| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sreejata Kamila, Koushik Kumar Dey, Ansuman Chattopadhya. Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2-Keap1-ARE, DNA Repair, and Intrinsic Apoptotic Pathways. Journal of applied toxicology : JAT. 2024-10-15. PMID:39402722. |
expressional alteration in bax, bcl2, caspase9, and caspase 3 indicated apoptosis (intrinsic pathway) induction, which was maximum in combined group. |
2024-10-15 |
2024-10-17 |
zebrafish |
| Hong Guo, Yuanwei Dong, Danqing Luo, Meng Gong, Jianfeng Sun, Zhipeng Wu, Zhixiang Liu, Lei Zhong, Song Ji. MRPL41, as a target for acupuncture, promotes neuron apoptosis in models of ischemic stroke via activating p53 pathway. Neurochemistry international. 2024-10-15. PMID:39406282. |
knockdown of mrpl41 increased cell viability and ani-apoptotic protein (bcl-2) expression, and reduced apoptosis intensity and pro-apoptotic protein (bax and cleaved caspase-3) of ogd/r neurons. |
2024-10-15 |
2024-10-18 |
Not clear |
| Ali Soleimanzadeh, Niki Karvani, Farshid Davoodi, Rahim Molaie, Abbas Rais. Efficacy of silver-doped Carbon dots in Chemical Castration: a rat model study. Scientific reports. vol 14. issue 1. 2024-10-15. PMID:39406851. |
histological and genes expression analysis also revealed apoptosis and testicular damage in the agcds groups, indicated by significant increases in p53, bax, and caspase-3 levels, and significant reductions in akt, pi3k, and bcl-2. |
2024-10-15 |
2024-10-18 |
rat |
| Sebastian Rühl, Zhenrui Li, Shagun Srivastava, Luigi Mari, Clifford S Guy, Mao Yang, Tudor Moldoveanu, Douglas R Gree. Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5. Cell death and differentiation. 2024-10-15. PMID:39406920. |
by promoting the binding of activated bak to mcl-1 or bcl-xl, bnip5 inhibits apoptosis when bax is absent. |
2024-10-15 |
2024-10-18 |
Not clear |
| Kangzhen Dong, Junhui Wang, Fangyuan Tang, Yong Liu, Li Ga. A polysaccharide with a triple helix structure from Agaricus bisporus: Characterization and anti-colon cancer activity. International journal of biological macromolecules. 2024-10-14. PMID:39401631. |
waap-2 promoted ht-29 cell apoptosis by up-regulating the expression of caspase-3 and bax proteins while down-regulating the expression of bcl-2 protein. |
2024-10-14 |
2024-10-17 |
Not clear |
| Guogeng Jia, Khaing Shwe Zin Thinn, Sun Ha Kim, Jiyoung Min, Sang-Keun O. Capsicum annuum NAC4 (CaNAC4) Is a Transcription Factor with Roles in Biotic and Abiotic Stresses. The plant pathology journal. vol 40. issue 5. 2024-10-14. PMID:39397305. |
the results showed a stronger hr in wild-type plants after infiltration with the apoptosis regulator, bax. |
2024-10-14 |
2024-10-16 |
Not clear |
| Sanaz Alaee, Fatemeh Zal, Vahid Razban, Tahereh Talaei-Khozani, Saeed Shokri, Zahra Khodabande. PRP Influences Maturation and Fertilisation of Immature Mouse Oocytes. Anatomia, histologia, embryologia. vol 53. issue 6. 2024-10-13. PMID:39396107. |
furthermore, the prp group demonstrated a significant decrease in the expression of transcripts associated with apoptosis (bax and caspase-3); however, in the prp group, a substantial increase in the expression of bcl2l1, an apoptosis inhibitor, was observed when compared to the control group (p < 0.05). |
2024-10-13 |
2024-10-15 |
mouse |
| Tianrui Qu, Yu Sun, Jingying Zhao, Nanqi Liu, Jianli Yang, Dantong Lyu, Wenjie Huang, Weizhen Zhan, Tao Li, Zichuan Yao, Rongbo Yan, Haiyan Zhang, Hong Hong, Liye Shi, Xin Meng, Bo Yi. Scoulerine: A natural isoquinoline alkaloid targeting SLC6A3 to treat RCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-12. PMID:39395255. |
in addition, scoulerine inhibited the viability of 769-p and 786-o cell lines in a time-dependent and dose-dependent manner, and promoted the level of apoptosis associated with b-cell lymphoma-2 associated x protein (bax). |
2024-10-12 |
2024-10-15 |
Not clear |
| Yunze Li, Xin Sun, Zhe Huan. USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling. Biochimica et biophysica acta. Molecular cell research. 2024-10-11. PMID:39393471. |
silencing lrrc42 suppressed cell proliferation, induced g0/g1 phase arrest, and promoted apoptosis by reducing bcl2 expression while elevating the expression of bax, cleaved parp and cleaved caspase 3. |
2024-10-11 |
2024-10-14 |
Not clear |
| Zhenqi Zhou, Brihget Sicairos, Jianhong Zhou, Yuchun D. Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells. Journal of proteome research. 2024-10-11. PMID:39392593. |
bioinformatics analysis suggests that e2 may enhance apoptosis by promoting the accumulation of the pore-forming protein bax in the mitochondria and inhibit apoptosis by activating the pi3k/akt/mtor signaling pathway. |
2024-10-11 |
2024-10-13 |
Not clear |
| Xiumei Bai, Yabin Song, Xiangyan Zhang, Liqiong Liu, Haixia Wu, Jiaqing Feng, Lihong Wu, Huizhen Liu, Diangui Zho. Curcumin ameliorates ischemic stroke injury by downregulating GMFB expression: An Biomolecules & biomedicine. 2024-10-10. PMID:39388704. |
gmfb overexpression promoted ogd/r-induced cell viability diminution, increased ldh and ros levels, lessened cell invasion ability, enhanced cell apoptosis, enhanced bax levels, and decreased bcl2 levels. |
2024-10-10 |
2024-10-13 |
Not clear |
| Ruijie Liu, Wenfang Wang, Wenfeng L. Bezafibrate mitigates cardiac injury against coronary microembolization by preventing activation of p38 MAPK/NF-κB signaling. Aging. vol 16. 2024-10-09. PMID:39383058. |
importantly, bezafibrate was found to mitigate cme-induced myocardial apoptosis by increasing the expression of bcl-2 and reducing the levels of bax and cleaved caspase-3. |
2024-10-09 |
2024-10-12 |
rat |
| Hong Chen, Jameel Ahmed Buzdar, Roshan Riaz, Dalia Fouad, Nisar Ahmed, Qurban Ali Shah, Shulin Che. Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway. Poultry science. vol 103. issue 12. 2024-10-09. PMID:39383667. |
whereas, mrna level of mitochondrial apoptosis related gene including bcl-2 (bak and bax), caspase-3 and caspase-9 was upregulated, while bcl2 gene were downregulated in afb1 group. |
2024-10-09 |
2024-10-12 |
chicken |
| Yichi Xu, Xiaoli Qin, Weihong Zeng, Fan Wu, Xiaowei Wei, Qian Li, Yi Li. DOCK1 deficiency drives placental trophoblast cell dysfunction by influencing inflammation and oxidative stress, hallmarks of preeclampsia. Hypertension research : official journal of the Japanese Society of Hypertension. 2024-10-08. PMID:39379467. |
moreover, dock1 knockout amplified apoptosis, as indicated by an altered bcl2: bax ratio and enhanced levels of cleaved parp. |
2024-10-08 |
2024-10-11 |
mouse |
| Rahul V G, Govindaraj Ellur, Amir A Gaber, Prem Kumar Govindappa, John C Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice. Cell death discovery. vol 10. issue 1. 2024-10-04. PMID:39366954. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-10-04 |
2024-10-07 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Peng Sun, Hanqing Huang, Jian-Chao Ma, Binyang Feng, Yiqing Zhang, Genggeng Qin, Weian Zeng, Zhong-Kai Cu. Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncology reports. vol 52. issue 5. 2024-10-04. PMID:39364744. |
propofol promoted apoptosis in 4t1 cells through upregulation of bax and cleaved caspase 3, while downregulating b‑cell lymphoma‑extra large. |
2024-10-04 |
2024-10-07 |
mouse |
| Lian Yi, Yewei Qu, Qi Zhang, Shanshan Shi, Fangqin Li, Changda Qu, Yushi Tang, Shirong Wen, Yujun Pa. Enforced HCELL Expression Enhances Bone Marrow Stromal Cells Homing and Amelioration of Cerebral Ischemia-Reperfusion Injury via induction of PGE2. Stem cells (Dayton, Ohio). 2024-10-04. PMID:39364762. |
furthermore, the transplantation led to a decrease in apoptosis by up-regulating bcl-2 and down-regulating bax, also reduced the mrna levels of inflammatory factors, such as interleukin-1β (il-1β), il-2, il-6 and tumor necrosis factor-alpha (tnf-α) in the ischemic brain tissue. |
2024-10-04 |
2024-10-07 |
Not clear |
| Tineng Yang, Xiaoyang Peng, Xi Huang, Peng Cao, Hualei Che. COL6A1 Inhibits the Malignant Development of Bladder Cancer by Regulating FBN1. Cell biochemistry and biophysics. 2024-10-04. PMID:39365515. |
moreover, the col6a1 overexpression suppressed the viability, migration, and invasion, while promoting apoptosis of blca cell lines, with increased caspase-3, bax, and p53, and decreased bcl-2. |
2024-10-04 |
2024-10-07 |
mouse |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |