| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuzana Fabová, Barbora Loncová, Abdel Halim Harrath, Alexander V Sirotki. Involvement of circular RNAs in the control of porcine ovarian cell functions: Upregulation by ciR-00596 and downregulation by ciR-00646. Reproductive biology. vol 24. issue 2. 2024-05-19. PMID:38762967. |
the relative expression of both circrnas, cell viability and proliferation (accumulation of pcna, cyclin b1, and xtt-positive cells), cytoplasmic (accumulation of bax and caspase-3) and nuclear (dna fragmentation) apoptosis, and the release of progesterone, testosterone, estradiol, igf-i, and oxytocin were evaluated. |
2024-05-19 |
2024-05-27 |
Not clear |
| Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Olivá. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. vol 933. 2024-05-17. PMID:38750761. |
likewise, cap, at all concentrations, exerted significant modulatory effects on the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3), organogenesis (tbx2a, tbx2b, and irx3b), and ion exchange (slc12a1 and kcnj1) in danio rerio embryos. |
2024-05-17 |
2024-05-27 |
zebrafish |
| Yida Lu, Bo Yang, Aolin Shen, Kexun Yu, Meng Di Ma, Yongxiang Li, Huizhen Wan. LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer. Carcinogenesis. 2024-05-14. PMID:38742453. |
mir-1-3p inhibited cell proliferation and vasculogenic mimicry (vm), and induced cell apoptosis by upregulating bax, bad, and tumor suppressor tp53 expression levels. |
2024-05-14 |
2024-05-27 |
Not clear |
| Marina Blanc, Lama Habbouche, Peng Xiao, Cynthia Lebeaupin, Marion Janona, Nathalie Vaillant, Marie Irondelle, Jérôme Gilleron, Florent Murcy, Déborah Rousseau, Carmelo Luci, Thibault Barouillet, Sandrine Marchetti, Sandra Lacas-Gervais, Laurent Yvan-Charvet, Philippe Gual, Alessandra K Cardozo, Béatrice Bailly-Maitr. Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744890. |
our results uncover a new role for bax inhibitor-one (bi-1), a negative regulator of inositol-requiring enzyme 1 (ire1α) in preserving β-cell health against terminal upr-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production. |
2024-05-14 |
2024-05-27 |
mouse |
| C Zhang, H X Li, Y Man, Z H Jiang, P Yin, K Y. Exploring the role of histone deacetylase inhibitors in cancer development and therapeutic potential. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 2. 2024-05-13. PMID:38736259. |
also, hdacis exhibit a significant capability to diminish the expression of apoptosis protein inhibitors such as bcl-2 and b-cell lymphoma-extra-large (bcl-xl), while concurrently up-regulating pro-apoptotic proteins such as bax, bad, and bim. |
2024-05-13 |
2024-05-27 |
Not clear |
| Jinmei Cheng, Junjie Xu, Yimin Gu, Yueming Wang, Jianyu Wang, Fei Su. Melatonin ameliorates 10-hydroxycamptothecin-induced oxidative stress and apoptosis via autophagy-regulated p62/Keap1/Nrf2 pathway in mouse testicular cells. Journal of pineal research. vol 76. issue 4. 2024-05-13. PMID:38738543. |
changes in apoptosis-associated protein levels (bax, bcl-2, p53, and cleaved caspase-3) and in reactive oxygen species-associated proteins (nrf2 and keap1) and index (malondialdehyde and glutathione) suggested that melatonin treatment relieved hcpt-induced cell apoptosis and oxidative damage, respectively. |
2024-05-13 |
2024-05-27 |
mouse |
| Heba A H Abd Elhameed, Mai S Attia, Amira A A Mohamed, Shaimaa M I Alexeree, Eman I El Behery, Mahmoud Alagawany, Mayada R Farag, Alessandro Di Cerbo, Mahmoud M Azzam, Suzan Attia Mawe. The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats. Biological trace element research. 2024-05-13. PMID:38739260. |
ag nps also upregulated the hepatic and renal genes involved in inflammation such as the interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), nuclear factor kappa b (nf-κβ), apoptosis such as the bcl2 associated x (bax), casp3, and other related to metabolism including asparagine synthetase (asns), suppressor of cytokine signaling 3 (socs3), myc proto-oncogene (myc), and c-c motif chemokine ligand 2 (ccl2). |
2024-05-13 |
2024-05-27 |
human |
| Xinrui Wang, Shengying Ye, Linge Tong, Jingwen Gao, Yixin Zhang, Yan Qi. Inhibition of ROS/caspase-3/GSDME-mediated pyroptosis alleviates high glucose-induced injury in AML-12 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 98. 2024-05-12. PMID:38723977. |
the results showed that high glucose activated apoptosis by regulating the apoptotic protein levels including bax, bcl-2, and enhanced cleavage of caspase-3 and parp. |
2024-05-12 |
2024-05-27 |
Not clear |
| Jiayan Lu, Qixia Guo, Hui Zhao, Hua Li. Hederagenin promotes lung cancer cell death by activating CHAC1-dependent ferroptosis pathway. Biochemical and biophysical research communications. vol 718. 2024-05-12. PMID:38735142. |
in this study, we used hed to treat lung cancer cells, and observed the effect of hed on cell proliferation (including cck-8 and colony formation experiments), apoptosis (including flow cytometry and apoptosis gene detection (bax and bcl-2)). |
2024-05-12 |
2024-05-27 |
Not clear |
| Shimaa A Abass, Abdullah A Elgazar, Sanad S El-Kholy, Amal I El-Refaiy, Reem A Nawaya, Mashooq Ahmad Bhat, Foad A Farrag, Abdelrahman Hamdi, Marwa Balaha, Mohammed A El-Mag. Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations. Molecules (Basel, Switzerland). vol 29. issue 9. 2024-05-11. PMID:38731418. |
papaverine also reduced apoptosis markers such as bcl2 and bcl-2-associated x protein (bax) and kidney injury molecule-1 (kim-1), and histological damage. |
2024-05-11 |
2024-05-27 |
rat |
| Hongzhen Lv, Miao Miao, Zhichao Wu, Cheng Huang, Xiaozhu Tang, Rugen Ya. Hyaluronic acid-coated liposomes for enhanced Journal of liposome research. 2024-05-11. PMID:38733152. |
mechanistically, elevation of bax and caspase-3 as well as downregulation of bcl-2 led to cell apoptosis. |
2024-05-11 |
2024-05-27 |
mouse |
| Hongzhen Lv, Miao Miao, Zhichao Wu, Cheng Huang, Xiaozhu Tang, Rugen Ya. Hyaluronic acid-coated liposomes for enhanced Journal of liposome research. 2024-05-11. PMID:38733152. |
immunohistochemistry analysis revealed the enhanced elevation of bax and caspase-3, and reduced expression of bcl-2 contribute to apoptosis in tumors. |
2024-05-11 |
2024-05-27 |
mouse |
| Ying-Xiu Hu, Ding-Ding Zhang, Chao Chen, Ang Li, Ding-Ping Ba. Mechanism of fibroblast growth factor 1 regulating fatty liver disorder in mule ducks. Poultry science. vol 103. issue 7. 2024-05-11. PMID:38733755. |
hepatocytes were induced by adding 1,500:750 µmol/l oleic and palmitic acid concentrations for 36 h, which were stimulated with fgf1 concentrations of 0, 10, 100, and 1000 ng/ml for 12 h. the results showed that fgf1 significantly reduced the hepatic lipid droplet deposition and triglyceride content induced by complex fatty acids; it also reduced oxidative stress; decreased reactive oxygen species fluorescence intensity and malondialdehyde content; upregulated the expression of antioxidant factors nuclear factor erythroid 2 related factor 2 (nrf2), ho-1, and nqo-1; significantly enhanced liver cell activity; promoted cell cycle progression; inhibited cell apoptosis; upregulated cyclin-dependent kinase 1 (cdk1) and bcl-2 mrna expression; and downregulated bax and caspase-3 expression. |
2024-05-11 |
2024-05-27 |
Not clear |
| Giovanni Luca Beretta, Desirè Alampi, Cristina Corno, Nives Carenini, Elisabetta Corna, Paola Pereg. KiSS-1 Modulation by Epigenetic Agents Improves the Cisplatin Sensitivity of Lung Cancer Cells. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732265. |
a modulation of proteins involved in apoptosis (p53, bax) was found in both sensitive and resistant cells, and compared to the treatment with epigenetic agents alone, the combination of cisplatin and saha or aza increased apoptosis induction. |
2024-05-11 |
2024-05-27 |
mouse |
| Yunfeng Liu, Zongyi Sun, Xiaoling Zhou, Haibin Wang, Miaomiao Yu, Dejun L. Protective Effects of Polysaccharide of Atractylodes Macrocephala Koidz against Porcine Aortic Valve Endothelial Cells Damage Induced by di (2-ethylhexyl) Phthalate. Cell biochemistry and biophysics. 2024-05-09. PMID:38722472. |
pamk up-regulated bcl-2 expression and down-regulated bax protein, suppressing apoptosis. |
2024-05-09 |
2024-05-27 |
Not clear |
| Decheng Wang, Pin Yu, Ruiping She, Kezhou Wan. Protective effects of rabbit sacculus-derived antimicrobial peptides on SPF chicken against infection with very virulent infectious bursal disease virus. Poultry science. vol 103. issue 7. 2024-05-07. PMID:38713990. |
moreover, rsrp treatment significantly decreased the expression of bax (p < 0.01) as well as remarkably promoted the expression of bcl-2 (p < 0.01), concomitantly alleviated the excessive apoptosis in the immune organs such as the bursa of fabricius during vvibdv infection. |
2024-05-07 |
2024-05-27 |
rabbit |
| Salwa S Younis, Amina M Salama, Dalia A Elmehy, Nehal A Heabah, Hanem M Rabah, Sara H Elakshar, Radwa A Awad, Ghada A Game. Trichinella spiralis Larval Extract as a Biological Anti-Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma. Parasite immunology. vol 46. issue 5. 2024-05-07. PMID:38712475. |
additionally, bcl2 and bcl2-associated protein x (bax) relative gene expression was assessed by molecular analysis for studying the effect of t. spiralis crude larval extract (cle) antigen on tumor necrosis, apoptosis, cell proliferation and angiogenesis. |
2024-05-07 |
2024-05-27 |
Not clear |
| Salwa S Younis, Amina M Salama, Dalia A Elmehy, Nehal A Heabah, Hanem M Rabah, Sara H Elakshar, Radwa A Awad, Ghada A Game. Trichinella spiralis Larval Extract as a Biological Anti-Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma. Parasite immunology. vol 46. issue 5. 2024-05-07. PMID:38712475. |
moreover, they led to increased apoptosis through activation of caspase-3, up-regulation of pro-apoptotic gene, bax and down-regulation of anti-apoptotic gene, bcl2. |
2024-05-07 |
2024-05-27 |
Not clear |
| Xiayang Liu, Zhuang Li, Qiwei Zhao, Xinyue Zhou, Yu Wang, Gang Zhao, Xiaohong Gu. Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis. Cell biology international. 2024-05-06. PMID:38706122. |
moreover, this combined treatment induced cell apoptosis and significantly upregulated the levels of proapoptotic proteins, such as bax, cleaved caspase-3, -7, and -9, and apoptosis-inducing factor. |
2024-05-06 |
2024-05-08 |
Not clear |
| YuXin Feng, ZhengXinYu Liu, CaoYuan Han, JiaQian Chen, XinHao Lin, WangHao Du, Yu Zhang, BeiBei Dong, YiKai Zheng, KeXiang Lu, QingJian Lian. Ficus hirta Vahl. alleviate LPS induced apoptosis via down-regulating of MiR-411 in orange-spotted grouper (Epinephelus coioides) spleen cell. Developmental and comparative immunology. 2024-05-05. PMID:38705263. |
inhibition of mir-411 further decreased the inhibitory effect of fas on apoptosis, which reduced bcl-2 expression and mitochondrial membrane potential, enhanced the protein expression of bax and fas. |
2024-05-05 |
2024-05-08 |
Not clear |