| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoumin Bai, Ting Chen, Xiaoli Yu, Ming Luo, Xianju Chen, Chunhao Lin, Yiming Lai, Hai Huan. [Corrigendum] The specific killing effect of matrine on castration‑resistant prostate cancer cells by targeting the Akt/FoxO3a signaling pathway. Oncology reports. vol 44. issue 6. 2021-08-02. PMID:33125118. |
in view of these corrections, in the "matrine induces cell apoptosis by increasing bim and bax and decreasing bcl‑2 protein levels in prostate cancer cell lines" subsection of the results section towards the bottom of p. 2822, in the penultimate sentence, the text "...ly294002 resulted in 25.88% cell apoptosis in the pc‑3 cells and 18.88% in the rwpe1 cells, compared to 3.11 and 6.89%, respectively, with ly294002 treatment only (fig. |
2021-08-02 |
2023-08-13 |
Not clear |
| Xia Ying Cui, Sun Hyang Park, Woo Hyun Par. Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase‑dependent apoptosis. Oncology reports. vol 44. issue 6. 2021-08-02. PMID:33125149. |
this agent also efficiently induced apoptosis, accompanied by loss of mitochondrial membrane potential (mmp; ∆Ψm), increases in cleavage forms of caspase‑3 and poly (adp‑ribose) polymerase (parp), and a high ratio of bax to bcl‑2 proteins. |
2021-08-02 |
2023-08-13 |
Not clear |
| Liang Pei, Linxi H. Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34051206. |
tunel staining and western blot revealed that anemoside b4 suppressed cell apoptosis, along with decreased bax, leaved caspase-3, cleaved parp, but increased bcl-2. |
2021-08-02 |
2023-08-13 |
mouse |
| Yang Zhang, Maria A Yapryntseva, Alexander Vdovin, Polina Maximchik, Boris Zhivotovsky, Vladimir Gogvadz. Modeling hypoxia facilitates cancer cell survival through downregulation of p53 expression. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34126102. |
deferoxamine-mediated suppression of apoptosis correlated with the level of pro-apoptotic bcl-2 family proteins bax, bid, and puma, which stimulate mitochondrial apoptotic pathway through permeabilization of the outer mitochondrial membrane and cytochrome c release. |
2021-08-02 |
2023-08-13 |
Not clear |
| Bo Wang, Dan Han, Fei Li, Weikun Hou, Lijuan Wang, Liesu Meng, Kuanhou Mou, Shemin Lu, Wenhua Zhu, Yan Zho. Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax. Apoptosis : an international journal on programmed cell death. vol 25. issue 9-10. 2021-07-30. PMID:32632545. |
the apoptosis induced by tnf-α and ifn-γ was inhibited in heks treated with il-22, since that il-22 upregulated bcl-xl and downregulated bax production in heks in the presence of tnf-α and ifn-γ. |
2021-07-30 |
2023-08-13 |
human |
| Faranak Aghaz, Asad Vaisi-Raygani, Mozafar Khazaei, Elham Arka. The Anti-oxidative Effects of Encapsulated Cysteamine During Mice In Vitro Matured Oocyte/Morula-Compact Stage Embryo Culture Model: a Comparison of High-Efficiency Nanocarriers for Hydrophilic Drug Delivery-a Pilot Study. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 5. 2021-07-30. PMID:33030694. |
in comparison, cys-sln (5 μm) is more effective than cys-cs-nc (10 μm) groups to improve the expression of antioxidant genes (sod, cat, gpx) or anti-apoptotic (bcl-2) gene and decreased apoptosis (bax and caspase-3) or intra-/extracellular ros levels. |
2021-07-30 |
2023-08-13 |
mouse |
| Lining Wang, Jingwen Zhang, Chengtian Zhao, Zhenzhen Jia, Xizeng Fen. Melatonin Reverses 10-Hydroxycamptothecin-Induced Apoptosis and Autophagy in Mouse Oocyte. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 7. 2021-07-30. PMID:33104985. |
compared with the control group, the expressions of key regulators of oocyte apoptosis (bax, caspase-3) and autophagy (lc3, beclin, atg12) pathway were increased in the hcpt-treated group. |
2021-07-30 |
2023-08-13 |
mouse |
| Suvesh Munakarmi, Lokendra Chand, Hyun Beak Shin, Usama Khamis Hussein, Bong-Sik Yun, Hae Ryong Park, Yeon Jun Jeon. Anticancer effects of Poncirus fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion. Oncology reports. vol 44. issue 6. 2021-07-30. PMID:33125135. |
pf treatment significantly decreased the proliferation of hep3b and huh7 cells in a dose‑dependent manner, reduced the mitochondrial membrane potential, increased ros levels, decreased the protein levels of bcl‑2, and increased the protein levels of bax and cleaved caspase‑3 and 9, suggesting that pf mediated hcc apoptosis via a mitochondrial pathway. |
2021-07-30 |
2023-08-13 |
Not clear |
| Yalda Baghay Esfandyari, Mohammad Amin Doustvandi, Mohammad Amini, Behzad Baradaran, Sheyda Jodeiry Zaer, Nazila Mozammel, Mehdi Mohammadzadeh, Ahad Mokhtarzade. MicroRNA-143 Sensitizes Cervical Cancer Cells to Cisplatin: a Promising Anticancer Combination Therapy. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 7. 2021-07-30. PMID:33569751. |
our results showed that mirna-143 overexpression could increase cisplatin-induced apoptosis and increase the sensitivity of caski cells to low doses of this chemotherapeutic agent via modulating the expression of apoptosis-related genes including bcl-2, bax, and caspase-9. |
2021-07-30 |
2023-08-13 |
Not clear |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
in pcos rats, the ovarian expression of cxcl12, cxcr4, and cxcr7 was reduced, and the apoptosis rate of granulosa cells was increased, accompanied by decreased expression of bcl2 and increased expression of bax and cleaved caspase3 (casp3). |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
we further showed that recombinant human cxcl12 treatment upregulated bcl2, downregulated bax, and cleaved casp3 in kgn cells to inhibit their apoptosis in a concentration-dependent manner; moreover, the effect of cxcl12 was weakened by cxcr4 antagonist amd3100 and anti-cxcr7 neutralizing antibody. |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
further, in human kgn cells, cxcl12 regulated the expression of bax, bcl2, and cleaved casp3 to inhibit apoptosis through cxcr4- and cxcr7-mediated signal transmission. |
2021-07-29 |
2023-08-13 |
human |
| Morgana Alves Borges, Fernanda S S Sousa, Júlia Damé Paschoal, Isadora A R Lopes, Ana Laura da S Feijó, Amilton Clair Pinto Seixas Neto, Luciano da Silva Pinto, Fabiana Kommling Seixas, Tiago Collare. Effect of supplementation of medium with Bauhinia forficata recombinant lectins on expression of oxidative stress genes during in vitro maturation of bovine oocytes. Reproductive toxicology (Elmsford, N.Y.). vol 103. 2021-07-29. PMID:34098044. |
in the groups treated with the concentration of 100 μg / ml, the gene expression of genes involved in oxidative stress sod2, cat, gpx-1, gsr, nos2 and apoptosis bax, casp3 were evaluated. |
2021-07-29 |
2023-08-13 |
cat |
| Leila Soufi, Alireza Farasat, Hossein Ahmadpour-Yazdi, Leila Zolghadr, Nematollah Gheib. The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells. Molecular biology reports. vol 48. issue 6. 2021-07-29. PMID:34254227. |
quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as bax and bcl2. |
2021-07-29 |
2023-08-13 |
Not clear |
| Mohamed Abd-Elbaset, Ahmed M Mansour, Osama M Ahmed, Amira M Abo-Yousse. The potential chemotherapeutic effect of β-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect, PPAR-γ, FOXO-1, Ki-67, Bax, and Bcl-2 signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 9. 2021-07-28. PMID:32270258. |
hcc is associated with ki-67 and bcl-2 overexpression, reduced bax expression inducing disturbance of equilibrium between cellular proliferation and apoptosis, and exacerbated by reduced expression of ppar-γ and foxo-1. |
2021-07-28 |
2023-08-13 |
rat |
| Chunyang Niu, Sujuan Zhang, Guilin Mo, Yilong Jiang, Liang Li, Hengyong Xu, Chunchun Han, Hua Zhao, Yanhong Yan, Shenqiang Hu, Jiwei Hu, Bo Kang, Dongmei Jian. Effects of ODC on polyamine metabolism, hormone levels, cell proliferation and apoptosis in goose ovarian granulosa cells. Poultry science. vol 100. issue 8. 2021-07-28. PMID:34175802. |
after odc downregulation, granulosa cell activity was significantly reduced, the apoptosis rate was significantly increased, and the bcl-2 / bax ratio was downregulated (p < 0.05). |
2021-07-28 |
2023-08-13 |
Not clear |
| Chunyang Niu, Sujuan Zhang, Guilin Mo, Yilong Jiang, Liang Li, Hengyong Xu, Chunchun Han, Hua Zhao, Yanhong Yan, Shenqiang Hu, Jiwei Hu, Bo Kang, Dongmei Jian. Effects of ODC on polyamine metabolism, hormone levels, cell proliferation and apoptosis in goose ovarian granulosa cells. Poultry science. vol 100. issue 8. 2021-07-28. PMID:34175802. |
under odc overexpression, the activity of gcs was notably increased, the apoptosis rate was significantly reduced, and the bcl-2 / bax protein ratio was upregulated (p < 0.05). |
2021-07-28 |
2023-08-13 |
Not clear |
| Yunyun Wang, Wei Shi, Chenliang Wu, Lin Wan, Yuxun Zhao, Chenglong Zhang, Wen Gu, Shifa Wan. Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-28. PMID:34243605. |
the study on molecular mechanism suggested that compound 3b induced apoptosis via activation of caspase-3 and parp, also via decreasing of bcl-2 and increasing of bax and p53. |
2021-07-28 |
2023-08-13 |
Not clear |
| Xu Luo, Lina Li, Weilin Xu, Yuan Cheng, Zongyi Xi. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neuroscience bulletin. vol 36. issue 10. 2021-07-27. PMID:32562163. |
the results demonstrated that hly78 attenuated neuronal apoptosis and the neurological deficits after sah through the activation of low-density lipoprotein receptor-related protein 6 (lrp6), which subsequently increased the level of phosphorylated glycogen synthesis kinase 3 beta (p-gsk3β) (ser9), β-catenin, and bcl-2, accompanied by a decrease of p-β-catenin, bax, and cleaved caspase 3. |
2021-07-27 |
2023-08-13 |
rat |
| Xiaojing Hu, Yuanyuan Zhu, Xiaoyan L V, Zhanbin Fen. Elucidation of the mechanism of action of pinitol against pressure overload-induced cardiac hypertrophy and fibrosis in an animal model of aortic stenosis. Bioscience, biotechnology, and biochemistry. vol 85. issue 3. 2021-07-27. PMID:33589894. |
the upregulated mrna expressions of cardiac anp, bnp, ctn-i, tnf-α, il-1β, il-6, bax, caspase-3, collagen-i, and cardiac apoptosis were markedly downregulated by pinitol. |
2021-07-27 |
2023-08-13 |
rat |