| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amina M Haroun, Wael M El-Sayed, Rasha E Hassa. Quercetin and L-Arginine Ameliorated the Deleterious Effects of Copper Oxide Nanoparticles on the Liver of Mice Through Anti-inflammatory and Anti-apoptotic Pathways. Biological trace element research. 2023-09-29. PMID:37775700. |
this copper accumulation increased oxidative stress, lipid peroxidation, inflammation, and apoptosis as manifested by elevation in malondialdehyde, nitric oxide, tumor necrosis factor-α, the expression level of caspase-3 and bax quantified by qpcr, and the activity of caspase-3, in addition to the reduction of superoxide dismutase activity. |
2023-09-29 |
2023-10-07 |
mouse |
| Carina Proença, Ana Teresa Rufino, Isabela Santos, Hélio M T Albuquerque, Artur M S Silva, Eduarda Fernandes, José Miguel P Ferreira de Oliveir. Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth. Antioxidants (Basel, Switzerland). vol 12. issue 9. 2023-09-28. PMID:37760046. |
apoptosis was also examined through the analysis of the bax expression and caspase-3 activity. |
2023-09-28 |
2023-10-07 |
human |
| Carina Proença, Ana Teresa Rufino, Isabela Santos, Hélio M T Albuquerque, Artur M S Silva, Eduarda Fernandes, José Miguel P Ferreira de Oliveir. Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth. Antioxidants (Basel, Switzerland). vol 12. issue 9. 2023-09-28. PMID:37760046. |
apoptosis was associated with enhanced caspase-3 activity and increased bax expression, indicating the involvement of the intrinsic pathway of apoptosis. |
2023-09-28 |
2023-10-07 |
human |
| Sheren A Al-Zahaby, Mayada R Farag, Mahmoud Alagawany, Heba S A Taha, Maria Vittoria Varoni, Giuseppe Crescenzo, Suzan Attia Mawe. Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760268. |
this induced a dramatically adverse effect on the cellular endoplasmic reticulum (er), revealed by higher chop protein expression, that suppresses the antioxidant effect of nrf2 and is followed by the induction of apoptosis via the up-regulation of bax expression and down-regulation of bcl-2 protein. |
2023-09-28 |
2023-10-07 |
zebrafish |
| Juanjuan Wei, Yurong Li, Zimao Ye, Yi Li, Zhiqin Zho. Citrus Carotenoid Extracts Exert Anticancer Effects through Anti-Proliferation, Oxidative Stress, and Mitochondrial-Dependent Apoptosis in MCF-7 Cells. Foods (Basel, Switzerland). vol 12. issue 18. 2023-09-28. PMID:37761178. |
apoptosis occurred through the mitochondrial-mediated pathway through the up-regulation of bax, caspase-3, and caspase-9 and the down-regulation of bcl-2. |
2023-09-28 |
2023-10-07 |
cat |
| De-Wei He, De-Zhao Liu, Xiao-Zhi Luo, Chuan-Bin Chen, Chuang-Hong Lu, Na Na, Feng Huan. HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice. Biological chemistry. 2023-09-28. PMID:37768929. |
then, we found that treatment with anti-hmgb1 or fps-zm1 performed the same effects in suppressing the autophagy and apoptosis, as reflected by the results of lower lamp2 and lc3b levels, increased bcl-2 level, reduced bax and caspase-3 levels. |
2023-09-28 |
2023-10-07 |
mouse |
| Yurim Jeong, Se Been Kim, Chae-Eun Yang, Min Seo Yu, Wan-Su Choi, Youngwoo Jeon, Jung-Yeon Li. Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt's lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib. Frontiers in oncology. vol 13. 2023-09-27. PMID:37752998. |
additionally, we investigated the underlying mechanisms of action and found that the combination therapy of ms1943 and ibrutinib led to the upregulation of mir29b-mediated p53-upregulated modulator of apoptosis puma, bax, cleaved parp, and cleaved caspase-3 in burkitt's lymphoma cells. |
2023-09-27 |
2023-10-07 |
Not clear |
| Kishan Das, Neelima Bhatt, Ajith Manayil Parambil, Kajal Kumari, Raj Kumar, Kamla Rawat, Paulraj Rajamani, Himadri B Bohidar, Ahmed Nadeem, Saravanan Muthupandian, Ramovatar Meen. Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core-Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis. Journal of functional biomaterials. vol 14. issue 9. 2023-09-27. PMID:37754862. |
increased cytochrome c levels, regulation of pro-apoptotic gene expression (e.g., p53, bax), and down-regulation of bcl-2 all suggested cellular apoptosis occurred via the intrinsic pathway. |
2023-09-27 |
2023-10-07 |
Not clear |
| Weichen Hong, Yuhao Liu, Jiatian Liang, Chunyu Jiang, Meijin Yu, Wei Sun, Bin Huang, Na Dong, Lu Kang, You Tan. Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis. Toxics. vol 11. issue 9. 2023-09-27. PMID:37755744. |
further, the anti-apoptotic gene bcl-2 decreased; on the contrary, four pro-apoptotic genes (p53, bax, cyt c, and caspase-3) increased under pb treatment, meaning that pb caused apoptosis via the p53-cyt c-caspase-3 pathway. |
2023-09-27 |
2023-10-07 |
chicken |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. Anti-apoptotic capacity of MALAT1 on hippocampal neurons correlates with CASP3 DNA methylation in a mouse model of autism. Metabolic brain disease. 2023-09-26. PMID:37751122. |
in vitro experiments reveal that reducing malat1 expression promotes the expression of casp3 and bax while suppressing bcl-2 expression, thereby enhancing cellular apoptosis. |
2023-09-26 |
2023-10-07 |
mouse |
| Lulu Li, Meichen Gao, Naixi Yang, Liwen Ai, Liyang Guo, Xuexue Xue, Zunlai Shen. Trimethyltin chloride induces apoptosis and DNA damage via ROS/NF-κB in grass carp liver cells causing immune dysfunction. Fish & shellfish immunology. 2023-09-25. PMID:37748585. |
furthermore, we observed an increase in cell apoptosis rate by ao/eb staining and cell flow cytometry, and the downregulation of bcl-2 and the upregulation of bax, cytc, caspase-9, and casp3 verified that tmt passed through the bcl2/bax/casp3 pathway induces apoptosis. |
2023-09-25 |
2023-10-07 |
cat |
| Yu Xia, Gaoran Ge, Haixiang Xiao, Mingzhou Wu, Tianhao Wang, Chengyong Gu, Huilin Yang, Dechun Gen. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. Cell death & disease. vol 14. issue 9. 2023-09-25. PMID:37749079. |
furthermore, the levels of bcl2 and bax, which play a key role in the mitochondrial apoptosis pathway, were affected. |
2023-09-25 |
2023-10-07 |
mouse |
| Yuying Guo, Xuejiao Li, Renbin Yuan, Jingming Ren, Yichi Huang, Hongqi Tia. Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment. Biochemical and biophysical research communications. vol 680. 2023-09-24. PMID:37742346. |
in addition, it can increase the expression of bax, reduce the expression of bcl-2 and caspase-3, a marker of apoptosis, which is beneficial to the survival of kidney cells. |
2023-09-24 |
2023-10-07 |
Not clear |
| Xing-Dong Chen, Jing-Xiang Wei, Hai-Yan Wang, Yu-Yuan Peng, Can Tang, Yang Ding, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats. Neuropharmacology. 2023-09-24. PMID:37742716. |
it was observed that sal protected against hippocampal neuronal apoptosis in ptsd rats by reducing the number of tunel-positive cells and modulating apoptosis-related proteins (bcl-2 and bax). |
2023-09-24 |
2023-10-07 |
rat |
| Yayun Chen, Qian Jiang, Furong Qing, Junxia Xue, Qiuxiang Xiao, Wenji He, Lina Sui, Zhiping Li. MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions. Inflammation. 2023-09-23. PMID:37740789. |
instead, mda5 exerted its influence on macrophages and kidneys by modulating the expression of noxa, bcl2, and bax, thereby promoting apoptosis. |
2023-09-23 |
2023-10-07 |
mouse |
| Negin Riazi-Tabrizi, Mohammad Khalaj-Kondori, Sahar Safaei, Mohammad Amini, Hamidreza Hassanian, Mohadeseh Maghsoudi, Shima Hasani, Behzad Baradara. NRF2 Suppression Enhances the Susceptibility of Pancreatic Cancer Cells, Miapaca-2 to Paclitaxel. Molecular biotechnology. 2023-09-23. PMID:37740817. |
finally, the expression of genes involved in apoptosis, bax, caspase-3, caspase-9, and genes related to migration pathway, mmp-2, and mmp-9 in different groups were measured using qrt-pcr. |
2023-09-23 |
2023-10-07 |
Not clear |
| Negin Riazi-Tabrizi, Mohammad Khalaj-Kondori, Sahar Safaei, Mohammad Amini, Hamidreza Hassanian, Mohadeseh Maghsoudi, Shima Hasani, Behzad Baradara. NRF2 Suppression Enhances the Susceptibility of Pancreatic Cancer Cells, Miapaca-2 to Paclitaxel. Molecular biotechnology. 2023-09-23. PMID:37740817. |
nrf2 suppression augmented the expression of bax, caspase-3, and caspase-9 genes and lowered the expression of bcl-2, mmp-2, and mmp-9 genes, which play crucial roles in the pathways of apoptosis and cell migration, respectively. |
2023-09-23 |
2023-10-07 |
Not clear |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Ho. Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis. Cell death & disease. vol 14. issue 9. 2023-09-22. PMID:37737207. |
mechanistically, the mitochondrial irg1 could associate and trap anti-apoptotic mcl-1 to inhibit the interaction between mcl-1 and pro-apoptotic bim, thus promoting bim activation and downstream bax mitochondrial translocation, and then releasing cytochrome c and initiating apoptosis. |
2023-09-22 |
2023-10-07 |
mouse |
| Zhihong Wang, Taifeng Li, Ruisheng Li, Bo Cao, Shiyuan Wang, Xiaofei Fei, Chunyu Li, Guohui L. Sijunzi Tang improves gefitinib resistance by regulating glutamine metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-22. PMID:37738796. |
notably, the co-administration of sjz and gefitinib synergistically promoted tumor cell apoptosis, potentially through the regulation of bax and bcl-2 expression. |
2023-09-22 |
2023-10-07 |
mouse |