| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hema Priya Manivannan, Vishnu Priya Veeraraghavan, Arul Prakash Franci. Identification of molecular targets of Trigonelline for treating breast cancer through network pharmacology and bioinformatics-based prediction. Molecular diversity. 2023-12-25. PMID:38145425. |
at the same time, parp1, ddit3, bax, and tnf were associated with the apoptosis pathway according to kegg pathway enrichment analyses. |
2023-12-25 |
2023-12-27 |
Not clear |
| Yiyang Chen, Jesse D Gelles, Jarvier N Mohammed, Jerry Edward Chipu. An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations. Frontiers in cell and developmental biology. vol 11. 2023-12-25. PMID:38143925. |
bax, a proapoptotic bcl-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane to activate the mitochondrial pathway of apoptosis. |
2023-12-25 |
2023-12-27 |
human |
| Jingjing Zhang, Yao Liu, Chao An, Chen Liu, Saijian Ma, Qiwen Zhang, Hao Ding, Jingjing Shao, Wenjiao Xu. Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A. Foods (Basel, Switzerland). vol 12. issue 24. 2023-12-23. PMID:38137182. |
meanwhile, ginsenoside ck suppressed hepatocyte apoptosis, which was observed in pathological data, and immunoblotting results showed that the expression of bax, bcl-2, and other proteins was regulated by ck. |
2023-12-23 |
2023-12-25 |
mouse |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
in kasumi-1 and aml5 cells, compared with vector group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were decreased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were increased in pax9 group. |
2023-12-23 |
2023-12-25 |
human |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
compared with mir-nc group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were increased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were decreased in mir-181b-5p group. |
2023-12-23 |
2023-12-25 |
human |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
compared with mir-181b-5p group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were decreased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were increased in mir-181b-5p combined with pax9 group. |
2023-12-23 |
2023-12-25 |
human |
| Wanzhuo Chen, Haining Zhan. Elucidating the mechanism of IL-1β-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling Pathway. Tissue & cell. vol 86. 2023-12-22. PMID:38134572. |
il-1β activates piezo1 to inhibit chondrocyte autophagy and promote chondrocyte apoptosis partially, represented by up-regulation of related proteins c-caspase 3, bax expression, and down-regulation of bcl2, lc3, p62 expression. |
2023-12-22 |
2023-12-25 |
human |
| Hong Ji, Qing Zhang, Lu Ding, Rongjuan Chen, Fu Liu, Ping L. Structural and metabolic cumulus cell alteration affects oocyte quality in underweight women. Zygote (Cambridge, England). 2023-12-22. PMID:38130161. |
the expression of various proteins including the oxidative stress-derived product 4-hydroxynonenal (4-hne) and autophagy and apoptosis markers such as vps34, atg-5, beclin 1, lc3-i, ii, bax, and bcl-2 was assessed and compared between groups. |
2023-12-22 |
2023-12-24 |
Not clear |
| Soad Ghabeshi, Leila Mousavizadeh, Sorayya Ghasem. Enhancing the Antiviral Potential and Anti-Inflammatory Properties of Astragalus membranaceus: A Comprehensive Review. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2023-12-20. PMID:38115620. |
the results of these studies show that aps can exert its antiviral effect by enhancing type i ifn signaling, inhibiting the expression of bax and caspase-3 proteins in the apoptosis path-way, and other antiviral mechanisms such as anti-inflammatory activities. |
2023-12-20 |
2023-12-23 |
Not clear |
| Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar Mv, Emily H Cheng, Evripidis Gavathioti. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. vol 14. issue 1. 2023-12-19. PMID:38104127. |
chemical modulation of cytosolic bax homodimer potentiates bax activation and apoptosis. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar Mv, Emily H Cheng, Evripidis Gavathioti. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. vol 14. issue 1. 2023-12-19. PMID:38104127. |
bax predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes conformational activation and mitochondrial translocation leading to mitochondrial outer membrane permeabilization, a critical event in apoptosis execution. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar Mv, Emily H Cheng, Evripidis Gavathioti. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. vol 14. issue 1. 2023-12-19. PMID:38104127. |
expression of inactive dimers, results in reduced bax activation, translocation and apoptosis upon pro-apoptotic drug treatments. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar Mv, Emily H Cheng, Evripidis Gavathioti. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. vol 14. issue 1. 2023-12-19. PMID:38104127. |
using the inactive bax dimer structure and a pharmacophore-based drug screen, we identify a small-molecule modulator, bdm19 that binds and activates cytosolic bax dimers and prompts cells to apoptosis either alone or in combination with bcl-2/bcl-xl inhibitor navitoclax. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar Mv, Emily H Cheng, Evripidis Gavathioti. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. vol 14. issue 1. 2023-12-19. PMID:38104127. |
our findings underscore the role of the cytosolic inactive bax dimer in resistance to apoptosis and demonstrate a strategy to potentiate bax-mediated apoptosis. |
2023-12-19 |
2023-12-21 |
Not clear |
| Hamidreza Salimi, Amir Hossein Haghighi, Shima Ababzadeh, Hamid Marefati, Sadegh Abbasian, Amber L Pond, Paulo Genti. Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine. European journal of translational myology. 2023-12-19. PMID:38112583. |
ma increased the expression of bax and tgf-β, and decreased the expression of bcl-2 and vegf, suggesting increased cardiac apoptosis. |
2023-12-19 |
2023-12-23 |
rat |
| Hamidreza Salimi, Amir Hossein Haghighi, Shima Ababzadeh, Hamid Marefati, Sadegh Abbasian, Amber L Pond, Paulo Genti. Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine. European journal of translational myology. 2023-12-19. PMID:38112583. |
in contrast, miat and vit.e decreased the expression of bax and tgf-β, suggesting a reduction in cardiac apoptosis induced by ma. |
2023-12-19 |
2023-12-23 |
rat |
| Laleh Pourmousavi, Rasoul Hashemkandi Asadi, Farzad Zehsaz, Roghayeh Pouzesh Jadid. Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats. PloS one. vol 18. issue 12. 2023-12-19. PMID:38113243. |
it also changes the balance of expression of genes associated with apoptosis control, increased bcl-2-associated x (bax) expression, and decreased bcl-2 expression (p <0.05). |
2023-12-19 |
2023-12-23 |
rat |
| Jing-Nan Yan, Ke Ma, Wen-Jie Liu, Ying Lin, Xiu-Yu Li, Dan W. [Blaps rynchopetera combined with cyclophosphamide affects proliferation and apoptosis of lung cancer cells via Wnt/β-catenin signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114153. |
compared with the control group, the b. rynchopetera, cyclophosphamide, and b. rynchopetera + cyclophosphamide groups showed increased proportion of lewis cells in g_0/g_1 phase, increased apoptosis rate, up-regulated expression of bax, and down-regulated expression of pcna, cyclind1, bcl-2, wnt1, and β-catenin. |
2023-12-19 |
2023-12-23 |
rat |
| Jing-Nan Yan, Ke Ma, Wen-Jie Liu, Ying Lin, Xiu-Yu Li, Dan W. [Blaps rynchopetera combined with cyclophosphamide affects proliferation and apoptosis of lung cancer cells via Wnt/β-catenin signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114153. |
compared with the cyclophosphamide group, the combination group showed increased proportion of cells in g_0/g_1 phase, increased apoptosis rate, up-regulated expression of bax, and down-regulated expression of pcna, cyclind1, bcl-2, wnt1, and β-catenin. |
2023-12-19 |
2023-12-23 |
rat |
| Jing-Nan Yan, Ke Ma, Wen-Jie Liu, Ying Lin, Xiu-Yu Li, Dan W. [Blaps rynchopetera combined with cyclophosphamide affects proliferation and apoptosis of lung cancer cells via Wnt/β-catenin signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114153. |
compared with the b. rynchopetera group, the b. rynchopetera + licl group had deceased proportion of cells in g_0/g_1 phase, decreased apoptosis rate, down-regulated expression of bax, and up-regulated expression of pcna, cyclind1, bcl-2, wnt1, and β-catenin. |
2023-12-19 |
2023-12-23 |
rat |