| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baowei Su, Xueli Zhang, Guang Lu. Homeobox B5 suppression attenuates proliferation and elevates apoptosis in hepatoma cell lines through ERK/MDM2 signalling. Clinical and experimental pharmacology & physiology. vol 47. issue 6. 2021-07-13. PMID:32037602. |
in hcc cells, inhibition of hoxb5 by transfection with hoxb5 sirna significantly constrained cell viability, and bcl-2 levels, and it increased cell apoptosis, cytochrome c levels, bax levels, and caspase-3 activity. |
2021-07-13 |
2023-08-13 |
Not clear |
| Puji Peng, Zhigang Nie, Fei Sun, Hao Pen. Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway. FEBS open bio. vol 11. issue 1. 2021-07-13. PMID:33190410. |
dexamethasone (dex) was used to induce apoptosis in osteoblasts, and this resulted in a significant increase in levels of p-jnk, p-c-jun, bax, caspase-3, caspase-9, cytochrome c, beclin-1, and lc3, and a decrease in levels of p62 and bcl-2. |
2021-07-13 |
2023-08-13 |
rat |
| Zhi Yang, Weigang Wu, Pengcheng Ou, Minna Wu, Furong Zeng, Boping Zhou, Shipin W. MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33247804. |
apap decreased cell viability, apoptosis resistance, and bcl-w and bcl-2 levels whereas increased bax level in thle-2 cells. |
2021-07-13 |
2023-08-13 |
rat |
| Song-Shu Lin, Chi-Chien Niu, Li-Jen Yuan, Tsung-Ting Tsai, Po-Liang Lai, Kowit-Yu Chong, Kuo-Chen Wei, Chiung-Yin Huang, Meng-Ling Lu, Chuen-Yung Yang, Steve W N Uen. Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment. Journal of orthopaedic surgery and research. vol 16. issue 1. 2021-07-13. PMID:33413477. |
mir-573 regulates cell proliferation and apoptosis by targeting bax in human degenerative disc cells following hyperbaric oxygen treatment. |
2021-07-13 |
2023-08-13 |
human |
| Kunchi Zhao, Ran Li, Qing Ruan, Chunyang Meng, Fei Yin, Qingsan Zh. microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury. Journal of cellular and molecular medicine. 2021-07-13. PMID:33951295. |
bbb scores were elevated, the expression of nestin, neun, gfap, nf-200 and bcl-2 protein was enhanced but that of bax protein was reduced, and cell apoptosis was inhibited in sci rats after up-regulating mir-125b or silencing atf2. |
2021-07-13 |
2023-08-13 |
rat |
| Zhi Zhou Li, Fei Wang, Shuang Liu, Hui Li, Yang Wan. Ablation of PKM2 ameliorated ER stress-induced apoptosis and associated inflammation response in IL-1β-treated chondrocytes via blocking Rspo2-mediated Wnt/β-catenin signaling. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31916291. |
simultaneously, elimination of pkm2 manifestly repressed il-1β-stimulated chondrocyte apoptosis, concomitant with attenuated in the proapoptotic protein markers bax and cleaved caspase-3, and elevated the antiapoptotic protein bcl-2. |
2021-07-12 |
2023-08-13 |
rat |
| Mengmeng Yu, Yang Wang, Ping Li, Meng Li, Xuejun Ga. Taurine attenuates gossypol-induced apoptosis of C2C12 mouse myoblasts via the GPR87-AMPK/AKT signaling. Amino acids. vol 52. issue 9. 2021-07-12. PMID:32918616. |
gossypol significantly induced apoptosis, decreased bcl2 expression, and increased the protein levels of bax and the cleaved caspase 3. |
2021-07-12 |
2023-08-13 |
mouse |
| Omeed Darweesh, Eman Al-Shehri, Hugo Falquez, Joachim Lauterwasser, Frank Edlich, Rajnikant Pate. Identification of a novel Bax-Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis. Journal of cell science. vol 134. issue 8. 2021-07-12. PMID:33722980. |
we show here that activated cdk1 forms a complex with the pro-apoptotic proteins bax and bak (also known as bak1) during sac-induced apoptosis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
dichloromethane fraction of moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (mcf7) by induction of apoptosis via upregulation of bax, p53 and caspase 8 expressions. |
2021-07-12 |
2023-08-13 |
Not clear |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
the apoptosis study was conducted using annexin v-fitc analysis and confirmed by western blotting using selected proteins, which are p53, bax, cytochrome c and caspase 8. |
2021-07-12 |
2023-08-13 |
Not clear |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
it also induced early apoptosis and increased the expressions of pro-apoptotic proteins bax, caspase 8 and p53 in mcf7 cells. |
2021-07-12 |
2023-08-13 |
Not clear |
| Rui Xiong, Wenyang Jiang, Ning Li, Bohao Liu, Ruyuan He, Bo Wang, Qing Gen. PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34146983. |
the level of apoptosis in lung tissue, measured by the tunel assay and apoptosis-related proteins (bax and bcl-2), was significantly increased. |
2021-07-12 |
2023-08-13 |
mouse |
| Margherita Maranesi, Cecilia Dall'Aglio, Gabriele Acuti, Katia Cappelli, Massimo Trabalza Marinucci, Roberta Galarini, Chiara Suvieri, Massimo Zeran. Effects of Dietary Polyphenols from Olive Mill Waste Waters on Inflammatory and Apoptotic Effectors in Rabbit Ovary. Animals : an open access journal from MDPI. vol 11. issue 6. 2021-07-10. PMID:34207896. |
the follicle counts and the relative mrna (rt-qpcr) and protein (immunohistochemistry) expression of the effectors involved in inflammation (cyclooxygenase-2; interleukin-1beta; tumor necrosis factor-alpha, tnfa) and apoptosis (bcl2-associated x protein, bax), detected in the ovaries of both groups, were examined. |
2021-07-10 |
2023-08-13 |
rabbit |
| Rui Peng, Jialin Zhu, Shujin Deng, Hui Shi, Shutao Xu, Hongjuan Wu, Fangdong Zo. Targeting BAX ubiquitin-binding sites reveals that BAX activation is essential for its ubiquitin-dependent degradation. Journal of cellular biochemistry. vol 121. issue 4. 2021-07-09. PMID:31692055. |
intriguingly, we found that abt-737, a bcl-2 inhibitor, significantly enhanced trail-induced bax degradation in hct116 cells and increased trail-induced apoptosis in the hct116 only with the bax k21r/k123r mutant, not other bax mutants. |
2021-07-09 |
2023-08-13 |
Not clear |
| Zhaofa Yin, Juan Li, Le Kang, Xiangyang Liu, Jianguo Luo, Ling Zhang, Yuting Li, Jiarong Ca. Epigallocatechin-3-gallate induces autophagy-related apoptosis associated with LC3B II and Beclin expression of bladder cancer cells. Journal of food biochemistry. vol 45. issue 6. 2021-07-09. PMID:33997996. |
in this study, we demonstrated low concentration of egcg-induced proliferation inhibition and increased apoptosis in bladder cancer cell lines (5,637 and t24 cells) indicated by the increased expression of apoptosis-related protein (caspase9, caspase3 and bax). |
2021-07-09 |
2023-08-13 |
Not clear |
| Fahimeh Safaeinejad, Sareh Asadi, Shiva Ghafghazi, Hassan Nikneja. The Synergistic Anti-Apoptosis Effects of Amniotic Epithelial Stem Cell Conditioned Medium and Ponesimod on the Oligodendrocyte Cells. Frontiers in pharmacology. vol 12. 2021-07-09. PMID:34234678. |
the combination treatment with cm and ponesimod reduced the expression of caspase-3, caspase-8, bax, and annexin v proteins and increased the relative bcl-2/bax ratio, indicating inhibition of apoptosis as a possible mechanism of action. |
2021-07-09 |
2023-08-13 |
Not clear |
| Luyao Xiao, Xiaojia Ge, Lin Yang, Xiaohong Chen, Qian Xu, Xin Rui, Xia Fan, Li Feng, Qiuqin Zhang, Mingsheng Dong, Wei L. Anticancer potential of an exopolysaccharide from Food & function. vol 11. issue 11. 2021-07-07. PMID:33164019. |
furthermore, lheps-1 enhanced the production of intracellular reactive oxygen species (ros) and the activity of caspases-8/9/3, increased the levels of pro-apoptotic bax and mitochondrial cytochrome c, while decreased the anti-apoptotic bcl-2 level, indicating that lheps-1 might induce the apoptosis of ht-29 cells through a ros-dependent pathway and a mitochondria-dependent pathway. |
2021-07-07 |
2023-08-13 |
human |
| Hanqing Liu, Wei Liu, Huiliang Qiu, Dezhi Zou, Huayang Cai, Qiuxiong Chen, Chaoyang Zheng, Danping X. Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:31853618. |
cardiac function, infarct size, myocardial injury marker levels, inflammatory response and cardiomyocyte apoptosis as well as bcl-2, bax, p-akt, hmgb1 and tlr4 expression were measured. |
2021-07-06 |
2023-08-13 |
rat |
| Ye Sun, Yi Liu, Yun Cai, Pingping Han, Rui Wang, Lijun Cao, Shuixiang H. Downregulation of LINC00958 inhibits proliferation, invasion and migration, and promotes apoptosis of colorectal cancer cells by targeting miR‑3619‑5p. Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945474. |
moreover, the rate of apoptosis was enhanced, accompanied by a decrease in the expression of bcl‑2 and an increase in the expression of bax and caspase‑3. |
2021-07-06 |
2023-08-13 |
human |
| Yangbiao He, Xujun Lang, Dong Cheng, Ting Zhang, Zhihao Yang, Rongbing Xion. miR‑30a‑5p inhibits hypoxia/reoxygenation‑induced oxidative stress and apoptosis in HK‑2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1). Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945480. |
in addition, mir‑30a‑5p mimic significantly decreased h/r‑mediated apoptosis, decreased the expression of bax and activity of caspase‑3 and enhanced the expression of bcl‑2. |
2021-07-06 |
2023-08-13 |
human |