| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanlin Luo, Yang Yang, Hongyu Zhang, Luyu Ren, Xueben Han, Yu Lin, Menghan Wu, Yun Ho. Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells. Ecotoxicology and environmental safety. vol 267. 2023-11-04. PMID:37924801. |
furthermore, we found that bps induced reactive oxygen species (ros) generation, nf-κb activation, promoted apoptosis, elevated expression of bax and caspase 3, and decreased expression of bcl-2 in h9c2 cells and huvecs. |
2023-11-04 |
2023-11-08 |
mouse |
| Hanlin Luo, Yang Yang, Hongyu Zhang, Luyu Ren, Xueben Han, Yu Lin, Menghan Wu, Yun Ho. Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells. Ecotoxicology and environmental safety. vol 267. 2023-11-04. PMID:37924801. |
however, after the addition of n-acetylcysteine or pyrrolidinedithiocarbamate, ros generation, nf-κb activation, apoptosis, and expression of bax and caspase 3 were reduced, whereas expression of bcl-2 was elevated. |
2023-11-04 |
2023-11-08 |
mouse |
| Łukasz Kopiasz, Katarzyna Dziendzikowska, Michał Oczkowski, Joanna Harasym, Joanna Gromadzka-Ostrowsk. Low-molar-mass oat beta-glucan impacts autophagy and apoptosis in early stages of induced colorectal carcinogenesis in rats. International journal of biological macromolecules. 2023-11-04. PMID:37924897. |
the expression of autophagy (lc3b, beclin-1) and apoptosis (caspase-3, cleaved caspase-3, bax, bcl-2 and parp-1) markers was determined by immunohistochemistry, western blot and pcr analysis. |
2023-11-04 |
2023-11-08 |
rat |
| Hongjia Wang, Xin Lian, Kexin Wang, Shuye Wan. WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2023-11-03. PMID:37921219. |
strikingly, wwp2 knockdown induced apoptosis, accompanied by upregulation of pro-apoptosis proteins cleaved caspase-9, bax and cleaved caspase-3 and downregulation of anti-apoptosis protein bcl-2. |
2023-11-03 |
2023-11-08 |
Not clear |
| Nuray Üremis, Yusuf Türköz, Muhammed Mehdi Üremiş, Yılmaz Çiğremiş, Emine Şalv. Investigating EGFR-VEGF-mediated apoptotic effect of cucurbitacin D and I combination with sorafenib via Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-02. PMID:37917368. |
combined administrations induced apoptosis by increasing caspase-9, bax activity and inhibiting bcl-xl activation, blocking the cell cycle in g2/m phase and causing loss of ΔΨm. |
2023-11-02 |
2023-11-08 |
Not clear |
| Kaitao Wang, Jiapeng Deng, Jialong Yang, An Wang, Minle Ye, Qingyu Chen, Guodong Chen, Dingsheng Li. Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway. Phytotherapy research : PTR. 2023-11-01. PMID:37909161. |
additionally, tetrandrine decreased the expression of bax, which is associated with the induction of apoptosis, and also decreased inflammation in the flap tissue. |
2023-11-01 |
2023-11-08 |
rat |
| Feng Gao, Qifu He, Shenghui Wu, Kang Zhang, Zhiming Xu, Jian Kang, Fusheng Qua. Catalpol ameliorates LPS-induced inflammatory response by activating AMPK/mTOR signaling pathway in rat intestinal epithelial cells. European journal of pharmacology. vol 960. 2023-11-01. PMID:37890606. |
meanwhile, catalpol also inhibited cell apoptosis, decreased the expression of b-cell lymphoma 2 (bcl-2) - associated x (bax), caspase 3 and caspase 9, and increased the expression of bcl-2. |
2023-11-01 |
2023-11-08 |
rat |
| Cui Wang, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yongfeng Wang, Nan Li, Xiangbo Huang, Xiaomei Hu, Nanchang Xi. ATF5 attenuates low-magnesium-induced apoptosis by inhibiting endoplasmic reticulum stress via the regulation of mitochondrial reactive oxygen species. Neuroscience. 2023-11-01. PMID:37913858. |
furthermore, atf5 overexpression rescued low-magnesium-induced neuronal apoptosis, as evidenced by the reduced expression levels of cleaved-caspase-3 and bax, and the restored levels of bcl2. |
2023-11-01 |
2023-11-08 |
Not clear |
| Yiyang Chen, Jesse D Gelles, Jarvier N Mohammed, Jerry Edward Chipu. An optimized high-yield protocol for expression and purification of monomeric full-length BAX protein. bioRxiv : the preprint server for biology. 2023-10-31. PMID:37905126. |
bax, a pro-apoptotic bcl-2 effector, directly forms proteolipid pores in the outer mitochondrial member to activate the mitochondrial pathway of apoptosis. |
2023-10-31 |
2023-11-08 |
human |
| Junwei Li, Wenming Zhao, Jiaqiao Zhu, Shuaibiao Wang, Huiming Ju, Shufang Chen, Athina Basioura, Graça Ferreira-Dias, Zongping Li. Temperature Elevation during Semen Delivery Deteriorates Boar Sperm Quality by Promoting Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 20. 2023-10-30. PMID:37893927. |
an increased temperature during delivery apparently promoted the conversion of sperm early apoptosis to late apoptosis, showing a significant increase in the expression levels of bax and caspase 3. |
2023-10-30 |
2023-11-08 |
Not clear |
| Eman E Mohamed, Osama M Ahmed, Khairy M A Zoheir, Ahmed A G El-Shahawy, Shadi Tamur, Anwar Shams, Jack T Burcher, Anupam Bishayee, Adel Abdel-Monei. Naringin-Dextrin Nanocomposite Abates Diethylnitrosamine/Acetylaminofluorene-Induced Lung Carcinogenesis by Modulating Oxidative Stress, Inflammation, Apoptosis, and Cell Proliferation. Cancers. vol 15. issue 20. 2023-10-30. PMID:37894468. |
regarding the effect on apoptosis, both naringin and nar-dx-ncs significantly reduced bcl-2 and increased bax and p53 expressions. |
2023-10-30 |
2023-11-08 |
rat |
| Sun-Young Hwang, Kwanhwan Wi, Goo Yoon, Cheol-Jung Lee, Soong-In Lee, Jong-Gil Jung, Hyun-Woo Jeong, Jeong-Sang Kim, Chan-Heon Choi, Chang-Su Na, Jung-Hyun Shim, Mee-Hyun Le. Licochalcone D Inhibits Skin Epidermal Cells Transformation through the Regulation of AKT Signaling Pathways. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899745. |
licod also induced apoptosis and increased apoptosis-related proteins such as cleaved-caspase-3, cleaved-caspase-7, and bax (bcl-2-associated x protein). |
2023-10-30 |
2023-11-08 |
Not clear |
| Yasameen Shakir Mahmood, Sarmed Hashim Kathe. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. Journal of medicine and life. vol 16. issue 7. 2023-10-30. PMID:37900084. |
apoptosis was evaluated by renal cleaved caspase-3 and bax levels. |
2023-10-30 |
2023-11-08 |
mouse |
| Barakat M ALRashdi, Roaya A Mohamed, Amal H Mohamed, Feryal A Samoul, Mazen I Mohamed, Mohsen M Moussa, Saad M Alrashidi, Bassel Dawod, Ola A Habotta, Ahmed Abdel Moneim, Shimaa S Ramada. Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress, and cell death in mice kidney. Bioscience reports. 2023-10-30. PMID:37902021. |
tur-senps treatment also restored the renal histological features attained by cddp challenge and hindered renal apoptosis through decreasing the bax levels and increasing bcl-2 levels. |
2023-10-30 |
2023-11-08 |
mouse |
| Yun-Zu Pan, Qiren Liang, Diana R Tomchick, Jef K De Brabander, Josep Riz. Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Communications biology. vol 6. issue 1. 2023-10-26. PMID:37875561. |
however, compounds that preclude beclin 1/bcl-2 binding might also induce apoptosis, which is inhibited by binding of bcl-2 to bh3-domains of pro-apoptosis factors such as bax. |
2023-10-26 |
2023-11-08 |
Not clear |
| Teng Ge, Bo Ning, Yongqing Wu, Xiaolin Chen, Hongfei Qi, Haifang Wang, Mingjun Zha. MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia-reperfusion injury. Molecular and cellular biochemistry. 2023-10-25. PMID:37878166. |
for example, the alteration of mitochondrial structure is facilitated by microrna-1 through the regulation of apoptosis-related proteins, such as bax and bcl-2, thereby mitigating cardiomyocyte apoptosis. |
2023-10-25 |
2023-11-08 |
Not clear |
| Yiwei Liao, Sha Huang, Yuhu Zhang, Honghai Zhang, Haiting Zha. Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice. Cellular and molecular neurobiology. 2023-10-21. PMID:37864627. |
silencing of ccn1 also reduces neuronal damage and apoptosis, decreases mrna and protein expression of proapoptotic proteins bax and caspase-3, increases mrna expression of antiapoptotic protein bcl2. |
2023-10-21 |
2023-11-08 |
mouse |
| Xinmin Guo, Jianru Lin, Liwen Pan, Kun He, Zhihui Huang, Jialin Chen, Cuiyan Lin, Baohui Zeng, Sijia Luo, Mengdie Wan. Ultrasound-triggered release of miR-199a-3p from liposome nanobubbles for enhanced hepatocellular carcinoma treatment. Artificial cells, nanomedicine, and biotechnology. vol 51. issue 1. 2023-10-18. PMID:37850395. |
quantitative reverse transcription-polymerase chain reaction analysis revealed significantly increased mrna expression levels of key apoptosis markers (bad, bax, caspase-9 and caspase-3) in the pfp@mir-rgd-lnbs + lifu group compared to other groups. |
2023-10-18 |
2023-11-08 |
Not clear |
| Yunhu Yu, Yunpeng Cai, Hang Zho. LncRNA SNHG15 regulates autophagy and prevents cerebral ischaemia-reperfusion injury through mediating miR-153-3p/ATG5 axis. Journal of cellular and molecular medicine. 2023-10-17. PMID:37845831. |
compared to cells transfected with nc suppression, cells transfected with mir-153-3p-inhibition had substantially greater overexpression of lc 3 ii/i, atg5, cle-caspase-3, and bax, as determined by a recovery experiment, the apoptosis rate was elevated, yet both p62 and bcl-2 were significantly lower and lc3+ puncta per cells were significantly increased. |
2023-10-17 |
2023-11-08 |
mouse |
| Didem Yilmaz-Oral, Sena F Sezen, Damla Turkcan, Heba Asker, Ecem Kaya-Sezginer, Omer Faruk Kirlangic, Cagla Zubeyde Kopru, Mualla Pınar Elci, Fatma Zeynep Ozen, Petek Korkusuz, Sema Oren, Cetin Volkan Oztekin, Ilker Ates, Serap Gu. Dual Strategy with Adipose-derived Stem Cells and L-arginine Recovered Cavernosal Functions in a Rat Model of Radical Prostatectomy. Stem cells and development. 2023-10-17. PMID:37847152. |
western blot and immunohistochemistry analyses were used to determine the expression and localization of endothelial nitric oxide synthases (enos), neuronal nos (nnos), transforming growth factor-beta 1 (tgf-1), hypoxia-inducible factor-1 (hif-1), and apoptosis markers (bax and bcl-2). |
2023-10-17 |
2023-11-08 |
rat |