| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| So-Young Lee, Geun-Hye Hong, Ji Hyung Chung, Kun-Young Par. Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. Journal of medicinal food. 2023-07-27. PMID:37498372. |
besides, wdsd regulated the protein expression of apoptosis (bcl-2-associated x protein [bax], b cell lymphoma-2 [bcl-2], b cell lymphoma-extra large [bcl-xl], and caspase 9, caspase 3), and p53, p21, and proinflammatory cytokines (interleukin [il]-6, tumor necrosis factor [tnf]- |
2023-07-27 |
2023-08-14 |
mouse |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. |
2023-07-27 |
2023-08-14 |
Not clear |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. |
2023-07-27 |
2023-08-14 |
Not clear |
| Nora M Aborehab, Mai A Abd-Elmawla, Abeer M ElSayed, Omar Sabry, Shahira M Ezza. Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes. Bioorganic chemistry. vol 139. 2023-07-25. PMID:37490810. |
the present study has proven that the underlying mechanism of acovenoside a is partially attributed to the upregulation of mir-630 and mir-181a gene expressions which in turn targets the intrinsic apoptosis genes as p53, bax and bcl2 as well as caspase 3. |
2023-07-25 |
2023-08-14 |
Not clear |
| Sema Serter Kocoglu, Ceren Oy, Mücahit Secme, F Bahar Suna. Investigation of the anticancer mechanism of monensin via apoptosis-related factors in SH-SY5Y neuroblastoma cells. Clinical and translational science. 2023-07-21. PMID:37477356. |
monensin caused apoptosis by increasing caspase-3, 7, 8, and 9 expressions and decreasing bax and bcl-2 expressions in neuroblastoma cells. |
2023-07-21 |
2023-08-14 |
Not clear |
| Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N Joshi, Johan Spetz, Xingping Qin, Sneh M Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A Sarosie. Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX. Cancer research. 2023-07-20. PMID:37470810. |
xrt induced apoptosis in primed neural cells by triggering a p53- and puma-initiated, pro-apoptotic feedback loop requiring cleavage of bid and culminating in bax oligomerization and caspase activation. |
2023-07-20 |
2023-08-14 |
mouse |
| Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N Joshi, Johan Spetz, Xingping Qin, Sneh M Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A Sarosie. Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX. Cancer research. 2023-07-20. PMID:37470810. |
notably, loss of bax protected against apoptosis induced by pro-apoptotic signaling in vitro and prevented xrt-induced apoptosis in neural cells in vivo as well as neurocognitive sequelae. |
2023-07-20 |
2023-08-14 |
mouse |
| Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N Joshi, Johan Spetz, Xingping Qin, Sneh M Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A Sarosie. Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX. Cancer research. 2023-07-20. PMID:37470810. |
based on these findings, preventing xrt-induced apoptosis specifically in immature neural cells by blocking bax, bim or bid via direct or upstream mechanisms is expected to ameliorate neurocognitive impairment in pediatric cns tumor patients. |
2023-07-20 |
2023-08-14 |
mouse |
| Sibel Çiğdem Tuncer, Serkan Ali Akarsu, Sefa Küçükler, Cihan Gür, Fatih Mehmet Kandemi. Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue. Environmental toxicology. 2023-07-20. PMID:37471654. |
while the levels of apoptosis markers bax, caspase-3, and apaf-1 increased in rats treated with pbac, the level of bcl-2 decreased, but snp inhibited this apoptosis markers. |
2023-07-20 |
2023-08-14 |
rat |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
besides, bbf led to apoptosis in leydig cells, and decreased expressions of p-akt and bcl2, while improving the expressions of p53, bax and cleaved caspase-3 in vivo and in vitro. |
2023-07-20 |
2023-08-14 |
mouse |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
similarly, p53 inhibitor pifithrin-α also significantly enhanced the cell vitality, alleviated the apoptosis of tm3 cells induced by bbf, and decreased the expressions of bax and cleaved caspase-3, with the up-regulation of bcl2. |
2023-07-20 |
2023-08-14 |
mouse |
| Jing He, Xiaoxiang Xi, Peng Cao, Jinxia Zhou, Hui Liu, Na L. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial-mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-07-19. PMID:37465347. |
downregulation of lncrna gnas-as1 remarkably suppressed cell proliferation, promoted cell apoptosis, decreased b-cell lymphoma-2 (bcl-2) expression, enhanced the bcl-2-associated x (bax) level, promoted e-cadherin expression, and reduced n-cadherin and rab3a levels. |
2023-07-19 |
2023-08-14 |
Not clear |
| Jun Du, Yingquan Zhuo, Xu Sun, Meilan Nie, Jiafei Yang, Xi Luo, Huajian G. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-07-19. PMID:37465351. |
the expression of proteins associated with apoptosis (bax and bcl-2) and the proteins associated with wnt/β-catenin (wnt, p-gsk-3β, gsk-3β, β-catenin, and c-myc) were quantified by western blotting. |
2023-07-19 |
2023-08-14 |
Not clear |
| Lin Kong, Jian Wang, Yunxiu Zhang, Ke Liang, Jian Li, Xiaokuang Xue, Tiejin Chen, Jiechao Ge, Pengfei Wan. Lysosome-targeted silicon quantum dots theranostics for simultaneous fluorescent imaging and photodynamic therapy. Biomedical materials (Bristol, England). 2023-07-19. PMID:37467765. |
furthermore, the results of cell experiments showed that l-si qds was accumulated in lysosomes after being taken up by cancer cells, and can efficiently produce 1o2 upon 635 nm laser irradiation, which can damage lysosomes, up-regulate cleavage caspase-3, increase bax release, down-regulate bcl-2 and induce cell apoptosis finally. |
2023-07-19 |
2023-08-14 |
Not clear |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| Yizhuo Luo, Yunlong Yang, Wenru Wang, Qi Gao, Ting Gong, Yongzhi Feng, Dongdong Wu, Xiaoyu Zheng, Guihong Zhang, Heng Wan. Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway. Virology journal. vol 20. issue 1. 2023-07-19. PMID:37468960. |
additionally, ae promoted apoptosis by upregulating the expression levels of cleaved-caspase3 and bax proteins and downregulating the expression levels of bcl-2 proteins. |
2023-07-19 |
2023-08-14 |
Not clear |
| Ashish Verma, Nilesh Rai, Priyamvada Gupta, Swati Singh, Harshita Tiwari, Shashi Bhushan Chauhan, Vikas Kailashiya, Vibhav Gauta. Exploration of in vitro cytotoxic and in ovo antiangiogenic activity of ethyl acetate extract of Penicillium oxalicum. Environmental toxicology. 2023-07-18. PMID:37461856. |
furthermore, the treatment of ea extract of p. oxalicum mediates apoptosis by increasing the expression of bax, p21, fadd, and caspase-8 genes, with increased caspase-3 activity. |
2023-07-18 |
2023-08-14 |
human |
| Yi Wang, Wei Zhang, Guozheng Xu, Changwei Shi, Xiang Wang, Jianfeng Qu, Hongmei Wang, Chunhua Li. The role of TRPV4 in the regulation of retinal ganglion cells apoptosis in rat and mouse. Heliyon. vol 9. issue 7. 2023-07-17. PMID:37456002. |
therefore, the expression of bax and caspase 9 increased, along with the apoptosis rate of rgcs compared with the control group. |
2023-07-17 |
2023-08-14 |
mouse |
| Yi Wang, Wei Zhang, Guozheng Xu, Changwei Shi, Xiang Wang, Jianfeng Qu, Hongmei Wang, Chunhua Li. The role of TRPV4 in the regulation of retinal ganglion cells apoptosis in rat and mouse. Heliyon. vol 9. issue 7. 2023-07-17. PMID:37456002. |
however, after trpv4 antagonist treatment, the expression of bax and caspase 9 decreased, and the apoptosis rate of rgcs decreased. |
2023-07-17 |
2023-08-14 |
mouse |
| Yi Wang, Wei Zhang, Guozheng Xu, Changwei Shi, Xiang Wang, Jianfeng Qu, Hongmei Wang, Chunhua Li. The role of TRPV4 in the regulation of retinal ganglion cells apoptosis in rat and mouse. Heliyon. vol 9. issue 7. 2023-07-17. PMID:37456002. |
thus, trpv4 may affect the mitochondrial apoptosis pathway, such as bax and caspase 9, leading to the apoptosis of rgcs. |
2023-07-17 |
2023-08-14 |
mouse |