| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thoa Thi Kim Nguyen, Seon Min Woo, Seung Un Seo, Asmita Banstola, Haesoo Kim, Ramesh Duwa, An Thi Thanh Vu, In-Sun Hong, Taeg Kyu Kwon, Simmyung Yoo. Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer. Biomaterials. vol 312. 2024-08-06. PMID:39106819. |
furthermore, trail-odn-plga-nps significantly inhibited xenograft tumor models of trail-resistant caki-1 and trail-sensitive mda-mb-231 cells.the inhibition was associated with apoptosis activation, raptor protein stabilizing bim protein downregulation, bax accumulation, and mitochondrial ros generation elevation. |
2024-08-06 |
2024-08-09 |
Not clear |
| Fenfen Zhan, Ronghui Zhang, Lanlan Qiu, Yuezhong Re. ACAP3 negatively regulated by HDAC2 inhibits the malignant development of papillary thyroid carcinoma cells. The international journal of biochemistry & cell biology. 2024-08-04. PMID:39098591. |
acap3 overexpression (oe-acap3) suppressed viability, proliferation, migration and invasion of ptc cells, facilitated apoptosis, downregulated the expressions of protein kinase b (bcl-2) and n-cadherin, upregulated the expressions of bcl-2 associated protein x (bax) and e-cadherin, diminished the p-akt/akt ratio and elevated the p-p53/p53 ratio; however, acap3 silencing or hdac2 overexpression (oe-hdac2) did the opposite. |
2024-08-04 |
2024-08-07 |
Not clear |
| Jinsen He, Lixin Huang, Linqi L. Idebenone protects the kidneys of rats with renovascular arterial hypertension by inhibiting oxidative stress and apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 7. 2024-08-04. PMID:39097876. |
the apoptosis key proteins (bad, bax, caspase9, gsk-3β) were detected via western blot. |
2024-08-04 |
2024-08-06 |
rat |
| Jinsen He, Lixin Huang, Linqi L. Idebenone protects the kidneys of rats with renovascular arterial hypertension by inhibiting oxidative stress and apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 7. 2024-08-04. PMID:39097876. |
besides, idb suppressed the expression of apoptosis key factors (bad, bax, caspase9, gsk-3β) in kidney of renal hypertensive rats' model. |
2024-08-04 |
2024-08-06 |
rat |
| Jiao Zhao, Jingru Zhang, Xiaojing Tong, Lili Zhao, Rong Ca. TRIM47 inhibits cisplatin chemosensitivity and endoplasmic reticulum stress-induced apoptosis of ovarian cancer cells. Molecular and cellular probes. 2024-08-03. PMID:39096978. |
oc cell viability was assessed with a cell counting kit-8 assay and oc cell apoptosis was assessed using flow cytometry, caspase-3 and caspase-9 activity, and bax and bcl-2 expression assays while gene and protein expression were assessed using qrt-pcr and western blot assays. |
2024-08-03 |
2024-08-06 |
Not clear |
| Haowen Wang, Yulai Wang, Yiwen Chai, Haoran Zhang, Qingqing Chang, Jianhong Li, Runxiang Zhang, Jun Ba. Prolonged exposure to a music-enriched environment mitigates acute noise-induced inflammation and apoptosis in the chicken spleen by modulating the Keap-1/Nrf2 and NF-κB pathways. Poultry science. vol 103. issue 10. 2024-08-02. PMID:39094500. |
noise-induced mitochondrial damage led to apoptosis, as observed by tunel staining, along with increased gene and protein expression of bcl-2, bax, cyt-c, casp-3, casp-8, and casp-9. |
2024-08-02 |
2024-08-06 |
chicken |
| Zhaojun Liu, Jianping Ji. Omaveloxolone Ameliorates Cognitive Deficits by Inhibiting Apoptosis and Neuroinflammation in APP/PS1 Mice. Molecular neurobiology. 2024-08-01. PMID:39088030. |
in vivo validation experiments indicated that omav attenuated neuronal apoptosis by regulating apoptotic proteins, including caspase 3, bax, and bcl-2. |
2024-08-01 |
2024-08-03 |
mouse |
| Zihao Li, Xiaoyang Li, Nicole A Seebacher, Xu Liu, Wence Wu, Shengji Yu, Francis J Hornicek, Changzhi Huang, Zhenfeng Dua. CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma. Carcinogenesis. 2024-07-31. PMID:39082894. |
this was accompanied by the promotion of apoptosis, as evidenced by enhanced bax expression and reduced bcl-xl expression. |
2024-07-31 |
2024-08-02 |
Not clear |
| Siying Wang, Xuyu Chen, Xiaofei Zhang, Kang Wen, Xin Chen, Jingyao Gu, Juan Li, Zhaoxia Wan. Pro-apoptotic gene BAX is a pan-cancer predictive biomarker for prognosis and immunotherapy efficacy. Aging. vol 16. 2024-07-29. PMID:39074253. |
apoptosis regulator bcl2 associated x (bax) is a pro-apoptotic gene. |
2024-07-29 |
2024-08-02 |
Not clear |
| Fangfang Li, Fengyu Zhu, Siyuan Wang, Huiqing Hu, Di Zhang, Zhouying He, Jiaqi Chen, Xuqing Li, Linghui Cheng, Fei Zhon. Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway. Scientific reports. vol 14. issue 1. 2024-07-28. PMID:39068256. |
moreover, ica reduced the expression levels of bax and γh2ax and inhibited ovarian apoptosis. |
2024-07-28 |
2024-08-02 |
mouse |
| Kholoud A Elzanaty, Gamal A Omran, Ehab Kotb Elmahallawy, Ashraf Albrakati, Ayman A Saleh, Naief Dahran, Alaa S Alhegaili, Ahmad Salahuddin, Heba Abd-El-Azim, Ahmed Noreldin, Tarek M Okd. Design and Optimization of Sesamol Nanosuspensions to Potentiate the Anti-Tumor Activity of Epirubicin against Ehrlich Solid Carcinoma-Bearing Mice. Pharmaceutics. vol 16. issue 7. 2024-07-27. PMID:39065634. |
the findings revealed reductions in tumor growth and proliferation using ses either alone or combined and evidenced by decreased akt (akt serine/threonine kinase1) levels, angiogenesis indicated by lower levels of vegfr (vascular endothelial growth factor), and apoptosis demonstrated by elevated caspase3 and bax levels. |
2024-07-27 |
2024-07-29 |
mouse |
| Xuecong Liang, Shugui Zheng, Yang Zhou, Jiguang Li, Zhuo Zhan. Luteolin, a flavonoid natural plant polyphenol, exhibits a protective effect on intestinal injury induced by soybean meal in early-weaned piglets. Journal of animal science. 2024-07-27. PMID:39066584. |
moreover, luteolin significantly decreased the gene expression of bax and caspase-3, reducing cell apoptosis in the intestinal mucosa. |
2024-07-27 |
2024-07-29 |
Not clear |
| Ya-Hui Chen, Jyun-Xue Wu, Shun-Fa Yang, Yun-Chia Wu, Yi-Hsuan Hsia. Molecular Mechanisms Underlying the Anticancer Properties of Pitavastatin against Cervical Cancer Cells. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063157. |
moreover, pitavastatin induced apoptosis via the activation of poly-adp-ribose polymerase (parp), bax and cleaved caspase 3; inactivated the expression of bcl-2; and increased mitochondrial membrane depolarization. |
2024-07-27 |
2024-07-29 |
mouse |
| Chenglin Yang, Hui Fan, You Wu, Zengenni Liang, Yongkang Wang, Aoao Wu, Yuanyuan Li, Zhihang Yuan, Jine Yi, Deming Yin, Jing W. T-2 toxin exposure induces ovarian damage in sows: lncRNA CUFF.253988.1 promotes cell apoptosis by inhibiting the SIRT3/PGC1α pathway. Ecotoxicology and environmental safety. vol 283. 2024-07-27. PMID:39067079. |
moreover, t-2 toxin induced cell apoptosis by upregulating the expression of cyt c, bax, cleaved-caspase-9, and cleaved-caspase-3 proteins. |
2024-07-27 |
2024-08-02 |
Not clear |
| Meixing Guo, Ran Peng, Kelan Jin, Xia Zhang, Huilan Mo, Xiang Li, Fufa Qu, Jianzhou Tang, Shenping Cao, Yonghua Zhou, Zhimin He, Zhuangwen Mao, Junde Fan, Jianzhong Li, Zhen Li. Effects of Aeromonas infection on the immune system, physical barriers and microflora structure in the intestine of juvenile grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. 2024-07-26. PMID:39059563. |
additionally, the expression levels of the intestinal pro-apoptotic genes tnfr1, tnfr2, tradd, caspase-8, caspase-3 and bax were significantly increased, whereas the expression of the inhibitory factor bcl-2 was significantly downregulated, indicating that aeromonas infection significantly induced apoptosis in the intestine of grass carp. |
2024-07-26 |
2024-07-29 |
Not clear |
| Geum-Lan Hong, Kyung-Hyun Kim, Sung-Pil Cho, Hui-Ju Lee, Yae-Ji Kim, Ju-Young Jun. Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission. Chinese journal of natural medicines. vol 22. issue 7. 2024-07-26. PMID:39059829. |
krg inhibited cell proliferation by downregulating cyclin d and proliferating cell nuclear antigen (pcna) levels, and it promoted apoptosis by increasing the ratio of b-cell lymphoma protein 2 (bcl-2)-associated x protein (bax) to bcl-2 expression. |
2024-07-26 |
2024-07-29 |
rat |
| Xiaoxiao Han, Yuan Huang, Junli Ha. Avian Coronavirus Infectious Bronchitis Virus Activates Mitochondria-Mediated Apoptosis Pathway and Affects Viral Replication by Inducing Reactive Oxygen Species Production in Chicken HD11 Cells. Biology. vol 13. issue 7. 2024-07-26. PMID:39056685. |
the two antioxidants significantly affected the expression of bcl-2 and bax and further inhibited the activation of caspase-3 and apoptosis in hd11 cells. |
2024-07-26 |
2024-07-28 |
chicken |
| Soha Osama Hassanin, Amany Mohammed Mohmmed Hegab, Reham Hassan Mekky, Mohamed Adel Said, Mona G Khalil, Alaaeldin Ahmed Hamza, Amr Ami. Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against Breast Cancer. Marine drugs. vol 22. issue 7. 2024-07-26. PMID:39057437. |
it also enhanced intrinsic apoptosis in mcf-7 cells by upregulating cytochrome c, bax, caspase-8, caspase-9, and caspase-7 proteins, while downregulating bcl-2 production. |
2024-07-26 |
2024-07-28 |
human |
| Tobias B Beigl, Alexander Paul, Thomas P Fellmeth, Dang Nguyen, Lynn Barber, Sandra Weller, Benjamin Schäfer, Bernhard F Gillissen, Walter E Aulitzky, Hans-Georg Kopp, Markus Rehm, David W Andrews, Kristyna Pluhackova, Frank Essman. BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains. EMBO reports. 2024-07-24. PMID:39048751. |
we developed a highly-specific split luciferase assay enabling the analysis of tmd interactions of pore-forming apoptosis effectors bax, bak, and bok with anti-apoptotic bcl-2 proteins in living cells. |
2024-07-24 |
2024-07-28 |
Not clear |
| Wenming Xue, Jiaxin Wang, Yao Hou, Di Wu, Hongwei Wang, Qiyue Jia, Qiyue Jiang, Yan Wang, Chenzhao Song, Yifei Wang, Zhonghui Zhu, Lin Tia. Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics. Heliyon. vol 10. issue 13. 2024-07-23. PMID:39040273. |
in the nrf2 knockout spheroids, bax is also significantly downregulated; after intervention with bax inhibitors, a significant downregulation of bax-induced apoptosis was also detected in the nrf2-overexpressed spheroids. |
2024-07-23 |
2024-07-25 |
mouse |