| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Zhong, Yongzhi Hua, Shuting Zou, Bo Wan. Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway. PloS one. vol 19. issue 5. 2024-05-30. PMID:38814975. |
additionally, juglone arrested the cell cycle, induced apoptosis, increased the cleavage of caspase 3 and the protein expression of bax and cyt c, and decreased the protein expression of bcl-2 and caspase-3. |
2024-05-30 |
2024-06-02 |
mouse |
| Jun-Yu He, Jia-Xin Yang, Shi-Ying Qin, Jing-Qi Zheng, Yi-Ran Guo, Tian-Xing M. [Exploration of mechanism of total triterpenoids from fruits of Chaenomeles speciosa against senescent GES-1 cells induced by D-galactose based on Gln/GLS1/α-KG metabolic axis and mitochondrial apoptosis signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 8. 2024-05-30. PMID:38812238. |
cyto c concentration in the cytoplasm, the mrna expressions of bax, bad, apoptosis protease activating factor 1(apaf-1), and protein expressions of cleaved-caspase-9, cleaved-caspase-3, cleaved-parp-1 were increased(p<0.01). |
2024-05-30 |
2024-06-08 |
Not clear |
| Jiangxia Cheng, Zhuo Wang, Hui Yu, Ye Chen, Zhengchao Wang, Liangcheng Zhang, Xiaohong Pen. The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808889. |
we found that neonatal exposure to sevoflurane promoted apoptosis in the hippocampus, and bax and caspase-3 were increased in a dose-dependent manner. |
2024-05-29 |
2024-06-02 |
rat |
| Jia He, Jia Zuo, Xiaochen Fan, Zhe L. Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808885. |
electro-acupuncture modulated mir-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting bax and trpv4 in osteoarthritis rats. |
2024-05-29 |
2024-06-02 |
rat |
| Jia He, Jia Zuo, Xiaochen Fan, Zhe L. Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808885. |
the expression of microrna-214 (mir-214) and its downstream targets involved in apoptosis and nociception, bax and trpv4, were examined. |
2024-05-29 |
2024-06-02 |
rat |
| Jia He, Jia Zuo, Xiaochen Fan, Zhe L. Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808885. |
by suppressing pro-apoptotic bax and pro-nociceptive trpv4, this ea-induced mir-214 upregulation ameliorated articular pain and prevented chondrocyte apoptosis. |
2024-05-29 |
2024-06-02 |
rat |
| Manoj Kumar Srinivasan, Briska Jifrina Premnath, Ramya Parimelazhagan, Nalini Namasivaya. Synthesis, characterization, and evaluation of the anticancer properties of pH-responsive carvacrol-zinc oxide quantum dots on breast cancer cell line (MDA-MB-231). Cell biochemistry and function. vol 42. issue 4. 2024-05-29. PMID:38807490. |
apoptosis markers such as bcl2, bax, caspase-3, and caspase-9, were also studied. |
2024-05-29 |
2024-06-03 |
Not clear |
| b' Mohammad Mijanur Rahman, Huixin Wu, Trygve O Tollefsbo. A novel combinatorial approach using\xa0sulforaphane- and withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and gut microbial mechanisms. Scientific reports. vol 14. issue 1. 2024-05-27. PMID:38802425.' |
at the molecular level, the bsp and ash combination upregulated tumor suppressors (p53, p57) along with apoptosis associated proteins (bax, puma) and bax:bcl-2 ratio. |
2024-05-27 |
2024-05-31 |
mouse |
| Rana M Gamal, Sara H Hazem, Mohamed F Hamed, Rania R Abdelazi. PI3K inhibitor "alpelisib" alleviates methotrexate induced liver injury in mice and potentiates its cytotoxic effect against MDA-MB-231 triple negative breast cancer cell line. Toxicology and applied pharmacology. 2024-05-26. PMID:38797265. |
finally, alp curbed mtx-induced hepatocyte apoptosis (nf-κb and bax) and shifted the cytokine milieu away from inflammation (il-17, il-22, il-6 and il- 10). |
2024-05-26 |
2024-05-31 |
mouse |
| Zhi-Hui Guan, Di Yang, Yi Wang, Jia-Bin Ma, Guo-Nian Wan. EDA2R knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway. Experimental animals. 2024-05-26. PMID:38797667. |
eda2r knockdown also resulted in downregulated expression of bax, and decreased activity of caspase-3 and caspase-9 in cardiomyocytes, reversing the effects of h/r on mitochondria-mediated apoptosis. |
2024-05-26 |
2024-05-31 |
mouse |
| Mingyu Bai, Yang Cui, Zelin Sang, Shuang Gao, Haosen Zhao, Xifan Me. Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway. Free radical biology & medicine. vol 221. 2024-05-25. PMID:38782079. |
single-cell sequencing analysis has identified lgals3 and bax as core genes in apoptosis. |
2024-05-25 |
2024-05-27 |
Not clear |
| Lyudmila Boyanova, José Medeiros, Daniel Yordanov, Raina Gergova, Rumyana Markovsk. Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: A narrative review. Letters in applied microbiology. 2024-05-25. PMID:38794899. |
curcumin also displayed numerous anticancer activities such as apoptosis induction, anti-inflammatory and anti-angiogenic effects, caspase-3 upregulation, bax protein enhancement, p53 gene activation, and chemosensitization. |
2024-05-25 |
2024-05-27 |
Not clear |
| Fariba Nikravesh, Roohollah Mirzaee Khalilabadi, Alireza Farsinejad, Hajar Mardani Valandan. Platelet microparticles influence gene expression and modulate biological activities of chronic myeloid leukemia cells (K562). Molecular biology reports. vol 51. issue 1. 2024-05-25. PMID:38796661. |
this study aimed to investigate the influence of platelet-derived microparticles on cell proliferation, apoptosis, and the expression of key genes, including p53, p21, cyclin d1, bax, and bcl-2, within the context of a chronic myeloid leukemia cell line (k562). |
2024-05-25 |
2024-05-31 |
Not clear |
| Jingjing Zhang, Jiayan Huang, Jinlian Lan, Qing Li, Lingling Ke, Qilong Jiang, Yanwu Li, Han Zhang, Huiya Zhong, Peidan Yang, Tongkai Chen, Yafang Son. Astragaloside IV protects against autoimmune myasthenia gravis in rats via regulation of mitophagy and apoptosis. Molecular medicine reports. vol 30. issue 1. 2024-05-24. PMID:38785143. |
moreover, the mrna and protein expression levels of phosphatase and tensin homolog‑induced putative kinase 1, parkin, lc3ii and bcl‑2, key signaling molecules for mitophagy and apoptosis, were upregulated, whereas the mrna and protein expression levels of p62, cyt‑c, bax, caspase 3 and caspase 9 were downregulated following as‑iv intervention. |
2024-05-24 |
2024-05-27 |
rat |
| Charlotte Palominos, Sebastián Fuentes-Retamal, Juan Pablo Salazar, Daniela Guzmán-Rivera, Pablo Correa, Mathias Mellado, Ramiro Araya-Maturana, Félix A Urr. Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy. Cancer letters. 2024-05-24. PMID:38788967. |
pro-survival bcl-2 proteins prevent the initiation of intrinsic apoptosis (mitochondria-dependent pathway) by inhibiting the pro-apoptotic proteins bax and bak, while bh3-only proteins promote apoptosis by blocking pro-survival bcl-2 proteins. |
2024-05-24 |
2024-05-27 |
Not clear |
| Jung-Yeon Kim, Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Yun-A Ki. Pharmacological inhibition of p300 ameliorates steatosis, inflammation, and fibrosis in mice with non-alcoholic steatohepatitis. Heliyon. vol 10. issue 9. 2024-05-23. PMID:38774067. |
this protective effect was achieved through the inhibition of apoptosis by reducing p53 and bax expression and the suppression of ferroptosis by decreasing lipid peroxidation while enhancing antioxidant defenses. |
2024-05-23 |
2024-05-27 |
mouse |
| Yae Rim Choi, Hyun-Jin Na, Jin-Ah Lee, Yiseul Kim, Young-Suk Kim, Min Jung Ki. Discovery of (-)-epigallocatechin gallate, a novel olfactory receptor 2AT4 agonist that regulates proliferation and apoptosis in leukemia cells. Heliyon. vol 10. issue 10. 2024-05-23. PMID:38778941. |
egcg increased the expression of cleaved caspase 3/8 and had no effect on the expression of bax and bcl-2, indicating that it induced apoptosis through the extrinsic pathway. |
2024-05-23 |
2024-05-27 |
Not clear |
| Sidika Genc, Betul Cicek, Yesim Yeni, Mehmet Kuzucu, Ahmet Hacimuftuoglu, Ismail Bolat, Serkan Yildirim, Himasadat Zaker, Athanasios Zachariou, Nikolaos Sofikitis, Charalampos Mamoulakis, Aristidis Tsatsakis, Ali Taghizadehghalehjough. Morinda citrifolia protective effects on paclitaxel-induced testis parenchyma toxicity: an experimental study. Reproductive toxicology (Elmsford, N.Y.). 2024-05-23. PMID:38782144. |
in addition, noni restored the testicular histopathological structure by reducing caspase-3 expression and significantly (61%) suppressed oxidative dna damage and apoptosis (by regulating the bax (bcl-2-like protein 4)/bcl-2 (b-cell lymphoma gene-2) ratio). |
2024-05-23 |
2024-05-27 |
rat |
| Shokooh Mohtadi, Maryam Salehcheh, Mohammad Reza Tabandeh, Layasadat Khorsandi, Mohammad Javad Khodaya. Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776675. |
moreover, ket treatment reversed the changes in the protein expression of markers related to apoptosis (bax, bcl2, caspase-3, and p53). |
2024-05-22 |
2024-05-27 |
mouse |
| Jaili Li, Ting Luo, Yao Zhao, Dou Wang, Yuanxiang Jin, Zufang Wu, Guiling Yang, Xingjiang Q. Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776683. |
myr effectively suppressed nlrp3 and asc gene expression levels to inhibit pyroptosis while regulating caspase1 and bax levels to reduce cardiac cell apoptosis. |
2024-05-22 |
2024-05-27 |
mouse |