| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadia Naseer, Muhammad Munam Mustafa, Noreen Latief, Numan Fazal, Muhammad Tariq, Afshan Afreen, Faiza Yaqub, Sheikh Riazuddi. Sarcococca saligna fabricated gold nanoparticles alleviated in vitro oxidative stress and inflammation in human adipose-derived stem cells. Journal of biomedical materials research. Part B, Applied biomaterials. 2023-08-10. PMID:37560935. |
the anti-inflammatory conduct assessed through nf-κb pathway and other associated inflammatory markers reported down-regulation of tnf-α (0.644 ± 0.045), il-1β (0.694 ± 0.147) and il-6 (0.622 ± 0.112), apoptosis causing genes like caspase-3 (0.734 ± 0.13) and bax (0.830 ± 0.12), nf-κb pathway, p65 (0.672 ± 0.084) and p105 (0.539 ± 0.083) associated genes. |
2023-08-10 |
2023-08-16 |
human |
| Suchanoot Kutpruek, Kanchana Suksri, Petcharee Maneethorn, Namoiy Semprasert, Pa-Thai Yenchitsomanus, Suwattanee Kooptiwu. Imatinib prevents dexamethasone-induced pancreatic β-cell apoptosis via decreased TRAIL and DR5. Journal of cellular biochemistry. 2023-08-09. PMID:37555250. |
moreover, key effectors in the extrinsic and intrinsic apoptosis pathways, such as b-cell lymphoma 2 (bcl-2) associated x (bax), nuclear factor kappa b (nf-κb), p73, caspase 8, and caspase 9, were upregulated, while the antiapoptotic protein bcl-2 was downregulated. |
2023-08-09 |
2023-08-16 |
mouse |
| Ming Liu, Xu Zhou, Xiao-Jie Wang, Yong-Sheng Wang, Sheng-Ji Yang, Zhi-Ming Ding, Shou-Xin Zhang, Li-Dan Zhang, Ze-Qun Duan, Ai-Xin Liang, Li-Jun Hu. Curcumin alleviates bisphenol AF-induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway. Environmental toxicology. 2023-08-09. PMID:37555465. |
the results showed that bpaf induces significant effects on eecs, including decreased cell viability and mitochondrial membrane potential (△ψm), elevating intracellular reactive oxygen species (ros), promoting cell apoptosis through upregulating the expression of bax, cytochrome c, and downregulating the expression of bcl-2. |
2023-08-09 |
2023-08-16 |
Not clear |
| Ruini Peng, Fan Gao, Yunhai Hu, Kangli Li, Ben Liu, Wenya Zheng, Xue Yang, Wei Hu, Lucheng Zheng, Qingcan Fan, Manxin Fan. Effects of transport stress on the oxidative index, apoptosis and autophagy in the small intestine of caprine. BMC veterinary research. vol 19. issue 1. 2023-08-09. PMID:37559056. |
meanwhile, bcl-2, bax, lc3b, pink1 and parkin are important proteins that participate in pathological cell apoptosis and autophagy. |
2023-08-09 |
2023-08-16 |
cat |
| Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Amanda da Silva Chaves, Diego de Sá Coutinho, Nathalia Dos Santos Magalhães, Ana Carolina Arantes, Adriana Ribeiro Silva, Patricia Machado Rodrigues E Silva, Marco Aurélio Martins, Vinicius Frias Carvalh. Pro-resolving role of glucagon in lipopolysaccharide-induced mice lung neutrophilia. The Journal of endocrinology. 2023-08-08. PMID:37552528. |
intranasal treatment with glucagon, at the peak of neutrophilic inflammation, reduced the neutrophil number in the bronchoalveolar lavage (bal) and lung tissue within 24 h. the reduction of neutrophilic inflammation provoked by glucagon was accompanied by neutrophilia in the blood, an increase in the apoptosis rate of neutrophils in the bal, enhance in the pro-apoptotic bax protein expression, and decrease in the anti-apoptotic bcl-2 protein levels in the lung. |
2023-08-08 |
2023-08-14 |
mouse |
| Mengqi Wu, Jinhao Bian, Shuang Han, Cheng Zhang, Wenping Xu, Liming Tao, Zhong Li, Yang Zhan. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae. Chemosphere. 2023-08-07. PMID:37549743. |
the results of fluorescent staining experiments and the expression of cytochrome c, bcl-2 and bax demonstrated that pyraclostrobin induced mitochondrial dysfunction, resulting in cell apoptosis. |
2023-08-07 |
2023-08-14 |
human |
| Weiren Xiao, Shouren Chen, Jinzhuan Chen, Jianzhong Huan. Dexmedetomidine alleviates propofol-induced neural injury in developing rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-08-07. PMID:37550504. |
dexmedetomidine reduced propofol-induced cell apoptosis in the hippocampus and modulated the mrna expression of bcl-2 and bax. |
2023-08-07 |
2023-08-14 |
rat |
| Kai Zhang, Jianzhao Liao, Zhuoying Hu, Quanwei Li, Lianmei Hu, Jianying Guo, Ying Li, Hui Zhang, Jiaqiang Pan, Zhaoxin Tan. Mitochondria-mediated apoptosis and endoplasmic reticulum stress are involved in the toxicity induced by copper in the porcine spleen. Environmental science and pollution research international. 2023-08-05. PMID:37542695. |
furthermore, cu exposure could induce apoptosis, as demonstrated by the increased expression level of related proteins and genes bak, bax, caspase-3, p53, and cytc. |
2023-08-05 |
2023-08-14 |
Not clear |
| Shan Ren, Yuge Wang, Yanyan Zhang, Peimei Yan, Dan Xiao, Yu Zhao, Weiwei Jia, Lin Ding, Haiying Dong, Can Wei, Song Lin, Yan Li. Paeoniflorin alleviates AngII-induced cardiac hypertrophy in H9c2 cells by regulating oxidative stress and Nrf2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-05. PMID:37542855. |
furthermore, in angii-induced cardiomyocyte hypertrophy, paeoniflorin restores h9c2 apoptosis by restoring bax, bcl-2 cyt-c, caspase 3, and caspase 9 levels. |
2023-08-05 |
2023-08-14 |
cat |
| Qoyama Noel Baito, Halmat M Jaafar, Talar Ahmad Merza Mohamma. Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition. Cellular immunology. vol 391-392. 2023-08-03. PMID:37536000. |
moreover, piperine directly reduced the phosphorylation of nf-kb and the expression of nf-κb target genes related to ra-flss proliferation (c-myc and cycline d1), apoptosis inhibition (bcl2 and bcl-xl) and inflammation (cox2, il-1β, tnf-α,il-6, ccl5 and cxcl10) while increasing the expression of apoptosis related ones (bax) in vitro. |
2023-08-03 |
2023-08-14 |
Not clear |
| Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Ji. REG1A protects retinal photoreceptors from blue light damage. Annals of the New York Academy of Sciences. 2023-08-02. PMID:37531162. |
we demonstrate that regenerating islet-derived 1 alpha (reg1a) prevents photoreceptors from undergoing this ld-induced apoptosis by increasing expression of the anti-apoptotic gene bcl2 and downregulating expression of the pro-apoptotic gene bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. |
2023-08-02 |
2023-08-14 |
human |
| Haixi Zhang, Jie Zhao, Arunachalam Chinnathambi, Velmurugan Meganathan, Xuezhong G. Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells. Journal of biochemical and molecular toxicology. 2023-07-31. PMID:37519128. |
in the scp-car-ncs treated u266 cells, it was found that the bax, caspase-3, and -9 activities had increased while the bcl-2 level had decreased. in conclusion, our findings show that scp-car-ncs treatment reduced the viability and increased apoptosis in the u266 cells, providing a new insight on scp-car-ncs' potential for usage in the future to treat mm. |
2023-07-31 |
2023-08-14 |
Not clear |
| Vasudevan Mani, Bander Shehail Alshammer. Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511284. |
the elisa tests were executed with oxidative [malondialdehyde (mda), catalase, and reduced glutathione (gsh)], inflammatory [cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), and tumor necrosis factor-alpha (tnf-α)], and apoptosis [b-cell lymphoma 2 (bcl2), bcl2 associated x protein (bax), and caspase-3] markers were assessed in the brain homogenate to explore the related mechanisms. |
2023-07-29 |
2023-08-14 |
rat |
| Vasudevan Mani, Bander Shehail Alshammer. Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511284. |
by improving the bcl-2 level and reducing both bax and caspase-3 levels, it protected against neuronal apoptosis. |
2023-07-29 |
2023-08-14 |
rat |
| Lu Ying, Mingxuan Hao, Zichen Zhang, Rui Guo, Youfeng Liang, Changyuan Yu, Zhao Yan. Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma. Chemical biology & drug design. 2023-07-29. PMID:37515387. |
medicarpin suppresses proliferation and triggeres apoptosis by upregulation of bid, bax, casp3, casp8, and cycs in glioblastoma. |
2023-07-29 |
2023-08-14 |
Not clear |
| Pu Yang, Haiyan Chen, Tian Wang, Ling Li, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture Attenuates Chronic Inflammatory Pain And Depression Comorbidity by Inhibiting Hippocampal Neuronal Apoptosis via the PI3K/Akt Signaling Pathway. Neuroscience letters. 2023-07-29. PMID:37516346. |
moreover, ea intervention remarkably reduced neuronal apoptosis and exhibited an upregulation of bcl-2 protein expression accompanied by a decrease in bax expression. |
2023-07-29 |
2023-08-14 |
rat |
| Monica Susan, Ioana Macasoi, Iulia Pinzaru, Cristina Dehelean, Iosif Ilia, Razvan Susan, Ioana Ionit. In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells. Current oncology (Toronto, Ont.). vol 30. issue 7. 2023-07-28. PMID:37504320. |
the viability of cells, the impact on the morphology and nuclei of cells, the potential antimigratory effect, and the impact on the expression of the major genes associated with cell apoptosis (bcl-2, bax, bad), as well as caspases 3 and 8, were evaluated. |
2023-07-28 |
2023-08-14 |
Not clear |
| Monica Susan, Ioana Macasoi, Iulia Pinzaru, Cristina Dehelean, Iosif Ilia, Razvan Susan, Ioana Ionit. In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells. Current oncology (Toronto, Ont.). vol 30. issue 7. 2023-07-28. PMID:37504320. |
the results indicated that the two compounds exerted a synergistic effect, causing a reduction in cell viability accompanied by changes characteristic of the apoptosis process-the condensation of nuclei and the reorganization of actin filaments in cells, the reduction in the expression of the bcl-2 gene, and the increase in the expression of bax and bad genes, along with caspases 3 and 8. |
2023-07-28 |
2023-08-14 |
Not clear |
| Di Jia, Zhirong Huan, Jiahui Han, Ce Xu, Lijun Sui, Xin G. HSF1 enhances the attenuation of exosomes from mesenchymal stem cells to hemorrhagic shock induced lung injury by altering the protein profile of exosomes. International immunopharmacology. vol 123. 2023-07-28. PMID:37506505. |
hsf1-evs suppressed the hs-induced apoptosis of lung cell and downregulated bcl-2 expression, while promoting bax expression. |
2023-07-28 |
2023-08-14 |
mouse |
| Yiwen Hu, Mengcheng Li, Yongpeng Wang, Qingwang Xue, Xiaodong Luo, Afsar Khan, Tianrui Zhao, Yaping Liu, Zhengxuan Wang, Yudan Wang, Guiguang Chen. Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-28. PMID:37506865. |
moreover, afw and afe decreased the mda and ros accumulations via activating nrf2 pathway to increase the hepatic gsh contents and activities of sod, cat, ho-1, and nqo-1, reduced the levels of no, tnf-α, il-1β, and il-6 by suppressing the jnk/p38/erk/nf-κb pathways, and alleviated apoptosis via regulating bcl-2, bax, caspase-3/9 protein expressions. |
2023-07-28 |
2023-08-14 |
mouse |