| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajia Shen, Hang Yang, Xinran Qiao, Yang Chen, Liyun Zheng, Jingyu Lin, Jingyu Lang, Qiang Yu, Zhen Wan. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Cell death and differentiation. 2023-09-11. PMID:37697039. |
the e3 ubiquitin ligase trim17 promotes gastric cancer survival and progression via controlling bax stability and antagonizing apoptosis. |
2023-09-11 |
2023-10-07 |
human |
| Jiajia Shen, Hang Yang, Xinran Qiao, Yang Chen, Liyun Zheng, Jingyu Lin, Jingyu Lang, Qiang Yu, Zhen Wan. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Cell death and differentiation. 2023-09-11. PMID:37697039. |
mechanistically, trim17 acts to interact with bax and promote its ubiquitination and proteasomal degradation, leading to a deficiency in bax-dependent apoptosis in gc cells in the absence and presence of apoptosis stimuli. |
2023-09-11 |
2023-10-07 |
human |
| Jiajia Shen, Hang Yang, Xinran Qiao, Yang Chen, Liyun Zheng, Jingyu Lin, Jingyu Lang, Qiang Yu, Zhen Wan. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Cell death and differentiation. 2023-09-11. PMID:37697039. |
our data thus suggest trim17 contributes to gastric cancer survival through regulating bax protein stability and antagonizing apoptosis, which provides a promising therapeutic target for gc treatment and a biomarker for prognosis. |
2023-09-11 |
2023-10-07 |
human |
| Liang Li, Xiao-Fang Wei, Zhi-Yong Yang, Rui Zhu, Deng-Lai Li, Guo-Jun Shang, Hao-Tong Wang, Si-Tong Meng, Yin-Tao Wang, Si-Ying Liu, Li-Fang W. Alleviative effect of poly-β-hydroxybutyrate on lipopolysaccharide-induced oxidative stress, inflammation and cell apoptosis in Cyprinus carpio. International journal of biological macromolecules. 2023-09-10. PMID:37690640. |
appropriate level of phb alleviated lps-induced inflammation and apoptosis by up-regulating tgf-β, il-10 and bcl-2 mrna, down-regulating nf-κb, tnf-α, il-6, bax, caspase-3, caspase-8 and caspase-9 mrna. |
2023-09-10 |
2023-10-07 |
cat |
| Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhan. Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37684994. |
zea also caused apoptosis in porcine small intestine cells, resulting in a significant reduction in protein and/or mrna expression of apoptosis-related pathway factors such as p53, caspase 3, caspase 9, bax, and cyt-c, which in turn caused a significant decrease in protein and/or mrna expression of inflammatory-related factors such as il-1β, il-2, cox-2, nf-κd, nlrp3, il-6, and il -18, which in turn caused a significant increase in protein and/or mrna expression levels. |
2023-09-09 |
2023-10-07 |
cat |
| Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. |
herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). |
2023-09-09 |
2023-10-07 |
zebrafish |
| Qian Yu, Tianwei Lan, Zhina Ma, Zhanlei Wang, Chunmei Zhang, Yichuan Jiang, Zhongyan Zha. Lobaplatin induces apoptosis in T24 and 5637 bladder cancer cells by regulating Bcl-2 and Bax expression and inhibiting the PI3K/Akt signaling pathway. Translational andrology and urology. vol 12. issue 8. 2023-09-08. PMID:37680227. |
lobaplatin induces apoptosis in t24 and 5637 bladder cancer cells by regulating bcl-2 and bax expression and inhibiting the pi3k/akt signaling pathway. |
2023-09-08 |
2023-10-07 |
Not clear |
| Qiuxiang Cai, Yajuan Li, Yung-Fu Chang, Zhaoxin Tang, Hui Zhang, Qingmei Xi. Pasteurella multocida causes liver injury in ducks by mediating inflammatory, apoptotic and autophagic pathways. Microbial pathogenesis. 2023-09-08. PMID:37683832. |
tumor necrosis factor induced hepatocyte apoptosis was implicated in a wide range of liver diseases; the release of tnf-α and activation with nf-κb further incite apoptotic pathways,such as bax/bcl2/caspase to promote apoptotic genes apaf1, bax, caspase3, bcl-2, p53, and cytc expression. |
2023-09-08 |
2023-10-07 |
Not clear |
| Huanyi Liu, Hongjin Lin, Tong Xu, Xu Shi, Yujie Yao, Pervez Ahmed Khoso, Zhihui Jiang, Shiwen X. New insights into brain injury in chickens induced by bisphenol A and selenium deficiency-Mitochondrial reactive oxygen species and mitophagy-apoptosis crosstalk homeostasis. The Science of the total environment. 2023-09-08. PMID:37683847. |
in addition, the results of immunofluorescence and flow cytometry analysis, as well as the elevated expressions of mitophagy related genes (pink1, parkin, atg5, and lc3ii/i) and pro-apoptotic markers (bax, cytc, caspase3, and caspase9) indicated that bpa exposure and se deficiency disrupted the crosstalk homeostasis between mitophagy and apoptosis. |
2023-09-08 |
2023-10-07 |
chicken |
| Jing-Yao Li, Xi-Ang Sun, Xin Wang, Ning-Hao Yang, Hong-Yan Xie, Heng-Jiang Guo, Li Lu, Xin Xie, Li Zhou, Jun Liu, Wei Zhang, Li-Min L. PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release. Acta pharmacologica Sinica. 2023-09-08. PMID:37684381. |
knockdown of bax attenuated pgam5 overexpression-induced cyt c release and tubular cell apoptosis. |
2023-09-08 |
2023-10-07 |
mouse |
| Jing-Yao Li, Xi-Ang Sun, Xin Wang, Ning-Hao Yang, Hong-Yan Xie, Heng-Jiang Guo, Li Lu, Xin Xie, Li Zhou, Jun Liu, Wei Zhang, Li-Min L. PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release. Acta pharmacologica Sinica. 2023-09-08. PMID:37684381. |
our results demonstrated that the increase in pgam5-mediated bax dephosphorylation and mitochondrial translocation was implicated in the development of aki by initiating mitochondrial cyt c release and activating the mitochondria-dependent apoptosis pathway. |
2023-09-08 |
2023-10-07 |
mouse |
| Jianyong Dong, Jun Cui, Xuanxuan Shi, Tao Wang, Shaohua Li. Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway. Heliyon. vol 9. issue 9. 2023-09-07. PMID:37674841. |
moreover, itraconazole induced apoptosis of hemecs by activating the expression of bax and inhibiting the expression of bcl2. |
2023-09-07 |
2023-10-07 |
human |
| Chunguang Sun, Lin Lia. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023-09-06. PMID:37670707. |
antithyroid cancer studies of shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial-mesenchymal transition; induced cell cycle arrest; induced dna damage and apoptosis by producing excessive reactive oxygen species; upregulated bax; increased the stability of p53; decreased the expression of mdm2; downregulated slug and mmp-2, mmp-9, and mmp-14; repressed the phosphorylation of erk and akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of dnmt1; reduced the pten gene methylation; increased the expression of pten, leading to the inhibition of migration; increased lc3-ii to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βii-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. |
2023-09-06 |
2023-10-07 |
mouse |
| Ana F B Silva, Ana N P Morais, Laritza F Lima, Anna C A Ferreira, Renato F Silva, Naiza A R Sá, Satish Kumar, Ariclécio C Oliveira, Benner G Alves, Ana P R Rodrigues, Eduardo L Gastal, Vilceu Bordignon, José R Figueired. Trimethylation profile of histones H3 lysine 4 and 9 in late preantral and early antral caprine follicles grown in vivo versus in vitro in the presence of anethole. Molecular reproduction and development. 2023-09-06. PMID:37671983. |
uncultured in vivo-grown follicles (pa, n = 64; ea, n = 73) were used as controls to assess the methylation profile and genes' expression related to apoptosis cascade (bax, proapoptotic; bcl2, antiapoptotic), steroidogenesis (cyp17, cyp19a1), and demethylation (kdm1ax1, kdm1ax2, kdm3a). |
2023-09-06 |
2023-10-07 |
Not clear |
| Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Ha. Solasonine ameliorates cerebral ischemia-reperfusion injury via suppressing TLR4/MyD88/NF-κB pathway and activating AMPK/Nrf2/HO-1 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-06. PMID:37672972. |
we also found that ss protected neurons from ogd/r-induced apoptosis by down-regulating bax and cleaved caspase-3 and up-regulating bcl-2. |
2023-09-06 |
2023-10-07 |
mouse |
| Yan Li, Huiwen Hou, Zengmei Liu, Wen Tang, Jie Wang, Lu Lu, Jiaai Fu, Didi Gao, Feiyan Zhao, XinQing Gao, Peixue Ling, Fengshan Wang, Feng Sun, Haining Ta. CD44 targeting nanodrug based on chondroitin sulfate for melanoma therapy by inducing mitochondrial apoptosis pathways. Carbohydrate polymers. vol 320. 2023-09-02. PMID:37659829. |
it also has been confirmed that ccea induced tumor cell apoptosis through promoting the expression of bax, suppressing the expression of bcl-2, decreasing mitochondrial membrane potential, releasing cytochrome c (cyto c), and enhancing the activities of caspase 9 and caspase 3. |
2023-09-02 |
2023-09-07 |
mouse |
| Alexander V Sirotkin, Richard Alexa, Abdullah Alshamrani, Abdel Halim Harrat. Fennel affects porcine ovarian cell functions: The interrelationships with the environmental contaminant benzene. Research in veterinary science. vol 164. 2023-09-01. PMID:37657392. |
the expression of the proliferation marker pcna and the apoptosis marker bax was analyzed by quantitative immunocytochemistry and enzyme-linked immunosorbent assay (elisa). |
2023-09-01 |
2023-09-07 |
Not clear |
| Banghua Zhang, Zhi-Yuan Chen, Zhengyu Jiang, Shiyu Huang, Xiu-Heng Liu, Lei Wan. Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis. Journal of agricultural and food chemistry. 2023-08-30. PMID:37646396. |
furthermore, experimental data validated that cad evidently decreased the reactive oxygen species (ros) production and malondialdehyde (mda) content while depressing the mrna and protein expression of inflammatory markers (tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), and il-1β) and inhibiting apoptosis as evidenced by decreased levels of p53, bax, cleaved caspase-3, and apoptotic rate in renal i/r and uuo models. |
2023-08-30 |
2023-09-07 |
human |
| Xin Li, Feiyang Gou, Kan Xiao, Jiang Zhu, Qian Lin, Minjie Yu, Qihua Hong, Caihong H. Effects of DON on Mitochondrial Function, Endoplasmic Reticulum Stress, and Endoplasmic Reticulum Mitochondria Contact Sites in the Jejunum of Piglets. Journal of agricultural and food chemistry. 2023-08-29. PMID:37643317. |
don was also found to induce mitochondrial dysfunction, trigger endoplasmic reticulum stress (ers) in the piglets' jejunum, and activate mitochondrial and er apoptosis pathways by upregulating apoptosis-related proteins (caspase-8, caspase-12, bax, and chop). |
2023-08-29 |
2023-09-07 |
Not clear |
| Seyed Mehdi Vatandoust, Javad Mahmoudi, Shahrbanoo Oryan, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Siamak Sandoghchian Shotorbani, Huaxi Xu, Delaram Eslimi Esfahan. Sericin improves memory and sociability impairments evoked by transient global cerebral ischemia through suppression of hippocampal oxidative stress, inflammation, and apoptosis. The Chinese journal of physiology. vol 66. issue 4. 2023-08-28. PMID:37635480. |
markers of apoptosis (pro- and cleaved caspase-9 and 3, bax, and bcl-2) were assessed by western blotting. |
2023-08-28 |
2023-09-07 |
mouse |