| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sirotkin, Z Fabová, B Loncová, K Popovičová, M Bauer, A Harrat. The Toxic Effect of Toluene on Ovarian Cells Can Be Prevented by the MicroRNA miR-152. Physiological research. vol 73. issue 5. 2024-11-16. PMID:39545793. |
the expression of mir-152; cell viability; proliferation (accumulation of pcna, cyclin b1 and brdu); cytoplasmic/mitochondrial apoptosis (accumulation of bax and caspase 3); and release of progesterone, testosterone and estradiol were quantified via rt-qpcr, the trypan blue exclusion test, quantitative immunocytochemistry, the brdu assay and elisa. |
2024-11-16 |
2024-11-18 |
Not clear |
| Langqun Chen, Siyu Cheng, Jiahui Ying, Qi Zhang, Chen Wang, Huimin Wu, Ying Wang, Hong Zhang, Jiahe Wang, Jing Ye, Liang Zhan. Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1). Toxicology letters. 2024-11-15. PMID:39547317. |
moreover, we discovered that inhibition of ido1 decreased the expression of the apoptotic protein bax, raised the expression of bcl-2 protein, and reduced apoptosis. |
2024-11-15 |
2024-11-18 |
mouse |
| Ke Yang, Xinran Li, Shuqing Yang, Yi Zheng, Sanjie Cao, Qigui Yan, Xiaobo Huang, Yiping Wen, Qin Zhao, Senyan Du, Yifei Lang, Shan Zhao, Rui W. Japanese encephalitis virus infection induces mitochondrial-mediated apoptosis through the proapoptotic protein BAX. Frontiers in microbiology. vol 15. 2024-11-14. PMID:39529669. |
japanese encephalitis virus infection induces mitochondrial-mediated apoptosis through the proapoptotic protein bax. |
2024-11-14 |
2024-11-17 |
Not clear |
| Biao Zhu, Lei Sun, Junyao Tong, Yan Ding, Yanbo Shan, Mingjuan He, Xiaoyu Tian, Wen Mei, Lisheng Zhao, Ying Wan. Neuregulin 4 attenuates pancreatic β-cell apoptosis induced by lipotoxicity via activating mTOR-mediated autophagy. Islets. vol 16. issue 1. 2024-11-14. PMID:39541216. |
results showed that nrg4 decreased pa-induced min6 apoptosis, enhanced anti-apoptotic protein b-cell lymphoma 2 (bcl-2) expression and reduced pro-apoptotic proteins bcl-2-associated x protein (bax) and cleaved-caspase 3 expressions. |
2024-11-14 |
2024-11-17 |
mouse |
| Yu Xiang, Li Mao, Zhao-Hui Dai, Xiao-Hua Liu, Zhong-Bao Yan. Neuroprotective Effect of Benzyl Ferulate on Ischemia/Reperfusion Injury via Regulating NOX2 and NOX4 in Rats: A Potential Antioxidant for CI/R Injury. Advances in pharmacological and pharmaceutical sciences. vol 2024. 2024-11-14. PMID:39524533. |
it also reduced total nox enzyme activity, enhanced superoxide dismutase (sod) activity, decreased ros and malondialdehyde (mda) production, and inhibited cleaved caspase-3 and bax expression-ultimately leading to reduced cell apoptosis. |
2024-11-14 |
2024-11-17 |
rat |
| Zijia Yin, Hongying Zhang, Kaiwen Zhao, Yulong Liu, Ru Guo, Pengxia Xu, Guannan Zhao, Menglei Hu, Chengyu Hu, Xiaowen X. Zebrafish FKBP5 facilitates apoptosis and SVCV propagation by suppressing NF-κB signaling pathway. Fish & shellfish immunology. 2024-11-13. PMID:39537119. |
finally, drfkbp5 activated the expression of apoptosis-related genes, including bax, bcl2, caspase-3 and induced apoptosis under svcv treatment. |
2024-11-13 |
2024-11-17 |
zebrafish |
| Michelle Salinger, Jaime Palomino, Oscar A Peralta, Victor H Parraguez, Monica De Los Reye. Early apoptosis detection in canine granulosa cells through the analysis of BCL-2 and BAX proteins during the follicular development associated with oocyte maturation. Animal reproduction science. vol 271. 2024-11-12. PMID:39532002. |
early apoptosis detection in canine granulosa cells through the analysis of bcl-2 and bax proteins during the follicular development associated with oocyte maturation. |
2024-11-12 |
2024-11-17 |
Not clear |
| Michelle Salinger, Jaime Palomino, Oscar A Peralta, Victor H Parraguez, Monica De Los Reye. Early apoptosis detection in canine granulosa cells through the analysis of BCL-2 and BAX proteins during the follicular development associated with oocyte maturation. Animal reproduction science. vol 271. 2024-11-12. PMID:39532002. |
the objective of this study was to investigate the early follicular apoptosis in canine ovarian follicles by examining the expression of anti-apoptotic bcl-2 and pro-apoptotic bax proteins throughout the estrous cycle associated with oocyte maturation. |
2024-11-12 |
2024-11-17 |
Not clear |
| Meiyue Yang, Zhibo Yang, Xiangjun Huang, Xiaoping Li, Fangqin Chou, Shuiqing Zen. Formononetin alleviates thermal injury-induced skin fibroblast apoptosis and promotes cell proliferation and migration. Burns : journal of the International Society for Burn Injuries. vol 51. issue 1. 2024-11-10. PMID:39522140. |
specifically, after thermal injury, cell viability, migration distance, and protein levels of collagen i, collagen iii, α-sma, mmp1, and mmp3 were reduced; cell apoptosis rate and tunel-positive cell numbers were increased; the levels of bax and cleaved caspase-3 were elevated, while bcl-2 level was reduced. |
2024-11-10 |
2024-11-17 |
human |
| Marwa Sharaky, Eman M E Dokla, Amal Kamal Abdel-Azi. Anticancer activity of EMD37 against human head and neck cancer: Impact on apoptotic and inflammatory machineries. Toxicology in vitro : an international journal published in association with BIBRA. vol 102. 2024-11-10. PMID:39510359. |
delving deeper, emd37 triggered intrinsic and extrinsic apoptosis in hnc cells as evidenced by increased levels of caspase-8, caspase-9, caspase-3, caspase-7, caspase-6, tp53bp1 tumor suppressor and bax, and downregulated anti-apoptotic bcl-2 protein. |
2024-11-10 |
2024-11-16 |
human |
| Yang Yu, Tianchan Zhang, Xin Li, Tianyang Yu, Fanci Meng, Yifeng Luan, Huifang Cong, Xiuhong W. Apigenin Improves Ovarian Dysfunction Induced by 4-Vinylcyclohexene Diepoxide via the AKT/FOXO3a Pathway. Cell biochemistry and function. vol 42. issue 8. 2024-11-08. PMID:39511926. |
apigenin alleviated vcd-induced cell apoptosis through regulating bax, bcl-2, cleaved parp1 and caspase-3. |
2024-11-08 |
2024-11-16 |
mouse |
| Qian-Qian Niu, Yu-Ting Xi, Chun-Rui Zhang, Xi-Yue Li, Cheng-Zhi Li, Hui-Dan Wang, Peng Li, Ya-Ling Yi. Potential Mechanism of Perillaldehyde in the Treatment of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking. European journal of pharmacology. 2024-11-07. PMID:39510336. |
immunohistochemical and immunofluorescence analysis showed that low dose (50mg/kg) pa could reduce hepatocyte apoptosis, decrease the content of pro-apoptosis protein bax, and increase the expression of anti-apoptosis protein bcl-2 in nafld mice. |
2024-11-07 |
2024-11-16 |
mouse |
| Fernando Macías, Miriam Ulloa, Carmen Clapp, Gonzalo Martínez de la Escalera, Edith Arnol. Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. PloS one. vol 19. issue 11. 2024-11-05. PMID:39499702. |
our findings indicate that prolactin exerts potent antioxidant and neuroprotective effects by modulating the expression of nox4 and bax, thereby reducing ros generation and neuronal apoptosis. |
2024-11-05 |
2024-11-08 |
mouse |
| Yanping Zhang, Lei Lv, Zhaokai Zhou, He Zhang, Qi Li, Shuai Yang, Yibo Wen, Qingwei Wang, Jinjin Feng, Wei Lu, Wei Jia, Jian Guo We. Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction. Renal failure. vol 46. issue 2. 2024-11-04. PMID:39496543. |
we performed the study with the piezo1 agonist yoda1, bax inhibitor bai1, piezo1 inhibitor gsmtx4 and detected the injury, fibrosis, apoptosis markers and mitochondrial dysfunction. |
2024-11-04 |
2024-11-07 |
Not clear |
| Moqbel Ali Moqbel Redhwan, M G Hariprasad, Suman Samaddar, Duaa Abdullah Bafail, Sumaia Abdulbari Ahmed Ali Hard, Sourav Guh. Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells. International journal of biological macromolecules. 2024-11-03. PMID:39490472. |
parp-1 inhibition reduced hg-induced inflammatory response, including nf-kb, il6, il1β, tnfα, inos, and tgf-β expression, and hg-induced apoptosis response, such as cas-3, cas-9, bak, bax, and aif expression. |
2024-11-03 |
2024-11-06 |
Not clear |
| Lu Wang, Zipei Wang, Yuanyuan Zhao, Bo Yang, Guobin Huang, Junbo Li, Xi Zhou, Hongmei Jiang, Peixiang Lan, Zhishui Che. Gut microbiota-mediated bile acid metabolism aggravates biliary injury after liver transplantation through mitochondrial apoptosis. International immunopharmacology. vol 143. issue Pt 3. 2024-11-01. PMID:39486182. |
interestingly, dca-induced apoptosis rate was significantly reduced in hibec when the fxr or bax gene was knocked down, suggesting that dca-induced apoptosis was dependent on fxr-mitochondrial pathway. |
2024-11-01 |
2024-11-05 |
mouse |
| Xin Yi, Huabin Cao, Jianzhao Liao, Wenlan Yu, Guoliang Hu, Zhaoxin Tang, Fan Yan. Metabolomics analysis reveals the effects of high dietary copper on mitochondria-mediated autophagy and apoptosis in spleen of broiler chicken. Avian pathology : journal of the W.V.P.A. 2024-11-01. PMID:39483061. |
meanwhile, high dose of cu promoted the splenocytes apoptosis by ascend the levels of p53, bak-1, bax, cyt c and caspase-3 and descend the level of bcl-2. |
2024-11-01 |
2024-11-03 |
chicken |
| Shun Wu, Fang Guo, Manxiu Li, Wei Chen, Liting Ji. Overexpression of SLAP2 inhibits triple-negative breast cancer progression by promoting macrophage M1-type polarization. Scientific reports. vol 14. issue 1. 2024-10-30. PMID:39472679. |
by transwell co-culture system, we further demonstrated that overexpression of slap2 inhibits cell proliferation and invasion, promotes apoptosis, up-regulates the expression of bax in cells, and down-regulates the expression of bcl-2 in cells by promoting macrophage m1-type polarization. |
2024-10-30 |
2024-11-02 |
mouse |
| Yifen Guo, Yingao Yang, Zixuan Zhou, Changyuan Zhao, Yanchun Li, Huanying Zhou, Shuyue Ren, Yan Gu, Zhixian Ga. Propylparaben Induces Reproductive Toxicity in Human Extravillous Trophoblast Cells via Apoptosis and Cell Cycle Pathways. Environment & health (Washington, D.C.). vol 2. issue 5. 2024-10-30. PMID:39474327. |
elevated propylparaben levels triggered apoptosis, evidenced by increased bax and activated caspase-3, and induced the g0/g1 cell cycle arrest. |
2024-10-30 |
2024-11-02 |
human |
| Alexander V Sirotkin, Zuzana Fabová, Zuzana Kislíková, Barbora Loncová, Miroslav Bauer, Maria Bauerová, Abdel Halim Harrat. Interplay Between the MicroRNA miR-152 and Quercetin in the Control of Ovarian Granulosa Cell Functions. Reproductive sciences (Thousand Oaks, Calif.). 2024-10-30. PMID:39476287. |
the expression levels of mir-152, cell viability, cell proliferation (accumulation of proliferating cell nuclear antigen, pcna), apoptosis (accumulation of bax) and the release of progesterone, estradiol, and insulin-like growth factor i (igf-i) were analyzed by real-time quantitative polymerase chain reaction (rt‒qpcr), the trypan blue exclusion test, quantitative immunocytochemistry, and enzyme-linked immunosorbent assays (elisas). |
2024-10-30 |
2024-11-02 |
Not clear |