| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yina Huang, Lu Zhang, Lingping Tan, Chi Zhang, Xiting Li, Panpan Wang, Li Gao, Chuanjiang Zha. Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis. Inflammation. 2023-06-13. PMID:37310646. |
we found that interleukin-22 inhibited apoptosis of gingival epithelial cells during periodontitis in vivo and in vitro, decreasing bax expression and increasing bcl-xl expression. |
2023-06-13 |
2023-08-14 |
mouse |
| Yaping Gan, Ting Liu, Weifeng Feng, Liang Wang, L I Li, Yingxia Nin. Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways. Oncology research. vol 31. issue 3. 2023-06-12. PMID:37305383. |
mechanistically, dsf treatment significantly reduced the expression of the anti-apoptosis marker b-cell lymphoma/leukemia-2 (bcl-2) and increase the expression of the apoptotic molecules bcl2 associated x (bax) and cleaved caspase-3 to promote human epithelial ovarian cancer cell apoptosis. |
2023-06-12 |
2023-08-14 |
human |
| Yahiya Ibrahim Yahiya, Najah Rayish Hadi, Ahmed Abu Raghif, Noor Ghaffar Said Al Haboob. Protective effect of IAXO-102 on renal ischemia-reperfusion injury in rats. Journal of medicine and life. vol 16. issue 4. 2023-06-12. PMID:37305825. |
iaxo-102 also decreased apoptosis by reducing pro-apoptotic bax and increasing anti-apoptotic bcl-2 without impacting hsp27. |
2023-06-12 |
2023-08-14 |
rat |
| Rui Zhang, Wanjun Tao, Lei Y. Overexpression of long non-coding RNA GASL1 induces apoptosis and G0/G1 cell cycle arrest in human oral cancer cells. Acta biochimica Polonica. 2023-06-12. PMID:37307139. |
overexpression of gasl1 led to the loss of viability of hn6 oral cancer cells by inducing apoptosis which was associated with upregulation of bax and downregulation of bcl-2. |
2023-06-12 |
2023-08-14 |
human |
| Esraa Almalki, Abdullah Al-Amri, Reem Alrashed, Mohamed Al-Zharani, Abdelhabib Semlal. The Curcumin Analog PAC Is a Potential Solution for the Treatment of Triple-Negative Breast Cancer by Modulating the Gene Expression of DNA Repair Pathways. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298600. |
these data have been established by the gene expression and indicate that pac-induced apoptosis by an increased bax and decreased bcl-2 expression. |
2023-06-11 |
2023-08-14 |
human |
| Mengyue Li, Geng Yang, Yue Zheng, Jiazhen Lv, Wanyi Zhou, Hanxi Zhang, Fengming You, Chunhui Wu, Hong Yang, Yiyao Li. NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy. Journal of nanobiotechnology. vol 21. issue 1. 2023-06-10. PMID:37301952. |
the downregulated bcl-2 and upregulated bax, cyt c, and cleaved caspase-3 indicate that the synergistic chemo-phototherapeutic effect of toadi induces the apoptosis of 4t1 cells, causing ~ 80% cell death. |
2023-06-10 |
2023-08-14 |
mouse |
| Haibo Dong, Wei Guo, Zhanxiang Zho. BAX/MLKL signaling contributes to lipotoxicity-induced lysosomal membrane permeabilization in alcohol-associated liver disease. Autophagy. 2023-06-08. PMID:37289043. |
we identified that the apoptotic protein bax (bcl2 associated x, apoptosis regulator) could recruit mlkl (mixed lineage kinase domain-like pseudokinase), a necroptotic executive protein, to lysosomes and induce lmp in various ald models. |
2023-06-08 |
2023-08-14 |
Not clear |
| Boru Hou, Dengfeng Wang, Cheng Jiang, Gang Wang, Dong Wang, Guizhong Yan, Xiumei Guo, Lixia Zhao, Zhuangzhuang Wan, Chenlong Fan, Wencheng Cao, Haijun Re. Neuroprotective Effects of Vinpocetine against Ischemia-Reperfusion Injury via Inhibiting NLRP3 Inflammasome Signaling Pathway. Neuroscience. 2023-06-08. PMID:37290685. |
vinpocetine can effectively inhibit the apoptosis of peri-infarct neurons, promote the expression of bcl-2, inhibit the expression of bax and cleaved caspase-3, and reduce the proliferation of peri-infarct microglia. |
2023-06-08 |
2023-08-14 |
mouse |
| Demiana H Sami, Ayman S Soliman, Akef A Khowailed, Reem S Alruhaimi, Emad H M Hassanein, Emadeldin M Kamel, Ayman M Mahmou. The protective effect of 7-hydroxycoumarin against cisplatin-induced liver injury is mediated via attenuation of oxidative stress and inflammation and upregulation of Nrf2/HO-1 pathway. Environmental science and pollution research international. 2023-06-08. PMID:37291353. |
liver nuclear factor (nf)-κb p65, inducible no synthase (inos), pro-inflammatory cytokines, bax, and caspase-3 were upregulated, and antioxidant defenses and bcl-2 were decreased in cis-treated rats, while 7-hc prevented liver injury and ameliorated os, inflammatory and apoptosis markers. |
2023-06-08 |
2023-08-14 |
rat |
| Min Yan, Lan Zhang, Lu-Lu Zhang, Zhen-Qiang Zhang, Hua-Hui Zeng, Xiang-Xiang W. [Effects of intranasal administration of tripterygium glycoside-bearing liposomes on behavioral cognitive impairment of mice induced by central nervous system inflammation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 9. 2023-06-07. PMID:37282872. |
neuronal cell damage was reduced, and the expression levels of inflammation and apoptosis related genes [tumor necrosis factor-α(tnf-α), interleukin-1β(il-1β), bcl2-associated x(bax), etc.] |
2023-06-07 |
2023-08-14 |
mouse |
| Yi Yang, Yan-E Hu, Mao-Yuan Zhao, Yi-Fang Jiang, Xi Fu, Feng-Ming Yo. [Decursin affects proliferation, apoptosis, and migration of colorectal cancer cells through PI3K/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 9. 2023-06-07. PMID:37282862. |
compared with the control group, decursin significantly inhibited the proliferation and colony number and promoted the apoptosis of ht29 and hct116 cells, and it significantly down-regulated the expression of bcl-2 and up-regulated the expression of bax. |
2023-06-07 |
2023-08-14 |
Not clear |
| Zong-Xing Zhang, Lu Jiang, Dao-Zhong Liu, Bo-Nan Tao, Zi-Ming Hou, Meng-Jie Tian, Jia Feng, Lin Yua. [Alcohol extract of root and root bark of Toddalia asiatica alleviates CIA in rats through anti-inflammatory and proapoptotic effects]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282908. |
in addition, rt-qpcr and western blot results showed that taae up-regulated the level of bax, down-regulated the level of bcl-2, and activated caspase-3 to promote apoptosis in synoviocytes. |
2023-06-07 |
2023-08-14 |
rat |
| Yu-Guo Wang, Yong-Qi Dou, Zi-Qiao Yan, Yue Ga. [Molecular mechanism of ginsenoside Rg_1 against radiation enteritis: based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 10. 2023-06-07. PMID:37282941. |
cellular experiment indicated that rg_1 can effectively improve cell viability and survival, decrease apoptosis after irradiation, promote the expression of akt1 and b-cell lymphoma-extra large(bcl-xl), and inhibit the expression of the pro-apoptotic protein bcl-2-associated x protein(bax). |
2023-06-07 |
2023-08-14 |
Not clear |
| Shu-Shong Hsu, Yung-Shang Lin, Hui-Ching Chen, Wei-Zhe Lian. Involvement of oxidative stress-related apoptosis in chlorpyrifos-induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells. Environmental toxicology. 2023-06-07. PMID:37283489. |
additionally, chlorpyrifos induced apoptosis by upregulating the protein levels of bax and cleaved caspase-9/caspase-3 and by downregulating the protein levels of bcl-2. |
2023-06-07 |
2023-08-14 |
human |
| Beril Kurban, Tuğba Tuncel, Şennur Görgülü, Fatih Kar, Alper Öztürk, Temel Öze. Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway. Journal of cellular and molecular medicine. 2023-06-07. PMID:37285457. |
bax and bcl-2 genes were studied with qrt-pcr to investigate the different ways that cancer cells undergo apoptosis. |
2023-06-07 |
2023-08-14 |
human |
| Kaihui Xie, Qiaoli Yang, Zunqiang Yan, Xiaoli Gao, Xiaoyu Huang, Pengfei Wang, Jie Li, Jiyou Li, Zike Wang, Yi Gao, Shuangbao Gu. Overexpression of SIRT1 alleviates oxidative damage and barrier dysfunction in CPB2 toxin-infected IPEC-J2 cells. Microbial pathogenesis. 2023-06-05. PMID:37276895. |
the results indicated that overexpression of sirt1 suppressed reactive oxygen species (ros) generates, the expression tumor necrosis factor-α (tnf-α), interleukin (il)-6 and bax, nuclear factor-kappa b (nf-κb p65), phospho (p)-nf-kb p65 and lactate dehydrogenase (ldh) activity and apoptosis in cpb2 toxin-treated ipec-j2 cells, and increased il-10, mitochondrial membrane potential (ΔΨm), bcl-2, claudin1 and occludin levels and cell viability. |
2023-06-05 |
2023-08-14 |
Not clear |
| Siwen Li, Jiaqi Xie, Xinlian Li, Qiuyue Li, Xiaoqing Tang, Dongke Yu, Xuan Xion. Genistein protects benzotriazole ultraviolet stabilizer UV-234-induced hepatotoxicity by modulating ROS/Nrf2 and NF-κB signaling in yellow catfish (Pelteobagrus fulvidraco). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-06-03. PMID:37269917. |
meanwhile, we confirmed that genistein supplement protected liver apoptosis induced by uv-234 via suppressing up-regulated expression levels of pro-apoptotic genes (bax, caspase3). |
2023-06-03 |
2023-08-14 |
Not clear |
| Hengjie Yuan, Ye Tian, Rongcai Jiang, Yuanzhi Wang, Meng Nie, Xiaochun Li, Yifan He, Xuanhui Liu, Ruiting Zhao, Jingyue Zhan. Susceptibility to Hepatotoxic Drug-induced Liver Injury Increased after Traumatic Brain Injury in Mice. Journal of neurotrauma. 2023-06-02. PMID:37265124. |
the results suggested that liver injury induced in the early stages of brain injury recovered in three days, but this state could still significantly aggravate dili, represented by higher liver enzymes (ast and alt), oxidative stress (increase in malondialdehyde concentration and deregulation of glutathione and superoxide dismutase activities), inflammatory response (activation of hmgb1/tlr4/nf-κb signaling pathway, and increased mrna and protein levels of pro-inflammatory cytokines including tnf-α, il-6, and il-1β), and apoptosis (tunel assay, upregulation of bax protein and deregulation of bcl-2 protein). |
2023-06-02 |
2023-08-14 |
mouse |
| Peijun Liu, Pan Zhou, Xinyue Zhang, Dong Zhao, Hao Chen, Ke H. Pterostilbene mediates glial and immune responses to alleviate chronic intermittent hypoxia-induced oxidative stress in nerve cells. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267263. |
the protein levels of p-erk1/2, tlr4, p-p38, p-p65, and bax, apoptosis rate, mda concentration, bcl-2 protein level, cell viability, and sod and gsh-px concentrations decreased after the activation of bv2 cells. |
2023-06-02 |
2023-08-14 |
mouse |
| Zi Ye, Xiaomin Guan, Wenyuan Shan, Baojun M. OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating MiR-128-3p/BAX axis. Preventive medicine. 2023-06-02. PMID:37268172. |
oip5-as1 interacts with mir-128-3p to overexpress bcl2-associated x (bax), thereby modulating cell apoptosis in ep cell models.oip5-as1 accelerates apoptosis of hippocampal neurons in cell models of ep by modulating mir-128-3p/bax axis. |
2023-06-02 |
2023-08-14 |
Not clear |