| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Padakanti Sandeep Chary, Ankush Bansode, Naveen Rajana, Valmala Bhavana, Siva Singothu, Anamika Sharma, Santosh Kumar Guru, Vasundhra Bhandari, Neelesh Kumar Mehr. Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed micelles through design, development, in-silico modelling, In-Vitro testing, and Ex-Vivo characterization. International journal of pharmaceutics. 2024-04-16. PMID:38626846. |
key players in the regulation of apoptosis, a fundamental process in cell death, are the b-cell lymphoma 2 (bcl-2) family proteins, namely bcl-2 and bax. |
2024-04-16 |
2024-04-19 |
Not clear |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Jiansheng Zhu, Mingtao Huang, Peiyun Jiang, Jingyu Wang, Renfei Zhu, Chunlan Li. Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio). Chemosphere. 2024-04-15. PMID:38621487. |
besides, myc activated autophagy through enhanced expression of the lc3-ii protein and suppressed expression of the p62 protein and autophagosome formation, subsequently triggering apoptosis by upregulating apoptotic genes (p53, bax, bcl-2 and caspase 3) and the cleaved caspase-3 protein in zebrafish and pc12 cells. |
2024-04-15 |
2024-04-18 |
zebrafish |
| Jian-Heng Hao, Bo-Ya Chang, Jia Ren, Hai-Jun Wang, Lai-Xi J. [Mechanism of resveratrol in protecting ovary in poor ovarian response mice by regulating Hippo signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 3. 2024-04-15. PMID:38621878. |
the results showed that compared with the blank group, the model group had an increased rate of estrous cycle disruption in mice, a decreased number of normally developing ovarian follicles, an increased number of blocked ovarian follicles, increased ovarian granulosa cell apoptosis, decreased ovulation, reduced ovarian wet weight and ovarian index, increased serum fsh and lh levels, decreased amh and e_2 levels, decreased protein expression levels of yap1 and taz in ovarian tissues, increased relative expression levels of mst1/2, lats1/2, and bax proteins, and decreased relative expression levels of yap1, taz, and bcl-2 proteins. |
2024-04-15 |
2024-04-18 |
mouse |
| Jian-Heng Hao, Bo-Ya Chang, Jia Ren, Hai-Jun Wang, Lai-Xi J. [Mechanism of resveratrol in protecting ovary in poor ovarian response mice by regulating Hippo signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 3. 2024-04-15. PMID:38621878. |
compared with the model group, the low-and high-dose res groups exhibited reduced estrous cycle disruption rates in mice, varying degrees of improvement in the number and morphology of ovarian follicles, reduced numbers of blocked ovarian follicles, improved ovarian granulosa cell apoptosis, increased ovulation, elevated ovarian wet weight and ovarian index, decreased serum fsh and lh levels, increased amh and e_2 levels, elevated protein expression levels of yap1 and taz in ovarian tissues, decreased relative expression levels of mst1/2, lats1/2, and bax proteins, and increased relative expression levels of yap1, taz, and bcl-2 proteins. |
2024-04-15 |
2024-04-18 |
mouse |
| Xin Qi, Xin Chen, Wen-Bo An, Zhi-Ming Xu, Duo-Xian Wang, Peng-Fei Luo, Yi-Xin Chen, Jiao-Jiao Ma, Zi-Yang Hu, Wei Qi, Jian-Jun Liu, Jun-Xi Li. [Ligusticum cycloprolactam inhibits IL-1β-induced apoptosis and inflammation of rat chondrocytes via HMGB1/TLR4/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621908. |
the modeled chondrocytes showed increased apoptosis rate, promoted expression of cox-2, pge2, and tnf-α, up-regulated protein levels of bax, caspase-3, hmgb1, tlr4, and nf-κb p65 and mrna levels of hmgb1, tlr4, nf-κb p65, and myd88, and down-regulated protein level of bcl-2. |
2024-04-15 |
2024-04-18 |
rat |
| Zhi Qin, Min Zho. [Tanshinone Ⅱ_A inhibits ferroptosis via Nrf2 signaling pathway to protect liver in rats of non-alcoholic fatty liver disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 6. 2024-04-15. PMID:38621946. |
the result showed that tsⅡ_a significantly reduced the content of mda, ast, alt, tc, and tg in the serum, increased the activity of sod, decreased the apoptosis rate, lipid deposition, ros, and iron deposition in the liver tissue, up-regulated the expression of nrf2, ho-1, fsp1, gpx, and bcl-2, and inhibited the expression of bax in the liver tissue of nafld rats. |
2024-04-15 |
2024-04-18 |
rat |
| Jingya Li, Daolei Cui, Ziyue Yang, Jiaoyang Ma, Jianjun Liu, Yingxin Yu, Xianfeng Huang, Ping Xian. Health risk assessment of heavy metal(loid)s in road dust via dermal exposure pathway from a low latitude plateau provincial capital city: The importance of toxicological verification. Environmental research. 2024-04-14. PMID:38615791. |
in addition, the dust extracts suppressed the cell viability, increased the reactive oxygen species (ros) level and dna damage, and eventually activated the mitochondria-mediated apoptosis pathway, evidenced by the upregulation of caspase-3/9, bax, and bak-1. |
2024-04-14 |
2024-04-17 |
human |
| Xiaomeng Xu, Cheng Yin, Bing Dong, Yuewen Li, Shi Liu, Jun Che. LncRNA XIST Protects Against Polycystic Ovary Syndrome via the Regulation of miR-212-3p/RASA1 Axis. Biochemical genetics. 2024-04-12. PMID:38609670. |
cell viability, apoptosis, protein expression of bcl-2 and bax were assessed by mtt, flow cytometry analysis, rt-qpcr and western blot, respectively. |
2024-04-12 |
2024-04-15 |
Not clear |
| Mahdieh Kelidari, Farshad Abedi, A Wallace Hayes, Vahid Jomehzadeh, Gholamreza Karim. The protective effects of protocatechuic acid against natural and chemical toxicants: cellular and molecular mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. 2024-04-12. PMID:38607443. |
in addition, pca inhibits apoptosis by lowering the expression of bax, caspase-3, and caspase-9 along with enhancing the level of the antiapoptotic protein bcl-2. |
2024-04-12 |
2024-04-14 |
Not clear |
| Zhenfeng Ye, Jing Zhang, Zhou Xu, Zhangwang Li, Gaomin Huang, Bin Tong, Panpan Xia, Yunfeng Shen, Honglin Hu, Peng Yu, Xiaoqing X. Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome. Human cell. 2024-04-12. PMID:38607518. |
pioglitazone treatment significantly attenuated renal cell apoptosis, decreased cytotoxicity, increased bcl-2 expression, and downregulated bax expression. |
2024-04-12 |
2024-04-14 |
rat |
| Weijia Zhao, Min Mo, Jia Yu, Sha Cheng, Guiping Long, Zhiqiong Luo, Wei Liang, Chen Yan, Heng Luo, Baofei Su. A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitor. Medical oncology (Northwood, London, England). vol 41. issue 5. 2024-04-11. PMID:38602586. |
sgp-17-s blocked hel cells in the g2 phase, induced apoptosis, decreased bcl-2 and caspase-8 protein expression, and increased bax and caspase-3 expression. |
2024-04-11 |
2024-04-13 |
Not clear |
| Yanlan Li, Shengliang Cao, Yubao L. Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells. Poultry science. vol 103. issue 6. 2024-04-11. PMID:38603929. |
heat shock proteins 60 overexpression led to a significant decrease in apoptosis levels in df-1 cells, which could be attributed to the downregulation of bax and bak expression, the upregulation of bcl-2, and the decreased expression of caspase 3. |
2024-04-11 |
2024-04-14 |
Not clear |
| Yanlan Li, Shengliang Cao, Yubao L. Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells. Poultry science. vol 103. issue 6. 2024-04-11. PMID:38603929. |
conversely, hsp60 knockdown led to a substantial increase in apoptosis levels in df-1 cells, facilitated by the downregulation of bax and bcl-2 expression, and the upregulation of bak expression, which increased caspase 3 levels, thereby promoting apoptosis. |
2024-04-11 |
2024-04-14 |
Not clear |
| Fahaid H Al-Hashem, Salah O Bashir, Amal F Dawood, Moutasem S Aboonq, Ismaeel Bin-Jaliah, Abdulaiziz M Al-Garni, Mohamed D Mors. Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through up-regulation of nuclear factor erythroid 2-related factor 2 gene and protein expression. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595292. |
additionally, vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers (interleukin-6, tumor necrosis factor-α, intracellular cell adhesive molecules) and apoptosis biomarkers (bax and cleaved caspase-3). |
2024-04-10 |
2024-04-12 |
rat |
| Furong Ma, Yulong Li, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong, Jiang-Jiang Qi. ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. European journal of medicinal chemistry. vol 270. 2024-04-09. PMID:38593589. |
on the other hand, gic-20 can also induce apoptosis via upregulating the level of apoptotic protein bax and downregulating the level of anti-apoptotic protein bcl-2 in ht1080 cells. |
2024-04-09 |
2024-04-12 |
Not clear |
| Jiayu Shen, Ningning Hu, Zetian Wang, Lina Yang, Rujun Chen, Liwen Zhang, Xiaoqin Wan. Ghrelin alleviates placental dysfunction by down-regulating NF-κB phosphorylation in LPS-induced rat model of preeclampsia. European journal of pharmacology. 2024-04-09. PMID:38593930. |
second, ghrelin clearly inhibited placental bax expression and circulating sflt-1 as well as elevated placental bcl-2 expression and circulating pigf, restored apoptosis and invasion deficiency of trophoblast cells caused by lps in vitro. |
2024-04-09 |
2024-04-12 |
human |
| Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. |
the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. |
2024-04-08 |
2024-04-10 |
human |
| Xiao-Yun Niu, Xi-Xiu Xie, Hou-Zhen Tuo, Cui-Ping Lv, Ya-Ru Huang, Jie Zhu, Shi-Yu Liang, Xiao-Yu Du, Cheng-Gang Yang, Sheng-Jie Hou, Xiao-Ying Sun, Ling-Jie Li, Fang Cui, Qi-Xin Huang, Ying-Bo Jia, Yu-Jiong Wang, Rui-Tian Li. Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson's disease. Cell death discovery. vol 10. issue 1. 2024-04-08. PMID:38589400. |
α-syn oligomers which formed from monomers increase the expression of p-p38, p53, c-caspase9, c-caspase3 and bax, decrease the level of bcl-2, cause mitochondrial damage and lead to oxidative stress, thus inducing neuronal apoptosis. |
2024-04-08 |
2024-04-11 |
mouse |