| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Muhammed Mehdi \\xc3\\x9cremi\\xc5\\x9f, Yusuf T\\xc3\\xbcrk\\xc3\\xb6z, Nuray \\xc3\\x9cremi\\xc5\\x9. Investigation of apoptotic effects of Cucurbitacin D, I, and E mediated by Bax/Bcl-xL, caspase-3/9, and oxidative stress modulators in HepG2 cell line. Drug development research. vol 85. issue 2. 2024-03-18. PMID:38494997.' |
the cucurbitacins induced apoptosis by increasing caspase-3, caspase-9, and bax activity, inhibiting bcl-xl activation, causing loss of ΔΨm, and suppressing cell migration. |
2024-03-18 |
2024-03-20 |
Not clear |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Nikoo Parham, Kaveh Rahimi, Zohreh Ghotbeddin, Mohammad Reza Tabande. Fish oil ameliorates ethanol-induced gastric injury in rat by modulating gene related to apoptosis. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38486044. |
to investigate apoptosis, the mrna levels of bax, bcl-2, and caspase 3 were analyzed. |
2024-03-15 |
2024-03-17 |
rat |
| Deema K Sabir, Abeer Al-Masri, Munirah F Aldayel, Abeer A Shara. Modulating oxidative stress, apoptosis and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol. Toxicology mechanisms and methods. 2024-03-15. PMID:38486414. |
also, the expression of bax and bcl-2, caspace-3 activity, and apoptosis were assessed. |
2024-03-15 |
2024-03-17 |
human |
| Deema K Sabir, Abeer Al-Masri, Munirah F Aldayel, Abeer A Shara. Modulating oxidative stress, apoptosis and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol. Toxicology mechanisms and methods. 2024-03-15. PMID:38486414. |
alp also significantly upregulated bax and downregulated bcl-2 expression, elevated caspace-3 activity, and apoptosis. |
2024-03-15 |
2024-03-17 |
human |
| Shuaichen Liu, Lan Hong, Song Zhang, Yuxin Tian, Yuchen Wang, Duanduan Zhao, Jingheng Lv, Jingjing Zhuang, Hongyan Xu, Guangjun Xi. Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites. International journal of biological macromolecules. 2024-03-15. PMID:38490380. |
epithelial cell apoptosis was inhibited by increased bcl-2 and decreased bax expression nlrp3, asc, and caspase-1 protein levels decreased. |
2024-03-15 |
2024-03-18 |
mouse |
| Chunyang Zhu, Yangyang Lu, Shasha Wang, Jialin Song, Yixin Ding, Yan Wang, Chen Dong, Jiani Liu, Wensheng Qiu, Weiwei Q. Nortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway. Scientific reports. vol 14. issue 1. 2024-03-14. PMID:38480798. |
moreover, ntp induces cell apoptosis by upregulating bax, bad, and c-parp and downregulating parp and bcl-2 expression. |
2024-03-14 |
2024-03-16 |
mouse |
| Heng Sun, Fenghui Liao, Yichen Tian, Yongrong Lei, Yuna Fu, Jianhua Wan. Molecular-Scale Investigations Reveal the Effect of Natural Polyphenols on BAX/Bcl-2 Interactions. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473728. |
apoptosis signaling controls the cell cycle through the protein-protein interactions (ppis) of its major b-cell lymphoma 2-associated x protein (bax) and b-cell lymphoma 2 protein (bcl-2). |
2024-03-13 |
2024-03-15 |
Not clear |
| Heng Sun, Fenghui Liao, Yichen Tian, Yongrong Lei, Yuna Fu, Jianhua Wan. Molecular-Scale Investigations Reveal the Effect of Natural Polyphenols on BAX/Bcl-2 Interactions. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473728. |
due to the antagonistic function of both proteins, apoptosis depends on a properly tuned balance of the kinetics of bax and bcl-2 activities. |
2024-03-13 |
2024-03-15 |
Not clear |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
the results show that overexpression of mir-128-3p inhibited the proliferation of kgn cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (pcna) and b-cell lymphoma-2 (bcl2) while promoting that of bcl-2 associated x protein (bax). |
2024-03-13 |
2024-03-15 |
human |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Aastha Mittal, Neelam Mahala, Nikhil Hanamant Dhanawade, Sunil Kumar Dubey, Uma S Dube. Evaluation of the cytotoxic activity of sorafenib-loaded camel milk casein nanoparticles against hepatocarcinoma cells. Biotechnology journal. vol 19. issue 3. 2024-03-12. PMID:38472095. |
gene and protein expression studies done by qpcr and western blotting depicted upregulation of tumor suppressor gene p53, pro-apoptotic bax, and caspase-3 along with downregulated anti-apoptotic bcl-2 gene and protein expression which further emphasized death by apoptosis. |
2024-03-12 |
2024-03-15 |
human |
| Yuying Wang, Zhiyuan Hu, Maojun Jiang, Yanxin Zhang, Linjie Yuan, Ziqian Wang, Ting Song, Zhichao Zhan. Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family. Biological chemistry. 2024-03-11. PMID:38465853. |
moreover, by using bax/bak double knockout mef cells, ybh3 was identified to induce apoptosis through forming oligomerization to trigger mitochondrial outer membrane permeabilization (momp) like bax. |
2024-03-11 |
2024-03-14 |
Not clear |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Mei Tong He, Ji Hyun Kim, Eun Ju Ch. Co-treatment with the seed of Food science & nutrition. vol 12. issue 3. 2024-03-08. PMID:38455162. |
the induction of neuronal apoptosis by aβ involves increased expression of b-cell lymphoma protein 2 (bcl-2)-associated x (bax) and decreased bcl-2 expression. |
2024-03-08 |
2024-03-10 |
Not clear |
| Anita Caroline Susanto, Laksmi Hartajanie, Chih-Chung W. α‑Phellandrene enhances the apoptosis of HT‑29 cells induced by 5‑fluorouracil by modulating the mitochondria‑dependent pathway. Oncology reports. vol 51. issue 4. 2024-03-08. PMID:38456489. |
the mechanism by which apoptosis is induced may involve the intrinsic apoptosis pathway that activates the mitochondria‑dependent pathway, including regulating the expression levels of bcl‑2 family members, including bax, bcl‑2 and bid, regulating mmp and hk‑2 expression levels, and increasing the expression of caspase cascade molecules, including caspase‑9 and caspase‑3. |
2024-03-08 |
2024-03-10 |
human |
| Ying Sun, Xiaohui Jin, Zuwang Yang, Zunhan Hu, Qiulu Li, Jingquan Dong, Mian F. Ferulic acid attenuates difenoconazole exposure induced liver injury in carp by modulating oxidative damage, inflammation and apoptosis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-05. PMID:38442785. |
additionally, tunel results demonstrated that dfz initiated apoptosis, while dietary supplementation with fa decreased the protein expression levels of bax and cytochrome c (cyt c) and the transcriptional levels of bax, caspase3, caspase9, p53 genes. |
2024-03-05 |
2024-03-08 |
Not clear |
| Vinayak Sharma, Eshu Singhal Sinha, Jagtar Sing. Investigation of In Vitro Anti-cancer and Apoptotic Potential of Onion-Derived Nanovesicles Against Prostate and Cervical Cancer Cell Lines. Applied biochemistry and biotechnology. 2024-03-05. PMID:38441782. |
finally, western blot analysis indicated changes in apoptosis-related proteins including bcl-2, bax, and caspase-3, emphasizing that the anti-cancerous effect of odnvs is attributed to the induction of apoptosis and suggests the unexplored anti-cancerous potential of odnvs. |
2024-03-05 |
2024-03-07 |
Not clear |
| Xiaoqi Ai, Rui Lin, Zeeshan Ali, Qingjun Zhu, Li Ding, Haitao Shi, Meiling Hon. Seasonal changes in hepatic lipid metabolism and apoptosis in Chinese soft-shelled turtle (Pelodiscus sinensis). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-04. PMID:38437998. |
also, the expression levels of genes (ask1, jnk1, and bax) associated with cell apoptosis increased in mid-h and ea, however, the expression of bcl2 was inhibited in mid-h. |
2024-03-04 |
2024-03-07 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Ahmed Magdy El-Ebiary, Abdulelah K Altowairqi, Atheer T Alharthi, Shahad M Alzahrani, Shomokh H Althagafi, Reema A Alotaibi, Ahmed Abd-Eltawab Tamma. Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats. Toxicology. 2024-03-03. PMID:38432408. |
in addition, chrysin significantly ameliorated the iol-induced apoptosis as indicated by reduction in caspase-3 activity and modulation of bax and bcl2 protein abundance. |
2024-03-03 |
2024-03-06 |
rat |