| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengying Li, Panpan Liu, Yucong Xue, Yingran Liang, Jing Shi, Xue Han, Jianping Zhang, Xi Chu, Li Ch. Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000240. |
in addition, ta treatment inhibited ato‑induced liver apoptosis and inflammatory responses, increased bcl‑2 protein expression level and reduced the levels of bax, caspase‑3, interleukin (il)‑1β, il‑6 and tumor necrosis factor (tnf)‑α. |
2021-07-06 |
2023-08-13 |
rat |
| Ryeo-Eun Go, Cho-Won Kim, Sung-Moo Lee, Hong Kyu Lee, Kyung-Chul Cho. Fenhexamid induces cancer growth and survival via estrogen receptor-dependent and PI3K-dependent pathways in breast cancer models. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 149. 2021-07-06. PMID:33484789. |
in addition, e2 and fen treatment resulted in elevated levels of the survival-related proteins (survivin and pcna), and inhibited apoptosis by increasing the mitochondrial membrane potential and regulating the apoptosis-related proteins (bax, bcl-2, and caspase-9). |
2021-07-06 |
2023-08-13 |
Not clear |
| Lei Mao, Qingcui Zeng, Wenjie Su, Menglong Song, Jiacen Li, Min Xi. Elevation of miR-146a Inhibits BTG2/BAX Expression to Ameliorate Postoperative Cognitive Dysfunction Following Probiotics (VSL#3) Treatment. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33725320. |
loss- and gain-function approaches were conducted to determine the roles of microrna (mir)-146a, b-cell translocation gene 2 (btg2), and bcl-2-associated x protein (bax) in post-operative effects on cognitive function and neuronal apoptosis. |
2021-07-06 |
2023-08-13 |
mouse |
| Lei Mao, Qingcui Zeng, Wenjie Su, Menglong Song, Jiacen Li, Min Xi. Elevation of miR-146a Inhibits BTG2/BAX Expression to Ameliorate Postoperative Cognitive Dysfunction Following Probiotics (VSL#3) Treatment. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33725320. |
btg2 knockdown suppressed neuronal apoptosis and contributed to shortened time of latency, prolonged time of mice spent in the target quadrant, and reduced oxidative stress through downregulating bax expression. |
2021-07-06 |
2023-08-13 |
mouse |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33733293. |
we found that gm1 protected against ketamine-induced apoptosis in the hippocampus and cortex by reducing the expression of bcl-2 and caspase-3, and by increasing the expression of bax. |
2021-07-06 |
2023-08-13 |
rat |
| Yan-Bo Peng, Wei He, Qiang Niu, Can Tao, Xiao-Lan Zhong, Cai-Ping Tan, Ping Zha. Mitochondria-targeted cyclometalated rhodium(III) complexes: synthesis, characterization and anticancer research. Dalton transactions (Cambridge, England : 2003). vol 50. issue 26. 2021-07-06. PMID:34113944. |
further studies illustrated that the rhodium complexes caused cell cycle arrest at the g2/m phase, upregulated the expression of p53 and reduced the ratio of b-cell lymphoma-2 (bcl-2)/bcl-2-associated x (bax), which ultimately resulted in cellular apoptosis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Wei Liang, Junfeng Shi, Haiyan Xia, Xiaowei We. A Novel Ruthenium-Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis via Activating the PI3K/Akt/mTOR/VEGF/MMP9 Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-07-06. PMID:34221232. |
in addition, the complex was able to modify p53 expressions to interfere with apoptosis in the carcinoma of the breast, stimulated by the intrinsic apoptotic path assisted by bcl2 and bax in vivo, yet at the same point, controlling the pi3k/akt/mtor/vegf pathway, as obtained from western blotting, correlates with the mmp9-regulated tumor mechanisms. |
2021-07-06 |
2023-08-13 |
Not clear |
| Sefa Küçükler, Selim Çomaklı, Selçuk Özdemir, Cüneyt Çağlayan, Fatih Mehmet Kandemi. Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1/VEGF. Environmental toxicology. vol 36. issue 8. 2021-07-05. PMID:33908150. |
real-time pcr (rt-pcr) was used to examine cas-3, bax, bcl-2, parp-1, and vegf, which are associated with apoptosis, autophagy, dna, and endothelial damage, respectively. |
2021-07-05 |
2023-08-13 |
rat |
| Zhiyong Zhang, Yan Pan, Yan Zhao, Mudan Ren, Yarui Li, Guifang Lu, Kaichun Wu, Shuixiang H. Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. Environmental toxicology. vol 36. issue 8. 2021-07-05. PMID:33955636. |
in this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro-apoptotic bax, caspase- 3,8 & 9, cytochrome c, and inhibition of anti-apoptotic protein expression. |
2021-07-05 |
2023-08-13 |
human |
| Yanqiu Jia, Zhe Li, Tianjun Wang, Mingyue Fan, Jiaxi Song, Peiyuan Lv, Wei Ji. Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-07-03. PMID:34211568. |
furthermore, as marker proteins of apoptosis, bcl-2 expression was decreased and bax expression was increased; thus, the ratio of bcl-2/bax was decreased in the vehicle group. |
2021-07-03 |
2023-08-13 |
rat |
| Yue Wang, Zhihua Han, Zuojun Xu, Junfeng Zhan. Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress: Roles of Mitophagy, Mitochondrial Fission, and MAPK/ERK Signaling. Oxidative medicine and cellular longevity. vol 2021. 2021-07-03. PMID:34211623. |
activation of opa1-mediated mitophagy suppressed cardiomyocyte apoptosis by downregulating bax, caspase-9, and caspase-12 and upregulating bcl-2 and c-iap. |
2021-07-03 |
2023-08-13 |
rat |
| Ying Liu, Jiawen Wang, Juhui Qiao, Shichao Liu, Siming Wang, Daqing Zhao, Xueyuan Bai, Meichen Li. Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1. International journal of molecular medicine. vol 46. issue 5. 2021-07-02. PMID:33000213. |
furthermore, 20(s)‑grh2 promoted bax transport from the cytoplasm to the mitochondria, and knockdown of vdac1 inhibited bax transport and apoptosis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Lingshan Xu, Liang Zhu, Ping Liu, Zhouquan Wu, Zhiqing Zo. Ozone induces tolerance against cardiomyocytes oxygen-glucose deprivation/reperfusion through inhibition of autophagy pathway. Experimental and therapeutic medicine. vol 22. issue 2. 2021-07-02. PMID:34194547. |
the expressions of apoptosis regulator b-cell lymphoma-2 (bcl-2), bcl-2 associated x protein (bax), cleaved caspase-3, markers of autophagy microtuble-associated protein 1 light chain 3 (lc3), autophagy-related protein 5 (atg5) and beclin-1 were measured by western blot analysis. |
2021-07-02 |
2023-08-13 |
rat |
| Lin Zhu, Mei Me. Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p. Experimental and therapeutic medicine. vol 22. issue 2. 2021-07-02. PMID:34194557. |
interference of haglros led to a decrease in the proliferation, but an increase in the apoptosis of ov cells, accompanied by downregulated expression levels of ki67 and bcl-2, and upregulated expression levels of bax and cleaved caspase-3. |
2021-07-02 |
2023-08-13 |
Not clear |
| Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng L. The E3 Ligase PIAS1 Regulates p53 Sumoylation to Control Stress-Induced Apoptosis of Lens Epithelial Cells Through the Proapoptotic Regulator Bax. Frontiers in cell and developmental biology. vol 9. 2021-07-02. PMID:34195189. |
the e3 ligase pias1 regulates p53 sumoylation to control stress-induced apoptosis of lens epithelial cells through the proapoptotic regulator bax. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yu Yuan, Weidong Men, Xiaosong Shan, Hexin Zhai, Xiaoxia Qiao, Lianting Geng, Chunhui L. Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway. Inflammopharmacology. vol 28. issue 5. 2021-07-01. PMID:32418004. |
the -inflammatory cytokines and oxidative stress were estimated in the region of the cortical along with the expression of apoptosis markers, such as b-cell lymphoma 2, bax, and caspase-3. |
2021-07-01 |
2023-08-13 |
rat |
| Li Cao, Yunjing Jiang, Lei Zhu, Wei Xu, Xiaoyan Chu, Yafei Zhang, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Deoxynivalenol Induces Caspase-8-Mediated Apoptosis through the Mitochondrial Pathway in Hippocampal Nerve Cells of Piglet. Toxins. vol 13. issue 2. 2021-07-01. PMID:33498252. |
increasing concentrations of don led to decreased b-cell lymphoma-2 (bcl-2) expression and increased expression of bcl2-associated x (bax) and b-cell lymphoma-2 homology 3 interacting domain death agonist (bid), which in turn increased transcriptional activity of the transcription factors aif and p53 (a tumor suppressor gene, promotes apoptosis). |
2021-07-01 |
2023-08-13 |
Not clear |
| Min Cheol Pyo, In-Geol Choi, Kwang-Won Le. Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1α Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells. Toxins. vol 13. issue 3. 2021-07-01. PMID:33800744. |
expression of emt markers (e-cadherin and fibronectin), apoptosis markers (caspase-3 and bax), and kidney injury molecule-1 (kim-1) was suppressed by inhibiting ahr expression using sirna, and the related transcription factors, smad2/3, and hif-1α were downregulated. |
2021-07-01 |
2023-08-13 |
Not clear |
| Yifeng Zhu, Heng Wang, Jianping Wang, Shunshun Han, Yao Zhang, Menggen Ma, Qing Zhu, Keying Zhang, Huadong Yi. Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways. Toxins. vol 13. issue 3. 2021-06-30. PMID:33802158. |
zea treatment up-regulated bax and downregulated bcl-2 expression, promoted cytochrome c release into the cytosol, and triggered mitochondria-mediated apoptosis. |
2021-06-30 |
2023-08-13 |
chicken |
| Kaili Ma, Zhi Zhang, Rui Chang, Hongcheng Cheng, Chenglong Mu, Tian Zhao, Linbo Chen, Chuanmei Zhang, Qian Luo, Jialing Lin, Yushan Zhu, Quan Che. Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate. Cell death and differentiation. vol 27. issue 3. 2021-06-29. PMID:31367011. |
in vinblastine-treated cells, pgam5 dephosphorylates bcl-xl at ser62 to restore bcl-xl sequestration of bax and bak and thereby resistance to apoptosis. |
2021-06-29 |
2023-08-13 |
Not clear |