| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheyda Jodeiry Zaer, Mahmoudreza Aghamaali, Souzan Najafi, Seyed Samad Hosseini, Mohammad Amini, Mohammad Amin Doustvandi, Nazila Mozammel, Behzad Baradaran, Amir Ali Mokhtarzade. MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine. Naunyn-Schmiedeberg's archives of pharmacology. 2024-07-15. PMID:39007927. |
the obtained results evidenced that mir-143 transfection could promote the sensitivity of a172 cells to carmustine and enhance carmustine-induced apoptosis via modulating the expression levels of caspase-3, caspase-9, bax, and bcl-2. |
2024-07-15 |
2024-07-18 |
human |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
in addition, in dss mice and tnf-α-induced colonic organoids, gk protected the intestinal barrier and inhibited intestinal epithelial cell apoptosis, by improving permeability and inhibiting the number of apoptotic cells and the expression of key apoptotic regulators (cleaved caspase 3, bax and bcl-2). |
2024-07-14 |
2024-07-16 |
mouse |
| Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping H. Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK Journal of Asian natural products research. 2024-07-13. PMID:39001813. |
additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of bcl-2 and bax. |
2024-07-13 |
2024-07-16 |
Not clear |
| Ping Li, Zhengang Li, Qixiu Sun, Wei Zhang, Xine Huang, Mohan Si, Xinjun Du, Shuo Wan. Protective effect and mechanism of Lycium ruthenicum Murray anthocyanins against retinal damage induced by blue light exposure. Journal of food science. 2024-07-12. PMID:38992868. |
furthermore, lra could ameliorate oxidative stress-induced apoptosis by upregulating bcl-2 and downregulating bax and caspase-3 protein expression. |
2024-07-12 |
2024-07-14 |
Not clear |
| Qian Zhang, Xiuzhi Fei, Yue Li, Hengwei Zhang, Lu Chen, Jianping Ruan, Ning Don. Epigallocatechin-3-gallate Attenuates Fluoride Induced Apoptosis Via PI3K/FoxO1 Pathway in Ameloblast-like Cells. Toxicon : official journal of the International Society on Toxinology. 2024-07-12. PMID:38996976. |
we observed that naf triggered apoptotic alterations in cell morphology, excessive naf arrested cell cycle at the g1, and induced apoptosis by up-regulating bax and down-regulating bcl-2. |
2024-07-12 |
2024-07-15 |
Not clear |
| Fei Zhao, Dan-Yang Chen, Bo Jing, Yu Jiang, Lan-Yue Liu, Hui Son. Effect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells. Scientific reports. vol 14. issue 1. 2024-07-12. PMID:38997305. |
the results of flow cytometry experiments and mitochondrial membrane potential, rt-qpcr, and western blot showed that fvp-s1 and fvp-c were able to decrease the mitochondrial membrane potential, increase the expression level of apoptotic proteins casepase-3 and casepase-9 proteins, and at the same time, increase the ratio of bax and bcl-2, which promoted apoptosis of tumor cells. |
2024-07-12 |
2024-07-15 |
Not clear |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. |
critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Toshiaki Nakajima, Akiko Haruyama, Taira Fukuda, Kentaro Minami, Suguru Hirose, Hiroko Yazawa, Takafumi Nakajima, Takaaki Hasegawa, Yoshiyuki Kitagawa, Syotaro Obi, Shu Inami, Gaku Oguri, Ikuko Shibasaki, Hirohisa Amano, Takuo Arikawa, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Shigeru Toyod. Left atrial reservoir strain is a marker of atrial fibrotic remodeling in patients undergoing cardiovascular surgery: Analysis of gene expression. PloS one. vol 19. issue 7. 2024-07-08. PMID:38976680. |
it also correlated ecm degradation-related genes (mmp2, timp1, and timp2), pro-fibrogenic cytokines (tgfb1 encoding tgfβ1, end1, pdgfd, ctgf), oxidant stress-related genes (nox2, nox4), ace, inflammation-related genes (nlrp, il1b, mcp-1), and apoptosis (bax). |
2024-07-08 |
2024-07-12 |
Not clear |
| Pan Chen, Wen-Li Ding, Bo-Wen Xu, Mujeeb Ur Rehman, Kai-Li Liu, Yan-Feng He, Sen-Yang Li, Fu-Chun Jian, Shu-Cheng Huan. Aflatoxin B1 as a complicit in intestinal damage caused by Eimeria ovinoidalis in lambs: Novel insights to reveal parasite-gut battle. The Science of the total environment. 2024-07-08. PMID:38977103. |
this may be closely linked to the destruction of the intestinal epithelial cell structure and its apoptosis, as indicated by a decreased ratio of bcl-2 to bax and increased caspase-3 levels. |
2024-07-08 |
2024-07-12 |
Not clear |
| Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. |
importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. |
2024-07-08 |
2024-07-11 |
mouse |
| Chenqu Wu, Yanqing Qian, Jun Jiang, Deming Li, Li Fen. Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating Biomolecules & biomedicine. 2024-07-07. PMID:38972051. |
piperine induced s-phase cell cycle arrest and facilitated apoptosis in coad cells, evidenced by changes in bax, bcl-2, cleaved caspase-3, and cleaved poly (adp-ribose) polymerase (parp) levels. |
2024-07-07 |
2024-07-11 |
human |
| Doaa Sedky, Tamer Helmi Abd El-Aziz, Soad Mohamed Nasr, Sekena Hassanien Abdel-Aziem, Noha Mahmoud Fahmy Hassan, Amira Hassan Mohamed, Hala Abdalla Ahmed Abou Zein. Regulatory effect of Balanites aegyptiaca ethanol extract on oxidant/antioxidant status, inflammatory cytokines, and cell apoptosis gene expression in goat abomasum experimentally infected with Haemonchus Contortus. Tropical animal health and production. vol 56. issue 6. 2024-07-04. PMID:38963478. |
the mrna gene expression of cytokines (il-3, il-6, il-10, tnf-α) and cell apoptosis markers (bax, bcl-2) were estimated. |
2024-07-04 |
2024-07-08 |
cat |
| Bo Yu, Kang Wang, Huijie Hao, Yan Liu, Yi Yue, Xiaorong Li, Xiaoli Xing, Xiaomin Zhan. Small extracellular vesicles derived from microRNA-22-3p-overexpressing mesenchymal stem cells protect retinal ganglion cells by regulating MAPK pathway. Communications biology. vol 7. issue 1. 2024-07-03. PMID:38961177. |
mir22-sevs treatment promotes viability, inhibits apoptosis and inhibits bax and caspase-3 expression in rgc-5 cells. |
2024-07-03 |
2024-07-08 |
mouse |
| Gulseren Turhal, Busra Demirkan, Izel Nermin Baslilar, Nimet Sule Yuncu, Sultan Nacak Baytas, Asuman Demiroglu-Zergerogl. Preliminary evaluation of antiproliferative and apoptotic activities of novel indolin-2-one derivatives. Drug development research. vol 85. issue 5. 2024-07-03. PMID:38958104. |
derivatives also initiated mitochondrial apoptosis through the upregulation of bax and downregulation of bcl-2 proteins, leading to the activation of caspase 3 and parp cleavage in exposed cells. |
2024-07-03 |
2024-07-06 |
Not clear |
| Masoumeh Sharifi-Azad, Masumeh Kaveh Zenjanab, Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Marziyeh Fathi, Rana Jahanban Esfahla. Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells. Biomedical materials (Bristol, England). 2024-07-02. PMID:38953496. |
further, nio@ms significantly reduced cell adhesion density, promoted apoptosis and increased gene expression level of caspase 3 and bax while promoted significant downregulation of bcl2. |
2024-07-02 |
2024-07-06 |
Not clear |
| Min Shao, Yujia Qiu, Mengxia Shen, Wei Liu, Dandan Feng, Ziqiang Luo, Yan Zho. Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 13. 2024-07-02. PMID:38953707. |
in addition, we found that pcc1 inhibited extracellular matrix deposition and promoted the apoptosis of senescent myofibroblasts by increasing puma expression and activating the bax signaling pathway. |
2024-07-02 |
2024-07-06 |
mouse |
| Bo Wang, Shan Long, Junjie Lan, Kaixiong Luo, Wangming Zhang, Xiaosong Li, Weidong Pan, Jielin Li. Derived from fangchinoline, LYY-35 exhibits an inhibiting effect on human NSCLC cancer A549 cells. Journal of Cancer. vol 15. issue 13. 2024-07-01. PMID:38947387. |
at the same time, lyy-35 induced increased apoptosis, increased expression of bax, cleaved caspase3, cleaved parp1, and decreased expression of bcl-xl, which blocked the cell cycle to g0/g1 phase. |
2024-07-01 |
2024-07-03 |
human |
| Qiong Xi, Lin Liu, Qin Zhao, Shan Zh. KLF13 Attenuates Lipopolysaccharide-Induced Alveolar Epithelial Cell Damage by Regulating Mitochondrial Quality Control via Binding PGC-1α. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2024-07-01. PMID:38949897. |
moreover, klf13 gain-of-function inhibited lps-induced apoptosis of a549 cells, accompanied by upregulated bcl2 expression and downregulated bax and cleaved caspase3 expression. |
2024-07-01 |
2024-07-04 |
human |
| Zorislava Bajic, Tanja Sobot, Ljiljana Amidzic, Natasa Vojinovic, Sanja Jovicic, Milica Gajic Bojic, Dragan M Djuric, Milos P Stojiljkovic, Sergey Bolevich, Ranko Skrbi. Liraglutide Protects Cardiomyocytes against Isoprenaline-Induced Apoptosis in Experimental Takotsubo Syndrome. Biomedicines. vol 12. issue 6. 2024-06-27. PMID:38927414. |
liraglutide reduced isoprenaline-induced cardiomyocyte apoptosis by decreasing cleaved caspase-3 (cc3), bcl-2-associated x protein (bax), and nf-κb and increasing b-cell lymphoma/leukemia-2 (bcl-2). |
2024-06-27 |
2024-06-29 |
rat |
| Abdulaziz Arif A Alshammari, Awyed Batah Almutairi, Minhajul Arfeen, Abdullah Saleh Alkhamiss, Maha A Aldubayan, Ahmad H Alhowail, Vasudevan Man. Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928574. |
additionally, elisa assays were performed to examine underlying mechanisms, including markers associated with inflammation (nf-κb, pge2, and tnf-α), apoptosis (bcl2, bax, and caspase-3), and oxidative stress (mda, catalase, and gsh). |
2024-06-27 |
2024-06-29 |
rat |