| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga O Gnedina, Alisa V Morshneva, Maria V Igott. Sodium Butyrate Enhances the Cytotoxic Effect of Etoposide in HDACi-Sensitive and HDACi-Resistant Transformed Cells. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958894. |
despite the inactivation of bax in hdaci-resistant cells, its accumulation in the cytoplasm upon nabut treatment makes it possible to enhance the apoptotic response against agents activating the intrinsic pathway of apoptosis. |
2023-11-14 |
2023-11-20 |
Not clear |
| Jun Huang, Wentao Jiang, Junping Pan, Xuetao X. Correlation of sLOX-1 and CSF1 with the pathological progression of hypoxic-ischemic encephalopathy in neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953571. |
compared with the blank group, slox-1-si and csf1-si groups showed significantly alleviated hippocampal damage, inhibited neuronal apoptosis, reduced 5-ht, da, ne, bax, and cl-caspase-3, and increased bcl-2 (p<0.05). |
2023-11-13 |
2023-11-20 |
rat |
| Yi Jia, Haiyan Xiao, Xiaolin Wang, Ying Liu, Jiaxin Wang, Haochen Xie, Hai Shang, Guibo Sun, Yu Tia. Design, synthesis, and evaluation of n-butylphthalide and ligustrazine hybrids as potent neuroprotective agents for the treatment of ischemic stroke in vitro and in vivo. Bioorganic chemistry. vol 142. 2023-11-13. PMID:37956636. |
in addition, 7m could regulate the levels of mitochondrial apoptosis pathway-related proteins bcl-2, bax, and caspase 3. |
2023-11-13 |
2023-11-20 |
rat |
| Christophe Le Clorennec, Divya Subramonian, Yuchen Huo, Peter E Zag. UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis. Cell death & disease. vol 14. issue 11. 2023-11-13. PMID:37957138. |
hdac inhibition induced ku70 acetylation, leading to release of c-flipl and bax from ku70, increased ku70 and c-flipl lys48/lys63 branched polyubiquitination via the itch-ube4b complex, and induction of apoptosis. |
2023-11-13 |
2023-11-20 |
Not clear |
| Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei She. Protective effects of melanoidins from black garlic on zearalenone-induced toxicity in zebrafish embryonic developmental model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-11-11. PMID:37951285. |
in addition, co-exposure of mlds significantly inhibited the zen-stimulated cellular apoptosis in zebrafish larvae through down-regulation of pro-apoptotic genes of bax, caspase-3 and caspase-9 and up-regulation of anti-apoptotic gene bcl-2. |
2023-11-11 |
2023-11-20 |
cat |
| Qingqing Wang, Huaifeng Liu, Zhiheng Wang, Yuxin Chen, Shujing Zhou, Xinyi Hu, Yangfei Xu, Xinxin Zhang, Yuanyuan Wang, Yu Gao, Shujing L. Circadian gene Per3 promotes astroblastoma progression through the P53/BCL2/BAX signalling pathway. Gene. 2023-11-11. PMID:37951372. |
the interference of per3 inhibited the migration and invasion of astroblastoma cells, while promoted the astroblastoma cell apoptosis and the expression of the apoptosis genes cleaved-casp3, p53, and bax. |
2023-11-11 |
2023-11-20 |
Not clear |
| Qingqing Wang, Huaifeng Liu, Zhiheng Wang, Yuxin Chen, Shujing Zhou, Xinyi Hu, Yangfei Xu, Xinxin Zhang, Yuanyuan Wang, Yu Gao, Shujing L. Circadian gene Per3 promotes astroblastoma progression through the P53/BCL2/BAX signalling pathway. Gene. 2023-11-11. PMID:37951372. |
the overexpression of per3 promoted the migration and invasion of astroblastoma cells, while inhibited the astroblastoma cell apoptosis and the expression of apoptosis genes cleaved-casp3, p53, and bax. |
2023-11-11 |
2023-11-20 |
Not clear |
| Fang Su, Xin Sui, Jiabao Xu, Qingling Liu, Junfeng Li, Wenhong Liu, Ye Xu, Zhiqian Zhang, Fangfang Ta. Hederagenin suppresses ovarian cancer via targeting mitochondrial fission through dynamin-related protein 1. European journal of pharmacology. 2023-11-11. PMID:37951490. |
furthermore, hederagenin may trigger bax mitochondrial translocation and apoptosis in oc cells. |
2023-11-11 |
2023-11-20 |
mouse |
| Pei-Qi Huang, Kai-Wen Kang, Dan-Yu Huang, Chun-Lin Zhao, Hao Zheng, Yong-Xin Luo, Yan Wen, Ming-Feng Zou, Dong-Li Li, Ri-Hui Wu, Yun-Cai Tian, Yong Tian, Wen-Huan Zhang, Jing-Wei Jin, Sheng Yin, Li-She Ga. Lignan glucosides from Gentiana macrophylla with potential anti-arthritis and hepatoprotective activities. Phytochemistry. 2023-11-11. PMID:37951561. |
flow cytometry and western blot analysis showed that compound 5 ameliorated d-galn induced aml12 cell apoptosis by upregulating the expression of anti-apoptotic bcl-2 protein and down-regulating the expression of pro-apoptotic bax protein. |
2023-11-11 |
2023-11-20 |
human |
| Najmeh Davoodian, Ali Kadivar, Hossein Mehrba. Supplementation of media with gamma-oryzanol as a novel antioxidant to overcome redox imbalance during bovine oocyte maturation in vitro. Reproduction in domestic animals = Zuchthygiene. 2023-11-09. PMID:37942895. |
the treated oocytes and their respective cumulus-granulosa cells showed a modulation in the expression of genes related to apoptosis (downregulation of bax and chop) and oxidative stress (upregulation of nrf2, cat, and sod). |
2023-11-09 |
2023-11-20 |
cat |
| Rashmi Puja, Shubhankar Dutta, Kakoli Bos. Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase2A(VRK2A) with B-cell lymphoma-extra Large(Bcl-xL) to decipher its anti-apoptotic role in cancer. The Biochemical journal. 2023-11-09. PMID:37943248. |
furthermore, this study also put forth a model that highlights the importance of vrk2a in stabilizing the ternary complex, formedwith bcl-xl and bax, thereby impeding bax dissociation and hence apoptosis. |
2023-11-09 |
2023-11-20 |
Not clear |
| Tianyi Liu, Guozhong L. miR-15b-5p transcription mediated by CREB1 protects against inflammation and apoptosis in Parkinson disease models by inhibiting AXIN2 and activating Wnt/β-catenin. Journal of neuropathology and experimental neurology. 2023-11-09. PMID:37944015. |
mir-15b-5p overexpression or axin2 knockdown alleviated the inflammatory response indicated by decreased levels of tnf-α, il-6, and il-1β and apoptosis indicated by decreased levels of cleaved caspase-3 and bax and elevated bcl-2. |
2023-11-09 |
2023-11-20 |
mouse |
| Di Li, Kaixuan Zhang, Chenchen Xu, Yangyang Jiang, Jianhua Shan, Ziwei Zhang, Jingzeng Ca. Cypermethrin induces apoptosis, autophagy and inflammation via ERS-ROS-NF-κB axis in hepatocytes of carp (Cyprinus carpio). Pesticide biochemistry and physiology. vol 196. 2023-11-09. PMID:37945258. |
we also found that cyp exposure increased the expression levels of endoplasmic reticulum-related genes (grp78, perk, ire-1, atf-6 and chop), apoptosis (bcl-2, bax, caspase-3, caspase-9 and cyt-c) and autophagy-related genes (lc3b, beclin1 and p62) also showed dose-dependent changes, and the expression levels of inflammation-related genes (nf-κb, tnf-α, il-1β, il-6) were also significantly elevated. |
2023-11-09 |
2023-11-20 |
cat |
| Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li, Meirong Li, Duo Xu, Zixi Yang, Xingwang Sun, Tao Yi. ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma. Scientific reports. vol 13. issue 1. 2023-11-09. PMID:37945707. |
in addition, adora2a also impacted the expression of apoptosis-related proteins, including bcl-2, bax, cleaved caspase-3 and cleaved caspase-9, and reduced apoptosis. |
2023-11-09 |
2023-11-20 |
human |
| Harika Atmaca, Suleyman Ilhan, Buse Aysen Dundar, Metin Zor. Bioevaluation of Spiro N-Propargylic β-Enaminones as Anti-Breast Cancer Agents: In Vitro and Molecular Docking Studies. Chemistry & biodiversity. 2023-11-08. PMID:37837366. |
spes induced apoptosis and caused significant changes in bcl-2 and bax levels. |
2023-11-08 |
2023-11-20 |
human |
| Li Zhao, Zhengliang Zhang, Ping Li, Yanxia Gao, Yu Sh. Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-06. PMID:37930390. |
bak also repressed pulmonary apoptosis by decreasing bax expression and enhancing bcl-2 expression. |
2023-11-06 |
2023-11-08 |
rat |
| Li Zhao, Zhengliang Zhang, Ping Li, Yanxia Gao, Yu Sh. Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-06. PMID:37930390. |
bak also suppressed cell apoptosis, reduced bax expression, and increased bcl-2 expression. |
2023-11-06 |
2023-11-08 |
rat |
| Vadavanath Prabhakaran Vineetha, Hemla Naik Tejaswi, Nediyirippil Suresh Sooraj, Sweta Das, Devika Pilla. Implications of deltamethrin on hematology, cardiac pathology, and gene expression in Nile tilapia (Oreochromis niloticus) and its possible amelioration with Shatavari (Asparagus racemosus). Veterinary research communications. 2023-11-06. PMID:37930611. |
significant modulations were observed in the expression of cardiac-specific genes (gata4, myh6, tnt, cox1) and apoptosis signaling genes and proteins (hsp70, bax, bcl-2, caspase3), in the cotreatment group compared to the dm-exposed group. |
2023-11-06 |
2023-11-08 |
Not clear |
| Mohd Afzal, Abdullah Alarifi, Naaser A Y Abduh, Arusha Ayub, Mohd Muddassi. Identification of anti-cancer organometallic compounds by inhibition of BCL-2/Bax interactions. Computers in biology and medicine. vol 167. 2023-11-06. PMID:37931525. |
apoptosis is regulated by the bcl-2 family, which includes the anti-apoptotic and pro-apoptotic proteins (bax, bok, bak, etc.). |
2023-11-06 |
2023-11-08 |
human |
| Atakan Karagöz, Merih Beler, Büşra Dilara Altun, İsmail Ünal, Derya Cansız, Hüseyin Gündüz, Ahmet Ata Alturfan, Ebru Emekli-Alturfan, Şebnem Erçalık Yalçınkay. Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos. Journal of stomatology, oral and maxillofacial surgery. vol 124. issue 6S. 2023-11-04. PMID:37866507. |
expressions of genes related with inflammation (tnfα, il6, ill15, il21), immunoregulation (ifng) and apoptosis (p53, bax, casp2, casp3, casp8) were determined by rt-pcr. |
2023-11-04 |
2023-11-08 |
zebrafish |