| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong Li, DaJing Su, HuaWen Lu, YunQing Gao, YongGang Liu, ShaoHua Wang, YuTing Hou, KeMin Qin, XianTing Que, XiaoPing Chen, BaiLing Qin, ZiJun Wang, Yan Den. Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway. Experimental brain research. 2023-10-17. PMID:37847304. |
cell apoptosis in hippocampus tissues of model mice was inhibited by rhbnp which was shown as the reduced tunel-positive cells, the decreased bax, cleaved caspase-3, and cleaved caspase-9 protein levels, and the enhanced bcl-2 protein level. |
2023-10-17 |
2023-11-08 |
mouse |
| Zuhair M Mohammedsaleh, Emad H M Hassanein, Fares E M Ali, Hanan S Althagafy, Nouf S Al-Abbas, Ahmed M Atw. Perindopril Dampens Cd-induced Nephrotoxicity by Suppressing Inflammatory Burden, Ang II/Ang 1-7, and Apoptosis Signaling Pathways. Biological trace element research. 2023-10-17. PMID:37848587. |
per inhibits cd-induced apoptosis by lowering bax, cytochrome c, and cleaved caspase 3 expressions while increasing bcl-2 expression. |
2023-10-17 |
2023-11-08 |
rat |
| Xingfu Shu, Jinxian Su, Yu Zhao, Chun Liu, Yao Chen, Xiaomei Ma, Zifan Wang, Jialin Bai, Haixia Zhang, Zhongren M. Regulation of HeLa cell proliferation and apoptosis by bovine lactoferrin. Cell biochemistry and function. 2023-10-16. PMID:37842864. |
furthermore, blf primarily induced apoptosis in hela cells by increasing the expression of the proapoptotic proteins p53, bax, and cleaved-caspase-3 and downregulating the expression of the antiapoptotic protein bcl-2. |
2023-10-16 |
2023-11-08 |
cattle |
| Nora M Aborehab, Maha M Salama, Shahira M Ezza. A novel lupene derivative from Thymus capitatus possesses an apoptosis-inducing effect via Let-7 miRNA/Cyclin D1/VEGF cascade in the A549 cell line. BMC complementary medicine and therapies. vol 23. issue 1. 2023-10-16. PMID:37845669. |
our results revealed that the three isolated compounds alup, lup, and ba caused cell cycle arrest at the g2/m phase with an increase in the apoptosis which may be attributed to their significant effect on raising bax, casp-8, and cd95 and reducing the mrna expression levels of bcl-2, kras, vegf, and cyclin d1 compared to control cells. |
2023-10-16 |
2023-11-08 |
Not clear |
| Doaa Ibrahim, Safaa I Khater, Ahmed Abdelfattah-Hassan, Leena S Alqahtani, Aya Shawky Mohamed Metwally, Sh M Bazeed, Aya Elgamal, Nagwa I Sheraiba, Elham M Hussein, Fatmah Ali Alasmary, Gamal A Salem, Mohamed Ali, Hala Mahfou. Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: an in vivo experimental model. International journal of pharmaceutics. 2023-10-15. PMID:37839495. |
liponio.br remarkably reduced crc development compared to fbr (free berberine), as it induced apoptosis via upregulating apoptotic genes (bax and caspase3, increased up to 7.89 and 6.25-fold, respectively) and downregulating the anti-apoptotic gene bcl-2 by 2.25-fold. |
2023-10-15 |
2023-11-08 |
rat |
| Qinghan Ren, Guoquan Zhang, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li, Jing Ya. SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833955. |
sam/sah mediates parental folate deficiency-induced neural cell apoptosis in neonatal rat offspring: the expression of bcl-2, bax, and caspase-3. |
2023-10-14 |
2023-10-15 |
rat |
| Kimberly B Johansson, Megan S Zimmerman, Iryna V Dmytrenko, Feng Gao, Daniel C Lin. Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia. 2023-10-14. PMID:37838759. |
treatment with idasanutlin, an mdm2 inhibitor, induced only modest apoptosis in t-all cells but upregulated the pro-apoptotic bh3 domain genes bax and bbc3, prompting us to evaluate the combination of idasanutlin with bh3 mimetics. |
2023-10-14 |
2023-11-08 |
Not clear |
| Su-Ji Jeon, Eun-Young Choi, Eun-Ji Han, Sang-Woo Lee, Jun-Mo Moon, Soo-Hyun Jung, Ji-Youn Jun. Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells. International journal of molecular medicine. vol 52. issue 6. 2023-10-13. PMID:37830157. |
and pl induced apoptosis by decreasing the expression of the anti‑apoptotic protein bcl‑2 and increasing that of the pro‑apoptotic proteins cleaved‑parp and bax. |
2023-10-13 |
2023-10-15 |
human |
| Chuang Liu, Haoyi Feng, Jinyi Han, Hao Zhou, Liwei Yuan, Hongshuang Pan, Xiaohan Wang, Xuelei Han, Ruimin Qiao, Feng Yang, Xinjian L. Effect of L-proline on sperm quality during cryopreservation of boar semen. Animal reproduction science. vol 258. 2023-10-13. PMID:37832280. |
total sperm motility, progressive motility, survival time at 37 °c, acrosome integrity, mitochondrial activity, dna integrity, the content of the lipid peroxidation product malondialdehyde (mda), total antioxidant capacity (t-aoc) and, expression levels of apoptosis protein (cleaved caspase 3 and bax) were evaluated after thawing. |
2023-10-13 |
2023-10-15 |
Not clear |
| Chuang Liu, Haoyi Feng, Jinyi Han, Hao Zhou, Liwei Yuan, Hongshuang Pan, Xiaohan Wang, Xuelei Han, Ruimin Qiao, Feng Yang, Xinjian L. Effect of L-proline on sperm quality during cryopreservation of boar semen. Animal reproduction science. vol 258. 2023-10-13. PMID:37832280. |
the expression levels of apoptosis protein (cleaved caspase 3 and bax) in the 10 mm l-proline supplemented group were lower than those in the control group. |
2023-10-13 |
2023-10-15 |
Not clear |
| Mohammed Yahya Awad Al-Salih, Vahid Pouresmaeil, Fatemeh Davoodi-Dehaghani, Hasti Nasiraei Haghighi, Masoud Homayouni Tabriz. Preparation and characterization of bovine serum albumin nanoparticles conjugated with folic acid and loaded with PEGylated thymol and evaluation of their anticancer properties. Chemistry & biodiversity. 2023-10-12. PMID:37823866. |
the subg1 phase arrest and increase in apoptotic cells in fluorescent staining, along with decreased expression of bcl-2 and increased expression of bax gene demonstrated the induction of apoptosis in treated cells. |
2023-10-12 |
2023-10-15 |
cattle |
| Tianyu Guan, Jianbin Feng, Qianqian Zhu, Long Wang, Peng Xie, Hui Wang, Jiale L. Effects of abamectin on nonspecific immunity, antioxidation, and apoptosis in red swamp caryfish (Procambarus clarkii). Fish & shellfish immunology. 2023-10-12. PMID:37827246. |
through tunel observation and apoptosis-related genes (pcctsl, bcl-2, bax, bi-1, pccytc, caspase-3) expression levels, with increasing abamectin concentration, apoptosis rate increased significantly. |
2023-10-12 |
2023-10-15 |
cat |
| W Chen, H DU, Y Sha, Y Zhou, J Liang, Y Chen, Q Ma, X Wu, G Qia. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 9. 2023-10-10. PMID:37814860. |
to investigate whether long noncoding rna h19 (lncrna h19) induces vascular calcification by promoting calcium deposition, osteogenic differentiation and apoptosis via inhibiting the bax inhibitor 1/optic atrophy 1 (bi-1/ opa1) pathway. |
2023-10-10 |
2023-10-15 |
Not clear |
| Nan Nan, Xiao-Li DU, Miao Chen, Jia-Qi Lu. [Qirong Tablets inhibits apoptosis of ovarian granulosa cells via PI3K/Akt/ HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 17. 2023-10-06. PMID:37802816. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling(tunel) assay was used to detect the apoptosis of granulosa cells, and western blot to determine the expression levels of b-cell lymphoma-2(bcl-2), bcl-2-associated x protein(bax), caspase-3, pi3k, akt, and hif-1. |
2023-10-06 |
2023-10-15 |
mouse |
| X Li, P Sung, D Zhang, L Ya. Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition. Physiological research. vol 72. issue 4. 2023-10-05. PMID:37795892. |
ogd/r-mediated apoptosis was suppressed by curcumin via upregulating b-cell lymphoma-2 (bcl-2) and downregulating bcl-associated x (bax), cleaved-caspase3 and tunel apoptosis marker. |
2023-10-05 |
2023-10-07 |
Not clear |
| Zhu Zhu, Ruixue Liao, Yang Shi, Jingyan Li, Jimin Cao, Bin Liao, Jianming Wu, Guang L. Polystyrene nanoplastics induce apoptosis of human kidney proximal tubular epithelial cells via oxidative stress and MAPK signaling pathways. Environmental science and pollution research international. 2023-10-04. PMID:37792190. |
mechanistically, transcriptional sequencing indicated the involvement of mapk pathway in apoptosis, which was further confirmed by the upregulation of p-p38, p-erk, chop, bax, cytochrome c, and caspase 3 expression. |
2023-10-04 |
2023-10-07 |
human |
| Mingming Han, Shayan Wang, Xuehua Zhou, Pengfei Zhang, Zhengyuan Han, Yang Chen, Haijian Cai, Lina Wu, Xiaoying Huang, Liangxing Wang, Yanfan Che. Baicalin alleviates bleomycin-induced early pulmonary fibrosis in mice via the mitoKATP signaling pathway. Toxicology. 2023-10-02. PMID:37783230. |
on day 14 of treatment, the levels of fibrosis and apoptosis were evaluated in mouse lungs via hydroxyproline analysis, western blotting (col1a1, tgf-β, bax, bcl-2, cleaved caspase-3), and masson, immunohistochemical (α-sma, aif, cyto c), and tunel staining. |
2023-10-02 |
2023-10-07 |
mouse |
| Mingming Han, Shayan Wang, Xuehua Zhou, Pengfei Zhang, Zhengyuan Han, Yang Chen, Haijian Cai, Lina Wu, Xiaoying Huang, Liangxing Wang, Yanfan Che. Baicalin alleviates bleomycin-induced early pulmonary fibrosis in mice via the mitoKATP signaling pathway. Toxicology. 2023-10-02. PMID:37783230. |
additionally, in vitro, apoptosis was assessed in mle-12 cells exposed to blm for 24h using the annexin v/pi assay and western blotting (bax, bcl-2, cleaved caspase-3, aif, cyto c). |
2023-10-02 |
2023-10-07 |
mouse |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
lca promoted excessive ros production, decreased mitochondrial membrane potential, and upregulated the expression of bax, caspase3 and caspase-9, all of which are involved in apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Zheng-Fa Li, Jia-Kun Feng, Xiao-Chen Zhao, Wei Liu, Shi-An Gu, Rui Li, Yang-Liu Lu, Rui-Jiao Mao, Li-Ling Xia, Lu-Lu Dong, Li-Wen Zhang, Jing-Yan Ruan, Jiao Liu, Guang-Fen Li, Tao Li, Rong Sun, Shui-Lan Qiu, Zhong-Zheng Zheng, Ting Don. The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice. Transplantation proceedings. 2023-09-30. PMID:37777366. |
the extract of pinellia ternata-induced apoptosis of leukemia cells by regulating the expression of bax, bcl-2 and caspase-3 protein expression in mice. |
2023-09-30 |
2023-10-07 |
mouse |