| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Şeyma Osmanlıoğlu, Mustafa Arslan, Rumeysa Osmanlıoğlu Dağ, Zeynep Yığman, Müşerref Şeyma Ceyhan, Fatma Er, Mustafa Kavutç. Artemisinin reduces acute ovarian ischemia-reperfusion injury in rats. Reproductive toxicology (Elmsford, N.Y.). 2023-06-01. PMID:37263547. |
furthermore, i/r injury resulted in a significant increase in apoptosis as shown by the increased levels of bax and casp-3, and decreased levels of bcl-2 whereas ars significantly reduced the impact of the injury. |
2023-06-01 |
2023-08-14 |
rat |
| Jie Wu, Xin Huang, Zhongqing Xiao, Qi Wang, Liufan Mu, Shanshan Yang, Shaoyi Miao, Jing Chen, Xinjie Deng, Chaoyang Deng, Hongyun L. Nano-Pt induced mitochondria-dependent apoptosis and cytoprotective autophagy in human NSCLC cells. Colloids and surfaces. B, Biointerfaces. vol 227. 2023-05-31. PMID:37257302. |
nano-pt also reduced mitochondrial membrane potential (mmp), increased permeability transition, and promoted apoptosis by upregulating bax and parp expression. |
2023-05-31 |
2023-08-14 |
human |
| Yixin Zhang, Yikang Wang, Yaozu Yang, Dongmei Zhao, Ruimeng Liu, Sihong Li, Xiuying Zhan. Proteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis. Ecotoxicology and environmental safety. vol 260. 2023-05-31. PMID:37257342. |
itpr2-activated endoplasmic reticulum stress-related proteins (calpain1, calpaini2, bcl-2, bax, cl-caspase-12, cl-caspase-3), apoptosis (parp) and pyroptosis (dfna5) related proteins were examined by western blotting. |
2023-05-31 |
2023-08-14 |
mouse |
| Jing Zhao, Meini Le, Jie Li, Qiong Huang, Haocong Chen, Wenyi Zhang, Huiwen Mao, Qing Sun, Aiguo Li, Yingmin Zhao, Lingling Yu, Mingjiang Yi, Jie Wang, Xinyuan Li, Guangming Zhang, Jun Ma, Xiaohua Don. LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway. Experimental neurology. 2023-05-31. PMID:37257715. |
knockdown of linc00938 induced the neural cell apoptosis by increased the protein level of bax, cleaved-caspase3 and decreased the expression of bcl-2. |
2023-05-31 |
2023-08-14 |
Not clear |
| Chenjun Guo, Xiaona Ning, Jie Zhang, Chen Zhang, Jue Wang, Liping Su, Jing Han, Nan M. Ultraviolet B radiation induces oxidative stress and apoptosis in human lens epithelium cells by activating NF-κB signaling to down-regulate sodium vitamin C transporter 2 (SVCT2) expression. Cell cycle (Georgetown, Tex.). 2023-05-29. PMID:37246402. |
svct2 abated apoptosis and bax expression and increased bcl-2 expression. |
2023-05-29 |
2023-08-14 |
human |
| Jian-Fei Wu, Yu Liu, San-Ni Gong, Xiang-Dong Zi, You-Guo Ta. Effects of vascular endothelial growth factor (VEGF) on the viability, apoptosis and steroidogenesis of yak (Bos grunniens) granulosa cells. Theriogenology. vol 207. 2023-05-28. PMID:37245256. |
this treatment significantly reduced gc apoptosis (p < 0.05) by promoting the expression of bcl2 and gdf9 (p < 0.01) and inhibiting the expression of bax and caspase3 (p < 0.05). |
2023-05-28 |
2023-08-14 |
Not clear |
| Mohamed F Balaha, Ahmed A Alamer, Alaa A Eisa, Hashim M Aljohan. Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades. Antibiotics (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237729. |
these potentials could be attributed to the modulation of the renal sirt1/nrf2/ho-1, tlr-4/nf-κb/mapk, and pi3k/akt cascades, which enhanced the renal antioxidant system and suppressed renal inflammation and apoptosis, as indicated by enhancements of sirt1, nrf2, ho-1, gsh, sod, tac, iκb-α, bcl-2, pi3k, and akt levels and mrna expressions, with reduction of tlr-4, nf-κb, mapk, il-1β, tnf-α, mda, inos, no, cytochrome c, caspase-3, bax levels, and bax/bcl-2 ratio. |
2023-05-27 |
2023-08-14 |
rat |
| Xiaojin Xu, Chenhan Mao, Chengbo Zhang, Meng Zhang, Jianbin Gong, Xindong Wan. Salvianolic Acid B Inhibits Ferroptosis and Apoptosis during Myocardial Ischemia/Reperfusion Injury via Decreasing the Ubiquitin-Proteasome Degradation of GPX4 and the ROS-JNK/MAPK Pathways. Molecules (Basel, Switzerland). vol 28. issue 10. 2023-05-27. PMID:37241859. |
sab downregulates jnk phosphorylation and the expression of bcl2-associated x (bax)/b-cell lymphoma-2 (bcl-2) and caspase-3 to inhibit apoptosis. |
2023-05-27 |
2023-08-14 |
rat |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Wenzhao Li, Cheng Tao, Minzhi Mao, Kewei Zh. The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis. Acta biochimica et biophysica Sinica. 2023-05-26. PMID:37232576. |
il-1β stimulation induces cell apoptosis, upregulates the mrna expression of inflammatory factors, decreases aggrecan, col2a1, and bcl-2 levels but increases adamts-5, adamts-4, mmp13, cleaved caspase 3, and bax levels, and promotes p65 phosphorylation. |
2023-05-26 |
2023-08-14 |
Not clear |
| Mamdoh S Moawadh, Rashid Mir, Faris J Tayeb, Orooba Asim, Mohammad Fahad Ulla. Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic ( Current issues in molecular biology. vol 45. issue 5. 2023-05-26. PMID:37232720. |
molecular evaluation of the impact of polymorphic variants in apoptotic ( the regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of bcl2 and bax. |
2023-05-26 |
2023-08-14 |
Not clear |
| Sameh M Shabana, Nahla S Gad, Azza I Othman, Aly Fahmy Mohamed, Mohamed Amr El-Missir. β-caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 7. 2023-05-26. PMID:37233859. |
in treated a549 cells, this was also associated with a significant induction of apoptosis, as shown by the upregulation of the expression of caspases 3, 7, and 9, as well as bax, and the downregulation of bcl-2. |
2023-05-26 |
2023-08-14 |
human |
| Sameh M Shabana, Nahla S Gad, Azza I Othman, Aly Fahmy Mohamed, Mohamed Amr El-Missir. β-caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 7. 2023-05-26. PMID:37233859. |
these events cause arrest of cell cycle which was associated with significant induction in apoptosis via increase expression of caspases (-3,-7,-9), and bax and downregulation of bcl-2. |
2023-05-26 |
2023-08-14 |
human |
| Xiu-Juan Liu, Jin-Lei Lv, Xin Zou, Yan-Yan Yu, Hong-Xia Zhou, Yu Wu, Yan-Qiu Geng, Cai-Hua Li. MiR-21 alleviates renal tubular epithelial cells injury induced by ischemia by targeting TLR4. Heliyon. vol 9. issue 5. 2023-05-26. PMID:37234634. |
overexpression of mir-21 decreased the protein expressions of cleaved caspase-3, bax, p53, cell apoptosis and increased bcl-2 expression in hk-2 cells with ogd injury. |
2023-05-26 |
2023-08-14 |
Not clear |
| Yan Li, Ying Zhang, Lei Gua. MiR-708 regulates the biological behavior of childhood leukemia cells by binding to the 3'utr end of the target gene and reducing the level of the target gene. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 2. 2023-05-25. PMID:37224029. |
the results showed that the cell proliferation inhibition rate, apoptosis rate, g1 phase ratio, bax protein, and cntfr protein in the mir-708 overexpression group were significantly lower than those in the control group at each time point, while the s phase ratio, bcl-2 protein, cell migration ability, jak3 and stat3 protein were significantly higher than those in the control group (p<0.05). |
2023-05-25 |
2023-08-14 |
human |
| Jiang Chen, Chao Xie, Zhen Y. Protective effect of dihydromyricetin against lipopolysaccharide-induced HK2 cells by upregulating HIF-1α. Biotechnology & genetic engineering reviews. 2023-05-25. PMID:37226671. |
the expression of hif-1α mrna and protein, cleaved caspase-3, bax protein, mda and ldh levels, and apoptosis rate were significantly decreased, while bcl-2 protein, cell viability, and sod activity were markedly increased in the lps+dhm group compared with the lps and lps+dhm+si-hif-1α groups. |
2023-05-25 |
2023-08-14 |
human |
| Amirabbas Rahimi, Morteza Karimipoor, Reza Mahdian, Atefeh Alipour, Saadi Hosseini, Marzieh Mohammadi, Hooman Kaghazian, Abdolrahim Abbasi, Hosein Shahsavarani, Mohammad Ali Shokrgoza. Efficient CRISPR/Cas9-Mediated BAX Gene Ablation in CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production. Iranian journal of biotechnology. vol 21. issue 2. 2023-05-25. PMID:37228627. |
efficient crispr/cas9-mediated bax gene ablation in cho cells to impair apoptosis and enhance recombinant protein production. |
2023-05-25 |
2023-08-14 |
Not clear |
| Wen-Juan Lin, Wen-Pu Shi, Wan-Yi Ge, Liang-Liang Chen, Wei-Hong Guo, Peng Shang, Da-Chuan Yi. Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441. Research (Washington, D.C.). vol 6. 2023-05-25. PMID:37228640. |
a decrease in the number of free hk molecules increased the chance of bax binding to vdac i, leading to increased bax-mediated apoptosis. |
2023-05-25 |
2023-08-14 |
Not clear |
| Wen-Juan Lin, Wen-Pu Shi, Wan-Yi Ge, Liang-Liang Chen, Wei-Hong Guo, Peng Shang, Da-Chuan Yi. Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441. Research (Washington, D.C.). vol 6. 2023-05-25. PMID:37228640. |
in the presence of a static mf, llps was marked inhibited and hk recruitment was reduced, resulting in an increased probability of hk binding to vdac i and a decreased probability of bax binding to vdac i, thus reducing bax-mediated apoptosis. |
2023-05-25 |
2023-08-14 |
Not clear |
| Roua Chaabani, Mohamed Bejaoui, Mohamed Amine Zaouali, Hassen Ben Abdenneb. Protective Effects of Diclofenac on Liver Graft Preservation. Canadian journal of physiology and pharmacology. 2023-05-24. PMID:37224567. |
transcription factors (ppar-γ and nf-κb), inflammation (cox-2, il-6, hmgb-1 and tlr-4) as well as apoptosis markers (bcl-2 and bax) were determined by quantitative rt-pcr. |
2023-05-24 |
2023-08-14 |
rat |