| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W-L Gong, Y-N Zhang, J Zhang, X Jiang, W-J Xia. Biological differences and molecular mechanism of different peripheral nerves after injury. European review for medical and pharmacological sciences. vol 28. issue 2. 2024-02-02. PMID:38305620. |
the aim of the study was to analyze the apoptosis of neurons and the differences in expression of bcl-2 and bax protein in the neurons in the corresponding spinal cord segment after the repair of the tibial nerve (tn) and common peroneal nerve (cpn) in rats. |
2024-02-02 |
2024-02-04 |
rat |
| Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jian. Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2. The American journal of Chinese medicine. 2024-01-31. PMID:38291582. |
for instance, it inhibits the expression of the nf-[formula: see text]b signaling pathway and induces cell apoptosis, affects the expression levels of mitochondrial apoptosis proteins bcl-2 and bax, and cooperates with the pd-1 blockade to reactivate t cells to promote an antitumor immune response. |
2024-01-31 |
2024-02-02 |
Not clear |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Mostafa Moradi Sarabi, Hassan Ahmadvan. Monoterpene linalool restrains gentamicin-mediated acute kidney injury in rats by subsiding oxidative stress, apoptosis, and the NF-κB/iNOS/TNF-α/IL-1β pathway and regulating TGF-β. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-31. PMID:38294506. |
interestingly, lin repressed gm-induced apoptosis, as reflected by a marked downregulation of bax and caspase-3 expression, concurrent with the upregulation of bcl2 expression. |
2024-01-31 |
2024-02-02 |
rat |
| Weam W Ibrahim, Rabab H Sayed, Mohamed F Abdelhameed, Enayat A Omara, Mahmoud I Nassar, Noha F Abdelkader, Mohamed A Farag, Abdelsamed I Elshamy, Sherif M Afif. Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS. Inflammopharmacology. 2024-01-31. PMID:38294617. |
moreover, e. bonariensis extract mitigated ovx/d-gal-induced aβ aggregation, tau hyperphosphorylation, ache activity, neuroinflammation (nf-κbp65, tnf-α, il-1β), and apoptosis (cytc, bax). |
2024-01-31 |
2024-02-02 |
rat |
| Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Naraya. Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics. Biomedical materials (Bristol, England). 2024-01-30. PMID:38290150. |
transfection of oscc cells with exogenous, anticancer gene p53 lipoplexed with crude saponin-based liposome induced apoptosis of cancer cells via regulation of bax and bcl2 protein levels at levels comparable with pre-established delivery systems based on synthetic shr ligands. |
2024-01-30 |
2024-02-02 |
human |
| Yingjun Qin, Yajing Huang, Wenting Lin, Rui Huang, Kan Li, Xing Han, Yuan Re. Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: Oxidative stress, apoptosis, and histone hypoacetylation. The Science of the total environment. 2024-01-30. PMID:38290676. |
the upregulation of apoptosis-related genes bax, p53, and bcl-2 confirmed the occurrence of apoptosis. |
2024-01-30 |
2024-02-02 |
human |
| Dong-Ge Xie, Xue-Mei Wang, Jun-Hao Li, Zheng-Yan Tan, Zhong-Qing Zhang, Shou-Tian L. Short-term postmortem interval estimation by detection of apoptosis-related protein in skin. Forensic science, medicine, and pathology. 2024-01-30. PMID:38289442. |
in this process, 0 h after death was used as the control group, and the expression levels of bax and caspase-3 reached the maximum value at 8-12 h, while bcl-2, as an inhibitor of apoptosis protein, peaked after 24 h. |
2024-01-30 |
2024-02-01 |
mouse |
| Wuhan Wei, Guoxiang Zhao, Qiang Li, Jingyu Zhang, Hanxiao Wei, Caiqi Shen, Bingkun Zhao, Zhe Ji, Linna Wang, Yanping Guo, Peisheng Ji. Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis. Aesthetic plastic surgery. 2024-01-29. PMID:38286898. |
mir-506-3p was found to interact with bax and inhibit apoptosis in dpcs by suppressing bax expression in response to dht-induced damage. |
2024-01-29 |
2024-02-01 |
Not clear |
| Jarosław Zalewski, Marta Szajna, Konrad Stępień, Karol Nowak, Aleksandra Karcińska, Alicia Del Carmen Yika, Kornelia Krawczyk, Krzysztof Karwat, Magdalena Zalewska, Piotr Pierzchalsk. Endothelial Cell Apoptosis but Not Necrosis Is Inhibited by Ischemic Preconditioning. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279236. |
necrosis was assessed by the release of lactate dehydrogenase (ldh) and apoptosis by double staining with propidium iodide/annexin v (pi/av), using tunel test, and bcl-2 and bax gene expression measured using rt-pcr. |
2024-01-27 |
2024-01-29 |
human |
| Kui Sheng, Linli Sang, Hui G. TRPM8 knockdown relieved inflammatory response and cell apoptosis in pneumonia model induced by Streptococcus pneumoniae in vitro. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279445. |
trpm8 knockdown attenuated the reduced cell viability and increased cell apoptosis (reflected by the upregulation of bax and downregulation of bcl-2) in d39 group (p<0.05). |
2024-01-27 |
2024-01-29 |
Not clear |
| Jinjie Zhang, Xiaowei Qin, ZhiBin Bi, Ruilong Niu, Kangkang Zhang, Xianghuang Mei, Wei Gu. Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 14. 2024-01-27. PMID:38279460. |
wb was used to detect the satb1, as well as the expression levels of proteins involved in apoptosis, including caspase-3, bax, and bcl-2, as well as matrix metalloproteinase 2 and 9 (mmp-2 and mmp-9) in sw620 cells. |
2024-01-27 |
2024-01-29 |
human |
| Jinjie Zhang, Xiaowei Qin, ZhiBin Bi, Ruilong Niu, Kangkang Zhang, Xianghuang Mei, Wei Gu. Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 14. 2024-01-27. PMID:38279460. |
the results indicate that mir-548b-5p showed low expression in hgccs; in contrast to the control group (p>0.05), the hs-746t cell viability, invasion, migration ability, mmp-2, mmp-9 protein significantly downregulated in mir-548b-5p mimic group (p<0.05), the apoptosis rate, caspase-3, bax protein expression were upregulated markedly, and bcl-2 protein expression was downregulated significantly (p<0.05); in contrast to mir-548b-5p mimic group, the hs-746t cell viability, invasion, migration ability, mmp-2, mmp-9 protein significantly were upregulated in mir-548b-5p mimic+pc-fzd7 group (p<0.05), the apoptosis rate, caspase-3, bax protein expression were significantly, and the level of bcl-2 was down-regulated significantly (p<0.05); double luciferase report shows that mir-548b-5p can target and regulate fzd7. |
2024-01-27 |
2024-01-29 |
human |
| Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Jiaquan Yan. Mechanism of TNF- α inducing apoptosis and autophagy of chondrocytes by activating NF- κ B signal pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279481. |
the levels of il-1, il-6, il-12, autophagy markers (atg5, atg7, lc3ii/i), apoptosis-related indexes (bax, bcl-2), nf-κb signal pathway-related indexes (p-p65, p65, iκbα) protein expression, mrna expression and apoptosis rate in chondrocytes were compared in each group. |
2024-01-27 |
2024-01-29 |
rat |
| Valerii E Orel, Anatoliy G Diedkov, Vasyl V Ostafiichuk, Oleksandra O Lykhova, Denys L Kolesnyk, Valerii B Orel, Olga Yo Dasyukevich, Oleksandr Yu Rykhalskyi, Serhii A Diedkov, Anna B Prosvietov. Combination Treatment with Liposomal Doxorubicin and Inductive Moderate Hyperthermia for Sarcoma Saos-2 Cells. Pharmaceuticals (Basel, Switzerland). vol 17. issue 1. 2024-01-26. PMID:38276006. |
we compared cell viability using a trypan blue assay, apoptosis and reactive oxygen species (ros) measured by flow cytometry and pro-apoptotic bax protein expression examined by immunocytochemistry in response to imh (42 mhz frequency, 15 w power for 30 min), ldox (0.4 μg/ml), and ldox plus imh. |
2024-01-26 |
2024-01-28 |
human |
| Ragini Singh, Aishwarya Jaiswal, Rana P Sing. Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells. Biochimica et biophysica acta. Molecular cell research. 2024-01-25. PMID:38272357. |
smg induced mitochondrial apoptosis with increased expression of bax, cleaved caspase-3 and cleaved poly-(adp-ribose) polymerase, and reduced bcl-2 level. |
2024-01-25 |
2024-01-28 |
Not clear |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
then, elisa, western blot and qt-pcr tests were used to assess the expression of the key components of the nlrp3 inflammasome and its downstream inflammatory effectors (e.g., il-1β, il-18), autophagy markers (beclin-1, lc3, p62) and apoptosis markers (bax, bcl-2) in mouse brain tissues. |
2024-01-25 |
2024-01-27 |
mouse |
| Wenjie Cheng, Yilin Ren, Chenwei Yu, Tianqi Zhou, Ye Zhang, Liqun Lu, Yanli Liu, Dan X. CyHV-2 infection triggers mitochondrial-mediated apoptosis in GiCF cells by upregulating the pro-apoptotic gene ccBAX. Fish & shellfish immunology. 2024-01-22. PMID:38253137. |
bax inhibitor peptide v5 (bip-v5), an inhibitor interfering with the function of bax proteins, inhibited bax-mediated apoptotic events through the mitochondrial pathway and attenuated apoptosis induced by cyhv-2. |
2024-01-22 |
2024-01-25 |
Not clear |
| Chao Jiang, Jiupan Zhang, Yaping Song, Xiaoyu Song, Hao Wu, Ruopu Jiao, Lanlan Li, Guijie Zhang, Dawei We. FOXO1 regulates bovine skeletal muscle cells differentiation by targeting MYH3. International journal of biological macromolecules. 2024-01-22. PMID:38253149. |
besides, interfering with foxo1 inhibited the apoptosis of bsmcs by up-regulating the expression of anti-apoptosis gene bcl2, while simultaneously down-regulating the expression of the pro-apoptosis genes bad and bax. |
2024-01-22 |
2024-01-25 |
cattle |
| Naveen Kumar, Alok Shukla, Sanjay Kumar, Ilya Ulasov, Rishi Kant Singh, Sandeep Kumar, Anand Patel, Lokesh Yadav, Ruchi Tiwari, Rachana Paswan, Shivashish Priyadarshi Mohanta, Kaushalendra, Jyeoti Antil, Arbind Achary. FNC (4'-azido-2'-deoxy-2'-fluoro(arbino)cytidine) as an Effective Therapeutic Agent for NHL: ROS Generation, Cell Cycle Arrest, and Mitochondrial-Mediated Apoptosis. Cell biochemistry and biophysics. 2024-01-22. PMID:38253918. |
dysregulation of apoptotic genes, with upregulation of bax and downregulation of bcl-2 and bcl-xl, implicates the mitochondrial-mediated apoptosis pathway. |
2024-01-22 |
2024-01-25 |
Not clear |
| Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C Lee, Bamidele Victor Owoyel. Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243560. |
vd3 significantly inhibited oxidative stress (p47phox), apoptosis (bax), inflammation (il-1β) and microglial activation (cd11b). |
2024-01-20 |
2024-01-22 |
mouse |