| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hoa Dinh, Zsuzsanna Z A Kovács, Fanni Márványkövi, Merse Kis, Klaudia Kupecz, Gergő Szűcs, Marah Freiwan, Gülsüm Yilmaz Lauber, Eylem Acar, Andrea Siska, Katalin Eszter Ibos, Éva Bodnár, András Kriston, Ferenc Kovács, Péter Horváth, Imre Földesi, Gábor Cserni, Bruno K Podesser, Peter Pokreisz, Attila Kiss, László Dux, Krisztina Csabafi, Márta Sárköz. The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Scientific reports. vol 13. issue 1. 2023-08-28. PMID:37640761. |
however, the higher dose of p234 led to reduced anterior and posterior wall thicknesses, more severe interstitial fibrosis, and overexpression of genes associated with left ventricular remodeling (ctgf, tgfb, col3a1, mmp9), stretch (nppa), and apoptosis (bax, bcl2, casp7) compared to the ckd group. |
2023-08-28 |
2023-09-07 |
rat |
| Marzena Szwed, Sylwia Michlewska, Katarzyna Kania, Marta Szczęch, Agnieszka Marczak, Krzysztof Szczepanowic. New SDS-Based Polyelectrolyte Multicore Nanocarriers for Paclitaxel Delivery-Synthesis, Characterization, and Activity against Breast Cancer Cells. Cells. vol 12. issue 16. 2023-08-26. PMID:37626862. |
in addition, ptx-loaded ncs triggered apoptosis and upregulated the transcription of bax, aif, cytochrome-c, and caspase-3 mrna. |
2023-08-26 |
2023-09-07 |
Not clear |
| Shanbin Chen, Dong Zhao, Chunguang Luan, Jia Zheng, Wei Liu, Zheng Feng, Ruiqi Luo, Xinglin Han, Deliang Wan. Ferulic Acid Induces Autophagy and Apoptosis in Colon Cancer CT26 Cells via the MAPK Pathway. Molecules (Basel, Switzerland). vol 28. issue 16. 2023-08-26. PMID:37630266. |
furthermore, fa inhibited the proliferation of ct26 cells and induced apoptosis, specifically by activating the phosphorylation of erk and jnk to enhance the essential proteins bcl-2 and bax in the apoptosis pathway. |
2023-08-26 |
2023-09-07 |
Not clear |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
hyperthyroidism significantly decreased the cardiac expression level of sirt1/pgc1α and its downstream involved in the regulation of mitochondrial biogenesis, mitophagy, and antioxidant enzyme activities including tfam, pink1/mfn2, drp1, and nrf2, respectively, as well as stimulated mitochondrial-dependent apoptosis by reducing bcl-2 expression and increasing bax expression. |
2023-08-26 |
2023-09-07 |
rat |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
moreover, dize suppressed apoptosis by normalizing the cardiac expression levels of bax and bcl-2. |
2023-08-26 |
2023-09-07 |
rat |
| Mirzahossein Norouzi Kamareh, Mohammad Samadi, Ehsan Arabzadeh, Mahkameh Abdollahi, Sadra Sheidaei, Shahin Riyahi Malayeri, Jeffrey Schlicht, Hossein Shirvani, Fatemeh Rostamkhan. The effect of 24-hour sleep deprivation and anaerobic exercise on the expression of BAX, BCL2, BMAL1 and CCAR2 genes in peripheral blood mononuclear cells after L-arginine supplementation. Gene. 2023-08-25. PMID:37625565. |
since a number of studies have shown the anti-apoptotic effect of l-arginine, so the aim of this study was to evaluate the effect of eight weeks of l-arginine supplementation on the expression of brain and muscle arnt-like protein 1 (bmal1), cell cycle and apoptosis regulator 2 (ccar2), and bax and bcl2 genes during sleep deprivation and acute anaerobic exercise. |
2023-08-25 |
2023-09-07 |
human |
| Jae Eun Park, Ji Sook Ha. Scopoletin protects INS-1 pancreatic β cells from glucotoxicity by reducing oxidative stress and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2023-08-24. PMID:37619648. |
these effects influenced the apoptosis pathway, raising levels of anti-apoptotic protein, bcl-2, and reducing levels of pro-apoptotic proteins, including jnk, bax, cytochrome c, and caspase 9. |
2023-08-24 |
2023-09-07 |
Not clear |
| - Liu Xianchu, - Liu Min. Roles of Ferulic acid on muscle atrophy and grip strength in diabetic mice. Pakistan journal of pharmaceutical sciences. vol 36. issue 4. 2023-08-21. PMID:37599475. |
lastly, ga increased bax expressions and decreased bcl-2 expressions to attenuate high glucose-mediated apoptosis. |
2023-08-21 |
2023-09-07 |
mouse |
| Yunpeng Luo, Na Hu, Yang Zhao, Jian Lai, Xi Luo, Jingchen Li. Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. Experimental and therapeutic medicine. vol 26. issue 3. 2023-08-21. PMID:37602306. |
however, rsv restored sirt1 protein expression, downregulated the expression of the pro-apoptotic protein bax, upregulated the expression of the anti-apoptotic protein bcl-2, decreased the apoptosis rate of the cells and increased cell viability. |
2023-08-21 |
2023-09-07 |
Not clear |
| Jinxia Zhai, Chao Wang, Liang Jin, Fangtao Liu, Yinzhu Xiao, Hongfeng Gu, Mingjie Liu, Yongjun Che. Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy. Molecular neurobiology. 2023-08-21. PMID:37605097. |
gut microbiota metabolites mediate bax to reduce neuronal apoptosis via cgas/sting axis in epilepsy. |
2023-08-21 |
2023-09-07 |
mouse |
| Jinxia Zhai, Chao Wang, Liang Jin, Fangtao Liu, Yinzhu Xiao, Hongfeng Gu, Mingjie Liu, Yongjun Che. Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy. Molecular neurobiology. 2023-08-21. PMID:37605097. |
the reduction of bax protein attenuated the hippocampal neuron cell apoptosis in ptz-induced ep and ep progression. |
2023-08-21 |
2023-09-07 |
mouse |
| Ning Zhang, Yong Liu, Fang-Yuan Tang, Lin-Yuan Yang, Jun-Hui Wan. Structural characterization and in vitro anti-colon cancer activity of a homogeneous polysaccharide from Agaricus bisporus. International journal of biological macromolecules. 2023-08-20. PMID:37598827. |
it promoted apoptosis and inhibited epithelial mesenchymal transition of ht-29 by up-regulating the expression of caspase-3, bax and e-cadherin proteins and down-regulating the expression of bcl-2 and vimentin proteins. |
2023-08-20 |
2023-09-07 |
Not clear |
| MuLan Bao, RenGui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Chen. Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation. European journal of pharmacology. 2023-08-20. PMID:37598923. |
bcl2 apoptosis regulator (bcl-2), pro-apoptotic bcl-2 protein bax, epidermal growth factor receptor (egfr), and receptor tyrosine phosphatase type c (ptprc) were screened for inflammation and microglia in the above targets by network pharmacology. |
2023-08-20 |
2023-09-07 |
Not clear |
| Mengqi Lu, Jingya Ruan, Rui Yu, Ying Zhang, Wei Zhao, Dingshan Yang, Wanxia Wang, Yi Zhang, Tao Wan. Neolignan derivatives from Penthorum chinense with antitumor activity in human colorectal cancer cells by regulating Wnt/β-catenin signaling pathway. Phytochemistry. vol 214. 2023-08-19. PMID:37595774. |
then, functional technologies such as the 5-ethyny1-2'-deoxyridine, wound healing, transwell, and western blot assays indicated that they could significantly inhibit the proliferation of ht29 and lovo cells, promote apoptosis by up-regulating bax, and down-regulating b-cell cll/lymphoma 2 and poly adp-ribose polymerase. |
2023-08-19 |
2023-09-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Fang Wang, Yinghong Yu, Gongjian He, Zhangxia Ren, Sizhe X. Downregulation of miR-4284 can inhibit the apoptosis of Human Arterial Smooth Muscle Cells (HASMCs) in arteriosclerosis obliterans (ASO). Combinatorial chemistry & high throughput screening. 2023-08-18. PMID:37594113. |
a western blot technique was used to identify b cell lymphoma-2 (bcl2), bcl2-associated x protein (bax), as well as x-linked inhibitors of apoptosis protein (xiap). |
2023-08-18 |
2023-09-07 |
human |
| Tianchao Xu, Jie Cui, Ran Xu, Jingwen Cao, Meng-Yao Gu. Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp. Aquatic toxicology (Amsterdam, Netherlands). vol 262. 2023-08-16. PMID:37586228. |
the nf-κb pathway (p-p65, iκbα), inflammatory cytokines (tnf-α, il-8, il-6) and apoptosis genes (bax, caspase3) were upregulated. |
2023-08-16 |
2023-09-07 |
Not clear |
| Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Gu. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience reports. 2023-08-15. PMID:37581369. |
our results showed that: (i) mir-21 overexpression or hipk3 downregulation significantly attenuated h9c2 cells apoptosis after h/r; (ii) suppression of mir-21 expression promoted apoptosis; (iii) mir-21 overexpression inhibited hipk3 expression; (iv) hipk3 was the direct and main target of mir-21; (v) mir-21/hipk3 formed part of a reciprocal, negative feedback loop; and (vi) hipk3 downregulation decreased fas-mediated apoptosis by inhibiting the phosphorylation of fadd, which subsequently inhibited the expression of bax and cleaved caspase-3 and increased the expression of bcl2. |
2023-08-15 |
2023-09-07 |
rat |
| Mohsen Alipour, Reza Sheikhnejad, Mohamad Hassan Fouani, Hassan Bardania, Saman Hosseinkhan. DNAi-peptide nanohybrid smart particles target BCL-2 oncogene and induce apoptosis in breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-13. PMID:37573657. |
it is also known that bcl-2 binds to and inactivates bax and other pro-apoptotic proteins, thereby inhibiting apoptosis. |
2023-08-13 |
2023-08-16 |
Not clear |
| Yaping Wang, Yi Wu, Mengen Xu, Muhammad Fakhar-E-Alam Kulyar, Mudassar Iqbal, Jingyi Wu, Xin Deng, Yaqiong Zhang, Bingtong Jiang, Mengmeng Hu, Yi Zhao, Kun Li, Yanyun Ch. Protective effects of Emblica officinalis polysaccharide against lead induced liver injury in mice model. International journal of biological macromolecules. 2023-08-13. PMID:37573920. |
the key proteins involved in hepatic oxidative stress and apoptosis, including nrf2, ho-1, bcl-2, and bax were quantified, which indicated eop as an effective approach in protecting against the liver injury induced by pb. |
2023-08-13 |
2023-08-16 |
mouse |