| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Rohrer, J I Korenbrot, M M LaVail, L F Reichardt, B X. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516311. |
brain-derived neurotrophic factor (bdnf) acts through trkb, a receptor with kinase activity, and mitigates light-induced apoptosis in adult mouse rod photoreceptors. |
1999-10-28 |
2023-08-12 |
mouse |
| M Encinas, M Iglesias, N Llecha, J X Comell. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501184. |
on the other hand, the phosphatidylinositol 3-kinase inhibitor ly249002 reverses the survival response elicited by bdnf, leading to a cell death with morphological features of apoptosis. |
1999-10-14 |
2023-08-12 |
Not clear |
| C Gaiddon, Y Larmet, E Trinh, A L Boutillier, B Sommer, J P Loeffle. Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501191. |
in neurons maintained in low k+ medium (5 mm k+) that will enter apoptosis, bdnf increases beta2-ar and beta2-ar transcripts. |
1999-10-14 |
2023-08-12 |
Not clear |
| V L Sheen, M W Arnold, Y Wang, J D Mackli. Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448417. |
these results suggested that these early hippocampal-derived precursors might not be fully competent to respond to later stage differentiation and/or survival signals important in neocortex and known to be upregulated in regions undergoing targeted neuronal apoptosis, including the trkb neurotrophin receptor ligands bdnf and nt-4/5. |
1999-09-09 |
2023-08-12 |
mouse |
| M Hetman, K Kanning, J E Cavanaugh, Z Xi. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 274. issue 32. 1999-09-02. PMID:10428835. |
here, we report that brain-derived neurotrophic factor (bdnf) protects cortical neurons against apoptosis induced by camptothecin or serum deprivation and activates the extracellular-signal-regulated kinase (erk) and the phosphatidylinositol 3-kinase (pi 3-kinase) pathways. |
1999-09-02 |
2023-08-12 |
Not clear |
| J M Frade, P Bovolenta, A Rodríguez-Téba. Neurotrophins and other growth factors in the generation of retinal neurons. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383117. |
thus, nt-3 promotes the conversion of neuroepithelial cells into neurons, whereas bdnf and ngf control the programmed cell death (apoptosis) that affects early postmitotic neuroblasts. |
1999-07-29 |
2023-08-12 |
chicken |
| N Takei, O Tanaka, Y Endo, D Lindholm, H Hatanak. BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. Neuropharmacology. vol 38. issue 2. 1999-06-24. PMID:10218870. |
bdnf and nt-3 but not cntf counteract the ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. |
1999-06-24 |
2023-08-12 |
rat |
| T Ikeuchi, K Shimoke, T Kubo, M Yamada, H Hatanak. [Apoptosis-inducing and -preventing signal transduction pathways in cultured cerebellar granule neurons]. Human cell. vol 11. issue 3. 1999-05-25. PMID:10086275. |
the low k(+)-induced apoptosis of cerebellar granule neurons is prevented by high k+ (membrane depolarization by high k+), bdnf, igf-1, bfgf or camp. |
1999-05-25 |
2023-08-12 |
Not clear |
| b' F J Gunn-Moore, J M Tavar\\xc3\\xa. Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation. Neuroscience letters. vol 250. issue 1. 1999-05-19. PMID:9696064.' |
bdnf and insulin can prevent apoptosis induced by serum withdrawal or the addition of glutamate or beta-amyloid peptide. |
1999-05-19 |
2023-08-12 |
Not clear |
| H Hatanak. [Neuroprotection by neurotrophic factors in apoptosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190124. |
in the present communication, we used cultured rat cerebellar granule neurons, in which low potassium concentration (lk+) in the medium induces apoptosis, and this apoptosis is prevented by high concentration of potassium (hk+), bdnf. |
1999-05-10 |
2023-08-12 |
mouse |
| H Hatanak. [Neuroprotection by neurotrophic factors in apoptosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190124. |
bdnf and high k+ prevented low k(+)-induced apoptosis via pi3-k. bdnf also promotes the survival of basal forebrain cholinergic neurons cultured from postnatal 2-week-old (p2w) rats. |
1999-05-10 |
2023-08-12 |
mouse |
| K Shimoke, S Yamagishi, M Yamada, T Ikeuchi, H Hatanak. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain research. Developmental brain research. vol 112. issue 2. 1999-04-13. PMID:9878764. |
to investigate the intracellular signaling mechanism of ly294002-induced apoptosis, the activities of akt and c-jun n-terminal kinase (jnk) were measured in cells in hk (26 mm potassium) medium or lk+ (5 mm potassium) medium containing bdnf, with or without 10 microm ly294002. |
1999-04-13 |
2023-08-12 |
Not clear |
| J Harada, M Sugimot. Inhibitors of interleukin-1 beta-converting enzyme-family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide in cerebellar granule neurons. Brain research. vol 793. issue 1-2. 1999-03-29. PMID:9630648. |
agents such as brain-derived neurotrophic factor (bdnf), dibutylyl camp, nmda, actinomycin d, s-adenosyl-l-methionine, and spermine prevented apoptosis. |
1999-03-29 |
2023-08-12 |
rat |
| I Ferrer, E Goutan, E Martí, E Arena. Brain-derived neurotrophic factor does not prevent ionizing radiation-induced apoptosis in the developing rat brain. Neuroscience letters. vol 257. issue 2. 1999-03-24. PMID:9865933. |
in an attempt to learn whether brain-derived neurotrophic factor (bdnf) is able to protect neural cells from ionizing radiation-induced apoptosis in the developing brain, bdnf-transfected (f3n-bdnf) and mock-transfected (f3a mt) fibroblasts were grafted into the right germinal periventricular zone of rats at postnatal day 1 (p1). |
1999-03-24 |
2023-08-12 |
rat |
| I Ferrer, E Goutan, E Martí, E Arena. Brain-derived neurotrophic factor does not prevent ionizing radiation-induced apoptosis in the developing rat brain. Neuroscience letters. vol 257. issue 2. 1999-03-24. PMID:9865933. |
these results show that bdnf has no capacity to prevent ionizing radiation-induced apoptosis in the developing rat brain. |
1999-03-24 |
2023-08-12 |
rat |
| L Tong, R Perez-Pol. Brain-derived neurotrophic factor (BDNF) protects cultured rat cerebellar granule neurons against glucose deprivation-induced apoptosis. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 8-9. 1999-03-16. PMID:9869325. |
brain-derived neurotrophic factor (bdnf) protects cultured rat cerebellar granule neurons against glucose deprivation-induced apoptosis. |
1999-03-16 |
2023-08-12 |
rat |
| Y Wang, V L Sheen, J D Mackli. Cortical interneurons upregulate neurotrophins in vivo in response to targeted apoptotic degeneration of neighboring pyramidal neurons. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878177. |
the genes for bdnf, nt-4/5, trkb receptors, and to a lesser extent nt-3 were upregulated specifically within the regions of neocortex undergoing targeted neuronal degeneration and specifically during the period of ongoing pyramidal neuron apoptosis. |
1999-02-04 |
2023-08-12 |
Not clear |
| P Kuner, C Herte. NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR. Journal of neuroscience research. vol 54. issue 4. 1999-01-19. PMID:9822157. |
here we demonstrate that ngf-but not neurotrophin-3 (nt-3) or brain-derived neurotrophic factor (bdnf)-induced apoptosis in p75ntr-expressing human neuroblastoma sk-n-mc cells. |
1999-01-19 |
2023-08-12 |
human |
| P Kuner, C Herte. NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR. Journal of neuroscience research. vol 54. issue 4. 1999-01-19. PMID:9822157. |
bdnf prevented ngf-induced apoptosis. |
1999-01-19 |
2023-08-12 |
human |
| S X Bamji, M Majdan, C D Pozniak, D J Belliveau, R Aloyz, J Kohn, C G Causing, F D Mille. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. The Journal of cell biology. vol 140. issue 4. 1998-03-16. PMID:9472042. |
when sympathetic neuron survival is maintained with low quantities of ngf or kcl, the neurotrophin brain-derived neurotrophic factor (bdnf), which does not activate trk receptors on sympathetic neurons, causes neuronal apoptosis and increased phosphorylation of c-jun. |
1998-03-16 |
2023-08-12 |
mouse |