| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Wu, Zhibin Zhang, Qingxia Xu, Fang Liu, Yu Zhan, Qiuxiao Wang, Lijuan Du, Xuegui Tan. Integration of network pharmacology and experimental verifications reveals the Bian-Se-Tong mixture can alleviate constipation in STC rats by reducing apoptosis of Cajal cells via activating PI3K-Akt signaling pathway. Heliyon. vol 10. issue 7. 2024-04-08. PMID:38586320. |
in-depth mechanistic studies have shown that bstm can significantly reduce the apoptosis of intestinal cajal cells, downregulate the expression of bax and c-caspase 3, upregulate the expression of bcl-2 and c-kit, and promote the phosphorylation of akt. |
2024-04-08 |
2024-04-10 |
rat |
| Seyedeh Zahra Bahojb Mahdavi, Nasser Pouladi, Mohammad Amini, Behzad Baradaran, Souzan Najafi, Shiva Vaghef Mehrabani, Amirhossein Yari, Sania Ghobadi Alamdari, Amir Ali Mokhtarzade. Let-7a-3p overexpression increases chemosensitivity to carmustine and synergistically promotes autophagy and suppresses cell survival in U87MG glioblastoma cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-04-08. PMID:38587542. |
combination treatment of let-7a-3p and carmustine synergistically increased arrested cells and induced apoptosis through regulating involved genes including p53, caspase-3, bcl-2, and bax. |
2024-04-08 |
2024-04-10 |
human |
| Heba A S El-Nashar, Mahmood A Al-Azzawi, Hassan Hadi Al-Kazzaz, Yasemin Khudiar Alghanimi, Shaden Mohamed Kocaebli, Moaz Alhmammi, Ahmed Asad, Tarek Salam, Mohamed El-Shazly, Mohamed A M Al. HPLC-ESI/MS-MS metabolic profiling of white pitaya fruit and cytotoxic potential against cervical cancer: Comparative studies, synergistic effects, and molecular mechanistic approaches. Journal of pharmaceutical and biomedical analysis. vol 244. 2024-04-06. PMID:38581932. |
besides, rt-pcr and western blotting analysis showed downregulation of bcl-2 and overexpression of p53, bax among hela cells treated with pitaya extracts, which eventually activated apoptosis process. |
2024-04-06 |
2024-04-10 |
Not clear |
| Mohammed Salama, Abeer Ali, Fawziya A R Ibrahim, Seham Elab. Citalopram, an antipsychotic agent, induces G1/G0 phase cell cycle arrest and promotes apoptosis in human laryngeal carcinoma HEP-2 cells. Medical oncology (Northwood, London, England). vol 41. issue 5. 2024-04-04. PMID:38573558. |
furthermore, citalopram treatment-induced hep-2 cell apoptosis; this was indicated by the significant increase of cytochrome c, cleaved caspases 3 and 9, and bax protein expression. |
2024-04-04 |
2024-04-06 |
human |
| Qiuyang Su, Chunhe Su, Yan Zhang, Yan Guo, Yang Liu, Yuanyuan Liu, V Wee Yong, Mengzhou Xu. Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice. International immunopharmacology. vol 132. 2024-04-02. PMID:38565042. |
furthermore, adjudin reduced brain cell apoptosis, as evidenced by increased expression of anti-apoptotic protein bcl-2, and decreased expression of apoptosis related proteins bax, cleaved caspase-3 and fewer tunel positive cells. |
2024-04-02 |
2024-04-05 |
mouse |
| Qiwen Yu, Jiye Li, Mengwei Cui, Chaopeng Mei, Qianqian He, Xiaoxiao D. 6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway. Scientific reports. vol 14. issue 1. 2024-04-02. PMID:38565569. |
the results show that 6-gingerol decreased serum alanine aminotransferase (alt), aspartate aminotransferase (ast) levels, liver necrosis, inflammatory cytokines il-1β, il-6, mcp-1, tnf-α expression, ly6g+ inflammatory cell infiltration, protein phosphorylation of nf-κb signaling pathway, terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) positive cells, cell apoptosis rate, the protein expression of pro-apoptotic protein bax and c-caspase3, increased cell viability, and expression of anti-apoptotic protein bcl-2. |
2024-04-02 |
2024-04-05 |
mouse |
| Eman Mansour, Ahmed A Abd-Rabou, Mohamed A El-Atawy, Hoda A Ahmed, Ahmed F El-Farargy, Heba K Abd El-Mawgou. Induction of breast cancer cell apoptosis by novel thiouracil-fused heterocyclic compounds through boosting of Bax/Bcl-2 ratio and DFT study. Bioorganic chemistry. vol 146. 2024-03-31. PMID:38555798. |
the results were confirmed in terms of the intrinsic mechanism of apoptosis, where compound 17 had the highest percentage in the case of both cancer cells and recorded bax (bcl-2 associated x)/bcl-2 (b-cell lymphoma 2) ratio 17.5 and 96.667 for mcf-7 and mda-mb-231 cells, while compound 19 came after 17 in the ability for induction of apoptosis, where the bax/bcl-2 ratio was 15.789 and 44.273 for both cancerous cells, respectively. |
2024-03-31 |
2024-04-03 |
Not clear |
| Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Li. Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2024-03-29. PMID:38551210. |
furthermore, it increased the expression of bcl-2 while reducing the expression of bax, thus inhibiting apoptosis. |
2024-03-29 |
2024-03-31 |
rat |
| Jia-Yuan Zhang, Szu-Kai Fu, Hsia-Ling Tai, Kuo-Wei Tseng, Chia-Yu Tang, Chia-Hsien Yu, Chang-Chi La. A Comparative Study: Cardioprotective Effects of High-Intensity Interval Training Versus Ischaemic Preconditioning in Rat Myocardial Ischaemia-Reperfusion. Life (Basel, Switzerland). vol 14. issue 3. 2024-03-28. PMID:38541636. |
furthermore, the expression of pro-apoptotic proteins pten, caspase-3, tnf-α, and bax in the myocardium was reduced, and the expression of anti-apoptotic b-cell lymphoma 2 (bcl-2) was increased, ultimately reducing cellular apoptosis in the myocardium. |
2024-03-28 |
2024-03-30 |
rat |
| Lin Zhang, Cai Zhang, Xiyi Peng, Zhaojuan Guo, Song Yang, Dongjun F. Evaluation on the Potential for Hepatotoxic Components from Herba Epimedii to Induce Apoptosis in HepG2 Cells and the Analysis of the Influence of Metabolism in Liver Microsomes. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542990. |
herein, the effects of sagittatoside a, icariside i, baohuoside i and icaritin on the apoptosis of hepg2 cells and the expression of key proteins, including bax, bcl-2, caspase-3 and caspase-9, were evaluated. |
2024-03-28 |
2024-03-30 |
Not clear |
| Qianping Mao, Chongyu Shao, Huifen Zhou, Li Yu, Yida Bao, Yali Zhao, Jiehong Yang, Haitong Wa. Exploring the Mechanism of Salvianolic Acid B against Myocardial Ischemia-Reperfusion Injury Based on Network Pharmacology. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543095. |
experimental results demonstrated that sal-b treatment not only mitigated myocardial infarction size following mi/ri injury in mice but also modulated the expression of key apoptotic regulators, including bcl-2-associated x (bax), caspase-3, jnk, and p38, alongside enhancing the b-cell lymphoma-2 (bcl-2) expression, thereby inhibiting myocardial tissue apoptosis. |
2024-03-28 |
2024-03-30 |
mouse |
| Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrashee. Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543160. |
western blotting and immunohistochemical studies revealed increased levels of ilk, p-pi3k, p-akt, and bcl2, as well as those of caspase 3, bax, and p-pten, indicating mitigation of cardiomyocyte apoptosis. |
2024-03-28 |
2024-03-30 |
rat |
| Jiamei Zhu, Xueyan Dai, Yan Wang, Ting Cui, Bingyan Huang, Dianyun Wang, Wenjing Pu, Caiying Zhan. Molybdenum and cadmium co-induce apoptosis and ferroptosis through inhibiting Nrf2 signaling pathway in duck (Anas platyrhyncha) testes. Poultry science. vol 103. issue 5. 2024-03-27. PMID:38537407. |
besides, mo or cd or both repressed nuclear factor erythroid 2-related factor 2 (nrf2) pathway via decreasing nrf2, heme oxygenase-1 (ho-1), nad(p)h quinone oxidoreductase 1 (nqo1), glutamate-cysteine ligase catalytic subunit (gclc) and glutamate-cysteine ligase modifier subunit (gclm) mrna expression of and nrf2 protein expression, then stimulated apoptosis by elevating bcl-2 antagonist/killer-1 (bak-1), bcl-2-associated x-protein (bax), cytochrome complex (cyt-c), caspase-3 mrna expression, cleaved-caspase-3 protein expression and apoptosis rate, as well as reducing b-cell lymphoma-2 (bcl-2) mrna expression and ratio of bcl-2 to bax, and triggered ferroptosis by upregulating acyl-coa synthetase long chain family member 4 (acsl4), transferrin receptor (tfr1) and prostaglandin-endoperoxide synthase 2 (ptgs2) expression levels, and downregulating ferritin heavy chain 1 (fth1), ferritin light chain 1 (ftl1), ferroportin 1 (fpn1), solute carrier family 7 member 11 (scl7a11) and glutathione peroxidase 4 (gpx4) expression levels. |
2024-03-27 |
2024-03-30 |
Not clear |
| Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong L. n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. Toxicological research. vol 40. issue 2. 2024-03-25. PMID:38525131. |
the mrna expressions of apoptosis, oxidative stress and inflammatory mediators, including b-cell lymphoma-2 (bcl2), bcl-2-associated x protein (bax), superoxide dismutase (sod), catalase (cat), interleukin 10 (il-10), tumor necrosis factor-α (tnf-α), caspase-3 and caspase-8 were analyzed in kidney tissues using real time pcr method. |
2024-03-25 |
2024-03-27 |
rat |
| Zheng Zhang, Yu Jing, Ang Zhang, JiShan Liu, Heming Yang, Xiaotong Lou, Liyan Xu, Min Liu, Yikun Zhang, Jianwen G. Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice. NPJ microgravity. vol 10. issue 1. 2024-03-24. PMID:38521778. |
the silencing of lncrna nonmmut004552.2 also decreased the osteoblast apoptosis and expression of bax and cleaved caspase-3, increased bcl-2 protein expression in mc3t3-e1 cells. |
2024-03-24 |
2024-03-26 |
mouse |
| Yu Jiang, Sunjie Xu, Miaomiao Guo, Zhi Lu, Xing Wei, Faliang An, Xiujuan Xi. DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level. Toxicology in vitro : an international journal published in association with BIBRA. 2024-03-23. PMID:38521250. |
the levels of pro-apoptosis protein bax and active caspase-3, cleaved parp and cell cycle related proteins, such as p21 and p27 increased, but apoptosis regulators, like bcl-2, cdc 2, cyclin b1, and lc3 ii decreased dramatically. |
2024-03-23 |
2024-03-26 |
Not clear |
| Xin Gao, Jiaqi Fu, DongHua Yu, Fang Lu, Shumin Li. Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38509878. |
western blot results showed that bct significantly regulated the protein expression levels of bax, caspase-3, lc3b, p53 and mtor and upregulated autophagy to alleviate apoptosis. |
2024-03-21 |
2024-03-23 |
mouse |
| Sarah V Schweighofer, Daniel C Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates, Stefan Jakob. Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria. Cell death and differentiation. 2024-03-20. PMID:38503846. |
one hallmark of apoptosis is the oligomerization of bax and bak to form a pore in the mitochondrial outer membrane, which mediates the release of pro-apoptotic intermembrane space proteins into the cytosol. |
2024-03-20 |
2024-03-23 |
human |
| Badrah Alghamdi, Emad H M Hassanein, Saif A Alharthy, Reem M Farsi, Steve Harake. Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats. Drug and chemical toxicology. 2024-03-20. PMID:38508707. |
additionally, vnp attenuated apoptosis by reducing hippocampal bax levels while increasing bcl2 levels in mtx-intoxicated rats. |
2024-03-20 |
2024-03-23 |
rat |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
also, lwa administration remarkably inhibited tumor cell proliferation by downregulating the expression of ki-67 and cyclin d1 and induced apoptosis by regulating the expression of bax, bcl2, and bcl xl levels. |
2024-03-20 |
2024-03-23 |
Not clear |