| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noah B Bloch, Thomas E Wales, Michelle S Prew, Hannah R Levy, John R Engen, Loren D Walensk. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature communications. vol 12. issue 1. 2021-08-30. PMID:34389733. |
during homeostasis, bax predominantly resides in the cytosol as a latent monomer but, in response to stress, transforms into an oligomeric protein that permeabilizes the mitochondria, leading to apoptosis. |
2021-08-30 |
2023-08-13 |
Not clear |
| Min Lu, Yujun Qi, Yu Han, Qiong Yi, Lei Xu, Wenlin Sun, Guihua Ni, Xiaoyu Ni, Changsong X. Design and development of novel thiazolidin-4-one-1,3,5-triazine derivatives as neuro-protective agent against cerebral ischemia-reperfusion injury in mice via attenuation of NF-ĸB. Chemical biology & drug design. vol 96. issue 5. 2021-08-27. PMID:32543026. |
results suggest that compound 8k causes attenuation of inflammation (tnf-α, il-β, and il-6), oxidative stress (sod, gsh, and mda), and apoptosis (bcl-2, bax, and cleaved caspase-3) in mcao mice in concentration-dependent manner. |
2021-08-27 |
2023-08-13 |
mouse |
| Hui Pei, Qian Peng, Shewei Guo, Yulei Gu, Tongwen Sun, Dong Xu, Yumin Jiang, Jiafeng Xie, Luanluan Zhang, Zhiqiang Zh. MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA. In vitro cellular & developmental biology. Animal. vol 56. issue 10. 2021-08-27. PMID:33150481. |
overexpression of mir-367 could significantly decrease the expressions of mhc-ІІ, il-1β, and bax, reduced apoptosis rate, and increased the expressions of cd206, bal-2, and arg-1 in erythrocyte lysate-treated microglia. |
2021-08-27 |
2023-08-13 |
Not clear |
| Zhimin Li, Xing Cao, Ligen Xiao, Ruijiao Zho. Aloperine protects against cerebral ischemia/reperfusion injury via activating the PI3K/AKT signaling pathway in rats. Experimental and therapeutic medicine. vol 22. issue 4. 2021-08-27. PMID:34434259. |
in addition, alo attenuated neuronal cell apoptosis, downregulated the expression of bax and upregulated that of bcl-2. |
2021-08-27 |
2023-08-13 |
rat |
| Cong Li, Suling Hu, Yan Yu. Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells. Ultrasound in medicine & biology. vol 47. issue 3. 2021-08-26. PMID:33261909. |
overexpression of liposome-mediated vhl inhibited the proliferation and migration; caused cell-cycle arrest; promoted apoptosis: downregulated the expressions of mmp2, mmp9, e-cadherin, akt and bcl-2; and upregulated the expressions of vhl and bcl2-associated x protein (bax) in ovcar-3 cells. |
2021-08-26 |
2023-08-13 |
Not clear |
| Ajay Tijore, Mingxi Yao, Yu-Hsiu Wang, Anushya Hariharan, Yasaman Nematbakhsh, Bryant Lee Doss, Chwee Teck Lim, Michael Sheet. Selective killing of transformed cells by mechanical stretch. Biomaterials. vol 275. 2021-08-26. PMID:34044258. |
the mechanism of mechanical apoptosis (mechanoptosis) of transformed cells involves calcium influx through the mechanosensitive channel, piezo1 that activates calpain 2 dependent apoptosis through the bax molecule and subsequent mitochondrial activation of caspase 3 on both fibronetin and collagen matrices. |
2021-08-26 |
2023-08-13 |
Not clear |
| T Takeda, M Tsubak, S Genno, T Matsuda, Y Yamamoto, E Ueda, M Imano, T Satou, S Nishid. CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 4. 2021-08-24. PMID:33214335. |
furthermore, we clarified that cd49d- and cd49e-mediated cam-dr could be attributed to an increase in the expression of b cell leukemia-xl (bcl-xl) and survivin proteins, and a decrease in the expression of bcl-2 associated x (bax), bcl-2 interacting mediator (bim) and p53 upregulated modulator of apoptosis (puma) proteins via nuclear factor kappab (nf-κb) activation. |
2021-08-24 |
2023-08-13 |
Not clear |
| Jun-Wei Liu, Yong-Li Wu, Wei Wei, Yan-Ling Zhang, Di Liu, Xiao-Xiu Ma, Chun Li, Yu-Yuan M. Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-24. PMID:34422071. |
in addition, warm acupuncture combined with bmscs treatment suppressed chondrocyte apoptosis in rabbits with knee osteoarthritis by reduced tunel-positive chondrocytes and simultaneously reversed the mrna expression of bax, bcl-2, and caspase-3. |
2021-08-24 |
2023-08-13 |
rabbit |
| Olena Kalashnyk, Olena Lykhmus, Kateryna Uspenska, Mykhailo Izmailov, Sergiy Komisarenko, Maryna Sko. Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction. The international journal of biochemistry & cell biology. vol 129. 2021-08-23. PMID:33147521. |
mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with vdac1 to form complexes with bax upon apoptosis induction. |
2021-08-23 |
2023-08-13 |
Not clear |
| Olena Kalashnyk, Olena Lykhmus, Kateryna Uspenska, Mykhailo Izmailov, Sergiy Komisarenko, Maryna Sko. Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction. The international journal of biochemistry & cell biology. vol 129. 2021-08-23. PMID:33147521. |
here we put an aim to explore the interaction of nachrs with voltage-dependent anion channels (vdac1) and pro-apoptotic protein bax in the course of apoptosis induction. |
2021-08-23 |
2023-08-13 |
Not clear |
| Guangwei Liu, Wenxia Zhao, Jiameng Bai, Jianjiao Cui, Haowei Liang, Baoping L. Formononetin protects against concanavalin-A-induced autoimmune hepatitis in mice through its anti-apoptotic and anti-inflammatory properties. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 99. issue 2. 2021-08-23. PMID:33749318. |
moreover, pretreatment with fmn inhibited the apoptosis of hepatocytes in the cona-treated mice through downregulating the expression of pro-apoptotic proteins (bax, cleaved caspase 9, and cleaved caspase 3) and upregulating the expression of anti-apoptotic protein (bcl-2). |
2021-08-23 |
2023-08-13 |
mouse |
| Yunlong Sun, Bo Pang, Yingzhe Wang, Jinglei Xiao, Dacheng Jian. Baohuoside I Inhibits the Proliferation of Hepatocellular Carcinoma Cells via Apoptosis Signaling and NF-kB Pathway. Chemistry & biodiversity. vol 18. issue 6. 2021-08-23. PMID:33904248. |
cell apoptosis was analyzed by flow cytometry, and the levels of cleaved caspase-3, bax, and bcl-2 were quantified by western blot. |
2021-08-23 |
2023-08-13 |
human |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary. Cytokine. vol 140. 2021-08-20. PMID:33476980. |
the inhibition of visfatin increased the ovarian proliferation (increase in pcna, gcna expression and brdu incorporation) and apoptosis (increase in bax and active caspase3 expression). |
2021-08-20 |
2023-08-13 |
mouse |
| Zohreh Zare, Sam Zarbakhsh, Shamim Mashhadban, Afshin Moradgholi, Moslem Mohammad. Apoptosis is involved in paraoxon-induced histological changes in rat cerebellum. Drug and chemical toxicology. 2021-08-20. PMID:34412520. |
in addition, exposure of rats to 1 mg/kg of paraoxon activated apoptosis pathway confirmed by an increase in bax and caspase-3 and a decrease in bcl-2 protein levels. |
2021-08-20 |
2023-08-13 |
rat |
| Anouar Feriani, Mariano Bizzarri, Meriam Tir, Nouf Aldawood, Hussah Alobaid, Mohamed Salah Allagui, Waleed Dahmash, Nizar Tlili, Kais Mnafgui, Saleh Alwasel, Abdel Halim Harrat. High-fat diet-induced aggravation of cardiovascular impairment in permethrin-treated Wistar rats. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34224971. |
furthermore, cardiac dna fragmentation and upregulation of bax and caspase-3 gene expression supported the ability of hfd and/or per to induce apoptosis and inflammation in rat hearts. |
2021-08-19 |
2023-08-13 |
rat |
| Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang L. Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34280841. |
in addition, pnd increased the expression of reactive oxygen species and malondialdehyde and reduced the activity of superoxide dismutase (antioxidant enzymes); we examined the expression of cardiac development-related genes and the apoptosis markers, and found changes of the following marker: vmhc, nppa, tbx5a, nkx2.5, gata4, tbx2b and foxo1, bax, bcl-2, p53, casp-9, casp-3. |
2021-08-19 |
2023-08-13 |
zebrafish |
| Jie Wu, Jing-Qiu Qu, Yan-Jun Zhou, Yong-Jian Zhou, Yuan-Yuan Li, Nan-Qu Huang, Cheng-Min Deng, Yong Lu. Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis in SAMP8 mice. Neuroreport. vol 31. issue 9. 2021-08-18. PMID:32427716. |
furthermore, ica siginificantly increase the bcl-2/bax ratio by increasing the expression of anti-apoptotic protein bcl-2, and decreasing the expression of pro-apoptotic protein bax, and thus inhibit neurons apoptosis. |
2021-08-18 |
2023-08-13 |
mouse |
| Yichen Liu, Hong Bai, Kaili Guo, Pan Wan. Hypocrellin B triggered sonodynamic therapy reverses multidrug resistance of doxorubicin-resistant SGC7901/ADR cells via down-regulation of P-gp expression. Journal of chemotherapy (Florence, Italy). vol 32. issue 7. 2021-08-18. PMID:32530372. |
meanwhile, western blotting assays display the expression of apoptosis related proteins bax and bcl-2 changed markedly after the combination treatment. |
2021-08-18 |
2023-08-13 |
human |
| Min Kyoon Kim, Yesl Kim, SeungHwa Park, Eunju Kim, Yerin Kim, Yuri Kim, Jung-Hyun Ki. Effects of Steady Low-Intensity Exercise on High-Fat Diet Stimulated Breast Cancer Progression Via the Alteration of Macrophage Polarization. Integrative cancer therapies. vol 19. 2021-08-18. PMID:32909498. |
steady low- and moderate-intensity exercise had no effect on cell proliferation but induced apoptosis by activating caspase-3 through the alteration of bcl-2, bcl-xl, and bax expression. |
2021-08-18 |
2023-08-13 |
mouse |
| Xiaoxiao Liu, Li Zhang, Pyone Myat Thu, Wenjian Min, Peng Yang, Ji Li, Ping Li, Xiaojun X. Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53. Science China. Life sciences. vol 64. issue 8. 2021-08-18. PMID:33165811. |
consistent with the previous results, sodium cantharidinate treatment decreased bcl-2 and mitochondrial cytochrome-c protein expression, as well as phosphorylation of mdm2; meanwhile, it increased the levels of cleaved-caspase-3, cleaved-caspase-9, cleaved-parp, bax, and phosphorylated p53, thus inducing the apoptosis of pancreatic cancer cells. |
2021-08-18 |
2023-08-13 |
human |