| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B H Han, A D'Costa, S A Back, M Parsadanian, S Patel, A R Shah, J M Gidday, A Srinivasan, M Deshmukh, D M Holtzma. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiology of disease. vol 7. issue 1. 2000-03-29. PMID:10671321. |
in a model of neonatal h-i injury in postnatal day 7 rats, our previous data have shown that cell death with features of apoptosis is prominent between 6 and 24 h after h-i and that neurotrophins, particularly bdnf, can markedly protect against tissue loss. |
2000-03-29 |
2023-08-12 |
rat |
| B H Han, A D'Costa, S A Back, M Parsadanian, S Patel, A R Shah, J M Gidday, A Srinivasan, M Deshmukh, D M Holtzma. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiology of disease. vol 7. issue 1. 2000-03-29. PMID:10671321. |
utilizing a specific molecular marker of an apoptotic pathway, these findings demonstrate that h-i injury to the developing brain is a strong apoptotic stimulus leading to caspase-3 activation, that bdnf can block this process in vivo, and that the ability of bdnf to inhibit caspase activation and subsequent apoptosis likely accounts in large part for its protection against neuronal injury in this model. |
2000-03-29 |
2023-08-12 |
rat |
| G W Glazner, M P Mattso. Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686066. |
neurons pretreated with bdnf exhibited increased levels of the nmda receptor subunits nr1 and nr2a, which was associated with increased calcium responses to nmda and vulnerability to excitotoxic necrosis and reduced vulnerability to apoptosis. |
2000-03-29 |
2023-08-12 |
Not clear |
| G W Glazner, M P Mattso. Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686066. |
our data show that, whereas bdnf increases neuronal responses to glutamate while adnf9 and tnfalpha decrease the same, all three protect against excitotoxic apoptosis. |
2000-03-29 |
2023-08-12 |
Not clear |
| S Linnarsson, C A Willson, P Ernfor. Cell death in regenerating populations of neurons in BDNF mutant mice. Brain research. Molecular brain research. vol 75. issue 1. 2000-03-07. PMID:10648888. |
we find that cells in nestin-positive regions of both the subgranular layer of the dentate gyrus and the subventricular zone of the olfactory bulb undergo apoptosis starting 2 weeks after birth in the absence of bdnf. |
2000-03-07 |
2023-08-12 |
mouse |
| T Kurokawa, N Katai, H Shibuki, S Kuroiwa, Y Kurimoto, C Nakayama, N Yoshimur. BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. Investigative ophthalmology & visual science. vol 40. issue 12. 1999-11-08. PMID:10549664. |
the purpose of this study was to examine the association of c-jun, caspase-1, -2, and -3 immunoreactivities and neuronal apoptosis in the retinal ganglion cell layer (gcl) and to study the effects of intravitreal brain-derived neurotrophic factor (bdnf) on the expression of these gene products in a rat model of retinal ischemia-reperfusion injury. |
1999-11-08 |
2023-08-12 |
rat |
| B Rohrer, J I Korenbrot, M M LaVail, L F Reichardt, B X. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516311. |
brain-derived neurotrophic factor (bdnf) acts through trkb, a receptor with kinase activity, and mitigates light-induced apoptosis in adult mouse rod photoreceptors. |
1999-10-28 |
2023-08-12 |
mouse |
| M Encinas, M Iglesias, N Llecha, J X Comell. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501184. |
on the other hand, the phosphatidylinositol 3-kinase inhibitor ly249002 reverses the survival response elicited by bdnf, leading to a cell death with morphological features of apoptosis. |
1999-10-14 |
2023-08-12 |
Not clear |
| C Gaiddon, Y Larmet, E Trinh, A L Boutillier, B Sommer, J P Loeffle. Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501191. |
in neurons maintained in low k+ medium (5 mm k+) that will enter apoptosis, bdnf increases beta2-ar and beta2-ar transcripts. |
1999-10-14 |
2023-08-12 |
Not clear |
| V L Sheen, M W Arnold, Y Wang, J D Mackli. Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448417. |
these results suggested that these early hippocampal-derived precursors might not be fully competent to respond to later stage differentiation and/or survival signals important in neocortex and known to be upregulated in regions undergoing targeted neuronal apoptosis, including the trkb neurotrophin receptor ligands bdnf and nt-4/5. |
1999-09-09 |
2023-08-12 |
mouse |
| M Hetman, K Kanning, J E Cavanaugh, Z Xi. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 274. issue 32. 1999-09-02. PMID:10428835. |
here, we report that brain-derived neurotrophic factor (bdnf) protects cortical neurons against apoptosis induced by camptothecin or serum deprivation and activates the extracellular-signal-regulated kinase (erk) and the phosphatidylinositol 3-kinase (pi 3-kinase) pathways. |
1999-09-02 |
2023-08-12 |
Not clear |
| J M Frade, P Bovolenta, A Rodríguez-Téba. Neurotrophins and other growth factors in the generation of retinal neurons. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383117. |
thus, nt-3 promotes the conversion of neuroepithelial cells into neurons, whereas bdnf and ngf control the programmed cell death (apoptosis) that affects early postmitotic neuroblasts. |
1999-07-29 |
2023-08-12 |
chicken |
| N Takei, O Tanaka, Y Endo, D Lindholm, H Hatanak. BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. Neuropharmacology. vol 38. issue 2. 1999-06-24. PMID:10218870. |
bdnf and nt-3 but not cntf counteract the ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. |
1999-06-24 |
2023-08-12 |
rat |
| T Ikeuchi, K Shimoke, T Kubo, M Yamada, H Hatanak. [Apoptosis-inducing and -preventing signal transduction pathways in cultured cerebellar granule neurons]. Human cell. vol 11. issue 3. 1999-05-25. PMID:10086275. |
the low k(+)-induced apoptosis of cerebellar granule neurons is prevented by high k+ (membrane depolarization by high k+), bdnf, igf-1, bfgf or camp. |
1999-05-25 |
2023-08-12 |
Not clear |
| b' F J Gunn-Moore, J M Tavar\\xc3\\xa. Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation. Neuroscience letters. vol 250. issue 1. 1999-05-19. PMID:9696064.' |
bdnf and insulin can prevent apoptosis induced by serum withdrawal or the addition of glutamate or beta-amyloid peptide. |
1999-05-19 |
2023-08-12 |
Not clear |
| H Hatanak. [Neuroprotection by neurotrophic factors in apoptosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190124. |
in the present communication, we used cultured rat cerebellar granule neurons, in which low potassium concentration (lk+) in the medium induces apoptosis, and this apoptosis is prevented by high concentration of potassium (hk+), bdnf. |
1999-05-10 |
2023-08-12 |
mouse |
| H Hatanak. [Neuroprotection by neurotrophic factors in apoptosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190124. |
bdnf and high k+ prevented low k(+)-induced apoptosis via pi3-k. bdnf also promotes the survival of basal forebrain cholinergic neurons cultured from postnatal 2-week-old (p2w) rats. |
1999-05-10 |
2023-08-12 |
mouse |
| K Shimoke, S Yamagishi, M Yamada, T Ikeuchi, H Hatanak. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain research. Developmental brain research. vol 112. issue 2. 1999-04-13. PMID:9878764. |
to investigate the intracellular signaling mechanism of ly294002-induced apoptosis, the activities of akt and c-jun n-terminal kinase (jnk) were measured in cells in hk (26 mm potassium) medium or lk+ (5 mm potassium) medium containing bdnf, with or without 10 microm ly294002. |
1999-04-13 |
2023-08-12 |
Not clear |
| J Harada, M Sugimot. Inhibitors of interleukin-1 beta-converting enzyme-family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide in cerebellar granule neurons. Brain research. vol 793. issue 1-2. 1999-03-29. PMID:9630648. |
agents such as brain-derived neurotrophic factor (bdnf), dibutylyl camp, nmda, actinomycin d, s-adenosyl-l-methionine, and spermine prevented apoptosis. |
1999-03-29 |
2023-08-12 |
rat |
| I Ferrer, E Goutan, E Martí, E Arena. Brain-derived neurotrophic factor does not prevent ionizing radiation-induced apoptosis in the developing rat brain. Neuroscience letters. vol 257. issue 2. 1999-03-24. PMID:9865933. |
in an attempt to learn whether brain-derived neurotrophic factor (bdnf) is able to protect neural cells from ionizing radiation-induced apoptosis in the developing brain, bdnf-transfected (f3n-bdnf) and mock-transfected (f3a mt) fibroblasts were grafted into the right germinal periventricular zone of rats at postnatal day 1 (p1). |
1999-03-24 |
2023-08-12 |
rat |