| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Sung Choi, Ji Hyeon Kim, Chae Yeon Lee, Yul Min Lee, Sukmook Lee, Ha Kyun Chang, Hyun Jung Kim, Kyun He. Gentian Violet Inhibits Cell Proliferation through Induction of Apoptosis in Ovarian Cancer Cells. Biomedicines. vol 11. issue 6. 2023-06-28. PMID:37371752. |
moreover, gv significantly increased reactive oxygen species (ros) and upregulated the expression of p53, puma, bax, and p21, critical components for apoptosis induction, in ovarian cancer cells. |
2023-06-28 |
2023-08-14 |
Not clear |
| Sara A Al-Kenany, Nada N Al-Shaw. Protective effect of cafestol against doxorubicin-induced cardiotoxicity in rats by activating the Nrf2 pathway. Frontiers in pharmacology. vol 14. 2023-06-28. PMID:37377932. |
in addition, cafestol significantly inhibited dox-induced cardiac oxidative stress as seen in the reduced level of mda and increased gsh, sod, cat, and gpx-1 cardiac tissue levels; cafestol significantly enhanced nrf2 gene and protein expression and promoted the expression of downstream antioxidant genes ho-1 and nqo-1 and downregulated keap1 and nf-κb genes' expression; in addition, caf significantly reduced inflammatory mediators, tnf-α, and il-1β levels and inhibited cardiac apoptosis by modulating bax and casp 3 tissue levels and reduced tunel-positive cardiomyocytes. |
2023-06-28 |
2023-08-14 |
rat |
| Dong-Ni Liu, Man Liu, Shan-Shan Zhang, Yu-Fu Shang, Wen-Fang Zhang, Fu-Hang Song, Hua-Wei Zhang, Guan-Hua Du, Yue-Hua Wan. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro. Marine drugs. vol 21. issue 6. 2023-06-27. PMID:37367654. |
western blotting revealed that chr-a disturbed the balance between bax and bcl-2, activating a caspase cascade reaction and downregulating the expression of p-akt and p-gsk-3β, suggesting that chr-a may contribute to glioblastoma regression modulating in the akt/gsk-3β signaling pathway to promote apoptosis of neuroglioma cells in vivo and in vitro. |
2023-06-27 |
2023-08-14 |
mouse |
| Ramin Masoudi, Ali Mohammadi, Solmaz Morovati, Amir Ali Heidari, Mehdi Asad-Sangab. Induction of apoptosis in colorectal cancer cells by matrix protein of PPR virus as a novel anti-cancer agent. International journal of biological macromolecules. 2023-06-27. PMID:37369256. |
by using bioinformatics modeling, we hypothesized that the m protein could interact with bax factor through its bh3-like motif and could further activate the intrinsic apoptosis pathway. |
2023-06-27 |
2023-08-14 |
Not clear |
| Lorena Polloni, Tássia Rafaella Costa, Lorena Pinheiro Morais, Bruna Cristina Borges, Samuel Cota Teixeira, Thales Alves de Melo Fernandes, Lucas Ian Veloso Correia, Luciana Machado Bastos, Fernanda Gobbi Amorim, Loïc Quinton, Andreimar Martins Soares, Marcelo José Barbosa Silva, Eloisa Amália Vieira Ferro, Daiana Silva Lopes, Veridiana de Melo Rodrigues Ávil. Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the cellular invasion process in vitro. Cellular signalling. 2023-06-26. PMID:37364850. |
pollonein-laao was able to increase the intracellular ros generation that culminates in cell death from apoptosis by both intrinsic and extrinsic pathways due to the up-regulation of tp53, bax, bad, tnfrsf10b and casp8. |
2023-06-26 |
2023-08-14 |
Not clear |
| Peng Huang, Jinliang Du, Liping Cao, Jiancao Gao, Quanjie Li, Yi Sun, Nailin Shao, Yuning Zhang, Gangchun X. Effects of prometryn on oxidative stress, immune response and apoptosis in the hepatopancreas of Eriocheir sinensis (Crustacea: Decapoda). Ecotoxicology and environmental safety. vol 262. 2023-06-25. PMID:37356403. |
histopathology showed that prometryn damaged the structure of the hepatopancreas cells and induced apoptosis, suggesting that the pi3k-akt signaling pathway may be involved in the damage process of hepatopancreas cells (pi3k, pdk and akt were downregulated whereas bax was upregulated), leading to their apoptosis. |
2023-06-25 |
2023-08-14 |
cat |
| Alexander V Sirotkin, Adam Tarko, Zuzana Fabova, Igor Valocky, Saleh Alwasel, Jan Kotwica, Abdel Halim Harrat. Can flaxseed, chia or puncture vine affect mare ovarian cell functions and prevent the toxic effect of the environmental contaminant toluene? Theriogenology. vol 208. 2023-06-24. PMID:37354861. |
markers of cell proliferation (accumulation of proliferating cell nuclear antigen, pcna) and apoptosis (accumulation of bax), viability (trypan blue extrusion) and the release of progesterone (p), oxytocin (ot) and prostaglandin f 2 alpha (pgf) were measured. |
2023-06-24 |
2023-08-14 |
Not clear |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
flow cytometry was used to detect cardiomyocyte apoptosis rate, and the expression levels of b cell lymphoma 2 (bcl2) and bcl2-related x protein (bax) were tested by western blot analysis. |
2023-06-21 |
2023-08-14 |
mouse |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
results viral myocarditis serum exosomes promoted cardiomyocyte apoptosis, and increased the level of bax while the level of bcl2 was decreased. |
2023-06-21 |
2023-08-14 |
mouse |
| Ju-Bin Kang, Murad-Ali Shah, Phil-Ok Ko. Neuroprotective effects of chlorogenic acid by controlling the Bcl-2 family protein in a stroke animal model. The Journal of veterinary medical science. 2023-06-21. PMID:37344388. |
bcl-2 and bcl-xl are proteins that inhibit apoptosis, and bax and bad induce apoptosis. |
2023-06-21 |
2023-08-14 |
rat |
| Hasan Aksit, Dilek Aksit, Eren Altu. Protective effects of scutellarin in experimental colitis in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-06-20. PMID:37337855. |
scutellarin suppressed apoptosis by down-regulation of bax, reduction of dna fragmentation and increased expression of bcl-2. |
2023-06-20 |
2023-08-14 |
rat |
| Changlun Chen, Yilin Liu, Yi Shen, Lili Zhu, Lumeng Yao, Xingxing Wang, Anna Zhang, Jiao Li, Jianjun Wu, Luping Qi. Rosmarinic acid, the active component of Rubi Fructus, induces apoptosis of SGC-7901 and HepG2 cells through mitochondrial pathway and exerts anti-tumor effect. Naunyn-Schmiedeberg's archives of pharmacology. 2023-06-20. PMID:37338574. |
the effect of ra on cell morphology and mobility was observed by inverted fluorescence microscopy, cell apoptosis and cell cycle were determined by flow cytometry, and the expression of apoptosis-related proteins cytochrome c, cleaved caspase-3, bax, and bcl-2 was detected by western blotting. |
2023-06-20 |
2023-08-14 |
Not clear |
| Changlun Chen, Yilin Liu, Yi Shen, Lili Zhu, Lumeng Yao, Xingxing Wang, Anna Zhang, Jiao Li, Jianjun Wu, Luping Qi. Rosmarinic acid, the active component of Rubi Fructus, induces apoptosis of SGC-7901 and HepG2 cells through mitochondrial pathway and exerts anti-tumor effect. Naunyn-Schmiedeberg's archives of pharmacology. 2023-06-20. PMID:37338574. |
the results revealed that, with an increase in the ra concentration, the cell viability, mobility, and bcl-2 expression decreased, while the apoptosis rate, bax, cytochrome c, and cleaved caspase-3 expression increased, and sgc-7901 and hepg2 cells could be induced to arrest their cell cycle in the g0/g1 and s phases, respectively. |
2023-06-20 |
2023-08-14 |
Not clear |
| Xuefeng Zhang, Zhikun Wang, Binbin Wang, Jingyi Li, Hui Yua. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333451. |
after the expression of oip5-as1 or mir-338-3p in interleukin (il)-1β-stimulated primary chondrocytes and chon-001 cells was manipulated, cell viability, proliferation, apoptosis rate, apoptosis-related protein (cleaved caspase-9, bax) expressions, extracellular matrix (ecm) (matrix metalloproteinase (mmp)-3, mmp-13, aggrecan, and collagen ii), pi3k/akt pathway, and mrna expressions of inflammatory factors (il-6 and il-8), oip5-as1, and mir-338-3p were determined by cell counting kit-8, edu, flow cytometry, western blot, and quantitative reverse transcription-polymerase chain reaction. |
2023-06-19 |
2023-08-14 |
Not clear |
| Xiaogang Huang, Xiongzhi He, Rongxian Qiu, Xuemei Xie, Fengfeng Zheng, Feihua Chen, Zhenting H. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333449. |
the expression levels of bmi1, kat2b, and proteins related to upr (p-eif2α, eif2α, atf4, and atf6), nf-κb (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-mlkl and mlkl) were determined by western blot. |
2023-06-19 |
2023-08-14 |
Not clear |
| Cong Liu, Qian Cao, Yueqin Chen, Xi Chen, Yujie Zhu, Zhonghua Zhang, Wei We. Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway. Journal of receptor and signal transduction research. 2023-06-18. PMID:37330920. |
moreover, rhein attenuated hg-induced apoptosis, evidenced by increase in bcl-2 level and decreases in the bax, caspase-3 expression. |
2023-06-18 |
2023-08-14 |
cat |
| Yi-Ru Pan, Chiao-En Wu, Shih-Ming Jung, Shih-Chiang Huang, Sheng-Hsuan Lin, Wen-Chi Chou, Yu-Chan Chang, Ming-Huang Chen, Tsai-Hsien Hung, Alice L Yu, Wen-Kuan Huang, Chun-Nan Ye. Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation. International journal of biological sciences. vol 19. issue 9. 2023-06-16. PMID:37324940. |
the muc4-akt axis induced bax s184 phosphorylation to inhibit apoptosis and downregulated gem transporter human equilibrative nucleoside transporter 1 (hent1) expression. |
2023-06-16 |
2023-08-14 |
human |
| Hong Qi, Yu-Song Yin, Zhi-Yong Yin, Xiang Li, Jian-Wei Shua. Mitochondrial outer membrane permeabilization and inner membrane permeabilization in regulating apoptosis and inflammation. Journal of theoretical biology. 2023-06-16. PMID:37327862. |
the model predicts that bax aggregation kinetic determines cells to undergo apoptosis or inflammation, and that modulating the inhibitory effect of caspase 3 on ifn-β production allows the concurrent occurrence of apoptosis and inflammation. |
2023-06-16 |
2023-08-14 |
Not clear |
| Francisco Javier Ramírez-Moreno, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, Luis Alberto Orozco-Hernández, José Manuel Orozco-Hernánde. Oxidative stress as regulator of neuronal impairment after exposure to hospital effluents in Danio rerio. The Science of the total environment. 2023-06-16. PMID:37327895. |
regarding gene expression, a significant disruption of genes related to antioxidant response (cat, sod, nrf2), apoptosis (casp6, bax, casp9), and detoxification (cyp1a1) was observed. |
2023-06-16 |
2023-08-14 |
cat |
| Sijing Zhao, Nan Jia, Zherui Shen, Caixia Pei, Demei Huang, Junling Liu, Yilan Wang, Shihua Shi, Xiaomin Wang, Mingjie Wang, Yacong He, Zhenxing Wan. Pretreatment with Notoginsenoside R1 attenuates high-altitude hypoxia-induced cardiac injury via activation of the ERK1/2-P90RSK-Bad signaling pathway in rats. Phytotherapy research : PTR. 2023-06-14. PMID:37313866. |
in addition, ng-r1 reduced cardiomyocyte apoptosis by down-regulating the expression of apoptotic proteins bax, cleaved caspase 3, cleaved caspase 9, and cleaved parp1 and up-regulating the expression of anti-apoptotic protein bcl-2 through activating the erk1/2-p90rsk-bad pathway. |
2023-06-14 |
2023-08-14 |
rat |