| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
our subsequent validation via qpcr and western blot analyses confirmed the attenuation of grp78 and bcl-2, coupled with the upregulation of ire1, chop, jnk, p-jnk, and bax in don-induced cells, indicating the instigation of er stress-associated apoptosis by don. |
2023-09-22 |
2023-10-07 |
Not clear |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
the addition of 5 mm 4-phenylbutyric acid (4-pba), an er stress inhibitor, decreased levels of chop, ire1, jnk, p-jnk, and bax, while increasing levels of grp78 and bcl-2, suggesting that 4-pba alleviated don-induced er stress and apoptosis. |
2023-09-22 |
2023-10-07 |
Not clear |
| Syu-Ichi Kanno, Akiyoshi Har. Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-22. PMID:37739323. |
in mitochondria, dox (1 μm) induced structural damage (decreased membrane potential and release of cytochrome c), increased superoxide levels, decreased apoptosis inhibitor bcl-2, and increased apoptosis inducer bax, leading to apoptosis and reduced viability in h9c2 cells. |
2023-09-22 |
2023-10-07 |
human |
| Alexander V Sirotkin, Martina Macejková, Adam Tarko, Zuzana Fabova, Abdel Halim Harrat. Can some food/medicinal plants directly affect porcine ovarian granulosa cells and mitigate the toxic effect of toluene? Reproduction in domestic animals = Zuchthygiene. 2023-09-21. PMID:37732358. |
cell viability, proliferation (pcna accumulation), apoptosis (accumulation of bax) and release of progesterone (p) and oestradiol (e) were measured. |
2023-09-21 |
2023-10-07 |
Not clear |
| Renfeng Xu, Siting Shen, Defan Wang, Jianqing Ye, Shiting Song, Zhengchao Wang, Zhicao Yu. The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury. Journal of molecular histology. 2023-09-20. PMID:37728670. |
further analysis by tunel staining and western blotting found that ir induced the apoptosis in a dose-dependent manner as indicated by increased expressions of cleaved caspase3, p53 and bax on day 15 after ir treatment. |
2023-09-20 |
2023-10-07 |
mouse |
| Zheng Jun, Wang Lei, Fang Ce, Ren Wen Tao, Meng Xiang Hui, Qing Ci Na. NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species. Acta biochimica Polonica. 2023-09-18. PMID:37722070. |
knockdown of nox4 or inhibition of nox4 by gkt137831 both decreased generation of ros, and induced growth inhibition and apoptosis in sw1353, accompanied with the activation of caspases (caspase-3, caspase-8 and caspses-9), upregulation of bax, cytochrome c(cyt-c), cleaved-parp and down-regulation of bcl-2. |
2023-09-18 |
2023-10-07 |
mouse |
| Zheng Jun, Wang Lei, Fang Ce, Ren Wen Tao, Meng Xiang Hui, Qing Ci Na. NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species. Acta biochimica Polonica. 2023-09-18. PMID:37722070. |
meanwhile, gkt137831 induced growth inhibition and apoptosis in sw1353 xenograft animals, together with increased expression of bax, cyt-c, cleaved-parp, and decreased expression of bcl-2, p-akt, p-erk and p-p65. |
2023-09-18 |
2023-10-07 |
mouse |
| Xinyu Wang, Chao Yan, Chaoyun Wang, Xiaoyan Xu, Zhihao Liu, Wang Xin, Jianwei Gon. Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism. Brain research. 2023-09-18. PMID:37722469. |
cornuside also downregulated apoptosis regulatory proteins (bax, bcl-2, caspase-3, caspase-9, and cytochrome c) and cell cycle regulatory proteins (cyclin b1, cyclin e, and p21). |
2023-09-18 |
2023-10-07 |
rat |
| Yalda Hekmatshoar, Tulin Ozkan, Mehmet Alp, A Selen Gurkan-Alp, Asuman Sungurogl. Some 2-[4-(1H-benzimidazol-1-yl) phenyl]-1H-benzimidazole derivatives overcome imatinib resistance by induction of apoptosis and reduction of P-glycoprotein activity. Chemical biology & drug design. 2023-09-18. PMID:37722976. |
apoptosis induction, caspase3/7 activity were investigated with flow cytometry and bax, bim, and bad genes expression levels were analyzed with qrt-pcr. |
2023-09-18 |
2023-10-07 |
Not clear |
| Lara Scheherazade Milane, Saket Dolare, Guangwen Ren, Mansoor Amij. Combination Organelle Mitochondrial Endoplasmic Reticulum Therapy (COMET) for multidrug resistant breast cancer. Journal of controlled release : official journal of the Controlled Release Society. 2023-09-17. PMID:37717658. |
the therapeutic rationale of comet is to reduce the apoptotic threshold in mdr cells with mind nps, followed by inducing the endoplasmic reticulum mediated unfolded protein response (upr) by stressing mdr cells with tunicamycin, and finally, directly inducing mitochondrial apoptosis with bam 7 which is a specific bcl-2 bax activator. |
2023-09-17 |
2023-10-07 |
Not clear |
| Jiansheng Zhu, Mingtao Huang, Chunlan Liu, Jingyu Wang, Li Zou, Fan Yang, Renfei Zh. Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress. Ecotoxicology and environmental safety. vol 264. 2023-09-16. PMID:37716069. |
in addition, fen enhanced oxidative stress via excessive reactive oxygen species and antioxidant enzyme inhibition, then triggered apoptosis by upregulation of apoptotic genes (p53, bcl-2, bax and caspase 3). |
2023-09-16 |
2023-10-07 |
human |
| Zhuna Yan, Yan Zhang, Liang Du, Lei Liu, Han Zhou, Wencheng Son. U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells. Chemosphere. 2023-09-15. PMID:37714482. |
the flow cytometry with annexin-v/pi double labeling demonstrated that the rate of late apoptosis increased with the increase of u(vi) concentration, resulting in decreased bcl-2 expression and increased bax expression. |
2023-09-15 |
2023-10-07 |
human |
| Gan Rao, Baoxin Qiao, Gaolong Zhong, Tong Li, Qian Su, Shaofeng Wu, Zhaoxin Tang, Lianmei H. Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice. Environmental toxicology. 2023-09-14. PMID:37705229. |
psnps and as combination also triggered testicular apoptosis, containing changes in apoptotic factors (p53, bax, bcl-2, cytc, caspase-8, caspase-9, and caspase-3). |
2023-09-14 |
2023-10-07 |
mouse |
| Khalid Alhazzani, Meshal Alsahli, Ahmed Z Alanazi, Mohammad Algahtani, Ahmad A Alenezi, Ali Alhoshani, Mohammed Alqinyah, Abdullah S Alhamed, Khaled Alhosain. Augmented antitumor effects of erlotinib and cabozantinib on A549 non-small cell lung cancer: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 10. 2023-09-14. PMID:37705877. |
furthermore, mrna expression analyses for assessing apoptosis, metastasis, and cell cycle-related genes, the results showed that combination therapy significantly inhibits levels of bcl-2, mmp-9, vegf, and tgf-β while inducing p53, p21, and bax expression. |
2023-09-14 |
2023-10-07 |
Not clear |
| Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Ten. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. European journal of medicinal chemistry. vol 261. 2023-09-14. PMID:37708799. |
the results in vitro indicated that compounds 3g and 3j can induce mda-mb-231 cells apoptosis, and inhibit its migration and angiogenesis through influencing protein expression such as bcl-2, bax, bcl-xl, p38, mmp2, mmp9, akt and egfr. |
2023-09-14 |
2023-10-07 |
Not clear |
| Dongze Qin, Xiaotong F Jia, Anis Hanna, Jaehoon Lee, Ryan Pekson, John W Elrod, John W Calvert, Nikolaos G Frangogiannis, Richard N Kitsi. BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction. Journal of molecular and cellular cardiology. 2023-09-14. PMID:37709008. |
the canonical function of the pro-cell death bcl-2 family proteins bax and bak is to mediate permeabilization of the outer mitochondrial membrane during apoptosis allowing apoptogen release. |
2023-09-14 |
2023-10-07 |
mouse |
| Dongze Qin, Xiaotong F Jia, Anis Hanna, Jaehoon Lee, Ryan Pekson, John W Elrod, John W Calvert, Nikolaos G Frangogiannis, Richard N Kitsi. BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction. Journal of molecular and cellular cardiology. 2023-09-14. PMID:37709008. |
genetic deletion of bax or both bax and bak in mice reduces infarct size following reperfused myocardial infarction (mi/r), but the contribution of bak itself to cardiomyocyte apoptosis and necrosis and infarction has not been investigated. |
2023-09-14 |
2023-10-07 |
mouse |
| Fatemeh Sanie-Jahromi, Mohammad Sadegh Sanie Jahrom. In Vitro Effect of Propofol on the Expression of Genes Involved in Inflammation and Apoptosis in Corneal Activated Keratocytes. Cornea. 2023-09-13. PMID:37702602. |
we investigated the effect of propofol (0.5, 5, and 50 μm) on the gene expression of inflammatory cytokines [il-1β, il-6, transforming growth factor β (tgf-β), and lif] and apoptosis process (bcl-2 and bax) in corneal activated keratocytes (caks). |
2023-09-13 |
2023-10-07 |
Not clear |
| Mengyuan Zhou, Jingchao Qiang, Jiajie Gan, Xuhui Xu, Xing Li, Shuai Zhang, Baoshi Xu, Zibo Don. Quercetin attenuates environmental Avermectin-induced ROS accumulation and alleviates gill damage in carp through activation of the Nrf2 pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-09-13. PMID:37704162. |
meanwhile, que inhibited apoptosis in the gills of carp by decreasing the levels of bax, cytochrome c(cytoc), caspase9, cleaved-caspase3, and elevating bax. |
2023-09-13 |
2023-10-07 |
cat |
| Xingfei Huang, Yumeng Wang, Xingyao Li, Feng Yuan, Guangxin Zhou, Dali Men. Triterpenoids from Meehania fargesii with cytotoxic activity. Chemistry & biodiversity. 2023-09-12. PMID:37697440. |
western blot analysis revealed that these compounds activated apoptosis in hct116 cells by promoting the bax protein and inhibiting the bcl-2 protein. |
2023-09-12 |
2023-10-07 |
Not clear |