| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samyah T Alanazi, Samir A Salama, Ahmed Magdy El-Ebiary, Abdulelah K Altowairqi, Atheer T Alharthi, Shahad M Alzahrani, Shomokh H Althagafi, Reema A Alotaibi, Ahmed Abd-Eltawab Tamma. Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats. Toxicology. 2024-03-03. PMID:38432408. |
in addition, chrysin significantly ameliorated the iol-induced apoptosis as indicated by reduction in caspase-3 activity and modulation of bax and bcl2 protein abundance. |
2024-03-03 |
2024-03-06 |
rat |
| Qingzhi Wan, Lisha Tang, Kaili Jin, Xuanyi Chen, Yinghuan Li, Xiaofeng X. Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430013. |
quercetin and tanshinone therapy suppressed kgn cell death and oxidation while also regulating the expression of critical apoptosis and oxidation-related markers such as b-cell lymphoma-2 (bcl-2) and bcl-2-associated x protein (bax). |
2024-03-02 |
2024-03-04 |
Not clear |
| Ruihong Lan, Yihong Yu, Jie Song, Mengdi Xue, Humin Gon. SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt/β‑catenin pathway. Molecular medicine reports. vol 29. issue 4. 2024-03-01. PMID:38426532. |
additionally, we evaluated the impact of sfrp2 overexpression on key proteins in the wnt/β‑catenin pathway and apoptosis markers (bax, cleaved‑caspase 3, bcl‑2, mmp9, e‑cadherin, wnt3a, axin2, cyclind1, c‑myc, p‑β‑catenin, β‑catenin, phosphorylated glycogen synthase kinase 3 beta (p‑gsk3β), and gsk3β) through western blotting. |
2024-03-01 |
2024-03-03 |
Not clear |
| Xin Fang, Yaoxuan Ji, Shuang Li, Lei Wang, Bo He, Bo Li, Boshen Liang, Hongke Yin, Haotian Chen, Duojie Dingda, Bing Wu, Fabao Ga. Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments. Journal of natural medicines. 2024-03-01. PMID:38427210. |
it also attenuated apoptosis, inflammation, and fibrosis by modulating bcl-2, bax, nlrp3, and oxidative stress markers. |
2024-03-01 |
2024-03-03 |
rat |
| Chihao Lin, Hongyi Jiang, Chao Lou, Weidan Wang, Tingwen Cai, Zhongnan Lin, Liting Jiang, Shida Lin, Xinghe Xue, Xiaoyun Pa. Asiatic acid prevents glucocorticoid-induced femoral head osteonecrosis via PI3K/AKT pathway. International immunopharmacology. vol 130. 2024-02-29. PMID:38422771. |
aa has demonstrated the inhibition of dex-induced osteoblast apoptosis by modulating apoptotic factors like bax, bcl-2, cleaved-caspase3, and cleaved-caspase9. |
2024-02-29 |
2024-03-03 |
rat |
| Ismail Koyuncu, Ebru Temiz, Eray Metin Güler, Mustafa Durgun, Ozgür Yuksekdag, Simone Giovannuzzi, Claudiu T Supura. Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors. ChemMedChem. 2024-02-27. PMID:38323458. |
the expression of pro-apoptotic regulatory proteins (bad, bax, bid, bim, cyt-c, fas, fasl, tnf-a, tnf-r1, htra, smac, casp-3, -8, p21, p27, and p53) was increased, while the expression of anti-apoptotic proteins, apoptosis inhibitor proteins (iaps), and heat shock proteins (hsps) (bcl-2, bcl-w, ciap-2, hsp27, hsp60, hsp70, survivin, livin, and xiap) was decreased. |
2024-02-27 |
2024-03-01 |
Not clear |
| Feibo Xu, Yu He, Aili Xu, Lihua Ren, Jinyu Xu, Yali Shao, Minxin Wang, Wei Zhao, Ying Zhang, Peng Lu, Lianshuang Zhan. Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice. Environmental pollution (Barking, Essex : 1987). 2024-02-26. PMID:38408505. |
it was also found that tphp could remarkably increase the expression levels of bax, cleaved caspase-9, cleaved caspase-3, and decreased bcl-2, thereby causing apoptosis in h9c2 cells. |
2024-02-26 |
2024-03-02 |
mouse |
| Rui-Jie Chen, Qian-Yu Bi, Jie-Min Shi, Jing Zhong, Jin-Tao Han, Xu-Ming J. [Mechanism of n-butanol fraction of Wenxia Formula combining with gefitinib in treating non-small cell lung cancer based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 2. 2024-02-25. PMID:38403323. |
the cell experiments demonstrated that nwxf combined with gef synergistically inhibited the proliferation, promoted the apoptosis, decreased p-egfr/egfr and p-jnk/jnk values, down-regulated the mrna levels of egfr and jnk, and up-regulated the mrna and protein levels of bax in a549 and pc-9 cells. |
2024-02-25 |
2024-02-28 |
human |
| Mei Li, Meng Wang, Yao Xi, Shantong Qiu, Qiaoying Zeng, Yangyang Pa. Isolation and Identification of a Tibetan Pig Porcine Epidemic Diarrhoea Virus Strain and Its Biological Effects on IPEC-J2 Cells. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396878. |
we then detected the expression of the p53, p38, jnk, bax, and bcl-2 genes in the apoptosis signal pathway. |
2024-02-24 |
2024-02-26 |
Not clear |
| Jie Cui, Mengran Zhu, Xiaoran Sun, Jie Yang, Mengyao Gu. Microplastics induced endoplasmic reticulum stress to format an inflammation and cell death in hepatocytes of carp (Cyprinus carpio). Aquatic toxicology (Amsterdam, Netherlands). vol 269. 2024-02-23. PMID:38395010. |
the enhanced expression of the caspase 12, caspase 3, and bax genes suggested that ps-mps led to the apoptosis of carp hepatocytes. |
2024-02-23 |
2024-02-26 |
Not clear |
| Wei Tan, Yanling Li, Lu Ma, Xinying Fu, Qingyin Long, Fanchen Yan, Wanyu Li, Xiaodan Liu, Huang Ding, Yang Wang, Wei Zhan. Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Scientific reports. vol 14. issue 1. 2024-02-23. PMID:38396011. |
notably, epc-exo can adhere to the injured vascular area, promoting enhanced endothelial function and inhibiting vascular endothelial hyperplasia moreover, they regulate the expression of proteins and genes associated with apoptosis, including b-cell lymphoma-2 (bcl2), bcl2-associated x (bax), and caspase-3. |
2024-02-23 |
2024-02-26 |
rat |
| Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsaye. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. vol 87. 2024-02-22. PMID:38387425. |
mrna expression of tnfα and il6; inflammatory markers, bcl-2, bax and caspase 3; apoptosis markers, were detected in midbrains. |
2024-02-22 |
2024-02-25 |
rat |
| Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Gu. Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis. Journal of molecular and cellular cardiology. 2024-02-22. PMID:38387723. |
pmaip1 potentially mediates havsmcs apoptosis by regulating bax and bcl2 expression. |
2024-02-22 |
2024-02-25 |
mouse |
| Ruiming Xu, Dawei Wang, Zhengyi Shao, Xiangbo Li, Qiumei Ca. Neoastilbin ameliorates sepsis-induced liver and kidney injury by blocking the TLR4/NF-κB pathway. Histology and histopathology. 2024-02-19. PMID:38372079. |
tunel assay and the expression of bcl-2 and bax showed that nas dramatically reduced apoptosis in liver and renal tissues. |
2024-02-19 |
2024-02-21 |
mouse |
| Tinglong Hou, Jinyu Yu, Chuntao Li, Zibin Wang, Huiru Li. Immunotoxicity of microplastics and polychlorinated biphenyls alone or in combination to Crassostrea gigas. Marine pollution bulletin. vol 200. 2024-02-16. PMID:38364644. |
the expression of three immune-related genes (nf-κb, tnf-α, tlr-6) was drastically suppressed by the pcbs and mps treatment, while the apoptosis pathway-related genes (bax and caspase-3) showed a significant increase. |
2024-02-16 |
2024-02-19 |
Not clear |
| Ge Jiang, Xingzhi Zhou, Ye Hu, Xiaoyu Tan, Dan Wang, Lina Yang, Qinggao Zhang, Shuangping Li. The antipsychotic drug pimozide promotes apoptosis through the RAF/ERK pathway and enhances autophagy in breast cancer cells. Cancer biology & therapy. vol 25. issue 1. 2024-02-15. PMID:38356266. |
pimozide down-regulated the phosphorylation of raf1, erk 1/2, bcl-2, and bcl-xl, up-regulated bax, and cleaved caspase-9 to induce apoptosis. |
2024-02-15 |
2024-02-17 |
human |
| Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hs. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis. Environmental toxicology. 2024-02-14. PMID:38351887. |
nlwe and nlpe attenuated scopolamine-induced apoptosis by reducing bax and increased bcl-2 expression. |
2024-02-14 |
2024-02-16 |
mouse |
| Fahime Edalat, Niloofar Khakpour, Hossein Heli, Arash Letafati, Amin Ramezani, Seyed Younes Hosseini, Afagh Moattar. Immunological mechanisms of the nucleocapsid protein in COVID-19. Scientific reports. vol 14. issue 1. 2024-02-14. PMID:38355695. |
the n protein exhibited an anti-apoptotic effect by modulating critical genes associated with apoptosis, including bak, bax, and bcl-2. |
2024-02-14 |
2024-02-17 |
Not clear |
| Behnam Najafiyan, Zahra Bokaii Hosseini, Samar Esmaelian, Faezeh Firuzpour, Shiva Rahimipour Anaraki, Leila Kalantari, Ali Hheidari, Hassan Mesgari, Mohsen Nabi-Afjad. Unveiling the potential effects of resveratrol in lung cancer treatment: Mechanisms and nanoparticle-based drug delivery strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-13. PMID:38295754. |
rv has varied effects on cancer cells, including promoting apoptosis by increasing pro-apoptotic proteins (bax and bak) and decreasing anti-apoptotic proteins (bcl-2). |
2024-02-13 |
2024-02-15 |
Not clear |
| Esther García-Díez, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. (-)-Epicatechin and colonic metabolite 2,3-dihydroxybenzoic acid, alone or in combination with metformin, protect cardiomyocytes from high glucose/high palmitic acid-induced damage by regulating redox status, apoptosis and autophagy. Food & function. 2024-02-13. PMID:38347828. |
additionally, all treatments mitigated hg + pa-induced apoptosis and activated autophagy by decreasing bax (∼15-25%), caspase-3 (∼20-40%) and p62 (∼20-40%), and increasing bcl-2, beclin-1 and lc3-ii/lc3-i (∼40-60%, ∼15-20%, and ∼25-30%, respectively). |
2024-02-13 |
2024-02-15 |
Not clear |