-08-17 |
2023-08-12 |
mouse |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
since both elevated intracellular sodium and apoptosis are believed to contribute to cellular dysfunction in bipolar disorder, it is important to determine the effect of exogenous bdnf on apoptosis induced by the high levels of intracellular sodium seen in ill bipolar patients. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
bdnf 100ng/ml pretreatment or co-treatment attenuated the monensin-induced apoptosis. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
pretreatment with bdnf for 24h reduced monensin-induced apoptosis by 93%. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
co-treatment of bdnf and monensin increased intracellular sodium concentration and reduced apoptosis by 66%. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
treatment with bdnf greatly attenuates or prevents monensin-induced apoptosis. |
2010-08-12 |
2023-08-12 |
human |
| L Zhang, Y Liang, Y Liu, C-L Xion. The role of brain-derived neurotrophic factor in mouse oocyte maturation in vitro involves activation of protein kinase B. Theriogenology. vol 73. issue 8. 2010-08-06. PMID:20171721. |
however, bdnf did not affect apoptosis of the cumulus cells during oocyte maturation in vitro. |
2010-08-06 |
2023-08-12 |
mouse |
| Ning Li, Geng-tao Li. The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta pharmacologica Sinica. vol 31. issue 3. 2010-06-14. PMID:20154710. |
the aim of this study was to study the effects of compound flz, a novel cyclic derivative of squamosamide from annona glabra, on brain-derived neurotrophic factor (bdnf)/tropomyosin receptor kinase b (trkb)/camp response element-binding protein (creb) signaling and neuronal apoptosis in the hippocampus of the amyloid precursor protein (app)/presenilin-1 (ps1) double transgenic mice. |
2010-06-14 |
2023-08-12 |
mouse |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
in this study, we reported that brain-derived growth factor (bdnf) protected neurons from phenylalanine-induced apoptosis and inhibition of trk receptor by k252a or downregulation of trkb abrogated the effect of bdnf. |
2010-04-30 |
2023-08-12 |
Not clear |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
we further demonstrated that phenylalanine-induced rhoa activation and myosin light chain phosphorylation were inhibited by pretreatment with bdnf, while phenylalanine activates the mitochondria-mediated apoptosis through the rhoa/rho-associated kinase pathway. |
2010-04-30 |
2023-08-12 |
Not clear |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
thus our studies indicate that the protective effect of bdnf against phenylalanine-induced neuronal apoptosis is probably mediated by suppression of rhoa signaling pathway via trkb receptor. |
2010-04-30 |
2023-08-12 |
Not clear |