| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonisamy William James, Ghaith A Bahader, Mohammad Albassan, Zahoor A Sha. The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. Neurochemistry international. 2023-07-16. PMID:37454816. |
in hyperglycemic conditions, bip protein expression was dramatically reduced in hmc3 cells, which led to increased apoptosis through the activation of chop and mitochondrial pro-apoptotic proteins (bax, bad, and cleaved caspase-3). |
2023-07-16 |
2023-08-14 |
mouse |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Lanlan Cheng, Yijing Xu, Yueming Long, Fangmei Yu, Li Gui, Qiu Zhang, Yunxia L. Liraglutide attenuates palmitate-induced apoptosis via PKA/β-catenin/Bcl-2/Bax pathway in MC3T3-E1 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-13. PMID:37439807. |
mc3t3-e1 cells were treated with different concentrations of pa, lrg, or pretreated with exendin 9-39 and h89, cell viability, intracellular reactive oxygen species (ros), camp levels, apoptosis and the expression of protein kinase a (pka) and phosphorylation of pka (p-pka), β-catenin and phosphorylation of β-catenin (ser675)(p-β-catenin), glp1r, cleaved-capase 3, bcl2-associated x protein (bax) and b-cell lymphoma-2 (bcl-2) along with expression of osteoprotegerin (opg) and receptor activator of nuclear factor-κb ligand (rankl) were evaluated. |
2023-07-13 |
2023-08-14 |
Not clear |
| Lanlan Cheng, Yijing Xu, Yueming Long, Fangmei Yu, Li Gui, Qiu Zhang, Yunxia L. Liraglutide attenuates palmitate-induced apoptosis via PKA/β-catenin/Bcl-2/Bax pathway in MC3T3-E1 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-13. PMID:37439807. |
pa treatment inhibited cell proliferation and camp levels, elevated intracellular ros levels and promoted apoptosis, increased protein expressions of rankl, bax and cleaved-caspase3, meanwhile decreased protein expression of opg and bcl-2 in a dose-dependent manner. |
2023-07-13 |
2023-08-14 |
Not clear |
| Lanlan Cheng, Yijing Xu, Yueming Long, Fangmei Yu, Li Gui, Qiu Zhang, Yunxia L. Liraglutide attenuates palmitate-induced apoptosis via PKA/β-catenin/Bcl-2/Bax pathway in MC3T3-E1 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-13. PMID:37439807. |
lrg inhibits pa-mediated apoptosis via glp1r-mediated pka/β-catenin/bcl-2/ bax pathway, while possibly enhances pa-inhibited differentiation by regulating the expression of opg and rankl. |
2023-07-13 |
2023-08-14 |
Not clear |
| Mona Dastgheib, Reza Falak, Maryam Vakilian Moghaddam, Gholamreza Hassanzadeh, Majid Safa, Asieh Hossein. Rolipram and pentoxifylline combination ameliorates the morphological abnormalities of dorsal root ganglion neurons in experimental diabetic neuropathy by reducing mitochondrial dysfunction and apoptosis. Journal of biochemical and molecular toxicology. 2023-07-11. PMID:37431890. |
rolipram and/or pentoxifylline treatment dramatically increased the camp level, prevented mitochondrial dysfunction, apoptosis and degeneration of drg neurons, which appears to be mediated by inducing atp and mmp, improving cytochrome c release, as well as regulating the expression of bax, bcl-2, and caspase-3 proteins, and improving morphological abnormalities of drg neurons. |
2023-07-11 |
2023-08-14 |
rat |
| Majid Ghorbani, Mohammad Soukhtanloo, Amir Salek Farrokhi, Seyed Mahdi Hassanian, Fatemeh Ghorbani, Amir Reza Afshari, Mohsen Taherian, Mohammad Hadi Sadeghia. Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines. Medical oncology (Northwood, London, England). vol 40. issue 8. 2023-07-11. PMID:37432498. |
auraptene induces cell cycle arrest the early and late phases of apoptosis by upregulation of bax and p53 proteins. |
2023-07-11 |
2023-08-14 |
Not clear |
| Papia Basuthakur, Arpita Roy, Chitta Ranjan Patra, Sumana Chakravart. Therapeutic potentials of terbium hydroxide nanorods for amelioration of hypoxia-reperfusion injury in cardiomyocytes. Biomaterials advances. vol 153. 2023-07-10. PMID:37429046. |
concurrently, thnr also exhibit apoptosis inhibitory effects mainly by suppression of pro-apoptotic proteins like cytochrome c, caspase 3, bax and p53 with simultaneous restoration of anti-apoptotic protein, bcl-2 and survivin. |
2023-07-10 |
2023-08-14 |
rat |
| Guangying Lu, Xuezhen Wang, Ming Cheng, Shijun Wang, Ke M. The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-09. PMID:37423169. |
pi3k/akt signaling pathway, jnk (cjun) signaling pathway, mitochondrial pathway, bcl-2 / bax signaling pathway, tgf-β/smad3 signaling pathway induced apoptosis of tumor cells and blocked emt process and mmp sdf1α/cxcr4 signaling pathway inhibits the metastasis and invasion of tumor cells, induces autophagy and affects tumor metabolic reprogramming to produce anti-tumor effects. |
2023-07-09 |
2023-08-14 |
Not clear |
| Lin-Lin Hu, Shun Chen, Meng-Ying Shen, Qiu-Yan Huang, Hong-Ge Li, Shao-Chen Sun, Jun-Li Wang, Xiao-Qiong Lu. Aflatoxin B1 impairs porcine oocyte quality via disturbing intracellular membrane system and ATP production. Ecotoxicology and environmental safety. vol 263. 2023-07-08. PMID:37421895. |
the oocytes under aflatoxin b1 exposure showed aberrant lysosome accumulation and higher lamp2 expression, a marker for lysosome membrane protection, and this might be due to the aberrant mitochondria function with low atp production and the increase of apoptosis, since we found that bax expression increased, and ribosomal protein which is also an apoptosis-related factor rps3 decreased. |
2023-07-08 |
2023-08-14 |
human |
| Heba M Mahmoud, Deiaa E Elsayed Abouzed, Amira M Abo-Youssef, Ramadan A M Hemeid. Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways. International immunopharmacology. vol 122. 2023-07-07. PMID:37418987. |
inflammatory cytokines, tumor necrosis factor alpha (tnf-α) and interleukin-33 (il-33), in addition to apoptosis biomarkers, bcl2 associated x protein (bax), b-cell lymphoma 2 (bcl2) and galactine-9 (gal9) proteins were also assessed. |
2023-07-07 |
2023-08-14 |
rat |
| Yun Teng, Zhige Li, Junsong Liu, Lesheng Teng, Hongdong L. Proliferation inhibition and apoptosis of liver cancer cells treated by blue light irradiation. Medical oncology (Northwood, London, England). vol 40. issue 8. 2023-07-06. PMID:37410177. |
the mechanism of apoptosis is related to the more production of reactive oxygen species (ros) induced by bl and the corresponding changes in the expression of apoptosis-related bcl-2, bax and bad proteins. |
2023-07-06 |
2023-08-14 |
human |
| Mohammadreza Dastouri, Nil Kilic, Humeyra Yilma. The apoptotic effects of NK-92 cells stimulated with an anti-CD226 antibody on MDA-MB-231 triple-negative breast cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 8. 2023-07-06. PMID:37410214. |
in addition, immunostaining was used to investigate the synthesis level of bax, casp3, and casp9 proteins to determine whether the observed cytotoxic effect was due to apoptosis. |
2023-07-06 |
2023-08-14 |
Not clear |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wan. CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway. European journal of pharmacology. 2023-07-05. PMID:37406849. |
also, ct2-3 downregulated the level of b-cell lymphoma-2 (bcl-2), and increased the level of bcl-2 associated x (bax), contributing to apoptosis of primary ra-flss and mh7a cells. |
2023-07-05 |
2023-08-14 |
Not clear |
| Rui Feng, Jieyu Liu, Zhao Yang, Tiantian Yao, Ping Ye, Xiuhan Li, Jiaxin Zhang, Hong Jian. Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis. Molecular neurobiology. 2023-07-03. PMID:37400749. |
its accumulation promotes neuronal apoptosis by upregulating the expression levels of bax and cleaved caspase-9, resulting in neurotoxicity. |
2023-07-03 |
2023-08-14 |
Not clear |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Meng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H Kaufmann, Jun Xiao, Haiming Da. Eltrombopag directly activates BAK and induces apoptosis. Cell death & disease. vol 14. issue 7. 2023-07-01. PMID:37393297. |
the thrombopoietin receptor agonist eltrombopag (eltro) inhibits bax activation and bax-mediated apoptosis. |
2023-07-01 |
2023-08-14 |
mouse |
| Yuhang Hong, Yi Huang, Yanzhen Dong, Dayong Xu, Qiang Huang, Zhiqiu Huan. Cytotoxicity induced by abamectin in hepatopancreas cells of Chinese mitten crab, Eriocheir sinensis: An in vitro assay. Ecotoxicology and environmental safety. vol 262. 2023-06-30. PMID:37390728. |
the up-regulation of the typical apoptosis-related protein bcl2-associated x protein (bax) and the down-regulation of b cell leukemia/lymphoma 2 (bcl-2) demonstrate apoptosis in hepatopancreas cells. |
2023-06-30 |
2023-08-14 |
cat |
| Yan Wang, Xiao-Bo Nie, Xia Jin, Jian-Ping Wang, Li-Hua Liu, Jiao Li. [Effect of Sparganii Rhizoma-Curcumae Rhizoma-medicated serum on proliferation, apoptosis, and migration of human ectopic endometrial stromal cells: based on JAK2/STAT3 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 12. 2023-06-29. PMID:37382003. |
the 10% sr-medicated serum, 10% cr-medicated serum, and 10% cm-medicated serum could increase the apoptosis rate(p<0.01), up-regulate the protein expression of caspase-3 and bax in cells(p<0.05 or p<0.01), down-regulate the expression of bcl-2(p<0.01), decrease the cell migration rate(p<0.05 or p<0.01), and reduce the secretion levels of il-1β, il-6, and tnf-α(p<0.05 or p<0.01), and levels of p-jak2 and p-stat3(p<0.05 or p<0.01). |
2023-06-29 |
2023-08-14 |
human |