| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinping Guo, Ziang Qian, Su Jiang, Xiaobin Qian, Xianhui Ning, Shaowu Yin, Kai Zhan. Assessing the ecotoxicity of florfenicol exposure at environmental levels: A case study of histology, apoptosis and microbiota in hepatopancreas of Eriocheir sinensis. Ecotoxicology and environmental safety. vol 272. 2024-02-13. PMID:38350219. |
combined with the increased expression of apoptosis-related genes (caspase 3, caspase 8, p53, bax and bcl-2) at mrna and protein levels, activation of catalase (cat) and superoxide dismutase (sod), and malondialdehyde (mda) accumulation, ff exposure also induced oxidative stress, and apoptosis in hepatopancreas. |
2024-02-13 |
2024-02-16 |
human |
| Maha Abdelmonem, Shimaa O Ali, Asmaa K Al-Mokaddem, Heba R Ghaia. Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine. BioFactors (Oxford, England). 2024-02-12. PMID:38344831. |
apoptosis was evaluated by immunohistochemical determination of b-cell lymphoma protein 2 (bcl-2), bcl-2 associated x-protein (bax), and caspase-3. |
2024-02-12 |
2024-02-15 |
rat |
| Maha Abdelmonem, Shimaa O Ali, Asmaa K Al-Mokaddem, Heba R Ghaia. Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine. BioFactors (Oxford, England). 2024-02-12. PMID:38344831. |
moreover, sulbutiamine treatment suppressed apoptosis triggered by stz as evidenced by elevated bcl-2, decreased bax and reduced caspase-3. |
2024-02-12 |
2024-02-15 |
rat |
| Shaikh Samia, Padakanti Sandeep Chary, Omar Khan, Neelesh Kumar Mehr. Recent trends and advances in novel formulations as an armament in Bcl-2/Bax targeted breast cancer. International journal of pharmaceutics. 2024-02-12. PMID:38346605. |
the b-cell lymphoma 2 (bcl-2) family proteins, bcl-2 and bax, play a crucial role in regulating apoptosis and thus are promising targets for bc therapy. |
2024-02-12 |
2024-02-15 |
Not clear |
| Yazhong Ma, Xiaotong Wang, Xin Li, Xi Chen, Zhifeng Teng, Xuekun Wang, Jie Yang, Guoyun Li. COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. Molecular neurobiology. 2024-02-12. PMID:38347285. |
we found that cop-22 could effectively protect against brain injury (sirt1, p53, p21, and p16) by inhibiting oxidative stress (nrf2 and ho-1), inflammation (il-6 and tnf-α), and apoptosis (bax and caspase-3) in d-gal-induced aging mice. |
2024-02-12 |
2024-02-15 |
mouse |
| Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. |
viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. |
2024-02-11 |
2024-02-14 |
human |
| Jing Qu, Zhenran Xia, Yu Liu, Mingzhong Li, Yufeng Xi. Targeting Antheraea pernyi silk fibroin modified dual-gene coexpressing vector enhances gene transport and promotes lung tumor suppression. International journal of biological macromolecules. 2024-02-11. PMID:38342259. |
the in vivo treatment of h460 human lung carcinoma xenograft tumors showed that the dual-gene coexpressing vector suppressed the proliferation of lung tumor cells by downregulating the expression of ki67 and bcl-2, promoted apoptosis by upregulating the expression of c caspase-3 and bax, and blocked tumor angiogenesis by downregulating the expression of vegf and cd31, thus exerting a multichannel tumor inhibition effect. |
2024-02-11 |
2024-02-14 |
human |
| Xihan Liu, Jiaojiao Zhang, Zixiang Wang, Mingyao Yan, Meining Xu, Gaoyuan Li, Victoria Shender, Jian-Jun Wei, Jianqiao Li, Changshun Shao, Shiqian Zhang, Beihua Kong, Kun Song, Zhaojian Li. Splicing Factor PQBP1 Curtails BAX Expression to Promote Ovarian Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-02-11. PMID:38342602. |
pqbp1 promotes bax exon 2 skipping to generate a truncated isoform that undergoes degradation by nonsense-mediated mrna decay, thus making cancer cells resistant to apoptosis. |
2024-02-11 |
2024-02-14 |
Not clear |
| Hao Zheng, Yunzhe Li, Yasi Deng, Huanjie Li, Xinyang Shen, Haokai Lin, Yong Yang, Xing Tian, Bin Li, Hanwen Yuan, Wenbing Sheng, Wei Wang, Huanghe Y. Xuetongsu attenuates bone destruction in collagen-induced arthritis mice by inhibiting osteoclast differentiation and promoting osteoclast apoptosis. The international journal of biochemistry & cell biology. 2024-02-10. PMID:38340949. |
mechanistic studies have indicated that xuetongsu promotes apoptosis of mature osteoclasts in joint tissues by activating caspase-3 and bax, while inhibiting bcl-2. |
2024-02-10 |
2024-02-14 |
mouse |
| Ribrio Ivan Tavares Pereira Batista, Jenniffer Hauschildt Dias, Joedson Dantas Gonçalves, Gabriel Brun Vergani, Maria Emilia Franco Oliveira, Joanna Maria Gonçalves Souza-Fabjan, Jeferson Ferreira Fonsec. The presence of estradiol benzoate in the cervical relaxation treatment for non-surgical embryo collection does not impair embryonic morphological quality, cryosurvival, and gene expression profile. Theriogenology. vol 218. 2024-02-09. PMID:38335708. |
additionally, the presence of eb did not affect (p > 0.05) the embryo's morphological quality, the development dynamics, or the abundance of transcripts associated with embryonic quality (oct4 and nanog), cellular stress (hsp90 and prdx1), and apoptosis (bcl2 and bax). |
2024-02-09 |
2024-02-12 |
Not clear |
| Liang Kun Huang, Xiao Shuang Zeng, Ze Wen Jiang, Hao Peng, Fei Su. Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway. Chemico-biological interactions. 2024-02-09. PMID:38336255. |
interestingly, dex upregulated the expression of foxo1, bax, cleaved-caspase-9, and cleaved-caspase-3 and enhanced mc3t3-e1 apoptosis; application of ech and sirna-foxo1 reversed these effects. |
2024-02-09 |
2024-02-12 |
rat |
| Huan Liu, Guizhi Zhou, Xin Fu, Haiyan Cui, Guangrui Pu, Yao Xiao, Wei Sun, Xinhua Dong, Libin Zhang, Sijia Cao, Guiqin Li, Xiaowei Wu, Xu Yan. Retraction: Long noncoding RNA TUG1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of BAX. Oncotarget. vol 15. 2024-02-08. PMID:38329724. |
retraction: long noncoding rna tug1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of bax. |
2024-02-08 |
2024-02-10 |
Not clear |
| Alexander V Sirotkin, Barbora Loncová, Zuzana Fabová, Michaela Bartušová, Iris Martín-García, Abdel Halim Harrath, Francisco Alons. Сopper nanoparticles supported on charcoal and betacellulin - Two novel stimulators of ovarian granulosa cell functions and their functional interrelationships. Theriogenology. vol 218. 2024-02-07. PMID:38325150. |
markers of cell proliferation (brdu incorporation), of the s-phase (pcna) and g-phase (cyclin b1) of the cell cycle, markers of extrinsic (nuclear dna fragmentation) and cytoplasmic/mitochondrial apoptosis (bax and caspase 3), and the release of progesterone and estradiol were assessed by brdu test, tunel, quantitative immunocytochemistry and elisa. |
2024-02-07 |
2024-02-10 |
Not clear |
| Jing-Yu Sun, Jun Zha, Yue Qiu, Ting-Jun Fa. Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells. Chemico-biological interactions. 2024-02-07. PMID:38325520. |
furthermore, continuous treatment with low betaxolol concentrations (0.00875%) for three generations of hcscs prevented apoptosis by promoting the expression of bcl-xl and suppressing that of bax. |
2024-02-07 |
2024-02-10 |
human |
| Mauro Torres, Dewi Mcconnaughie, Samia Akhtar, Claire E Gaffney, Bruno Fievet, Catherine Ingham, Mark Stockdale, Alan J Dickso. Engineering mammalian cell growth dynamics for biomanufacturing. Metabolic engineering. 2024-02-07. PMID:38325641. |
initially, we engineered mammalian death phase by employing crispr/cas9 to knockout pro-apoptotic proteins bax and bak, resulting in a substantial attenuation of apoptosis by improving cell viability and extending culture lifespan. |
2024-02-07 |
2024-02-10 |
Not clear |
| V V Sathibabu Uddandrao, Seshathri Eraniappan, Asokan Balakrishnan Ramajayam, Sengottuvelu Singaravel, Anitha Roy, Brahma Naidu Parim, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikuma. Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation. Systems biology in reproductive medicine. vol 70. issue 1. 2024-02-07. PMID:38323592. |
moreover, after hcc treatment, testicular tissues showed a remarkable decrease in mrna levels responsible for inflammation (tnf-α, il-6, nf-κb) and apoptosis (bax and bcl-2). |
2024-02-07 |
2024-02-09 |
rat |
| Pengfei Jiao, Yingrui Wang, Gaofei Ren, Dan Chu, Yameng Li, Yingwu Yang, Tianqing San. Urolithin A exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating HMGB1-mediated MAPK and NF-κB signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2024-02-06. PMID:38319388. |
ua also inhibited cell apoptosis in lung tissues by decreasing bax expression and increasing bcl-2 expression. |
2024-02-06 |
2024-02-09 |
mouse |
| Xia Wu, Ijaz Khan, Xiaoqi Ai, Jiliang Zhang, Haitao Shi, Ding Li, Meiling Hon. Effects of butyl paraben on behavior and molecular mechanism of Chinese striped-necked turtle (Mauremys sinensis). Aquatic toxicology (Amsterdam, Netherlands). vol 268. 2024-02-06. PMID:38320419. |
meanwhile, the mrna expression level of bax, bcl-2, caspase-9 and tunel assay indicated the occurrence of cell apoptosis in the brains of the higher bup exposed groups, which may play an important role in neuronal death inducing behavior change. |
2024-02-06 |
2024-02-09 |
Not clear |
| Tiantian Shan, Xiaoying Li, Wenzhi Xie, Shaoqin Wang, Yan Gao, Yan Zheng, Guohai Su, Ying Li, Zhuo Zha. Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway. Cellular signalling. 2024-02-06. PMID:38320624. |
seven days after mi, rap1gap expression in the hearts of control mice peaked, the expression of proapoptotic markers (bax and cleaved caspase-3) increased, the expression of antiapoptotic factors (bcl-2) decreased, and the expression of the inflammatory factors il-6 and tnf-α increased; thus, apoptosis occurred, inflammation, infarct size, and left ventricular dysfunction increased, while the heart changes caused by mi were alleviated in rap1gap-cko mice. |
2024-02-06 |
2024-02-09 |
mouse |
| Barbora Loncová, Zuzana Fabová, Vladimíra Mondočková, Radoslav Omelka, Abdel Halim Harrath, Alexander V Sirotki. Inhibition of vinculin activity has an adverse effect on porcine ovarian cells. Experimental cell research. 2024-02-03. PMID:38309674. |
the expression of vcl, accumulation of vcl protein, cell viability, proliferation (accumulation of pcna and cyclin b1), proportion of proliferative active cells, apoptosis (accumulation of bax, caspase 3, p53, antiapoptotic marker bcl2, and bax/bcl-2 ratio), dna fragmentation, and release of steroid hormones and igf-i were analyzed by rt‒qpcr, trypan blue exclusion test, quantitative immunocytochemistry, xtt assay, tunel assay, and elisa. |
2024-02-03 |
2024-02-06 |
Not clear |