| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Heng Hao, Yue-Meng Zhao, Hai-Jun Wang, Yu-Xia Cao, Ying Lan, Lai-Xi J. [Mechanism of protective effect of resveratrol on poor ovarian response in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114185. |
animal experiments showed that the model group had higher rate of estrous cycle disorders, lower number and poorer morphology of normally developed follicles at all levels, more atretic follicles, higher apoptosis of ovarian granulosa cells, lower number of retrieved oocytes, lower ovarian wet weight and ovarian index, higher serum levels of fsh and lh, lower levels of amh and e_2, higher expression levels of hif-1α, foxo3a and bax, and lower expression levels of pi3k, akt, and bcl-2 in the ovarian tissue than the normal group. |
2023-12-19 |
2023-12-23 |
mouse |
| Ting-Ting Li, Jie Chen, En-Sheng Ji, Ya-Jing Gu. [Effect and mechanism of Danggui Buxue Decoction-containing serum in mitigating H9c2 cell injury caused by exposure to intermittent low oxygen]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114184. |
western blot was employed to determine the expression levels of the autophagy-related proteins microtubule-associated proteins light chain 3Ⅱ(lc3Ⅱ), microtubule-associated proteins light chain 3Ⅰ(lc3Ⅰ), p62, parkin and apoptosis related proteins pro caspase-3, caspase-3, b-cell lymphoma-2(bcl-2), bcl-2-associated x(bax). |
2023-12-19 |
2023-12-23 |
Not clear |
| Taghrid G Kharboush, Inas A Ahmed, Amina A Farag, Tayseir Kharboush, Alaa El-Din H Sayed, Amal M Abdel-Kareim, Mohammed Al Mohaini, Hend Attia, Refaat A Eid, Mohamed Samir A Zaki, Al-Shaimaa M Al-Tabbak. Epigenetic alterations of miR-155 and global DNA methylation as potential mediators of ochratoxin A cytotoxicity and carcinogenicity in human lung fibroblasts. Environmental science and pollution research international. 2023-12-19. PMID:38114706. |
bax downregulation, reduced bax/bcl-2 ratio together with mir-155 upregulation indicated either the inhibition of tp53-dependent apoptosis or a tissue specific response to ota exposure. |
2023-12-19 |
2023-12-23 |
human |
| Radwa H Lutfy, Amina E Essawy, Haitham S Mohammed, Marwa M Shakweer, Sherine Abdel Sala. Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1. Neurochemical research. 2023-12-19. PMID:38114728. |
nir pbm had an inhibitory effect on ache, enhanced the production of ach, attenuated ros, and regulated cell apoptosis factors such as bax and bcl-2. |
2023-12-19 |
2023-12-23 |
rat |
| Sefa Küçükler, Cuneyt Caglayan, Selçuk Özdemir, Selim Çomaklı, Fatih Mehmet Kandemi. Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats. Metabolic brain disease. 2023-12-18. PMID:38108941. |
furthermore, cpf increased mrna transcript levels of caspase-3, bax, parp-1, and vegf, which are associated with apoptosis and endothelial damage in rat brain tissues. |
2023-12-18 |
2023-12-21 |
human |
| Min Wu, Xudong Liu, Qiwen Yu, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway. European journal of pharmacology. 2023-12-18. PMID:38110141. |
serum alt and ast levels, and h&e staining were used to measure liver damage; mda content, superoxide dismutase and glutathione activities, and dihydroethidium staining were used to measure oxidative stress; mrna expression levels of tumor necrosis factor-α, interleukin(il)-1β, il-6, mcp-1, and ly6g staining were used to measure inflammatory response; and protein expression of bax, bcl-2, c-caspase3, and terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling staining were used to measure apoptosis. |
2023-12-18 |
2023-12-21 |
mouse |
| Yanqing Su, Yao Lu, Honglin An, Jinhong Liu, Feimin Ye, Jiayu Shen, Zhuona Ni, Bin Huang, Jiumao Li. MicroRNA-204-5p Inhibits Hepatocellular Carcinoma by Targeting the Regulator of G Protein Signaling 20. ACS pharmacology & translational science. vol 6. issue 12. 2023-12-14. PMID:38093845. |
transfection of mir-204-5p inhibited the hyperplasia, migration, and invasion of hcc cells, but promoted apoptosis and influenced the levels of cyclin-dependent kinase 2 (cdk2), cyclin e1, b-cell lymphoma-2 (bcl-2), bax, and cleaved caspase-3/8. |
2023-12-14 |
2023-12-17 |
Not clear |
| Xiaodan Wang, Jiatong Sun, Tong Xu, Yutian Lei, Meichen Gao, Hongjin Li. Resveratrol alleviates imidacloprid-induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway. Environmental toxicology. 2023-12-14. PMID:38095043. |
additionally, imi resulted in upregulation of mitochondrial apoptosis (caspase 3, caspase 9, bax, and cyt-c) and necroptosis (caspase 8, ripk1, ripk3, and mlkl) related factors expression, downregulation of bcl-2 expression, induction of upregulation of cytokine il-6 and tnf-α expression, and downregulation of ifn-γ expression. |
2023-12-14 |
2023-12-17 |
cat |
| Solmaz Morovati, Ali Mohammadi, Ramin Masoudi, Amir Ali Heidari, Mehdi Asad Sangab. The power of mumps virus: Matrix protein activates apoptotic pathways in human colorectal cell lines. PloS one. vol 18. issue 12. 2023-12-13. PMID:38091318. |
based on our bioinformatics studies, we proposed that the bh3 motif in the m protein may trigger apoptosis in crc cells by interacting with cellular bax. |
2023-12-13 |
2023-12-17 |
human |
| Mojdeh Soltani, Mahshid Vosoughi, Mazdak Ganjalikhani-Hakemi, Hoorieh Shapoorian, Pezhman Beshkar, Nahid Eskandari, Behrooz Ghezelbas. PD-1/PD-L1 Interaction Regulates BCL2, KI67, BAX, and CASP3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia. Iranian journal of allergy, asthma, and immunology. vol 22. issue 5. 2023-12-12. PMID:38085150. |
pd-1/pd-l1 interaction regulates bcl2, ki67, bax, and casp3, altering proliferation, survival, and apoptosis in acute myeloid leukemia. |
2023-12-12 |
2023-12-17 |
human |
| Mojdeh Soltani, Mahshid Vosoughi, Mazdak Ganjalikhani-Hakemi, Hoorieh Shapoorian, Pezhman Beshkar, Nahid Eskandari, Behrooz Ghezelbas. PD-1/PD-L1 Interaction Regulates BCL2, KI67, BAX, and CASP3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia. Iranian journal of allergy, asthma, and immunology. vol 22. issue 5. 2023-12-12. PMID:38085150. |
findings reveal that pd-l1 stimulation augments aml cell proliferation and survival by enhancing mki67 and bcl2 expressions while concurrently inhibiting cell apoptosis due to decreased bax and casp3 expression following pd-l1 stimulation. |
2023-12-12 |
2023-12-17 |
human |
| Yang-Yang Lu, Chun-Yang Zhu, Yi-Xin Ding, Bing Wang, Shu-Fen Zhao, Jing Lv, Shu-Ming Chen, Sha-Sha Wang, Yan Wang, Rui Wang, Wen-Sheng Qiu, Wei-Wei Q. Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway. Cell death discovery. vol 9. issue 1. 2023-12-12. PMID:38086844. |
cep-induced apoptosis reduced bcl-2 expression and increased cleaved caspase 3, cleaved caspase 9, bax, and bad expression. |
2023-12-12 |
2023-12-17 |
mouse |
| Matthias Nöbel, Craig Barry, Michael A MacDonald, Kym Baker, Evan Shave, Stephen Mahler, Trent Munro, Verónica S Martínez, Lars K Nielsen, Esteban Marcelli. Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation. Biotechnology and bioengineering. 2023-12-11. PMID:38079117. |
to improve the cell's resilience and viability during perfusion culture, we cultured a triple knockout cho cell line, deficient in three apoptosis related genes bax, bak, and bok in a perfusion system. |
2023-12-11 |
2023-12-17 |
Not clear |
| Xue Zhang, Chen Mei, Zhixuan Liang, Yan Zhi, Haojun Xu, Hongjun Wang, Hong Don. Homoharringtonine induces apoptosis of mammary carcinoma cells by inhibiting the AKT/mTOR signaling pathway. Veterinary and comparative oncology. 2023-12-11. PMID:38081660. |
moreover, the gene expression of b-cell lymphoma-2 (bcl-2) and bcl-2 associated x protein (bax) were analysed using quantitative reverse transcription-polymerase chain reaction (rt-qpcr), and the protein expression of protein kinase b/mammalian target of rapamycin (akt/mtor) and mitochondrial apoptosis proteins were determined by western blotting. |
2023-12-11 |
2023-12-17 |
mouse |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
then the levels of mda, sod and gsh-px in each group were detected by elisa method; cell apoptosis was detected by flow cytometry; the protein expression levels of bax and bcl-2 were detected by western blot; the expression level of mir-483-5p was detected by rt-qpcr. |
2023-12-08 |
2023-12-17 |
Not clear |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
compared with the control group, mda content, apoptosis rate, and the expression of bax protein and mir-483-5p increased in the ad group (p<0.05), while the activity of sod and gsh-px and the expression of bcl-2 protein decreased (p<0.05). |
2023-12-08 |
2023-12-17 |
Not clear |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
compared with the ad group, mda content, apoptosis rate, and the expression of bax protein and mir-483-5p decreased in the ad+l-sax group, ad+m-sax group and ad+h-sax group (p<0.05), while the activity of sod and gsh-px and the expression of bcl-2 protein increased (p<0.05). |
2023-12-08 |
2023-12-17 |
Not clear |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
compared with ad+anti-mir-nc group, mda content, apoptosis rate, and the expression of bax protein and mir-483-5p decreased in the ad+anti-mir-483-5p group (p<0.05), while the activity of sod and gsh-px and the expression of bcl-2 protein increased (p<0.05). |
2023-12-08 |
2023-12-17 |
Not clear |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
compared with ad+sax+mir-nc group, mda content, apoptosis rate, and the expression of bax protein and mir-483-5p increased in the ad+sax+mir-483-5p group (p<0.05), while the activity of sod and gsh-px and the expression of bcl-2 protein decreased (p<0.05). |
2023-12-08 |
2023-12-17 |
Not clear |
| Huamin Zhang, Mengru Zhou, Chongtao Ye, Jiahao Qin, Xuan Lu, Chunyan Wang, Xude Wang, Xuejun Ji. Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway. Toxicology in vitro : an international journal published in association with BIBRA. 2023-12-07. PMID:38061603. |
in amc-hn-8 cancer cells, ba induced apoptosis, activated caspase-3/9/parp, significantly reduced mitochondrial membrane potential (mmp), increased the expression of cytochrome c in the cytoplasm, transported bax to the mitochondria, increased the production of reactive oxygen species (ros), and the ros scavenger n-acetylcysteine can reduce apoptosis. |
2023-12-07 |
2023-12-17 |
human |