| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaqi Wang, Jilang Tang, Xueqin Li, Xiaqing Ning, Chen Sun, Nuannuan Zhang, Shixia Zhan. Curcumin alleviates spleen immunotoxicity induced by decabrominated diphenyl ethers (BDE-209) by improving immune function and inhibiting inflammation and apoptosis in broilers. Ecotoxicology and environmental safety. vol 259. 2023-05-24. PMID:37224787. |
cur reduced bde-209-induced apoptosis by increasing the expression of the bcl-2 protein, decreasing the expression of cleaved caspase-3 and bax proteins, decreasing the bax/bcl-2 protein ratio, and decreasing the mean optical density of tunel. |
2023-05-24 |
2023-08-14 |
Not clear |
| Hasan Şimşek, Nurhan Akaras, Cihan Gür, Sefa Küçükler, Fatih Mehmet Kandemi. Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways. Gene. 2023-05-24. PMID:37224935. |
in addition, cd application caused apoptosis by increasing bax, apaf-1 and caspase-3 mrna transcripts and decreasing bcl-2 mrna transcript level. |
2023-05-24 |
2023-08-14 |
rat |
| Yoonhang Lee, HyeongJin Roh, Ahran Kim, Jiyeon Park, Ju-Yeop Lee, Yoon-Jae Kim, Yu-Ra Kang, Hyoyeong Kang, Suhkmann Kim, Heui-Soo Kim, Hee-Jae Cha, Yung Hyun Choi, Bo-Hye Nam, Chan-Il Park, Do-Hyung Ki. Molecular mechanisms underlying the vulnerability of Pacific abalone (Haliotis discus hannai) to Vibrio harveyi infection at higher water temperature. Fish & shellfish immunology. 2023-05-24. PMID:37225060. |
notably, in the apoptosis pathway, genes encoding executor caspases (casp3 and casp7) and pro-apoptotic factor, bax were significantly up-regulated only in the 25v group, while the apoptosis inhibitor, bcl2l1 was significantly up-regulated only in the 20v group compared to the control group at the respective temperatures. |
2023-05-24 |
2023-08-14 |
Not clear |
| Devaraj Ezhilarasa. Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms. Drug metabolism reviews. 2023-05-23. PMID:37218081. |
inf + rif treatments alter bcl-2 and bax homeostasis, mitochondrial membrane potential, and cytochrome c release, thereby triggering apoptosis. |
2023-05-23 |
2023-08-14 |
Not clear |
| Xinliang Wang, Chanjuan Yang, Yanrong Li, Qiang Gong, Yi Ru, Liangqi Xie, Baoguo Xiao, Xiaoming Jin, Cungen Ma, Zhi Chai, Huijie Fa. Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-05-22. PMID:37211717. |
our results demonstrated that wyp significantly reduced the incidence of ntds induced by atra; increased the activity of catalase (cat), superoxide dismutase (sod), glutathione peroxidase (gsh-px), and content of glutathione (gsh); decreased the apoptosis of neural tube cells; up-regulated the expression of phosphatidylinositol 3 kinase (pi3k), phospho protein kinase b (p-akt), nuclear factor erythroid-2 related factor (nrf2), and b-cell lymphoma-2 (bcl-2); and down-regulated the expression of bcl-2-associated x protein (bax). |
2023-05-22 |
2023-08-14 |
mouse |
| Youchao Zeng, Yongsu Xu, Yongjie Pan, Hong Gu. KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway. Tissue & cell. vol 82. 2023-05-21. PMID:37210762. |
as a result, the expression of klf10 was increased in ogd/r-induced hbmecs and downregulation of klf10 could promote the viability, migration and suppress the apoptosis, oxidative stress and endothelial permeability by downregulating the expression of caspase 3, bax, cleaved parp, ros, mda, and upregulating the expression of bcl-2, sod, gsh-px, zo-1, occludin, claudin-5. |
2023-05-21 |
2023-08-14 |
human |
| Qingmiao Li, Yongfu Chen, Xiaolin Zhao, Bocheng Lu, Tingli Qu, Li Tang, Qian Zhen. Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia by activating the mitochondrial pathway. PloS one. vol 18. issue 5. 2023-05-19. PMID:37205671. |
moreover, 24-oh-pd treatment increased the expression of bax and caspase family members, thereby releasing cytochrome c (cytc) and inducing apoptosis. |
2023-05-19 |
2023-08-14 |
mouse |
| Hanlin Luo, Yang Yang, Yanqiu Zhou, Xianyong Bai, Yun Ho. 1,4,5,6,7,8‑Hexahydropyrido[4,3‑d]pyrimidine inhibits HepG2 cell proliferation, migration and invasion, and induces apoptosis through the upregulation of miR‑26b‑5p by targeting CDK8. Oncology letters. vol 25. issue 6. 2023-05-19. PMID:37205919. |
flow cytometry results showed that ppm promoted apoptosis of hepg2 cells by upregulating mirna (mir)-26b-5p, and western blotting results showed that ppm promoted the expression of apoptosis-associated protein bax and inhibited the expression of bcl-2 by upregulating mir-26b-5p. |
2023-05-19 |
2023-08-14 |
Not clear |
| Liang Zhang, Shuxian Wang, Ying Zhang, Fenghuan Li, Chaoxiao Y. Sulforaphane alleviates lung ischemia‑reperfusion injury through activating Nrf‑2/HO‑1 signaling. Experimental and therapeutic medicine. vol 25. issue 6. 2023-05-19. PMID:37206558. |
in addition, sfn ameliorated i/r-induced lung apoptosis in rats by suppressing bax and cleaved caspase-3 levels and increased bcl-2 expression. |
2023-05-19 |
2023-08-14 |
rat |
| Bo Xiong, Lihua Chen, Yue Huang, Guanyu Lu, Cai Chen, Jiao Nong, Haida Pa. ZBTB16 eases lipopolysaccharide‑elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing GRK2 transcription. Experimental and therapeutic medicine. vol 25. issue 6. 2023-05-19. PMID:37206562. |
a tunel assay and western blotting were used to assess cell apoptosis and apoptosis-related markers, including bcl-2, bax and cleaved caspase-3. |
2023-05-19 |
2023-08-14 |
human |
| Jialin Zheng, Shijian Zhao, Qishi Yang, Yantao Wei, Jianmei Li, Tao Gu. Sympathetic Activation Promotes Cardiomyocyte Apoptosis in a Rabbit Susceptibility Model of Hyperthyroidism-Induced Atrial Fibrillation via the p38 MAPK Signaling Pathway. Critical reviews in eukaryotic gene expression. vol 33. issue 5. 2023-05-18. PMID:37199311. |
primary rabbit cardiomyocytes were cultured and identified by immunofluorescence staining, and terminal deoxynucleotidyl transferase dutp nick end labeling staining was used to measure cardiomyocyte apoptosis; western blot was used to detect the expression of apoptosis-related proteins, including bax, bcl-2, and cleaved caspase-3, as well as to measure the phosphorylation states of p38 mitogen-activated protein kinase (mapk) pathway proteins. |
2023-05-18 |
2023-08-14 |
rabbit |
| Yuhe Zhang, Yan Chen, Shushu Yuan, Qingxia Yu, Jianjiong Fu, Luyun Chen, Jiaming Liu, Yuping H. Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis. Experimental brain research. 2023-05-18. PMID:37199774. |
moreover, gas treatment increased the level of bcl-2 and decreased level of bax and ultimately inhibited neuronal apoptosis. |
2023-05-18 |
2023-08-14 |
mouse |
| Tao Wei, Jun-Da Li, Yu-Jing Wang, Wei Zhao, Fan Duan, Yan Wang, Ling-Ling Xia, Zhao-Bin Jiang, Xun Song, Yu-Qiong Zhu, Wen-Yi Shao, Ze Wang, Kang-Sheng Bi, Hui Li, Xiao-Chu Zhang, Dong-Liang Jia. p-Nrf2/HO-1 Pathway Involved in Methamphetamine-induced Executive Dysfunction through Endoplasmic Reticulum Stress and Apoptosis in the Dorsal Striatum. Neurotoxicity research. 2023-05-18. PMID:37199892. |
immunoblot analysis of nuclear factor-e2-related factor 2 (nrf2), phosphorylated nrf2 (p-nrf2), heme-oxygenase-1 (ho-1), glucose regulated protein 78(grp78), c/ebp homologous protein (chop), bcl-2, bax and caspase3 was performed to evaluate the levels of oxidative stress, endoplasmic reticulum (er) stress and apoptosis in the dorsal striatum (dstr). |
2023-05-18 |
2023-08-14 |
mouse |
| Magdalena Wronka, Julia Krzemińska, Ewelina Młynarska, Jacek Rysz, Beata Franczy. New Insights into the Use of Liraglutide-Impact on Cardiovascular Risk and Microvascular Outcomes. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189777. |
by reducing the generation of reactive oxygen species (ros), thereby affecting bax, bcl-2 protein levels, and restoring signaling pathways, liraglutide reduces oxidative stress, inflammation, and prevents endothelial cell apoptosis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Tao Zhou, Yuanyuan Zhang, Shilin Zheng, Fuhua Wang, Shengpan Jiang, Wenfeng Lei, Lili Xu, Yiqing Ta. hsa_circ_0051428 Facilitates the Progression of Thyroid Cancer by Sponging miR-1248 to Up-Regulate FN1. Critical reviews in eukaryotic gene expression. vol 33. issue 4. 2023-05-15. PMID:37183944. |
cell apoptosis was identified by the expression of apoptosis-related proteins (bax and bcl-2) using western blotting. |
2023-05-15 |
2023-08-14 |
Not clear |
| Wenyuan Zhang, Songjuan Zhuang, Hui Guan, Feng Li, Hui Zou, Dapeng L. New insights into the anti-apoptotic mechanism of natural polyphenols in complex with Bax protein. Journal of biomolecular structure & dynamics. 2023-05-15. PMID:37184126. |
bax is the major pro-apoptotic protein that disrupts the outer mitochondrial membrane to induce apoptosis, but limited studies have focused on the interaction between polyphenols and bax and the associated anti-apoptotic mechanisms, especially at the atomic level. |
2023-05-15 |
2023-08-14 |
Not clear |
| Fariborz Ahmadi, Abbas Sahebghadam Lotfi, Mona Navaei-Nigjeh, Mehdi Kadiva. Trimetazidine Preconditioning Potentiates the Effect of Mesenchymal Stem Cells Secretome on the Preservation of Rat Pancreatic Islet Survival and Function In Vitro. Applied biochemistry and biotechnology. 2023-05-15. PMID:37184724. |
insulin content, glucose-stimulated insulin secretion, islet cell apoptosis, and mrna expression of pro-apoptotic (bax, bak-1, and puma) and anti-apoptotic factors (bcl-2, bcl-xl, and xiap) in rat islets were assessed after 24 and 48 h of culture. |
2023-05-15 |
2023-08-14 |
rat |
| Yan Fu, Junzhe Zhang, Wenjie Cheng, Xingyu Cheng, Liqun Lu, Lang Gui, Yousheng Jiang, Ye Zhang, Dan X. miR-124 mediates the expression of ccBax to regulate Cyprinid herpesvirus 2 (CyHV-2)-induced apoptosis and viral replication. Journal of fish diseases. 2023-05-15. PMID:37186311. |
in this study, we revealed the molecular mechanism of mirna-mediated silver crucian carp bax (ccbax) in cyhv-2-induced apoptosis for the first time and demonstrated that the overexpression of mir-124 suppressed ccbax expression and significantly down-regulated apoptosis in caudal fin cells of carassius auratus gibelio (gicf), while mir-124 inhibitors were the opposite. |
2023-05-15 |
2023-08-14 |
Not clear |
| Su Jiang, Weijian Zhang, Xiaobin Qian, Jie Ji, Xianhui Ning, Fei Zhu, Shaowu Yin, Kai Zhan. Effects of hypoxia and reoxygenation on apoptosis, oxidative stress, immune response and gut microbiota of Chinese mitten crab, Eriocheir sinensis. Aquatic toxicology (Amsterdam, Netherlands). vol 260. 2023-05-14. PMID:37182272. |
moreover, the level of oxidative stress increased, which led to upregulated apoptosis rate and expression of apoptosis-related genes (caspase 3, caspase 8 and bax). |
2023-05-14 |
2023-08-14 |
cat |
| Francisco Javier Ramírez-Moreno, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores, Sandra García-Medina, José Félix Aguirre-Garrido, Luis Mario Hernández-Sot. A comprehensive approach to how hospital effluents lead to oxidative stress and shift the gene expression in target organs of Danio rerio. The Science of the total environment. 2023-05-13. PMID:37178842. |
upregulation of transcripts related to antioxidant processes (sod, cat, nrf2), detoxification (cyp1a1) and apoptosis (bax, casp6, and casp9) was observed in response to oxidative imbalance. |
2023-05-13 |
2023-08-14 |
cat |